SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE TO/A
                                (AMENDMENT NO. 1)

        TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR SECTION 13(E)(1)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
                                (Name of Issuer)

               INTEGRA LIFESCIENCES HOLDINGS CORPORATION (ISSUER)
 (Name of Filing Person (Identifying Status as Offeror, Issuer or Other Person))

            2 1/2% CONTINGENT CONVERTIBLE SUBORDINATED NOTES DUE 2008
                         (Title of Class of Securities)

                      (CUSIP NOS. 457985AA7 AND 457985AB5)
                      (CUSIP Number of Class of Securities)

                              MAUREEN B. BELLANTONI
              EXECUTIVE VICE PRESIDENT AND CHIEF FINANCIAL OFFICER
                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
                              311 ENTERPRISE DRIVE
                          PLAINSBORO, NEW JERSEY 08536
                                 (609) 275-0500

           (Name, Address and Telephone Number of Person Authorized to
      Receive Notices and Communications on Behalf of the Filing Person(s))

                                    COPY TO:
                              PETER LABONSKI, ESQ.
                              LATHAM & WATKINS LLP
                                885 THIRD AVENUE
                               NEW YORK, NY 10022
                                 (212) 906-1200


                            CALCULATION OF FILING FEE

TRANSACTION VALUATION*                               AMOUNT OF FILING FEE**
- ----------------------                              ------------------------
    $120,000,000                                            $12,840

*        Calculated  solely  for the  purpose of  determining  the amount of the
         filing fee, based upon the exchange of $120,000,000 aggregate principal
         amount of the Issuer's 2 1/2% Contingent Convertible Subordinated Notes
         due 2008 in exchange for Integra LifeSciences Holdings  Corporation's 2
         1/2% Contingent Convertible Subordinated Notes due 2008.

**       Previously paid.

[ ]      Check  box if any  part  of the fee is  offset  as  provided  by Rule
         0-11(a)(2)  and identify the filing with which the  offsetting  fee was
         previously paid. Identify the previous filing by registration statement
         number, or the form or schedule and the date of its filing.

  Amount Previously Paid:   Not applicable.      Filing party:   Not applicable.
  Form or Registration No.:   Not applicable.     Date Filed:   Not applicable.

[ ] Check the box if the filing  relates  solely to  preliminary  communications
made before the commencement of a tender offer.

Check the appropriate boxes below to designate any transactions to which the statement relates: [ ]third-party tender offer subject to Rule 14d-1 [X]issuer tender offer subject to Rule 13e-4 [ ]going private transaction subject to Rule 13e-3 [ ]amendment to Schedule 13D under Rule 13d-2 Check the following box if the filing is a final amendment reporting the results of the tender offer [ ] 2

This Amendment No. 1 to Schedule TO (this "Amendment") amends and supplements the Tender Offer Statement on Schedule TO ("Schedule TO") filed by Integra LifeSciences Holdings Corporation, a Delaware corporation, (the "Issuer") on July 17, 2006. This Amendment relates to the offer by the Issuer (i) to exchange $1,000 in principal amount of 2 1/2% Contingent Convertible Subordinated Notes due 2008 (the "New Notes") and (ii) a one time cash payment (an "Exchange Fee") equal to $2.50 for each $1,000 in principal amount of the Issuer's outstanding 2 1/2% Contingent Convertible Subordinated Notes due 2008 (the "Old Notes" and together with the New Notes, the "Notes") that is properly tendered and accepted for exchange upon the terms and subject to the conditions set forth in the Offer to Exchange (this "Offer to Exchange") and in the related Letter of Transmittal (the "Letter of Transmittal"), as each may be amended from time to time. The offer to exchange the Notes (including the payment of an Exchange Fee) pursuant to the Offer to Exchange is referred to herein as an "Offer." This Amendment amends and supplements Schedule TO as set forth below. This Amendment is filed to satisfy the reporting requirements of Rule 13e-4 under the Securities Exchange Act of 1934, as amended. The information in the Offer to Exchange and the related Letter of Transmittal, copies of which were previously filed on Schedule TO as exhibits (a)(1)(i) and (a)(1)(ii) thereto, is incorporated in this Amendment by reference, except that such information is hereby amended and supplemented to the extent specifically provided herein. INTRODUCTION (1) The final two sentences of the first paragraph of the Schedule TO are hereby deleted and replaced with the following: "The Offer is contingent upon the tender or exchange of at least 50% of the principal amount of Old Notes outstanding and the satisfaction of certain other conditions." ITEMS 1, 4, 6, 7 AND 11 Items 1, 4, 6, 7 and 11 of the Schedule TO, which incorporate by reference the information contained in the Offer to Exchange, are hereby amended and supplemented as follows: (2) The last sentence of the second paragraph on page 1 of the Offer to Exchange under the heading "Summary" is hereby deleted. (3) The first paragraph on page 5 of the Offer to Exchange under the heading "New Notes" is hereby amended and restated in its entirety as follows: The following summary contains basic information about the New Notes. For a complete understanding of the New Notes and before you decide whether to tender your Old Notes in the Offer, please refer to the section of this document entitled "Description of New Notes." For purposes of the description of the New Notes included in this Offer to Exchange, references to "the Company," "Integra," "us," "we," and "our" refer only to Integra LifeSciences Holdings Corporation and do not include our subsidiaries. (4) The first sentence of the last paragraph on page 6 of the Offer to Exchange under the heading "New Notes--Conversion Rights" is hereby amended and replaced in its entirety with the following: Upon conversion of each $1,000 principal amount of New Notes, you will receive: (a) cash and (b) common stock, determined in the manner set forth herein. 3

