UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
                       Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934

       Date of Report (Date of earliest event reported): November 2, 2006

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
             (Exact name of Registrant as specified in its charter)

 Delaware                                 0-26224                  51-0317849
(State or other jurisdiction of   (Commission File Number)      (I.R.S. Employer
incorporation or organization)                               Identification No.)

                              311 Enterprise Drive
                              Plainsboro, NJ 08536
              (Address of principal executive offices) (Zip Code)

       Registrant's telephone number, including area code: (609) 275-0500

                                 Not Applicable
         (Former name or former address, if changed since last report)


Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions:

[ ]    Written communications pursuant to Rule 425 under the Securities
       Act (17 CFR 230.425)

[ ]    Soliciting material pursuant to Rule 14a-12 under the Exchange Act
       (17 CFR 240.14a-12)

[ ]    Pre-commencement communications pursuant to Rule 14d-2(b) under the
       Exchange Act (17 CFR 240.14d-2(b))

[ ]    Pre-commencement communications pursuant to Rule 13e-4(c) under the
       Exchange Act (17 CFR 240.13e-4(c))

ITEM 2.02. RESULTS OF OPERATIONS AND FINANCIAL CONDITION. On November 2, 2006, Integra LifeSciences Holdings Corporation issued a press release announcing financial results for the quarter ended September 30, 2006. A copy of the press release is attached as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated by reference into this Item. The information contained in Item 2.02 of this Current Report on Form 8-K (including the press release) is being furnished and shall not be deemed "filed" for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that Section. The information contained in Item 2.02 of this Current Report on Form 8-K (including the press release) shall not be incorporated by reference into any registration statement or other document pursuant to the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in any such filing. DISCUSSION OF ADJUSTED FINANCIAL MEASURES In addition to our GAAP results, we provide adjusted net income and adjusted earnings per diluted share. Adjusted net income consists of net income excluding equity-based compensation charges, acquisition-related charges, charges incurred in connection with the Company's exchange offer of convertible notes and the termination of the Company's interest rate swap agreement, facility consolidation, manufacturing transfer and system integration charges and certain employee termination and related costs. Adjusted earnings per diluted share is calculated by dividing adjusted net income for diluted earnings per share by adjusted diluted weighted average shares outstanding. Because all equity-based compensation expense is added back in the calculation of adjusted net income, the calculation of diluted weighted average shares outstanding is adjusted to exclude the benefits of unearned equity-based compensation costs attributable to future services and not yet recognized in the financial statements. These unearned equity-based compensation costs are treated as proceeds assumed to be used to repurchase shares, based on the average trading price of Integra common stock during the period reported, in the calculation of GAAP diluted weighted average shares outstanding. Integra believes that the presentation of adjusted net income and adjusted earnings per diluted share provides important supplemental information to management and investors regarding non-cash expenses and financial and business trends relating to the Company's financial condition and results of operations. Management uses non-GAAP financial measures in the form of adjusted net income and adjusted earnings per diluted share when evaluating operating performance because we believe that the inclusion or exclusion of the items described below, for which the amounts and/or timing may vary significantly depending upon the Company's acquisition and restructuring activities, provides a supplemental measure of our operating results that facilitates comparability of our operating performance from period to period, against our business model objectives, and against other companies in our industry. We have chosen to provide this information to investors so they can analyze our operating results in the same way that management does and use this information in their assessment of our core business and the valuation of our Company. Internally, adjusted net income and adjusted earnings per diluted share are significant measures used by management for purposes of: o supplementing the financial results and forecasts reported to the Company's board of directors; o evaluating, managing and benchmarking the operating performance of the Company; o establishing internal operating budgets; o determining compensation under bonus or other incentive programs;

