UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
                       Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934

        Date of Report (Date of earliest event reported): August 11, 2006

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
             (Exact name of Registrant as specified in its charter)



            Delaware                      0-26224                51-0317849
(State or other jurisdiction of   (Commission File Number)    (I.R.S. Employer
 incorporation or organization)                              Identification No.)


                              311 Enterprise Drive
                              Plainsboro, NJ 08536
               (Address of principal executive offices) (Zip Code)

       Registrant's telephone number, including area code: (609) 275-0500

                                 Not Applicable
          (Former name or former address, if changed since last report)


Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

[ ]    Written communications pursuant to Rule 425 under the Securities Act
       (17 CFR 230.425)

[ ]    Soliciting material pursuant to Rule 14a-12 under the Exchange Act
       (17 CFR 240.14a-12)

[ ]    Pre-commencement communications pursuant to Rule 14d-2(b) under the
       Exchange Act (17 CFR 240.14d-2(b))

[ ]    Pre-commencement communications pursuant to Rule 13e-4(c) under the
       Exchange Act (17 CFR 240.13e-4(c))



ITEM 1.01.  ENTRY INTO A MATERIAL DEFINITVE AGREEMENT.

On August 11, 2006, Integra LifeSciences Corporation ("ILS"), a wholly-owned
subsidiary of Integra LifeSciences Holdings Corporation (the "Company"), entered
into an amendment with Sorrento Montana, L.P. relating to one of the buildings
in its San Diego facility.

The amendment provides for the addition of approximately 5,000 square feet to
the leased space, effective August 15, 2006, and for approximately 1,800 square
feet (consisting of two suites) to be added to the leased space when such
additional space becomes vacant on approximately October 1, 2006. The monthly
base rate payable by ILS was increased, effective August 1, 2006, to $24,515.17.
It will increase when each additional suite is added to the leased space by an
additional $937.20 for one suite and additional $1,232.40 for the other suite.

The amendment provides for the exercise of ILS's option to extend the lease an
additional 24 months, through June 30, 2009. The monthly base rate payable from
July 1, 2007 through June 30, 2009 will be 104% of the base rate payable by ILS
for the month of June 2007.

In addition, ILS has a two-year option, exercisable before December 31, 2008, to
extend its occupancy through June 30, 2011. The monthly base rate payable from
July 1, 2009 through June 30, 2011 will be the then-prevailing market rate for
comparable space in the Sorrento Mesa and Sorrento Valley areas of San Diego

A copy of the amendment is attached as Exhibit 10.1 to this Current Report on
Form 8-K and is incorporated by reference into this Item.


ITEM 8.01.  OTHER EVENTS.

On August 14, 2006, the Company announced that it modified and extended its
offer in which holders of its outstanding 2 1/2% Contingent Convertible
Subordinated Notes due 2008 may exchange these notes for new 2 1/2% Contingent
Convertible Subordinated Notes due 2008.

A copy of this press release is filed herewith as Exhibit 99.1 and is
incorporated herein by reference.


ITEM 9.01.  FINANCIAL STATEMENTS AND EXHIBITS.

(d) Exhibits.

Exhibit Number        Description of Exhibit
- --------------        ----------------------

10.1                  Fourth Amendment to Sublease dated as of August 15, 2006
                      by and between Sorrento Montana, L.P. and Integra
                      LifeSciences Corporation

99.1                  Press release issued August 14, 2006 (Incorporated by
                      reference to Exhibit (a)(5)(iii) to the Company's Schedule
                      TO/A filed on August 15, 2006)



                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended,
the Registrant has duly caused this report to be signed on its behalf by the
undersigned, hereunto duly authorized.

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION

        DATE: AUGUST 17, 2006          BY: /s/ STUART M. ESSIG
                                           -----------------------------
                                           STUART M. ESSIG
                                           PRESIDENT AND CHIEF EXECUTIVE OFFICER



                                 EXHIBIT INDEX


Exhibit Number        Description of Exhibit
- --------------        ----------------------

10.1                  Fourth Amendment to Sublease dated as of August 15, 2006
                      by and between Sorrento Montana, L.P. and Integra
                      LifeSciences Corporation

99.1                  Press release issued August 14, 2006 (Incorporated by
                      reference to Exhibit (a)(5)(iii) to the Company's Schedule
                      TO/A filed on August 15, 2006)
                                                                         EX-10.1


FOURTH AMENDMENT TO SUBLEASE


THIS FOURTH AMENDMENT TO SUBLEASE ("Fourth Amendment") is made as of August 15,
2006 by and between Sorrento Montana, L.P., a California Limited Partnership
("Landlord") and Integra LifeSciences Corporation, a Delaware Corporation
("Tenant"), with reference to the following facts and circumstances:

     I.        Landlord and Camino NeuroCare, Inc. entered into a Sublease dated
               July 1, 2001 for approximately 16,205 square feet of premises
               commonly known as Suites #706 through #714 and Suite #716, 5965
               Pacific Center Boulevard, San Diego, California 92121
               ("Premises").