(5) On page 10 of the Offer to Exchange, the section entitled "Summary Comparison of the Old Notes and the New Notes" is hereby amended to add the following subsection under "--Maturity": Subordination........................ The Old Notes are unsecured, subordinated Same as the Old Notes. obligations of the Company. They rank junior in right of payment to all of the Company's existing and future senior indebtedness (as defined), and rank equally with all of our future subordinated indebtedness. The notes are also effectively subordinated to all existing and future indebtedness and other liabilities of our subsidiaries. Neither we nor our subsidiaries are restricted under the indenture from incurring senior debt or other additional indebtedness. (6) The disclosure in the New Notes column "Summary Comparison of the Old Notes and the New Notes--Conversion Price" on page 11 of the Offer to Exchange is hereby amended and replaced in its entirety with the following: Same as the Old Notes, except that, subject to certain exceptions described in "Description of New Notes," upon conversion of each $1,000 principal amount of New Notes, holders will receive cash and, if applicable, shares of our common stock in an amount determined in the manner set forth under "Description of New Notes--Payment Upon Conversion." The amount of cash and common stock payable will depend upon the value of our common stock over a 15 day observation period beginning on the third trading day after a holder delivers a notice of conversion. (7) The last sentence of the paragraph on page 31 of the Offer to Exchange under the heading "Selected Financial Information" is hereby deleted. (8) The first bullet under the heading "Important Reservation of Rights Regarding the Offer" on page 34 of the Offer to Exchange is hereby amended and restated in its entirety as follows: All questions as to the validity, form, eligibility, time of receipt and acceptance of Old Notes tendered for exchange, including the Letter of Transmittal and the instructions to such Letter of Transmittal, will be determined by us in our sole discretion and our determination shall be final and binding on all persons participating in the Offer, subject to such Offer participant's disputing such determination in a court of competent jurisdiction. (9) The penultimate bullet on page 35 of the Offer to Exchange under the heading "Important Reservation of Rights Regarding the Offer" is hereby amended and restated in its entirety as follows: We also reserve the absolute right to waive any defects or irregularities or conditions of the Offer as to any particular Old Notes, other than those conditions that are dependent upon the receipt of government approvals, before the Expiration Date. In the case of those conditions of the Offer that are dependent upon the receipt of government approvals, we reserve the absolute right to waive such conditions before or after the Expiration Date. 4

(10) The last sentence in the first paragraph under the heading "Legal Limitation" on page 36 of the Offer to Exchange is hereby deleted and replaced in its entirety with the following: Any determination by us concerning the conditions described above will be final and binding on all parties participating in the Offer, subject to such Offer participant's disputing such determination in a court of competent jurisdiction. (11) The penultimate paragraph on page 40 of the Offer to Exchange under the heading "Withdrawal of Tenders" is hereby amended and restated in its entirety as follows: All questions as to form and validity (including time of receipt) of any delivery or revocation of a tender will be determined by us, in our sole discretion, which determination will be final and binding on all persons participating in the Offer, subject to such Offer participant's disputing such determination in a court of competent jurisdiction. (12) The first full paragraph on page 48 of the Offer to Exchange is hereby amended to add the following sentence prior to the final sentence of the paragraph: At our option, we may issue one share of our common stock instead of paying cash in lieu of fractional shares. (13) The disclosure under the heading "Description of New Notes--Payment Upon Conversion" on page 48 of the Offer to Exchange is hereby amended and replaced in its entirety with the following: Upon conversion of a holder's New Note, we shall deliver, through the conversion agent, the following to such holder for each $1,000 principal amount of New Notes being converted, subject to our right to elect to pay the net share amount in cash: (1) cash equal to the sum of the daily cash amounts (as defined below), and (2) shares ("net shares") of common stock, if any, with a value equal to the sum of the daily share amounts (as defined below) (the "net share amount"), in each case for each of the 15 trading days during the related observation period. We shall deliver the foregoing on the third trading day immediately following the last day of the related observation period. The "observation period" with respect to any New Note converted means the 15 consecutive trading-day period beginning on and including the third trading day after a holder delivers a conversion notice to the conversion agent or, if the we have elected to pay the net share amount in cash, the trading day after the last day of the conversion retraction period. The "daily settlement amount," for each of the 15 trading days during the observation period, shall consist of: o cash (the "daily cash amount") equal to the lesser of $66.67 and the daily conversion value relating to such day; and o if such daily conversion value exceeds $66.67, a number of shares of common stock with a value (the "daily share amount") equal to (A) the difference between such daily conversion value and $66.67, divided by (B) the daily VWAP for such day. Instead of delivering shares of common stock in satisfaction of our obligation to deliver the net share amount upon conversion of Notes, we may elect to deliver an additional amount of cash. The amount shall be equal to the net share amount. 5

We will inform the holders through the trustee if we choose to satisfy our obligation to deliver the net share amount upon conversion with additional cash no later than two trading days following the conversion date. If we do not give any notice within the time periods described as to how we intend to settle, we will satisfy our obligation to deliver the net share amount only in shares of common stock (and cash in lieu of fractional shares). We will treat in the same manner all holders converting on the same trading day. Subject to the foregoing, we will not, however, have any obligation to settle our conversion obligations arising on different trading days in the same manner. For holders converting on any trading day, we may choose to settle the net share amount in cash and shares of common stock only and for holders converting on another trading day, choose to settle exclusively in cash. If we elect to satisfy any portion of our obligation to deliver the net share amount in cash (other than cash in lieu of fractional shares), holders may retract their conversion notice at any time during the three trading day period beginning on the trading day after we have notified the trustee of our method of settlement. The "daily conversion value" means, for each of the 15 consecutive trading days during the observation period, one-fifteenth (1/15) of the product of (1) conversion rate on such day and (2) the daily VWAP of common stock (or the value of the securities into which common stock has been converted) for such day. The "daily VWAP" for the common stock means, for each of the 15 consecutive trading days during the observation period, the per share volume-weighted average price as displayed under the heading "Bloomberg VWAP" on Bloomberg page IART [EQUITY] AQR in respect of the period from 9:30 a.m. to 4:00 p.m. (New York City time) on such trading day (or if such volume-weighted average price is unavailable, the market value of one share of common stock on such trading day as the board of directors determines in good faith using a volume-weighted method, which determination shall be conclusive). (14) The last sentence in the paragraph under the heading "Calculations in Respect of New Notes" on page 56 of the Offer to Exchange is hereby amended and restated in its entirety as follows: We will make all these calculations in good faith and, absent manifest error, our calculations will be final and binding on holders of New Notes, subject to such holder's disputing such calculation in a court of competent jurisdiction. (15) The penultimate and last sentences of the first paragraph on page 58 of the Offer to Exchange under the heading "Description of Capital Stock" are hereby deleted. (16) The third sentence of the third paragraph on page 71 of the Offer to Exchange under the heading "Where You Can Find More Information" is hereby deleted. (17) The second bullet on page 71 of the Offer to Exchange under the heading "Where You Can Find More Information" is hereby amended and restated in its entirety as follows: Current Reports on Form 8-K filed on January 9, 2006, January 17, 2006, March 8, 2006 (as amended on May 12, 2006), March 10, 2006, April 13, 2006, April 25, 2006, May 17, 2006 (as amended on July 28, 2006), July 7, 2006, July 14, 2006 and July 17, 2006; and ITEM 12. EXHIBITS. Item 12 of the Schedule TO is hereby amended and supplemented by adding the following exhibits: 6

