SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE TO/A
                                (AMENDMENT NO. 2)

        TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR SECTION 13(E)(1)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
                                (Name of Issuer)

               INTEGRA LIFESCIENCES HOLDINGS CORPORATION (ISSUER)
 (Name of Filing Person (Identifying Status as Offeror, Issuer or Other Person))

            2 1/2% CONTINGENT CONVERTIBLE SUBORDINATED NOTES DUE 2008
                         (Title of Class of Securities)

                      (CUSIP NOS. 457985AA7 AND 457985AB5)
                      (CUSIP Number of Class of Securities)

                              MAUREEN B. BELLANTONI
              EXECUTIVE VICE PRESIDENT AND CHIEF FINANCIAL OFFICER
                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
                              311 ENTERPRISE DRIVE
                          PLAINSBORO, NEW JERSEY 08536
                                 (609) 275-0500

(Name, Address and Telephone Number of Person Authorized to Receive Notices and
               Communications on Behalf of the Filing Person(s))

                                    COPY TO:
                              PETER LABONSKI, ESQ.
                              LATHAM & WATKINS LLP
                                885 THIRD AVENUE
                               NEW YORK, NY 10022
                                 (212) 906-1200


                            CALCULATION OF FILING FEE

             TRANSACTION VALUATION*                     AMOUNT OF FILING FEE**
          ----------------------------               ---------------------------
                  $120,000,000                                 $12,840

*     Calculated  solely for the purpose of determining the amount of the filing
      fee, based upon the exchange of $120,000,000 aggregate principal amount of
      the Issuer's 2 1/2% Contingent Convertible  Subordinated Notes due 2008 in
      exchange for Integra LifeSciences Holdings Corporation's 2 1/2% Contingent
      Convertible Subordinated Notes due 2008.

**    Previously paid.

[ ]   Check box if any part of the fee is offset as provided by Rule  0-11(a)(2)
      and identify the filing with which the offsetting fee was previously paid.
      Identify the previous filing by registration statement number, or the form
      or schedule and the date of its filing.


      Amount Previously Paid: Not applicable.      Filing party: Not applicable.
      Form or Registration No.: Not applicable.    Date Filed: Not applicable.


[ ]   Check the box if the filing relates  solely to preliminary  communications
      made before the commencement of a tender offer.



Check the  appropriate  boxes below to designate any  transactions  to which the
statement relates:


         [ ] third-party tender offer subject to Rule 14d-1


         [X] issuer tender offer subject to Rule 13e-4


         [ ] going private transaction subject to Rule 13e-3


         [ ] amendment to Schedule 13D under Rule 13d-2


Check the following box if the filing is a final amendment reporting the results
of the tender offer [ ]

                                       2



                  This Amendment No. 2 to Schedule TO (this "Amendment")  amends
and  supplements  the Tender  Offer  Statement  on  Schedule TO filed by Integra
LifeSciences  Holdings Corporation,  a Delaware  corporation,  (the "Issuer") on
July 17, 2006, and amended by Amendment No. 1 thereto filed on July 31, 2006 (as
so amended,  the  "Schedule  TO").  This  Amendment  relates to the offer by the
Issuer  (i)  to  exchange  $1,000  in  principal  amount  of 2  1/2%  Contingent
Convertible  Subordinated  Notes due 2008 (the "New  Notes") and (ii) a one time
cash  payment (an  "Exchange  Fee") equal to $2.50 for each $1,000 in  principal
amount of the Issuer's  outstanding 2 1/2% Contingent  Convertible  Subordinated
Notes due 2008 (the "Old Notes" and  together  with the New Notes,  the "Notes")
that is properly  tendered and accepted for exchange  upon the terms and subject
to the  conditions set forth in the Offer to Exchange (this "Offer to Exchange")
and in the related Letter of Transmittal (the "Letter of Transmittal"),  as each
may be amended from time to time. The offer to exchange the Notes (including the
payment of an  Exchange  Fee)  pursuant  to the Offer to Exchange is referred to
herein as an "Offer." This Amendment  amends and supplements  Schedule TO as set
forth below.  This Amendment is filed to satisfy the reporting  requirements  of
Rule 13e-4 under the Securities Exchange Act of 1934, as amended.