     II.       Landlord and Integra NeuroSciences CA Corporation ("Integra CA")
               subsequently modified and amended the Sublease through First
               Amendment to Sublease dated July 1, 2003, which in part extended
               the term of the Sublease two additional years through June 30,
               2005 and granted Tenant one Option to Renew the Sublease for an
               additional two-year term through June 30, 2007.

     III.      Landlord and Integra CA again modified and amended the Sublease
               through Second Amendment to Sublease dated June 1, 2004, which in
               part added the approximately 1,180 square foot Suite #717 to
               Tenant's Sublease effective June 1,2004.

     IV.       Landlord and Tenant further amended the Sublease through Third
               Amendment to Sublease dated June 15, 2004, which (a) exercised
               Tenant's Option To Renew the Sublease two additional years
               through June 30, 2007, (b) granted Tenant one additional Option
               To Renew the Sublease two Additional years through June 30, 2009,
               and (c) Granted Tenant a one-time Right of First Refusal to add
               Suites #701, #702 through #705 and #715 to Tenant's Sublease at
               such time as they become available.

Landlord and Tenant desire to further modify, amend and supplement the Sublease
through this Fourth Amendment as follows:

               a.   Paragraph 1.4 ("PREMISES") is hereby amended to add the
                    approximately 4,956 square foot Suites #702 through #705 to
                    Tenant's Premises effective August 15, 2006. The
                    approximately 781 square foot Suite #701 and the
                    approximately 1,027 square foot Suite #715, both of which
                    are currently occupied, will be added to Tenant's Premises
                    the first day of the month following the vacating of the
                    respective spaces by their present occupants, which it is
                    anticipated will occur on or about October 1, 2006. Suites
                    #701, #702 through #705 and #715 will be added to Tenant's
                    Premises in an "as is" condition.

               b.   Tenant hereby exercises the Option to Renew granted in Third
                    Amendment to Sublease, and Paragraph 1.5 ("SUBLEASE TERM")
                    is therefore and hereby amended to extend the term of the
                    Sublease an additional twenty-four months through June 30,
                    2009. Tenant's Beginning Base Rent for the Option term
                    commencing July 1, 2007 shall be one hundred four percent
                    (104%) of the Base Rent payable by Tenant for the month of
                    June 2007.

               c.   Paragraph 1.9.1 ("BASE RENT") is hereby amended to provide
                    for payment of Base Rent by Tenant of Twenty-Four Thousand
                    Five Hundred Fifteen and 17/100 Dollars ($24,515.17) per
                    month effective August 1, 2006 with the addition of the
                    approximately 4,956 square foot Suites #702 through #705.
                    Tenants monthly Base Rent shall be further increased by (a)
                    Nine Hundred Thirty-Seven and 20/100 Dollars ($937.20) with
                    the addition of the approximately 781 square foot Suite #701
                    and (b) One Thousand Two Hundred



                    Thirty-Two and 40/100 Dollars ($1,232.40) with the addition
                    of the approximately 1,023 square foot Suite #715.

               d.   Paragraph 14.0 ("OPTION TO RENEW") is hereby amended to
                    provide Tenant with an Option to Renew ("Option") this
                    Sublease for one additional two-year term commencing July 1,
                    2009 and continuing for twenty-four consecutive months.
                    Provided Tenant is not in default of this Sublease or
                    Tenant's July 1, 2001 Sublease of 5955 Pacific Center
                    Boulevard as subsequently amended, Tenant shall exercise the
                    Option by notifying Landlord in writing on or before
                    December 31, 2008 of Tenant's intention to renew. Tenant's
                    Beginning Base Rent for the option term shall be the
                    then-prevailing market rate for comparable space in the
                    Sorrento Mesa and Sorrento Valley areas of San Diego.


     Except as specifically provided in this Fourth Amendment, all of the terms,
conditions and definitions set forth in the Sublease shall remain unchanged and
in full force and effect. In the event of any conflict between this Fourth
Amendment and the Sublease, the terms of this Fourth Amendment shall prevail.

IN WITNESS WHEREOF, the parties hereto have executed this Fourth Amendment To
Sublease effective the day and year first written above:

LANDLORD:                                             TENANT:

SORRENTO MONTANA, L.P.,                       INTEGRA LIFESCIENCES
                                              CORPORATION,
a California Limited Partnership              a Delaware Corporation
By: Sorrento Commercial Properties, Inc.,
a California Corporation doing business as    By: Donald Nociolo
Sorrento Management Company                      -------------------------------
                                              Title: Senior VP Operations
                                                    ------------------------

                                              Date:  8/9/06
                                                     ------
   By:   /s/ Roger W. Hillbrook
       ---------------------------
   Roger W. Hillbrook
   Vice President/Corporate Broker

Date:   8/11/06
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