(a)(i)(vi) Supplement to Offer to Exchange, dated July 31, 2006. (a)(5)(ii) Press Release, dated July 31, 2006. Letter of Transmittal (1) The first sentence of the second paragraph under "Item 8. No Conditional Tenders" on page 14 of the Letter of Transmittal is hereby amended and restated in its entirety as follows: The Company will determine, in its sole discretion, all questions as to the form, validity, eligibility (including time of receipt) and acceptance for exchange of any tender of Old Notes, which determination will be final and binding on all persons participating in the Offer, subject to such Offer participant's disputing such determination in a court of competent jurisdiction. (2) The third sentence of the second paragraph under "Item 8. No Conditional Tenders" on page 14 of the Letter of Transmittal is hereby amended and restated in its entirety as follows: The Company also reserves the absolute right, in its sole discretion, to waive any defects or irregularities or conditions of the Offer as to any particular Old Notes, other than those dependent upon the receipt of government approvals, before the Expiration Date (including the right to waive the ineligibility of any Holder who seeks to tender Old Notes in the Offer). In the case of those conditions of the Offer that are dependent upon the receipt of government approvals, the Company reserves the absolute right to waive such conditions before or after the Expiration Date. (3) The third to last sentence of the second paragraph under "Item 8. No Conditional Tenders" on page 14 of the Letter of Transmittal is hereby amended and restated in its entirety as follows: The interpretation of the terms and conditions of the Offer as to any particular Old Notes either before or after the Expiration Date (including the Letter of Transmittal and the instructions thereto) by the Company shall be final and binding on all parties participating in the Offer, subject to such Offer participant's disputing such interpretation in a court of competent jurisdiction. (4) The third sentence of the first paragraph on page 18 of the Letter of Transmittal is hereby amended and restated in its entirety as follows: All questions as to the validity, form and eligibility (including time of receipt) of such notices will be determined by the Company, whose determination shall be final and binding on all parties participating in the Offer, subject to such Offer participant's disputing such determination in a court of competent jurisdiction. (5) The first sentence of the final paragraph of "Item 10. Withdrawal of Tenders" on page 15 of the Letter of Transmittal is hereby and amended and restated in its entirety as follows: All questions as to form and validity (including time of receipt) of any delivery or revocation of a tender will be determined by the Company, in its sole discretion, which determination will be final and binding on all parties participating in the Offer, subject to such Offer participant's disputing such determination in a court of competent jurisdiction. 7

SIGNATURE After due inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Dated: July 31, 2006 INTEGRA LIFESCIENCES HOLDINGS CORPORATION By: /s/ MAUREEN B. BELLANTONI -------------------------------- Name: Maureen B. Bellantoni Title: Executive Vice President and Chief Financial Officer 8

EXHIBIT INDEX EXHIBIT NUMBER DESCRIPTION - -------- ------------ (a)(1)(i) Offer to Exchange, dated July 17, 2006.* (a)(1)(ii) Letter of Transmittal.* (a)(1)(iii) Notice of Guaranteed Delivery.* (a)(1)(iv) Letter to Brokers, Dealers, Commercial Banks, Trust Companies and Other Nominees.* (a)(1)(v) Letter to Clients for use by Brokers, Dealers, Commercial Banks, Trust Companies and Other Nominees.* (a)(1)(vi) Supplement to Offer to Exchange, dated July 31, 2006. (a)(5)(i) Press Release, dated July 17, 2006.* (a)(5)(ii) Press Release, dated July 31, 2006. * Previously filed. 9

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION

                         SUPPLEMENT TO OFFER TO EXCHANGE

            2 1/2% CONTINGENT CONVERTIBLE SUBORDINATED NOTES DUE 2008

                           FOR ANY AND ALL OUTSTANDING

            2 1/2% CONTINGENT CONVERTIBLE SUBORDINATED NOTES DUE 2008

                      (CUSIP NOS. 457985AA7 AND 457985AB5)

THE OFFER WILL  EXPIRE AT 5:00 P.M.,  NEW YORK CITY  TIME,  ON AUGUST 14,  2006,
UNLESS  EXTENDED OR EARLIER  TERMINATED  (SUCH TIME AND DATE, AS THE SAME MAY BE
EXTENDED OR EARLIER  TERMINATED,  THE "EXPIRATION  DATE").  HOLDERS OF OLD NOTES
MUST TENDER,  AND NOT WITHDRAW,  THEIR OLD NOTES PRIOR TO THE EXPIRATION DATE TO
BE ELIGIBLE TO EXCHANGE THEIR OLD NOTES FOR NEW NOTES (AS DESCRIBED BELOW).

         This Supplement to the Offer to Exchange (this "Supplement") amends and
supplements  the Offer to Exchange and related Letter of Transmittal  dated July
17,  2006 (the "Offer to  Exchange"),  pursuant  to which  Integra  LifeSciences
Holdings  Corporation,  a Delaware  corporation  ("Integra"  or the  "Company"),
offered  (i) to  exchange  $1,000  in  principal  amount  of 2  1/2%  Contingent
Convertible  Subordinated  Notes due 2008 (the "New  Notes") and (ii) a one time
cash  payment (an  "Exchange  Fee") equal to $2.50 for each $1,000 in  principal
amount of our outstanding 2 1/2% Contingent  Convertible  Subordinated Notes due
2008 (the "Old Notes" and  together  with the New Notes,  the  "Notes")  that is
properly  tendered and  accepted for exchange  upon the terms and subject to the
conditions  set  forth in the  Offer to  Exchange,  this  Supplement  and in the
related  Letter of  Transmittal  (the  "Letter  of  Transmittal").  The offer to
exchange the Notes  (including  the payment of an Exchange  Fee) pursuant to the
Offer to Exchange and this  Supplement  is referred to herein as an "Offer." The
Offer is contingent upon the tender or exchange of at least 50% of the principal
amount  of  Old  Notes   outstanding  and  the  satisfaction  of  certain  other
conditions.