                  The  information  in the  Offer to  Exchange  and the  related
Letter of Transmittal,  copies of which were previously  filed on Schedule TO as
exhibits (a)(1)(i) and (a)(1)(ii)  thereto, is incorporated in this Amendment by
reference,  except that such  information is hereby amended and  supplemented to
the extent specifically provided herein.

ITEMS 1 AND 4

         Items 1 and 4 of the Schedule TO, which  incorporate  by reference  the
information  contained  in  the  Offer  to  Exchange,  are  hereby  amended  and
supplemented as follows:

         (1)      The condition that the Offer is contingent  upon the tender or
         exchange  of at  least  50%  of  the  principal  amount  of  Old  Notes
         outstanding, as described in the Offer to Exchange on the cover, page 2
         of the Summary and page 35, is hereby waived.

         (2)      The Offer has been  extended  from  5:00  p.m.,  New York City
         time,  on August 14,  2006,  until 5:00  p.m.,  New York City time,  on
         August 28, 2006,  unless further extended by the Company and subject to
         the right of the Company, in its sole discretion, subject to applicable
         law, to terminate, withdraw or amend the Offer at any time as discussed
         below. Any additional extension of the Offer will be announced by press
         release  no later than 9:00 a.m.  New York City  time,  on the next New
         York  Stock  Exchange  trading  day  after  the  previously   scheduled
         Expiration Date.

ITEM 11. ADDITIONAL INFORMATION

         Item 11 of the Schedule TO is hereby amended and supplemented by adding
the following language:

         On August 14, 2006,  the Company  announced  the extension of the Offer
         and the waiver of a condition as described above under Items 1 and 4 of
         this Amendment, a copy of which is filed as Exhibit (a)(5)(iii) to this
         Amendment and is incorporated herein by reference.

ITEM 12. EXHIBITS.

         Item 12 of the Schedule TO is hereby amended and supplemented by adding
the following exhibits:

(a)(5)(iii) Press Release, dated August 14, 2006.


                                       3


SIGNATURE

                  After due inquiry and to the best of my knowledge  and belief,
I certify that the information set forth in this statement is true, complete and
correct.

Dated: August 14, 2006           INTEGRA LIFESCIENCES HOLDINGS
                                 CORPORATION




                                 By: /s/ Maureen B. Bellantoni
                                     -------------------------------------------
                                     Name:   Maureen B. Bellantoni
                                     Title:  Executive Vice President and Chief
                                             Financial Officer


                                       4


EXHIBIT INDEX

EXHIBIT
NUMBER          DESCRIPTION
- ------          -----------

(a)(1)(i)       Offer to Exchange, dated July 17, 2006.*

(a)(1)(ii)      Letter of Transmittal.*

(a)(1)(iii)     Notice of Guaranteed Delivery.*

(a)(1)(iv)      Letter to Brokers, Dealers, Commercial Banks, Trust Companies
                and Other Nominees.*

(a)(1)(v)       Letter to Clients for use by Brokers, Dealers, Commercial Banks,
                Trust Companies and Other Nominees.*

(a)(1)(vi)      Supplement to Offer to Exchange, dated July 31, 2006.*

(a)(5)(i)       Press Release, dated July 17, 2006.*

(a)(5)(ii)      Press Release, dated July 31, 2006.*

(a)(5)(iii)     Press Release, dated August 14, 2006.



* Previously filed.


                                       5
                                                               EX-99.(a)(5)(iii)

NEWS RELEASE

CONTACTS:

INTEGRA LIFESCIENCES HOLDINGS CORPORATION

MAUREEN B. BELLANTONI                      MARIA PLATSIS
EXECUTIVE VICE PRESIDENT                   VICE PRESIDENT, CORPORATE DEVELOPMENT
AND CHIEF FINANCIAL OFFICER                (609) 936-2333
(609) 936-6822                             mplatsis@Integra-LS.com
maureen.bellantoni@Integra-LS.com


       INTEGRA LIFESCIENCES ANNOUNCES AMENDMENT TO EXCHANGE OFFER FOR ITS
           2 1/2% CONTINGENT CONVERTIBLE SUBORDINATED NOTES DUE 2008


