May 9, 2007

Integra LifeSciences Reports First Quarter 2007 Financial Results

Revenues for the First Quarter Increase 60 Percent to $123.0 Million

PLAINSBORO, N.J., May 9, 2007 (PrimeNewswire via COMTEX News Network) -- Integra LifeSciences Holdings Corporation (Nasdaq:IART) today reported its financial results for the first quarter ending March 31, 2007. Total revenues in the first quarter of 2007 were $123.0 million, reflecting an increase of $45.9 million, or 60%, over the first quarter of 2006. Revenues from products acquired in 2006 were $34.7 million for the first quarter of 2007, as compared to $3.4 million in the first quarter of 2006.

The company reported GAAP net income of $9.1 million, or $0.30 per diluted share, for the first quarter of 2007, compared to GAAP net income of $8.7 million, or $0.28 per diluted share, in the first quarter of 2006.

"We achieved strong revenue growth in the first quarter from increased sales of our existing product lines and acquired products," said Stuart M. Essig, Integra's President and Chief Executive Officer. "During the quarter, we announced our agreement to acquire LXU Healthcare, the market-leading provider of surgical headlight systems, and we acquired the DenLite(TM) illuminated dental mirror product line to complement our Miltex(R) brand of dental instruments. We also launched the Integra Mozaik(TM) Osteoconductive Scaffold through our Integra NeuroSciences sales force and our newly created 20-person orthopedic spine sales organization. We are very excited about the launch of the Integra Mozaik product, which is an innovative bone graft substitute that addresses the estimated $350 million market for spinal fusion procedures. Initial customer feedback has been very positive."

Operating income for the first quarter of 2007 was $16.5 million, a 21% increase over the prior year period.

Integra generated $15.3 million in cash flows from operations in the first quarter of 2007, an increase of 41% over the year ago period.

"Our objectives include growing operating income and cash flows, which increased significantly over the prior year period," said Maureen B. Bellantoni, Integra's Executive Vice President and Chief Financial Officer. "During the past five years, we have generated in excess of 35% average annual growth in our operating cash flows. This has greatly improved our access to debt capital, which we have increasingly used to support our growth."

In addition to GAAP results, Integra reports adjusted net income and adjusted diluted earnings per share. A further discussion of these non-GAAP financial measures can be found below, and reconciliations of GAAP net income to adjusted net income and GAAP diluted earnings per share to adjusted diluted earnings per share for the quarters ended March 31, 2007 and 2006 appear in the financial statements attached to this release. Please note that as presented in this release Integra's adjusted net income and adjusted diluted earnings per share for these periods are not adjusted for compensation expense associated with FAS 123R. Integra will no longer be adjusting its net income and diluted earnings per share for these expenses.

Adjusted net income for the first quarter of 2007, computed with the adjustments to GAAP reporting set forth in the attached reconciliation, was $9.8 million, or $0.33 per diluted share. In the first quarter of 2006, adjusted net income was $10.4 million, or $0.31 per diluted share.

Integra LifeSciences presents its revenues in two categories: a) Neurosurgical and Orthopedic Implants and b) Medical Surgical Equipment.

The company's revenues for the periods were as follows:


                                                  Three Months
                                                 Ended March 31,
                                              2007           2006
                                            --------       --------
 Revenue: ($ in thousands)
 Neurosurgical and Orthopedic
  Implants                                  $ 47,087       $ 36,746
 Medical Surgical Equipment
  and other                                   75,945         40,389
                                            --------       --------
     Total Revenue                          $123,032       $ 77,135

Sales of our DuraGen(R) family of products, extremity reconstruction implants and bone growth products led revenue growth in the Neurosurgical and Orthopedic Implants category. In particular, sales of the NeuraGen(R) and Newdeal(R) family of products once again showed strong growth of approximately 25%. Sales of product lines acquired in 2006 contributed $2.4 million to the increase in neurosurgical and orthopedic implant sales.