         The Offer will expire at 5:00 p.m.,  New York City time,  on August 14,
2006 unless extended by the Company and subject to the right of the Company,  in
its sole discretion,  subject to applicable law, to terminate, withdraw or amend
the Offer at any time as  discussed  below.  Any  extension of the Offer will be
announced by press  release no later than 9:00 a.m.  New York City time,  on the
next Nasdaq  Global  Select Market  trading day after the  previously  scheduled
Expiration Date.

         Any questions or requests for  assistance  concerning  the Offer may be
directed to Georgeson Inc.  (referred to herein as the  "Information  Agent") at
the address and telephone number set forth on the back cover of this Supplement.
Requests for additional  copies of the Offer to Exchange,  any supplements,  the
Letter of  Transmittal  or any other  related  documents  may be directed to the
Information  Agent at the  address and  telephone  numbers set forth on the back
cover of this  Supplement.  Beneficial  owners may also  contact  their  broker,
dealer,   commercial  bank,  trust  company  or  other  nominee  for  assistance
concerning the Offer.

                     The Information Agent for the Offer is:

                                 Georgeson Inc.
                          17 State Street - 10th Floor
                               New York, NY 10004
                     Banks and Brokers Call: (212) 440-9800
                    All Others Call Toll Free: (866) 482-4943






July 31, 2006



Integra is amending and supplementing the Offer to Exchange and the related Letter of Transmittal. The following information supplements, amends and revises the information provided in the Offer to Exchange and therefore should be read carefully in conjunction with the Offer to Exchange and the related Letter of Transmittal. (1) The last sentence of the second paragraph on page 1 of the Offer to Exchange under the heading "Summary" is hereby deleted. (2) The first paragraph on page 5 of the Offer to Exchange under the heading "New Notes" is hereby amended and restated in its entirety as follows: The following summary contains basic information about the New Notes. For a complete understanding of the New Notes and before you decide whether to tender your Old Notes in the Offer, please refer to the section of this document entitled "Description of New Notes." For purposes of the description of the New Notes included in this Offer to Exchange, references to "the Company," "Integra," "us," "we," and "our" refer only to Integra LifeSciences Holdings Corporation and do not include our subsidiaries. (3) The first sentence of the last paragraph on page 6 of the Offer to Exchange under the heading "New Notes--Conversion Rights" is hereby amended and replaced in its entirety with the following: Upon conversion of each $1,000 principal amount of New Notes, you will receive: (a) cash and (b) common stock, determined in the manner set forth herein. (4) On page 10 of the Offer to Exchange, the section entitled "Summary Comparison of the Old Notes and the New Notes" is hereby amended to add the following subsection under "--Maturity": Subordination........................ The Old Notes are unsecured, subordinated Same as the Old Notes. obligations of the Company. They rank junior in right of payment to all of the Company's existing and future senior indebtedness (as defined), and rank equally with all of our future subordinated indebtedness. The notes are also effectively subordinated to all existing and future indebtedness and other liabilities of our subsidiaries. Neither we nor our subsidiaries are restricted under the indenture from incurring senior debt or other additional indebtedness.

(5) The disclosure in the New Notes column "Summary Comparison of the Old Notes and the New Notes--Conversion Price" on page 11 of the Offer to Exchange is hereby amended and replaced in its entirety with the following: Same as the Old Notes, except that, subject to certain exceptions described in "Description of New Notes," upon conversion of each $1,000 principal amount of New Notes, holders will receive cash and, if applicable, shares of our common stock in an amount determined in the manner set forth under "Description of New Notes--Payment Upon Conversion." The amount of cash and common stock payable will depend upon the value of our common stock over a 15 day observation period beginning on the third trading day after a holder delivers a notice of conversion. (6) The last sentence of the paragraph on page 31 of the Offer to Exchange under the heading "Selected Financial Information" is hereby deleted. (7) The first bullet under the heading "Important Reservation of Rights Regarding the Offer" on page 34 of the Offer to Exchange is hereby amended and restated in its entirety as follows: All questions as to the validity, form, eligibility, time of receipt and acceptance of Old Notes tendered for exchange, including the Letter of Transmittal and the instructions to such Letter of Transmittal, will be determined by us in our sole discretion and our determination shall be final and binding on all persons participating in the Offer, subject to such Offer participant's disputing such determination in a court of competent jurisdiction. (8) The penultimate bullet on page 35 of the Offer to Exchange under the heading "Important Reservation of Rights Regarding the Offer" is hereby amended and restated in its entirety as follows: We also reserve the absolute right to waive any defects or irregularities or conditions of the Offer as to any particular Old Notes, other than those conditions that are dependent upon the receipt of government approvals, before the Expiration Date. In the case of those conditions of the Offer that are dependent upon the receipt of government approvals, we reserve the absolute right to waive such conditions before or after the Expiration Date. (9) The last sentence in the first paragraph under the heading "Legal Limitation" on page 36 of the Offer to Exchange is hereby deleted and replaced in its entirety with the following: Any determination by us concerning the conditions described above will be final and binding on all parties participating in the Offer, subject to such Offer participant's disputing such determination in a court of competent jurisdiction. (10) The penultimate paragraph on page 40 of the Offer to Exchange under the heading "Withdrawal of Tenders" is hereby amended and restated in its entirety as follows: All questions as to form and validity (including time of receipt) of any delivery or revocation of a tender will be determined by us, in our sole discretion, which determination will be final and binding on all persons participating in the Offer, subject to such Offer participant's disputing such determination in a court of competent jurisdiction.