o enhancing comparability from period to period; o comparing performance with internal forecasts and targeted business models; and o evaluating and valuing potential acquisition candidates. Adjusted net income reflects net income adjusted for the following items: o EQUITY-BASED COMPENSATION. Equity-based compensation relates primarily to stock options and restricted stock issued by the Company. Although recurring in nature, equity-based compensation expense is heavily influenced by management decisions regarding equity-based awards that were granted at a time when different accounting rules applied to such awards and is a non-cash expense that varies in amount from period to period and is affected by market forces that are difficult to predict and are not within the control of management, such as the price of our common stock. Accordingly, management excludes this item from its internal operating forecasts and models and as it assesses the Company's performance. Management believes that exclusion of this item is consistent with the guidance in Staff Accounting Bulletin No. 107. o ACQUISITION-RELATED CHARGES. Acquisition-related charges include in-process research and development charges, charges related to discontinued research and development projects for product technologies that were made redundant by an acquisition and inventory fair value purchase accounting adjustments. Inventory fair value purchase accounting adjustments consist of the increase to cost of goods sold that occur as a result of expensing the "step up" in the fair value of inventory that we purchased in connection with acquisitions as that inventory is sold during the financial period. Although recurring given the ongoing character of our acquisition program, these acquisition-related charges are not factored into the evaluation of our performance by management after completion of acquisitions because they are of a temporary nature, they are not related to our core operating performance and the frequency and amount of such charges vary significantly based on the timing and magnitude of our acquisition transactions as well as the level of inventory on hand at the time of acquisition. o FACILITY CONSOLIDATION, MANUFACTURING TRANSFER AND SYSTEM INTEGRATION CHARGES. These charges, which include employee termination and other costs associated with exit or disposal activities and costs associated with the worldwide implementation of a single enterprise resource planning system, result from rationalizing our existing manufacturing, distribution and administrative infrastructure. Many of these cost-saving and efficiency-driven activities are identified as opportunities in connection with acquisitions that provide the Company with additional capacity or economies of scale. Although recurring in nature given management's ongoing review of the efficiency of our manufacturing, distribution and administrative facilities and operations, management excludes these items when evaluating the operating performance of the Company because the frequency and amount of such charges vary significantly based on the timing and magnitude of the Company's rationalization activities and are, in some cases, dependent upon opportunities identified in acquisitions, which also vary in frequency and magnitude. o EMPLOYEE TERMINATION AND RELATED COSTS. Employee termination and related costs consist of charges related to significant reductions in force that are not initiated in connection with facility consolidations or manufacturing transfers. Management excludes these items when evaluating Integra's operating performance because these amounts do not affect our core operations and because of the infrequent and large-scale nature of these activities. o CONVERTIBLE NOTE EXCHANGE OFFER CHARGES / SWAP TERMINATION CHARGES. The convertible note exchange offer charges consist of fees paid in connection with the exchange offer and the write-off of the unamortized debt issuance costs associated with the old contingent convertible notes that were exchanged. The interest rate swap termination charges result from the write-off of the unamortized mark-to-market fair value adjustment recorded under hedge accounting against the contingent convertible notes.