PLAINSBORO,  NEW  JERSEY,  AUGUST  14,  2006  -  INTEGRA  LIFESCIENCES  HOLDINGS
CORPORATION  (NASDAQ:  IART)  ANNOUNCED TODAY THAT IT HAS WAIVED A CONDITION AND
EXTENDED  THE  EXPIRATION  DATE OF ITS  OFFER  TO  EXCHANGE  UP TO $120  MILLION
PRINCIPAL  AMOUNT OF NEW NOTES WITH A "NET SHARE  SETTLEMENT"  MECHANISM FOR ITS
CURRENTLY OUTSTANDING 2 1/2% CONTINGENT CONVERTIBLE SUBORDINATED NOTES DUE 2008.

INTEGRA HAS WAIVED THE CONDITION TO THE EXCHANGE  OFFER THAT AT LEAST 50% OF THE
OUTSTANDING OLD NOTES BE EXCHANGED.

IN ADDITION,  THE  EXPIRATION  DATE OF THE EXCHANGE OFFER HAS BEEN EXTENDED FROM
5:00 P.M., NEW YORK CITY TIME, ON AUGUST 14, 2006 UNTIL 5:00 P.M., NEW YORK CITY
TIME,  ON AUGUST 28, 2006,  UNLESS  FURTHER  EXTENDED OR EARLIER  TERMINATED  BY
INTEGRA.  AS OF 5:00 P.M.,  NEW YORK CITY TIME, ON AUGUST 14, 2006, AN AGGREGATE
PRINCIPAL AMOUNT OF $22,858,000 OF OLD NOTES HAD BEEN TENDERED.

OLD NOTES MUST BE  TENDERED  ON OR PRIOR TO THE  EXPIRATION  OF THE  OFFER,  AND
TENDERED OLD NOTES MAY BE WITHDRAWN AT ANY TIME ON OR PRIOR TO THE EXPIRATION OF
THE  OFFER.  VALIDLY  WITHDRAWN  OLD NOTES  WILL BE  RETURNED  TO THE  HOLDER IN
ACCORDANCE  WITH THE TERMS OF THE OFFER.  FOLLOWING THE  EXPIRATION OF THE OFFER
AND SUBJECT TO THE TERMS OF THE OFFER, INTEGRA WILL ACCEPT ALL OLD NOTES VALIDLY
TENDERED AND NOT VALIDLY WITHDRAWN PRIOR TO THE EXPIRATION OF THE OFFER AND WILL
ISSUE THE NEW NOTES IN EXCHANGE PROMPTLY THEREAFTER.

THIS PRESS RELEASE IS FOR INFORMATIONAL PURPOSES ONLY AND IS NOT AN OFFER TO BUY
OR THE SOLICITATION OF AN OFFER TO SELL SECURITIES OF INTEGRA.  THE SOLICITATION
OF OFFERS TO EXCHANGE THE OUTSTANDING 2 1/2% CONTINGENT CONVERTIBLE SUBORDINATED
NOTES IS ONLY BEING MADE PURSUANT TO THE EXCHANGE OFFER DOCUMENTS, INCLUDING THE
OFFER TO EXCHANGE (AS  SUPPLEMENTED)  AND THE RELATED LETTER OF TRANSMITTAL THAT
INTEGRA HAS  DISTRIBUTED OR WILL BE  DISTRIBUTING  TO ITS NOTEHOLDERS AND FILING
WITH THE SECURITIES AND EXCHANGE  COMMISSION.  NOTEHOLDERS AND INVESTORS  SHOULD
READ  CAREFULLY  THE  OFFER TO  EXCHANGE  AND  RELATED  MATERIALS  WHEN THEY ARE
AVAILABLE BECAUSE THEY CONTAIN IMPORTANT INFORMATION.  NOTEHOLDERS AND INVESTORS
MAY  OBTAIN A FREE COPY  (WHEN  AVAILABLE)  OF THE OFFER TO  EXCHANGE  AND OTHER
DOCUMENTS  THAT  WILL BE  FILED BY  INTEGRA  WITH THE  SECURITIES  AND  EXCHANGE
COMMISSION AT THE SECURITIES AND EXCHANGE COMMISSION'S WEBSITE AT WWW.SEC.GOV OR
FROM THE  INFORMATION  AGENT,  GEORGESON  INC.,  AT (212)  440-9800  (BANKS  AND
BROKERS) OR (866) 482-4943 (ALL OTHERS). NOTEHOLDERS ARE URGED TO CAREFULLY READ
THESE MATERIALS BEFORE MAKING ANY DECISION WITH RESPECT TO THE EXCHANGE OFFER.