(11) The first full paragraph on page 48 of the Offer to Exchange is hereby amended to add the following sentence prior to the final sentence of the paragraph: At our option, we may issue one share of our common stock instead of paying cash in lieu of fractional shares. (12) The disclosure under the heading "Description of New Notes--Payment Upon Conversion" on page 48 of the Offer to Exchange is hereby amended and replaced in its entirety with the following: Upon conversion of a holder's New Note, we shall deliver, through the conversion agent, the following to such holder for each $1,000 principal amount of New Notes being converted, subject to our right to elect to pay the net share amount in cash: (1) cash equal to the sum of the daily cash amounts (as defined below), and (2) shares ("net shares") of common stock, if any, with a value equal to the sum of the daily share amounts (as defined below) (the "net share amount"), in each case for each of the 15 trading days during the related observation period. We shall deliver the foregoing on the third trading day immediately following the last day of the related observation period. The "observation period" with respect to any New Note converted means the 15 consecutive trading-day period beginning on and including the third trading day after a holder delivers a conversion notice to the conversion agent or, if the we have elected to pay the net share amount in cash, the trading day after the last day of the conversion retraction period. The "daily settlement amount," for each of the 15 trading days during the observation period, shall consist of: o cash (the "daily cash amount") equal to the lesser of $66.67 and the daily conversion value relating to such day; and o if such daily conversion value exceeds $66.67, a number of shares of common stock with a value (the "daily share amount") equal to (A) the difference between such daily conversion value and $66.67, divided by (B) the daily VWAP for such day. Instead of delivering shares of common stock in satisfaction of our obligation to deliver the net share amount upon conversion of Notes, we may elect to deliver an additional amount of cash. The amount shall be equal to the net share amount. We will inform the holders through the trustee if we choose to satisfy our obligation to deliver the net share amount upon conversion with additional cash no later than two trading days following the conversion date. If we do not give any notice within the time periods described as to how we intend to settle, we will satisfy our obligation to deliver the net share amount only in shares of common stock (and cash in lieu of fractional shares). We will treat in the same manner all holders converting on the same trading day. Subject to the foregoing, we will not, however, have any obligation to settle our conversion obligations arising on different

trading days in the same manner. For holders converting on any trading day, we may choose to settle the net share amount in cash and shares of common stock only and for holders converting on another trading day, choose to settle exclusively in cash. If we elect to satisfy any portion of our obligation to deliver the net share amount in cash (other than cash in lieu of fractional shares), holders may retract their conversion notice at any time during the three trading day period beginning on the trading day after we have notified the trustee of our method of settlement. The "daily conversion value" means, for each of the 15 consecutive trading days during the observation period, one-fifteenth (1/15) of the product of (1) conversion rate on such day and (2) the daily VWAP of common stock (or the value of the securities into which common stock has been converted) for such day. The "daily VWAP" for the common stock means, for each of the 15 consecutive trading days during the observation period, the per share volume-weighted average price as displayed under the heading "Bloomberg VWAP" on Bloomberg page IART [EQUITY] AQR in respect of the period from 9:30 a.m. to 4:00 p.m. (New York City time) on such trading day (or if such volume-weighted average price is unavailable, the market value of one share of common stock on such trading day as the board of directors determines in good faith using a volume-weighted method, which determination shall be conclusive). (13) The last sentence in the paragraph under the heading "Calculations in Respect of New Notes" on page 56 of the Offer to Exchange is hereby amended and restated in its entirety as follows: We will make all these calculations in good faith and, absent manifest error, our calculations will be final and binding on holders of New Notes, subject to such holder's disputing such calculation in a court of competent jurisdiction. (14) The penultimate and last sentences of the first paragraph on page 58 of the Offer to Exchange under the heading "Description of Capital Stock" are hereby deleted. (15) The third sentence of the third paragraph on page 71 of the Offer to Exchange under the heading "Where You Can Find More Information" is hereby deleted. (16) The second bullet on page 71 of the Offer to Exchange under the heading "Where You Can Find More Information" is hereby amended and restated in its entirety as follows: Current Reports on Form 8-K filed on January 9, 2006, January 17, 2006, March 8, 2006 (as amended on May 12, 2006), March 10, 2006, April 13, 2006, April 25, 2006, May 17, 2006 (as amended on July 28, 2006), July 7, 2006, July 14, 2006 and July 17, 2006; and (17) The first sentence of the second paragraph under "Item 8. No Conditional Tenders" on page 14 of the Letter of Transmittal is hereby amended and restated in its entirety as follows: The Company will determine, in its sole discretion, all questions as to the form, validity, eligibility (including time of receipt) and acceptance for exchange of any tender of Old Notes, which determination will be final and binding on all persons participating in the Offer, subject to such Offer participant's disputing such determination in a court of competent jurisdiction.

(18) The third sentence of the second paragraph under "Item 8. No Conditional Tenders" on page 14 of the Letter of Transmittal is hereby amended and restated in its entirety as follows: The Company also reserves the absolute right, in its sole discretion, to waive any defects or irregularities or conditions of the Offer as to any particular Old Notes, other than those dependent upon the receipt of government approvals, before the Expiration Date (including the right to waive the ineligibility of any Holder who seeks to tender Old Notes in the Offer). In the case of those conditions of the Offer that are dependent upon the receipt of government approvals, the Company reserves the absolute right to waive such conditions before or after the Expiration Date. (19) The third to last sentence of the second paragraph under "Item 8. No Conditional Tenders" on page 14 of the Letter of Transmittal is hereby amended and restated in its entirety as follows: The interpretation of the terms and conditions of the Offer as to any particular Old Notes either before or after the Expiration Date (including the Letter of Transmittal and the instructions thereto) by the Company shall be final and binding on all parties participating in the Offer, subject to such Offer participant's disputing such interpretation in a court of competent jurisdiction. (20) The third sentence of the first paragraph on page 18 of the Letter of Transmittal is hereby amended and restated in its entirety as follows: All questions as to the validity, form and eligibility (including time of receipt) of such notices will be determined by the Company, whose determination shall be final and binding on all parties participating in the Offer, subject to such Offer participant's disputing such determination in a court of competent jurisdiction. (21) The first sentence of the final paragraph of "Item 10. Withdrawal of Tenders" on page 15 of the Letter of Transmittal is hereby and amended and restated in its entirety as follows: All questions as to form and validity (including time of receipt) of any delivery or revocation of a tender will be determined by the Company, in its sole discretion, which determination will be final and binding on all parties participating in the Offer, subject to such Offer participant's disputing such determination in a court of competent jurisdiction. Integra has filed an amendment to the Tender Offer Statement on Schedule TO (as amended, "Schedule TO") with the SEC furnishing the above information and may file further amendments thereto with respect to the Offer. The Schedule TO and any and all amendments thereto, including exhibits, may be examined and copies may be obtained from the SEC in the manner described on page 71 of the Offer to Exchange under the section entitled "Where You Can Find More Information." Except as modified by this Supplement and any amendments to Schedule TO, the terms and conditions set forth in the Offer to Exchange remain applicable in all respects to the Offer, and this Supplement should be read in conjunction with the Offer to Exchange and the related Letter of Transmittal. To obtain additional copies of the Offer to Exchange or any supplements, please contact the Information Agent. Any questions about the Offer or procedures for accepting the Offer may be directed to the Information Agent.