The Company discontinued hedge accounting following termination of the interest rate swap. Management excludes these items when evaluating Integra's operating performance because these amounts do not affect our core operations and because of the infrequent and large-scale nature of these activities. o INCOME TAX EXPENSE (BENEFIT). Income tax expense is adjusted by the amount of additional tax expense or benefit that the Company estimates that it would record if it used non-GAAP results instead of GAAP results in the calculation of its tax provision. Such additional tax expense or benefit is calculated at the statutory rate applicable to jurisdictions in which such non-GAAP adjustments relate. The calculation of adjusted earnings per diluted share is further adjusted for the following item: o As noted above, in calculating adjusted net income, one of the Company's adjustments is to add back all equity-based compensation expense determined in accordance with FASB 123R to be more comparable to prior years. In order to make the 2006 presentation more comparable to prior years, the calculation of weighted average shares outstanding on a diluted basis had to be conformed as well. In calculating diluted earnings per share, the dilutive effect of restricted stock and stock options on the denominator is determined through application of the treasury stock method, and unearned equity-based compensation is one factor that is used to calculate assumed share repurchases under the treasury stock method. Because the unrecognized equity-based compensation expense under FAS 123R is higher than if no equity-based compensation charges are assumed (which is how we calculate adjusted net income), the number of shares that are included in the denominator of diluted earnings per share when applying FAS 123R is less than the number of shares that are included in our method of reporting adjusted earnings per diluted share (i.e. in order to be consistent, since all equity-based compensation expense was added back in the calculation of adjusted net income, the weighted average shares used to calculate adjusted earnings per diluted share were also adjusted so that no unearned equity-based compensation is considered in the treasury stock method). As a result, our calculation of adjusted earnings per diluted share is based on a different number of shares than GAAP earnings per share. Adjusted net income and adjusted earnings per diluted share are not calculated in accordance with GAAP, and should be considered supplemental to, and not as a substitute for, or superior to, financial measures calculated in accordance with GAAP. Non-GAAP financial measures have limitations in that they do not reflect all of the costs or benefits associated with the operations of the Company's business as determined in accordance with GAAP. As a result, you should not consider these measures in isolation or as a substitute for analysis of Integra's results as reported under GAAP. Integra expects to continue to incur expenses of a nature similar to the non-GAAP adjustments described above, and exclusion of these items from its adjusted net income should not be construed as an inference that all of these costs are unusual, infrequent or non-recurring. Some of the limitations in relying on adjusted net income and adjusted earnings per diluted share are: o Adjusted net income does not include equity-based compensation expense related to equity awards granted to our workforce or third parties. Our equity incentive plans are important components of our employee incentive compensation arrangements and are reflected as expenses in our GAAP results in accordance with Statement of Financial Accounting Standards No. 123R, Share-Based Payment, commencing with the first quarter of 2006. While we include the dilutive impact of such equity awards in weighted average shares outstanding, the expense associated with equity-based awards is excluded from adjusted net income. o Integra periodically acquires other companies or businesses, and we expect to continue to incur acquisition-related expenses and charges in the future. These costs can directly impact the amount of the Company's available funds or could include costs for aborted deals which may be significant and reduce GAAP net income.

o Although the charges related to the restructuring of our operations and changes to our capital structure occur on a sporadic basis and the charges relating to the convertible note exchange offer and the interest rate swap termination did not previously occur, they may recur in the future and they are, in many cases, cash charges that reduce our available cash. There is no assurance that we will not incur other similar charges and expenditures in the future. o All of the adjustments have been tax effected at Integra's actual tax rates. Depending on the nature of the adjustments and the tax treatment of the underlying items, the effective tax rate related to adjusted net income could differ significantly from the effective tax rate related to GAAP income. In the financial statements portion of its earnings press release for the third quarter of 2006, which is attached hereto as Exhibit 99.1, the Company has included a reconciliation of GAAP net income to adjusted net income and GAAP earnings per diluted share to adjusted earnings per diluted share used by management for the three months ended September 30, 2006 and 2005. Also included are reconciliations for future periods. ITEM 9.01. FINANCIAL STATEMENTS AND EXHIBITS. (d) Exhibits. Exhibit Number Description of Exhibit - ------------------- --------------------------- 99.1 Press release issued November 2, 2006 regarding earnings for the quarter ended September 30, 2006

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the Registrant has duly caused this report to be signed on its behalf by the undersigned, hereunto duly authorized. INTEGRA LIFESCIENCES HOLDINGS CORPORATION DATE: NOVEMBER 2, 2006 BY: /s/ STUART M. ESSIG ----------------------------- STUART M. ESSIG PRESIDENT AND CHIEF EXECUTIVE OFFICER

EXHIBIT INDEX Exhibit Number Description of Exhibit - ------------------- --------------------------- 99.1 Press release issued November 2, 2006 regarding earnings for the quarter ended September 30, 2006