In the Medical Surgical Equipment category, acquired products, surgical instruments and ultrasonic surgical systems provided most of the year-over-year growth in product revenues for the first quarter. The growth in this category came across multiple product lines, with our Jarit(R) surgical instruments, MAYFIELD(R)(1) cranial fixation systems and our monitoring product lines all generating double-digit growth in the quarter. Radionics(TM) products, Miltex(R) products and products of other companies sold through our former Canadian distributor (all acquired in 2006) contributed $32.3 million of product revenues during the quarter.

Gross margin on total revenues in the first quarter of 2007 was 60.5%. Cost of goods sold included charges related to the start up of CUSA manufacturing, a product withdrawal and employee severance costs, which together adversely affected the gross margin by one half of a percentage point.

Research and development expense increased $2.9 million in the first quarter of 2007 to $6.1 million. The increase came principally from increased spending on collagen regenerative technology and ultrasonic aspirator product development programs.

Selling, general and administrative expense increased by $18.0 million to $49.1 million in the first quarter of 2007, or 40% of revenue, consistent with the first quarter of 2006.

We reported a $1.9 million increase in net interest expense to $2.5 million for the first quarter of 2007, primarily from increased borrowings under our credit facility. We reported an effective income tax rate of 34%.

During the first quarter of 2007, we repurchased 264,000 shares of our common stock for an aggregate purchase price of $11.1 million. As of March 31, 2007, there was approximately $25.7 million available for repurchases under our existing share repurchase authorization, which will expire on December 31, 2007.

At March 31, 2007, our cash totaled $29.3 million and we had outstanding borrowings of $100 million under our credit facility. In the first quarter of 2007, we increased the borrowing capacity under our credit facility to $300 million.

We are updating our guidance for the full year 2007 and 2008. We are also providing guidance for each quarterly period for the next twelve months. Our estimates assume foreign currency exchange rates remain unchanged throughout 2007 and 2008. In accordance with our usual practice, our expectations for 2007 and 2008 financial performance do not include the impact of acquisitions or other strategic corporate transactions that have not yet closed.

The acquisition of LXU Healthcare, which we announced last night, is included in our guidance. We expect this acquisition to increase our revenues in 2007 by approximately $19 million and in 2008 by approximately $30 million.

We estimate that we will incur approximately $1.25 million of inventory purchase accounting charges and $0.75 million of acquisition and integration related costs during the balance of 2007 related to the LXU Healthcare acquisition. In the future we may record, or expect to record, certain additional revenues, gains, expenses or charges (such as acquisition-related charges, facility consolidation, manufacturing transfer and system integration charges, and certain employee termination and related costs) that we will exclude in the calculation of adjusted earnings per share for historical periods and in providing adjusted earnings per share guidance.

We do not expect the LXU Healthcare acquisition to impact adjusted earnings per share in 2007 or 2008.

Our quarterly and full-year revenue and GAAP and adjusted earnings per share expectations are as follows:


                                        GAAP               Adjusted
                  Revenues           Earnings Per          Earnings
                   Guidance             Share              Per Share
 Period         (in millions)         Guidance             Guidance
 ----------      -----------        -------------       --------------
 Second
  Quarter
  2007           $124 - $127        $0.33 - $0.35       $0.34 - $0.36
 Third
  Quarter
  2007           $136 - $139        $0.44 - $0.48       $0.46 - $0.49
 Fourth
  Quarter
  2007           $150 - $153        $0.56 - $0.60       $0.58 - $0.61

 First
  Quarter
  2008           $142 - $147        $0.46 - $0.50        same as GAAP

 2007            $533 - $542        $1.63 - $1.73       $1.70 - $1.80

 2008            $600 - $620        $2.05 - $2.25        same as GAAP

On a quarterly basis, we expect to incur approximately $3.7 million, or $0.08 per share, of compensation expense associated with FAS 123R in 2007 and 2008. This non-cash compensation expense is included in both the GAAP and adjusted earnings per share guidance for 2007 and 2008 provided above.