The Information Agent for the Offer is: Georgeson Inc. Banks and Brokers Call: (212) 440-9800 All Others Call Toll Free: (866) 482-4943 The Exchange Agent for the Offer is: Wells Fargo Bank, National Association Call Toll Free: (800) 344-5128 BY REGISTERED AND CERTIFIED MAIL BY OVERNIGHT COURIER OR REGULAR MAIL: BY HAND DELIVERY Wells Fargo Bank, N.A. Wells Fargo Bank, N.A. Wells Fargo Bank, N.A. Corporate Trust Operations Corporate Trust Operations Corporate Trust Services MAC N9303-121 MAC N9303-121 608 2nd Avenue South P.O. Box 1517 6th & Marquette Avenue Northstar East Building - 12th Floor Minneapolis, MN 55480 Minneapolis, MN 55479 Minneapolis, MN 55402 or BY FACSIMILE TRANSMISSION: (612) 667-6282 If you have questions about the Company you may contact the Company at the address or telephone number set forth below: Integra LifeSciences Holdings Corporation 311 Enterprise Drive Plainsboro, New Jersey, 08536 Attention: Investor Relations Department (609) 936-2491

NEWS RELEASE

CONTACTS:

INTEGRA LIFESCIENCES HOLDINGS CORPORATION

MAUREEN B. BELLANTONI                      MARIA PLATSIS
EXECUTIVE VICE PRESIDENT                   VICE PRESIDENT, CORPORATE DEVELOPMENT
AND CHIEF FINANCIAL OFFICER                (609) 936-2333
(609) 936-6822                             MPLATSIS@INTEGRA-LS.COM
MAUREEN.BELLANTONI@INTEGRA-LS.COM


   INTEGRA LIFESCIENCES ANNOUNCES AMENDMENT TO EXCHANGE OFFER FOR ITS 2 1/2%
               CONTINGENT CONVERTIBLE SUBORDINATED NOTES DUE 2008


Plainsboro,   New  Jersey,  July  31,  2006  -  Integra  LifeSciences   Holdings
Corporation  (NASDAQ:  IART)  announced  today that it has modified its offer to
exchange  up to $120  million  principal  amount of new notes  with a "net share
settlement"   mechanism  for  its  currently   outstanding  2  1/2%   Contingent
Convertible  Subordinated  Notes due 2008.  Holders who exchange their old notes
will still receive new notes with the net share settlement feature and otherwise
substantially  similar  terms to the old notes plus an exchange fee of $2.50 per
$1,000  principal  amount of their old notes  validly  tendered and accepted for
exchange.  However,  the method for calculating the  consideration to be paid to
holders of the new notes upon the conversion of those notes has been modified to
reflect a daily calculation of the consideration payable upon conversion.

The exchange  offer will expire at 5:00 p.m.,  New York City time, on August 14,
2006,  unless  extended  or earlier  terminated  by  Integra.  Old notes must be
tendered on or prior to the expiration of the offer,  and tendered old notes may
be withdrawn  at any time on or prior to the  expiration  of the offer.  Validly
withdrawn old notes will be returned to the holder in accordance  with the terms
of the offer.  Following the expiration of the offer and subject to the terms of
the offer,  Integra will accept all old notes  validly  tendered and not validly
withdrawn  prior to the  expiration of the offer and will issue the new notes in
exchange promptly thereafter.

This press release is for informational purposes only and is not an offer to buy
or the solicitation of an offer to sell securities of Integra.  The solicitation
of offers to exchange the outstanding 2 1/2% Contingent Convertible Subordinated
Notes is only being made pursuant to the exchange offer documents, including the
Offer to Exchange (as  supplemented)  and the related Letter of Transmittal that
Integra has  distributed or will be  distributing  to its noteholders and filing
with the Securities and Exchange  Commission.  Noteholders and investors  should
read  carefully  the  Offer to  Exchange  and  related  materials  when they are
available because they contain important information.  Noteholders and investors
may  obtain a free copy  (when  available)  of the Offer to  Exchange  and other
documents  that  will be  filed by  Integra  with the  Securities  and  Exchange
Commission at the Security and Exchange  Commission's  website at www.sec.gov or
from the  information  agent,  Georgeson  Inc.,  at (212)  440-9800  (banks  and
brokers) or (866) 482-4943 (all others). Noteholders are urged to carefully read
these materials before making any decision with respect to the exchange offer.