                                                                    Exhibit 99.1


NEWS RELEASE

Contacts:

Integra LifeSciences Holdings Corporation

Maureen B. Bellantoni                     John Bostjancic
Executive Vice President                  Vice President, Corporate Development
and Chief Financial Officer               and Investor Relations
(609) 936-6822                            (609) 936-2239
maureen.bellantoni@Integra-LS.com         jbostjancic@Integra-LS.com


        INTEGRA LIFESCIENCES REPORTS THIRD QUARTER 2006 FINANCIAL RESULTS

                    REVENUES FOR QUARTER EXCEED $116 MILLION

Plainsboro,  New  Jersey,  November  2,  2006 -  Integra  LifeSciences  Holdings
Corporation  (NASDAQ:  IART) today reported its third quarter financial results.
Total revenues in the third quarter of 2006 were $116.6  million,  reflecting an
increase of $47.3 million, or 68%, over the third quarter of 2005. Revenues from
products acquired in 2006 totaled $35.7 million for the quarter.

We reported  net income of $2.6  million,  or $0.09 per diluted  share,  for the
third  quarter of 2006,  compared to net income of $10.5  million,  or $0.33 per
diluted  share in the third  quarter of 2005.  Reported  earnings  for the third
quarter of 2006 include $3.8 million of share-based compensation expense related
to the implementation of SFAS 123R Share-Based Payment in January 2006. Reported
earnings for the third quarter of 2005 do not reflect the impact of  share-based
compensation expense.

In addition to GAAP results,  Integra  reports  adjusted net income and adjusted
diluted  earnings per share. A further  discussion of these  non-GAAP  financial
measures can be found below, and  reconciliations of GAAP net income to adjusted
net income and GAAP diluted  earnings per share to adjusted diluted earnings per
share for the three  months  ended  September  30,  2006 and 2005  appear in the
financial statements attached to this release.

Adjusted net income for the third quarter of 2006, computed with the adjustments
to GAAP reporting set forth in the attached  reconciliation,  was $13.7 million,
or $0.43 per diluted share. In the third quarter of 2005 adjusted net income was
$11.5 million, or $0.36 per diluted share.

"We  achieved  record  revenues  in the third  quarter,"  said  Stuart M. Essig,
Integra's  President  and Chief  Executive  Officer.  "During  the  quarter,  we
acquired  Kinetikos  Medical  (KMI) and  launched a direct sales force in Canada
through  the  acquisition  of our  longstanding  Canadian  distributor.  We have
integrated   Radionics  and  Miltex  and  are  now   integrating  KMI  into  our
Reconstructive Surgery sales channel."

We present our  revenues in two  categories:  a)  Neurosurgical  and  Orthopedic
Implants and b) Medical Surgical Equipment.