THIS  ANNOUNCEMENT IS NEITHER AN OFFER TO SELL NOR A SOLICITATION OF AN OFFER TO
BUY ANY SECURITIES AND SHALL NOT  CONSTITUTE AN OFFER,  SOLICITATION  OR SALE IN
ANY JURISDICTION IN WHICH SUCH OFFER,  SOLICITATION OR SALE IS UNLAWFUL. THE NEW
NOTES WILL NOT BE REGISTERED  UNDER THE SECURITIES  ACT OF 1933, AS AMENDED,  OR
ANY STATE SECURITIES LAWS, AND UNLESS SO REGISTERED,  MAY NOT BE OFFERED OR SOLD
IN THE UNITED  STATES  EXCEPT  PURSUANT TO AN  EXEMPTION  FROM THE  REGISTRATION
REQUIREMENTS  OF THE  SECURITIES  ACT OF 1933, AS AMENDED AND  APPLICABLE  STATE
LAWS.

INTEGRA  LIFESCIENCES  HOLDINGS  CORPORATION IS A DIVERSIFIED MEDICAL TECHNOLOGY
COMPANY THAT DEVELOPS,  MANUFACTURES,  AND MARKETS  MEDICAL DEVICES FOR USE IN A
VARIETY  OF  APPLICATIONS.   THE  PRIMARY  APPLICATIONS  FOR  OUR  PRODUCTS  ARE
NEUROSURGERY, RECONSTRUCTIVE SURGERY AND GENERAL SURGERY. INTEGRA IS A LEADER IN
APPLYING  THE  PRINCIPLES  OF  BIOTECHNOLOGY  TO MEDICAL  DEVICES  THAT  IMPROVE
PATIENTS'  QUALITY OF LIFE. OUR CORPORATE  HEADQUARTERS  ARE IN PLAINSBORO,  NEW
JERSEY, AND WE HAVE MANUFACTURING AND RESEARCH FACILITIES LOCATED THROUGHOUT THE
WORLD.  WE HAVE  APPROXIMATELY  1,650  EMPLOYEES.  PLEASE  VISIT OUR  WEBSITE AT
(http://www.Integra-LS.com).

THIS NEWS RELEASE CONTAINS FORWARD-LOOKING  STATEMENTS WITHIN THE MEANING OF THE
PRIVATE  SECURITIES   LITIGATION  REFORM  ACT  OF  1995.  SUCH   FORWARD-LOOKING
STATEMENTS  INVOLVE RISKS AND  UNCERTAINTIES  THAT COULD CAUSE ACTUAL RESULTS TO
DIFFER  MATERIALLY  FROM  PREDICTED  OR EXPECTED  RESULTS.  AMONG OTHER  THINGS,
INTEGRA'S ABILITY TO SUCCESSFULLY COMPLETE THE EXCHANGE OFFER ON THE ABOVE TERMS
COULD AFFECT  INTEGRA'S  FUTURE FINANCIAL  RESULTS.  IN ADDITION,  THE ECONOMIC,
COMPETITIVE, GOVERNMENTAL,  TECHNOLOGICAL AND OTHER FACTORS IDENTIFIED UNDER THE
HEADING  "FACTORS  THAT MAY  AFFECT  OUR  FUTURE  PERFORMANCE"  INCLUDED  IN THE
BUSINESS  SECTION  OF  INTEGRA'S  ANNUAL  REPORT ON FORM 10-K FOR THE YEAR ENDED
DECEMBER  31, 2005 AND  INFORMATION  CONTAINED  IN  SUBSEQUENT  FILINGS WITH THE
SECURITIES AND EXCHANGE COMMISSION COULD AFFECT ACTUAL RESULTS.

SOURCE: INTEGRA LIFESCIENCES HOLDINGS CORPORATION