This  announcement is neither an offer to sell nor a solicitation of an offer to
buy any securities and shall not  constitute an offer,  solicitation  or sale in
any jurisdiction in which such offer,  solicitation or sale is unlawful. The new
notes will not be registered  under the Securities  Act of 1933, as amended,  or

any state securities laws, and unless so registered, may not be offered or sold in the United States except pursuant to an exemption from the registration requirements of the Securities Act of 1933, as amended and applicable state laws. Integra LifeSciences Holdings Corporation is a diversified medical technology company that develops, manufactures, and markets medical devices for use in a variety of applications. The primary applications for our products are neurosurgery, reconstructive surgery and general surgery. Integra is a leader in applying the principles of biotechnology to medical devices that improve patients' quality of life. Our corporate headquarters are in Plainsboro, New Jersey, and we have manufacturing and research facilities located throughout the world. We have approximately 1,600 employees. Please visit our website at (http://www.integra-ls.com). This news release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from predicted or expected results. Among other things, Integra's ability to successfully complete the exchange offer on the above terms could affect Integra's future financial results. In addition, the economic, competitive, governmental, technological and other factors identified under the heading "Factors That May Affect Our Future Performance" included in the Business section of Integra's Annual Report on Form 10-K for the year ended December 31, 2005 and information contained in subsequent filings with the Securities and Exchange Commission could affect actual results. SOURCE: INTEGRA LIFESCIENCES HOLDINGS CORPORATION

[GRAPHIC OMITTED]                  53rd at Third
                                   885 Third Avenue
                                   New York, New York  10022-4834
                                   Tel: (212) 906-1200  Fax: (212) 751-4864
                                   www.lw.com

                                   FIRM / AFFILIATE OFFICES
                                   Brussels      New York
                                   Chicago       Northern Virginia
                                   Frankfurt     Orange County
                                   Hamburg       Paris
                                   Hong Kong     San Diego
July 31, 2006                      London        San Francisco
                                   Los Angeles   Shanghai
                                   Milan         Silicon Valley
                                   Moscow        Singapore
                                   Munich        Tokyo
                                   New Jersey    Washington, D.C.

VIA EDGAR
- ---------
Ms. Celeste M. Murphy, Esq.
U.S. Securities and Exchange Commission
Special Counsel
Office of Mergers and Acquisitions
Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549

                  Re:      Integra LifeSciences Holdings Corporation Schedule
                           TO-I filed
                           July 17, 2006
                           (File No. 005-45421)

Dear Ms. Murphy:

         On behalf of Integra LifeSciences Holdings Corporation (the "Company"),
we are  responding  to the  comments  of the  Staff of the U.S.  Securities  and
Exchange  Commission (the  "Commission") set forth in your letter dated July 27,
2006,  with respect to the  above-referenced  Tender Offer Statement on Schedule
TO-I filed with the  Commission on July 17, 2006 (the  "Schedule  TO").  Earlier
today,  the  Registrant  filed  via EDGAR  Amendment  No. 1 to the  Schedule  TO
("Amendment No. 1") revised to reflect changes  prompted by your comments and to
include  certain  other  information.  Amendment  No.  1  contains  the  various
revisions described below.

         The  Staff's  comments  are set forth  below in bold,  followed  by the
Company's response to each comment.

SCHEDULE TO

SUMMARY, PAGE 2

1.       PLEASE  ELIMINATE THE PHRASE FROM THE SECOND PARAGRAPH THAT THE SUMMARY
         "IS  QUALIFIED IN ITS  ENTIRETY" BY REFERENCE TO THE TERMS OF THE OFFER
         DESCRIBED MORE FULLY IN THE OFFER TO EXCHANGE AND IN THE RELATED LETTER
         OF TRANSMITTAL. THE QUALIFICATION

JULY 31, 2006 PAGE 2 [GRAPHIC OMITTED] SUGGESTS THAT THE OFFER SUMMARY MAY NOT BE MATERIALLY COMPLETE. NOTE THAT THIS LANGUAGE IS ALSO INAPPROPRIATELY USED IN OTHER PLACES IN THE: DOCUMENT WITH RESPECT TO SUMMARY OF VARIOUS AGREEMENTS INCLUDING AT PAGES 30, 58, AND 71. PLEASE REVISE ACCORDINGLY. RESPONSE: We have deleted the last sentence of the second paragraph of the "Summary" on page 1 that qualified the Summary by reference. We have also deleted the last sentence on page 31 under "Selected Financial Information," the penultimate and last sentences of the first paragraph under "Description of Capital Stock" on page 58 and the third sentence of the third paragraph under "Where You Can Find More Information" on page 71. Please see numbered paragraphs (2), (7), (15) and (17) under Items 1, 4, 6, 7 and 11 of Amendment No. 1. NEW NOTES, PAGE 5 - ------------------ 2. PLEASE REVISE YOUR CHARACTERIZATION OF THE INFORMATION IN THE SUMMARY AS "NOT COMPLETE." THE SUMMARY TERM SHEET MUST DESCRIBE THE MOST MATERIAL TERMS OF THE PROPOSED TRANSACTION. THE SUMMARY TERM SHEET MUST PROVIDE SECURITY HOLDERS WITH SUFFICIENT INFORMATION TO UNDERSTAND THE ESSENTIAL FEATURES AND SIGNIFICANCE OF THE PROPOSED TRANSACTION. PLEASE SEE ITEM 1 OF SCHEDULE TO AND ITEM 1000 OF REGULATION M-A. SUCH SUMMARY MAY NOT BE CHARACTERIZED AS INCOMPLETE. RESPONSE: The first sentence under "New Notes" on page 5 has been revised to delete the following: "and is not intended to be complete. It does not contain all the information that is important to you." Please see numbered paragraph (3) under Items 1, 4, 6, 7 and 11 of Amendment No. 1. SUMMARY COMPARISON OF THE OLD NOTES AND THE NEW NOTES, PAGE 10 - --------------------------------------------------------------- 3. IN A PROMINENT LOCATION IN THIS COMPARISON CHART, PLEASE INCLUDE A SUBORDINATION ENTRY, THAT DETAILS THE DIFFERENCES OF THE PRIORITY OF THE NEW NOTES, AS DESCRIBED ON PAGES 43-46, WITH THE PRIORITY OF THE OLD NOTES, IF ANY. FURTHER, WE BELIEVE THAT IF SUCH DIFFERENCES EXIST, YOU SHOULD ADD DISCLOSURE ON SUCH MATTER IN YOUR RISK FACTOR ON PAGE 27. RESPONSE: A section entitled "Subordination" has been added to the "Summary Comparison of the Old Notes and the New Notes" on page 10, which explains that the priority of the new notes is the same as that of the old notes. For this reason, we believe that no additional disclosure is needed in the risk factor on page 27. Please see numbered paragraph (5) under Items 1, 4, 6, 7 and 11 of Amendment No. 1. IMPORTANT RESERVATION OF RIGHTS REGARDING THE OFFER, PAGE 34 - ------------------------------------------------------------- 4. THE STAFF BELIEVES THAT ALL CONDITIONS TO THE OFFER, EXCEPT THOSE CONDITIONS SUBJECT TO REGULATORY APPROVALS, MUST BE SATISFIED OR WAIVED PRIOR TO EXPIRATION OF THE OFFER. BECAUSE THE LANGUAGE IN THE PENULTIMATE BULLET OF THIS SECTION STATES THAT THE OFFEROR MAY WAIVE ANY OF THE CONDITIONS AT ANY TIME, BOTH BEFORE AND AFTER THE EXPIRATION, IT APPEARS THE OFFEROR INTENDS FOR ITS CONDITIONS TO SURVIVE OFFER EXPIRATION. PLEASE