Our revenues for the period were as follows: Three Months Ended September 30, % Increase/ 2006 2005 (Decrease) ---- ---- ---------- ($ in thousands) Revenue: Neuro/Ortho Implants $43,136 $33,516 29% MedSurg Equipment 73,511 35,818 105% ------ ------- ---- Total Revenue $116,647 $69,334 68% In the Neuro/Ortho Implants category, sales of our reconstructive surgery implant products continued to grow strongly. Rapid growth in nerve and dermal repair products and sales of products for the hand, foot and ankle accounted for much of the increase in implant product revenues. INTEGRA(TM) dermal repair product revenues increased 32% over the third quarter of 2005, nerve repair product revenues increased by 44%, and our hand, foot and ankle products more than doubled. Revenues from bone graft and collagen dental products increased by 57% over the third quarter of 2005. KMI products contributed $1.9 million of sales to the quarter. In the MedSurg Equipment category, acquired products, surgical instruments, and monitoring products provided most of the year-over-year growth in product revenues for the third quarter. Radionics, Miltex and non-Integra distributed products sold through our former Canadian distributor (all acquired in 2006) contributed $33.8 million of sales to the quarter. Gross margin on total revenues in the third quarter of 2006 was 59%. In cost of product revenues, we recognized $1.4 million in inventory fair value purchase accounting adjustments from recent acquisitions. These charges reduced our gross margin by approximately 1%. Research and development expense increased $7.9 million in the third quarter of 2006 to $11.0 million. In the third quarter of 2006, we recorded an in-process research and development charge of $5.6 million related to the KMI acquisition and a $0.5 million charge related to an upfront payment pursuant to a new product development alliance. Selling, general and administrative expense increased by $20.8 million to $43.4 million in the third quarter of 2006, or 37% of revenue, as compared to 33% in the third quarter of 2005. Included in this increase was $3.5 million of share-based compensation expense attributable to the impact of adopting FAS 123R. Operating income for the third quarter of 2006 was $11.8 million. We reported net interest expense of $4.0 million in the third quarter of 2006, which includes $1.4 million of interest expense under our revolving line of credit. In September 2006, Integra completed an exchange of $115.2 million (out of a total of $120.0 million) of its old contingent convertible notes for the equivalent amount of new notes with a "net share settlement" feature and takeover protection. In connection with the exchange offer, Integra recorded a $1.8 million charge in the third quarter of 2006 related to $0.6 million of fees paid in connection with the exchange and a $1.2 million write-off of the unamortized debt issuance costs associated with the old contingent convertible notes that were exchanged. We reported $1.5 million of this charge in net interest expense. In October 2006, Integra issued an additional $4.3 million of new notes in exchange for an equal amount of old notes. We reported $1.8 million of other expense in the third quarter of 2006. In September 2006, Integra terminated its $50.0 million notional amount interest rate swap, which was used to hedge the risk of changes in fair value attributable to interest rate risk with respect to a portion of Integra's old

contingent convertible notes. The interest rate swap qualified as a fair value hedge under Statement of Financial Accounting Standard No. 133, as amended, "Accounting for Derivative Instruments and Hedging Activities." In connection with the termination of the interest rate swap, Integra discontinued hedge accounting and recorded a $1.4 million charge to other expense in the third quarter of 2006 to write-off the unamortized mark-to-market fair value adjustment recorded against the contingent convertible notes. Our effective income tax rate was 57% for the third quarter of 2006, or a 37% effective rate for the year-to-date period. In the first half of 2006, we recorded income tax expense at an expected full year effective rate of 31%. The increase in the expected year-to-date effective rate was primarily driven by the nondeductible nature of the $5.6 million in-process research and development charge recorded in connection with the KMI acquisition in the third quarter of 2006. We expect an effective income tax rate for 2007 of approximately 31%. We generated $24.2 million in cash flow from operations in the third quarter of 2006. We repurchased 456,750 shares of our common stock in the quarter at an average price of $36.46 per share for an aggregate purchase price of approximately $16.7 million. On October 30, 2006 our Board of Directors authorized us to repurchase up to an additional $75 million of our common stock through December 31, 2007. At September 30, 2006, our cash totaled $24.2 million and we had outstanding borrowings of $87.0 million under our credit facility. We are updating our guidance for total revenues for the full years 2006 and 2007. We are also updating our expectations for earnings per share and providing guidance for the fourth quarter of 2006. In accordance with our usual practice, our expectations for 2006 and 2007 financial performance do not include the impact of acquisitions or other strategic corporate transactions that have not yet closed. For the fourth quarter of 2006, we expect total revenues to be in the range of $116 million to $121 million and earnings per diluted share in the range of $0.37 to $0.43. Accordingly, we expect total revenues in 2006 to be between $410 million and $415 million and earnings per diluted share to be between $1.00 and $1.05. We expect adjusted earnings per diluted share, computed with the adjustments to GAAP reporting set forth in the attached reconciliation, to be in the range of $0.47 and $0.52 for the fourth quarter of 2006 and $1.68 and $1.73 for the full year 2006. For 2007, we expect total revenues to be between $500 million and $520 million and earnings per diluted share to be between $1.76 and $1.85. We expect adjusted earnings per diluted share, computed with the adjustments to GAAP reporting set forth in the attached reconciliation, to be in the range of $2.08 and $2.17. Integra has incurred significant costs in 2006 in connection with restructuring and integration activities, including inventory purchase accounting charges, in-process research and development charges, and discontinued research and development projects related to the acquisitions we have closed this year, and charges related to the contingent convertible notes exchange offer and the termination of our interest rate swap. We currently expect these charges to total approximately $16.2 million in 2006, of which $15.6 million have already been incurred through the end of the third quarter. We have scheduled a conference call for 9:00 am EST today, November 2, 2006, to discuss the financial results for the third quarter of 2006 and forward-looking financial guidance. The call is open to all listeners and will be followed by a question and answer session. Access to the live call is available by dialing (913) 981-5560 or through a listen-only webcast via a link provided on the home page of Integra's website at www.Integra-LS.com. A replay of the conference call will be accessible starting one hour following the live event. Access to the replay is available through November 16, 2006 by dialing (719) 457-0820 (access code 5413428) or through the webcast accessible on our home page.