We have scheduled a conference call for 9:00 am EST today, May 9, 2007, to discuss the financial results for the first quarter of 2007 and forward-looking financial guidance. The call is open to all listeners and will be followed by a question and answer session. Access to the live call is available by dialing (913) 312-6687 or through a listen-only webcast via a link provided on the Investor Relations homepage of Integra's website at www.Integra-LS.com. A replay of the conference call will be accessible starting one hour following the live event. Access to the replay is available through May 23, 2007 by dialing (719) 457-0820 (access code 7954405) or through the webcast accessible on our home page.

Integra LifeSciences Holdings Corporation, a world leader in regenerative medicine, is dedicated to improving the quality of life for patients through the development, manufacturing, and marketing of cost-effective surgical implants and medical instruments. Our products, used primarily in neurosurgery, extremity reconstruction, orthopedics and general surgery, are used to treat millions of patients every year. Integra's headquarters are in Plainsboro, New Jersey, and we have research and manufacturing facilities throughout the world. Please visit our website at (http://www.Integra-LS.com).

This news release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements concerning future financial performance, including projections for revenues, GAAP and adjusted net income, GAAP and adjusted earnings per diluted share, acquisition and integration related costs and non-cash compensation expense associated with FAS 123R. Such forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from predicted or expected results. Among other things, our ability to maintain relationships with customers of acquired entities, physicians' willingness to adopt our recently launched and planned products, third-party payors' willingness to provide reimbursement for these products, initiatives launched by our competitors, our ability to secure regulatory approval for products in development and our ability to comply with recently enacted regulations regarding products containing materials derived from animal sources may adversely affect our future product revenues; the timing of and our ability to integrate acquired businesses, increase product sales and gross margins, and control non-product costs may affect our net income and earnings per share; the amount and timing of acquisition and integration related costs; and the timing and amount of share-based awards granted to employees may affect the amount of non-cash compensation expense associated with FAS 123R. In addition, the economic, competitive, governmental, technological and other factors identified under the heading "Risk Factors" included in the Business section of Integra's Annual Report on Form 10-K for the year ended December 31, 2006 and information contained in subsequent filings with the Securities and Exchange Commission could affect actual results.

Discussion of Adjusted Financial Measures

Adjusted net income consists of net income excluding acquisition-related charges, facility consolidation, manufacturing transfer and system integration charges, certain employee termination and related costs, charges associated with discontinued or withdrawn product lines, and income tax expense/benefit related to these adjustments. Adjusted earnings per diluted share are calculated by dividing adjusted net income for diluted earnings per share by diluted weighted average shares outstanding.

Integra believes that the presentation of adjusted net income and adjusted earnings per diluted share provides important supplemental information to management and investors regarding financial and business trends relating to the Company's financial condition and results of operations. For further information regarding why Integra believes that these non-GAAP financial measures provide useful information to investors, the specific manner in which management uses these measures, and some of the limitations associated with the use of these measures, please refer to the Company's Current Report on Form 8-K regarding this earnings press release filed today with the Securities and Exchange Commission. This Current Report on Form 8-K is available on the SEC's website at www.sec.gov or on our website at www.Integra-LS.com.


                INTEGRA LIFESCIENCES HOLDINGS CORPORATION
            CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                           (UNAUDITED)

 (In thousands, except per share amounts)
                                              Three Months Ended
                                                   March 31,
                                            2007               2006
 TOTAL REVENUE                            $123,032          $ 77,135

 COSTS AND EXPENSES
 Cost of product revenues                   48,577            27,937
 Research and development                    6,060             3,173
 Selling, general and administrative        49,105            31,120
 Intangible asset amortization               2,787             1,281
                                          --------          --------

      Total costs and expenses             106,529            63,511

 Operating income                           16,503            13,624

 Interest income                               223             1,024
 Interest expense                           (2,759)           (1,682)
 Other income (expense), net                  (208)               32
                                          --------          --------

 Income before income taxes                 13,759            12,998

 Income tax expense                          4,685             4,293
                                          --------          --------

 Net income                                  9,074          $  8,705

 Add back of after tax interest
  expense                                        3               813
                                          --------          --------

 Net income for diluted earnings per
  share                                   $  9,077          $  9,518

 Diluted net income per share             $   0.30          $   0.28

 Weighted average common shares
  outstanding for diluted net income
  per share                                 29,965            33,828

Listed below are the items included in net income that management excludes in computing the adjusted financial measures referred to in the text of this press release and further described under Discussion of Adjusted Financial Measures.