JULY 31, 2006 PAGE 3 [GRAPHIC OMITTED] REVISE HERE AND THROUGHOUT YOUR DISCLOSURE TO MAKE CLEAR THAT ALL CONDITIONS TO THE OFFER, OTHER THAN THOSE CONDITIONS DEPENDENT UPON THE RECEIPT OF GOVERNMENT APPROVALS, WILL BE RAISED OR ASSERTED PRIOR TO OFFER EXPIRATION. RESPONSE: The penultimate bullet on page 35 of the section entitled "Important Reservation of Rights Regarding the Offer" has been revised to make it clear that all conditions to the offer, other than those conditions dependent upon the receipt of government approvals, will be raised or asserted prior to the expiration of the offer. The corresponding language has also been revised on page 14 of the Letter of Transmittal. Please see numbered paragraph (9) under Items 1, 4, 6, 7 and 11 of Amendment No. 1 and numbered paragraph (2) under Item 12 of Amendment No. 1. CONDITIONS OF THE OFFER, PAGE 36 - --------------------------------- 5. WE NOTE YOUR STATEMENT ON PAGE 36, REGARDING THE CONDITIONS, THAT "[A]NY DETERMINATION BY US CONCERNING THE EVENTS DESCRIBED ABOVE WILL BE FINAL AND BINDING UPON ALL PARTIES." PLEASE REVISE THIS SENTENCE TO MORE PRECISELY DEFINE ITS SCOPE. IT APPEARS THAT YOUR INTERPRETATION OF THE TERMS OF THE TENDER OFFER MAY NOT NECESSARILY BE FINAL AND BINDING ON ALL PERSONS. FOR EXAMPLE, WHILE YOU MAY ASSERT AN OFFER CONDITION WHEN IT IS TRIGGERED, WHEN PARTIES CONTEST ASSERTED CONDITIONS, THE JUDGMENTS OF COURTS OF LAW ARE GENERALLY CONSIDERED FINAL AND BINDING IN SUCH MATTERS. PLEASE MAKE CORRESPONDING CHANGES THROUGHOUT YOUR DOCUMENT INCLUDING ON PAGE 36. RESPONSE: We have revised the disclosure on pages 34, 36, 40 and 56 of the Offer to Exchange to more clearly define the scope of "final and binding" determinations, and we have revised the corresponding language in the Letter of Transmittal. Please see numbered paragraphs (8), (10), (11) and (14) under Items 1, 4, 6, 7 and 11 of Amendment No. 1 and paragraphs (1), (3), (4) and (5) under Item 12 of Amendment No. 1. CLOSING COMMENTS Supplementally, we note that the Company will file as correspondence a letter under separate cover including a written statement acknowledging that: |X| the Company is responsible for the adequacy and accuracy of the disclosure in the filings; |X| Staff comments or changes to disclosure in response to Staff comments in the filings reviewed by the Staff do not foreclose the Commission from taking any action with respect to the filing; and |X| the Company may not assert Staff comments as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

JULY 31, 2006 PAGE 4 [GRAPHIC OMITTED] We hope the foregoing answers are responsive to your comments and look forward to resolving any outstanding issues as quickly as possible. If you have any questions in connection with the responses to your comments, please feel free to call me at (212) 906-1323 or Shari Fallis at (212) 906-1709. Truly yours, /s/ Peter M. Labonski --------------------------- Peter M. Labonski of LATHAM & WATKINS LLP

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
                              311 ENTERPRISE DRIVE
                          PLAINSBORO, NEW JERSEY 08536

July 31, 2006


CONFIDENTIAL

VIA EDGAR
Ms. Celeste M. Murphy, Esq.
U.S.  Securities and Exchange  Commission
Special Counsel
Office of Mergers and Acquisitions
Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549

                  Re:    Integra LifeSciences Holdings Corporation Schedule
                         TO-I filed
                         July 17, 2006
                         (File No. 005-45421)
                         --------------------

Dear Ms. Murphy:

         Pursuant to your letter dated July 27, 2006, we acknowledge that:

         |X|      the Company is  responsible  for the  adequacy and accuracy of
                  the disclosure in the filings;

         |X|      Staff  comments or changes to  disclosure in response to Staff
                  comments in the filings reviewed by the Staff do not foreclose
                  the  Commission  from  taking any action  with  respect to the
                  filing; and

         |X|      the Company may not assert Staff  comments as a defense in any
                  proceeding initiated by the Commission or any person under the
                  federal securities laws of the United States.

         In  addition,   we  acknowledge  that  the  Commission's   Division  of
Enforcement  has access to all  information  that we may provide to the Staff of
the Commission's Division of Corporation Finance in its review of our filings or
in response to its comments on our filing.

         Should you have any  questions  relating  to  foregoing,  please do not
hesitate to contact the  undersigned  at (609)  275-0500 or Peter M. Labonski of
Latham & Watkins LLP at (212) 906-1323.  Thank you for your cooperation and your
attention in this matter.


                                                    Very Truly Yours,

                                                    /s/ MAUREEN B. BELLANTONI
                                                    ----------------------------
                                                    Maureen B. Bellantoni
                                                    Executive Vice President and
                                                    Chief Financial Officer



cc:      Latham & Watkins LLP