Integra LifeSciences Holdings Corporation is a diversified medical technology company. We develop, manufacture, and market medical devices for use in a variety of applications. The primary applications for our products are neurosurgery, reconstructive surgery and general surgery. Integra is a leader in applying the principles of biotechnology to medical devices that improve patients' quality of life. Our corporate headquarters are in Plainsboro, New Jersey. We have research, manufacturing and distribution facilities throughout the world. Please visit our website at (http://www.Integra-LS.com). This news release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements concerning future financial performance, including projections for revenues, GAAP and adjusted earnings per diluted share, and costs to be incurred in connection with restructuring and integration activities. Such forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from predicted or expected results. Among other things, our ability to maintain relationships with customers of acquired entities, physicians' willingness to adopt our recently launched and planned products, third-party payors' willingness to provide reimbursement for these products and our ability to secure regulatory approval for products in development may adversely affect our future product revenues; our ability to integrate acquired businesses, increase product sales and gross margins, and control non-product costs may affect our GAAP and adjusted earnings per share; and the ultimate scope of our restructuring and integration activities and our ability to complete these activities may affect the total costs to be incurred in connection with these activities. In addition, the economic, competitive, governmental, technological and other factors identified under the heading "Factors That May Affect Our Future Performance" included in the Business section of Integra's Annual Report on Form 10-K for the year ended December 31, 2005 and information contained in subsequent filings with the Securities and Exchange Commission could affect actual results. Discussion of Adjusted Financial Measures Adjusted net income consists of net income excluding equity-based compensation charges, acquisition-related charges, charges incurred in connection with the exchange offer of convertible notes and the termination of the interest rate swap agreement, facility consolidation, manufacturing transfer and system integration charges, and certain employee termination and related costs. Adjusted earnings per diluted share are calculated by dividing adjusted net income for diluted earnings per share by adjusted diluted weighted average shares outstanding. Because all equity-based compensation expense is added back in the calculation of adjusted net income, the calculation of diluted weighted average shares outstanding is adjusted to exclude the benefits of unearned equity-based compensation costs attributable to future services and not yet recognized in the financial statements. These unearned equity-based compensation costs are treated as proceeds assumed to be used to repurchase shares, based on the average trading price of Integra common stock during the period reported, in the calculation of GAAP diluted weighted average shares outstanding. Integra believes that the presentation of adjusted net income and adjusted earnings per diluted share provides important supplemental information to management and investors regarding non-cash expenses and financial and business trends relating to the Company's financial condition and results of operations. For further information regarding why Integra believes that these non-GAAP financial measures provide useful information to investors, the specific manner in which management uses these measures, and some of the limitations associated with the use of these measures, please refer to the Company's Current Report on Form 8-K regarding this earnings press release filed today with the Securities and Exchange Commission. The section of the Company's report is available on the SEC's website at www.sec.gov or on our website at www.Integra-LS.com.

