UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     FORM 4

                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

[ ]  Check  this  box if no  longer  subject  to  Section  16.  Form 4 or Form 5
     obligations may continue.

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1. Name and Address of Reporting Person(s)


   Essig,            Stuart                   M.
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   (Last)            (First)              (Middle)

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   311 Enterprise Drive
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                                    (Street)

   Plainsboro,                  New Jersey                08536
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     (City)                      (State)                  (Zip)

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2. Issuer Name and Ticker or Trading Symbol


   Integra LifeSciences Holdings Corp. (IART)
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3. I.R.S. Identification Number of Reporting Person, if an entity (Voluntary)

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4. Statement for Month/Day/Year

   03/18/2003

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5. If Amendment, Date of Original (Month/Day/Year)

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6. Relationship of Reporting Person(s) to Issuer (Check all applicable)

   [X] Director                        [ ] 10% Owner
   [X] Officer (give title below)      [ ] Other (specify below)
   President and Chief Executive
   Officer

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7. Individual or Joint/Group Filing (Check Applicable Line)

   [X] Form filed by One Reporting Person
   [ ] Form filed by More than One Reporting Person
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Table I Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned - ------------------------------------------------------------------------------------------------------------------------------------ 1)Title of Security 2)Trans- 3.Trans- 4.Securities Acquired(A) 5)Amount of 6) 7)Nature of action action or Disposed of (D) Securities Indirect Date Code A Beneficially D Beneficial (Month/ or Owned at or Ownership Day/Year) Code V Amount D Price End of Month I - ------------------------------------------------------------------------------------------------------------------------------------ Common Stock 03/18/03 M 161,000 A $5.8750 D Direct Common Stock 03/18/03 S 161,000 D $22.0000 D Direct Common Stock 03/18/03 M 39,000 A $5.8750 D Direct Common Stock 03/18/03 S 39,000 D $22.0000 71,261 D Direct Table II (PART 1) Derivative Securities Acquired, Disposed of, or Beneficially Owned (Columns 1 through 6) - ------------------------------------------------------------------------------------------------------------------------------------ 1)Title of Derivative 2)Conversion 3)Trans- 4)Trans- 5)Number of Derivative 6)Date Exercisable and Security or Exercise action action Securities Acquired (A) Expiration Date Price of Date Code or Disposed of (D) Derivative Security Code V A D Exercisable Expiration - ------------------------------------------------------------------------------------------------------------------------------------ Non-Qualified Stock Option $5.8750 03/18/03 M 39,000 (1) 12/31/05 (right to buy) Non-Qualified Stock Option $5.8750 03/18/03 M 161,000 (1) 12/26/07 (right to buy) (2) Table II (PART 2) Derivative Securities Acquired, Disposed of, or Beneficially Owned (Columns 1,3 and 7 through 11) - ------------------------------------------------------------------------------------------------------------------------------------ 1)Title of Derivative 3)Trans- 7)Title and Amount 8)Price 9)Number of 10) 11)Nature of Security action of Underlying of Deri- Derivative Indirect Date Securities vative Securities D Beneficial Amount or Security Beneficially or Ownership Number of Owned at I - Title Shares End of Month - ------------------------------------------------------------------------------------------------------------------------------------ Non-Qualified Stock Option 03/18/03 Common Stock 39,000 1,875 D Direct (right to buy) Non-Qualified Stock Option 03/18/03 Common Stock 161,000 339,000 D Direct (right to buy) (2) Explanation of Responses: (1) 25% of the options vest one year after the grant date, with the remaining 75% vesting monthly thereafter over 36 months (2) Granted on December 27, 1997
SIGNATURE OF REPORTING PERSON /S/ Essig, Stuart M. DATE 03/18/03