INTEGRA LIFESCIENCES HOLDINGS CORPORATION CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (UNAUDITED) (In thousands, except per share amounts) Three Months Ended September 30, -------------------------- 2006 2005 --------- --------- TOTAL REVENUE $ 116,647 $ 69,334 COSTS AND EXPENSES Cost of product revenues 47,559 26,394 Research and development 10,991 3,110 Selling, general and administrative 43,431 22,653 Intangible asset amortization 2,852 1,085 --------- --------- Total costs and expenses 104,833 53,242 Operating income 11,814 16,092 Interest income 375 952 Interest expense (4,362) (1,345) Other income (expense), net (1,765) (4) --------- --------- Income before income taxes 6,062 15,695 Income tax expense 3,468 5,213 --------- --------- Net income $ 2,594 $ 10,482 Add back of after tax interest expense -- 800 Net income for diluted earnings per share $ 2,594 $ 11,281 Diluted net income per share $ 0.09 $ 0.33 Weighted average common shares outstanding for diluted net income per share 29,863 34,297

Listed below are the items included in net income that management excludes in computing the adjusted financial measures referred to in the text of this press release and further described under Discussion of Adjusted Financial Measures. Three Months Ended September 30, ----------------------- 2006 2005 ------- ------- Equity-based compensation $ 3,809 $ -- Acquisition-related charges 6,999 500 Facility consolidation, manufacturing transfer and system integration charges -- 365 Employee termination and related costs -- 794 Charges associated with convertible debt exchange offer 1,792 Charges associated with termination of interest rate swap 1,425 Income tax expense (benefit) related to above adjustments (2,969) (623)

INTEGRA LIFESCIENCES HOLDINGS CORPORATION RECONCILIATION OF NON-GAAP ADJUSTMENTS - HISTORICAL (UNAUDITED) (In thousands, except per share amounts) Three Months Ended September 30, ---------------------- 2006 2005 -------- -------- GAAP net income $ 2,594 $ 10,481 Non-GAAP adjustments: Equity-based compensation 3,809 -- Acquisition-related charges 6,999 500 Facility consolidation, manufacturing transfer and system integration charges -- 365 Employee termination and related costs -- 794 Charges associated with convertible debt exchange offer 1,792 -- Charges associated with termination of interest rate swap 1,425 -- Income tax expense (benefit) related to above adjustments (2,969) (623) -------- -------- Total of non-GAAP adjustments 11,056 1,036 Adjusted net income $ 13,650 $ 11,517 Add back of after tax interest expense (1) 755 800 -------- -------- Adjusted net income for diluted earnings per share $ 14,405 $ 12,317 Weighted average common shares outstanding for diluted net income per share 29,863 34,297 Shares issuable upon conversion of convertible notes (1) 3,381 -- Non-GAAP adjustment 106 -- -------- -------- Adjusted weighted average common shares outstanding for adjusted diluted net income per share 33,350 34,297 GAAP diluted net income per share $ 0.09 $ 0.33 Non-GAAP adjustments detailed above (per share) $ 0.34 $ 0.03 -------- -------- Adjusted diluted net income per share $ 0.43 $ 0.36 (1) The "as if converted" method related to the convertible notes is applied in the calculation of adjusted diluted net income per share for the three months ended September 30, 2006 because its effects are more dilutive.

INTEGRA LIFESCIENCES HOLDINGS CORPORATION RECONCILIATION OF NON-GAAP ADJUSTMENTS - GUIDANCE (In thousands, except per share amounts) Projected Three Months Ended Projected Year Ended December 31, 2006 December 31, 2006 ---------------------------- -------------------------- Low High Low High GAAP net income $ 11,150 $ 12,800 $ 30,426 $ 32,076 Add back of after tax interest expense -- -- 2,252 2,252 -------- -------- -------- -------- GAAP net income for diluted earnings per share 11,150 12,800 32,678 34,328 Non-GAAP adjustments: Equity-based compensation 3,600 3,600 13,882 13,882 Acquisition-related charges 600 600 11,790 11,790 Facility consolidation, manufacturing transfer and system integration charges -- -- 717 717 Employee termination and related costs -- -- 421 421 Charges associated with convertible debt exchange offer -- -- 1,879 1,879 Charges associated with termination of interest rate -- -- 1,425 1,425 swap Income tax expense (benefit) related to above adjustments (1,325) (1,325) (7,814) (7,814) -------- -------- -------- -------- Total of non-GAAP adjustments 2,875 2,875 22,300 22,300 -------- -------- -------- -------- Adjusted net income $ 14,025 $ 15,675 $ 54,978 $ 56,628 Weighted average common shares outstanding for diluted net income per share 29,875 29,875 32,688 32,688 Non-GAAP adjustment (1) 106 106 126 126 -------- -------- -------- -------- Adjusted weighted average common shares outstanding for adjusted diluted net income per share 29,981 29,981 32,814 32,814 GAAP diluted net income per share $ 0.37 $ 0.43 $ 1.00 $ 1.05 Non-GAAP adjustments detailed above (per share) 0.10 0.09 0.68 0.68 -------- -------- -------- -------- Adjusted diluted net income per share $ 0.47 $ 0.52 $ 1.68 $ 1.73 (1) For ease of computation, the Company has assumed that the same adjustment that applied for the three months ended September 30, 2006 (106 shares) is the applicable adjustment for the projected three months ended December 31, 2006 and the year ended December 31, 2007.

INTEGRA LIFESCIENCES HOLDINGS CORPORATION RECONCILIATION OF NON-GAAP ADJUSTMENTS - GUIDANCE (In thousands, except per share amounts) Projected Year Ended December 31, 2007 ------------------------ Low High GAAP net income $ 52,000 $ 54,500 Add back of after tax interest expense -- -- -------- -------- GAAP net income for diluted earnings per share 52,000 54,500 Non-GAAP adjustments: Equity-based compensation 14,000 14,000 Income tax expense (benefit) related to above adjustments (4,300) (4,300) -------- -------- Total of non-GAAP adjustments 9,700 9,700 -------- -------- Adjusted net income $ 61,700 64,200 Weighted average common shares outstanding for diluted net income per share 29,500 29,500 Non-GAAP adjustment (1) 106 106 -------- -------- Adjusted weighted average common shares outstanding for adjusted diluted net income per share 29,606 29,606 GAAP diluted net income per share $ 1.76 1.85 Non-GAAP adjustments detailed above (per share) 0.32 0.32 -------- -------- Adjusted diluted net income per share $ 2.08 $ 2.17 (1) For ease of computation, the Company has assumed that the same adjustment that applied for the three months ended September 30, 2006 (106 shares) is the applicable adjustment for the projected three months ended December 31, 2006 and the year ended December 31, 2007.

Condensed Balance Sheet Data: September 30, December 31, 2006 2005 ---- ---- Cash and marketable securities, including non-current portion $ 24,322 $143,384 Accounts receivable, net 76,715 49,007 Inventory, net 93,773 67,476 Total current assets 219,115 265,952 Total assets 593,667 448,432 Bank line of credit 87,000 -- Demand notes (1) 115,205 -- Total current liabilities 255,456 31,287 Long term debt (1) 4,889 118,378 Total liabilities 288,186 158,614 Stockholders' equity 305,481 289,818 (1) The closing price of Integra's common stock on the issuance date of the new convertible notes was higher than the market price trigger of the new notes. Therefore, the new notes are considered demand debt and are classified as current liabilities on the balance sheet since the holders have the option to call this debt at any time. SOURCE: INTEGRA LIFESCIENCES HOLDINGS CORPORATION