 (In thousands)
                                            Three Months Ended
                                                March 31,
                                      -------------------------------
                                           2007             2006
                                      -------------    --------------

 Acquisition-related charges                  --                464

 Facility consolidation,
  manufacturing transfer
  and system integration charges             499                518

 Employee termination and
  related costs                              123                213


 Charges associated with
  discontinued or withdrawn
  product lines                              500                 --

 Income tax expense (benefit)
  related to above adjustments              (380)              (309)



                 INTEGRA LIFESCIENCES HOLDINGS CORPORATION
             RECONCILIATION OF NON-GAAP ADJUSTMENTS - HISTORICAL
                             (UNAUDITED)

 (In thousands, except per share amounts)

                                                Three Months Ended
                                                     March 31,
                                              2007              2006
                                            --------          --------
 GAAP net income                            $  9,074          $  8,705

 Non-GAAP adjustments:

  Acquisition-related charges                     --               464

  Facility consolidation,
   manufacturing transfer
   and system integration
   charges                                       499               518

  Employee termination and
   related costs                                 123               213

  Charges associated with
   discontinued or withdrawn
   product lines                                 500                --

  Income tax expense (benefit)
   related to above adjustments                 (380)             (309)
                                            --------          --------

  Total of non-GAAP adjustments                  742               886
                                            --------          --------

 Adjusted net income                           9,816             9,591
 Add back of after tax interest
  expense                                          3               813
                                            --------          --------

 Adjusted net income for diluted
  earnings per share                           9,819            10,404
                                            ========          ========

 Weighted average common shares
  outstanding for diluted net
  income per share                            29,965            33,828

                                            --------          --------
 Adjusted diluted net income
  per share                                 $   0.33          $   0.31
                                            ========          ========


 Condensed Balance Sheet Data (in thousands):

                                            March 31,        December 31,
                                              2007              2006
                                            --------          --------
 Cash and marketable securities,
  including non-current portion              $29,329           $22,697
 Accounts receivable, net                     85,884            85,018
 Inventory, net                               95,591            94,387


 Bank line of credit                         100,000           100,000
 Convertible Securities                      120,000           119,542

 Long term debt                                   --               508

 Stockholders' equity                        305,546           296,162




               INTEGRA LIFESCIENCES HOLDINGS CORPORATION
            RECONCILIATION OF NON-GAAP ADJUSTMENTS - GUIDANCE

 (In thousands, except per share amounts)

                            Projected Three          Projected Three
                              Months Ended            Months Ended
                             June 30, 2007         September 30, 2007
                          -------------------     --------------------
                            Low         High        Low         High
 GAAP net income          $ 9,790     $10,511     $13,410     $14,490

 Non-GAAP adjustments:

 Acquisition-related
  charges                     250         250         500         500
 Facility consolidation,
  manufacturing transfer
  and system
  integration charges         250         250         250         250

 Income tax expense
  (benefit) related
  to above adjustments       (170)       (170)       (255)       (255)
                          -------     -------     -------     -------

 Total of non-GAAP
  adjustments                 330         330         495         495
                          -------     -------     -------     -------

 Adjusted net income      $10,120     $10,841     $13,905     $14,985

 Weighted average
  common shares
  outstanding for
  diluted net income
  per share                30,119      30,119      30,294      30,294

 GAAP diluted net
  income per share        $  0.33     $  0.35     $  0.44     $  0.48
   Non-GAAP adjustments
    detailed above
    (per share)              0.01        0.01        0.02        0.01
                          -------     -------     -------     -------
 Adjusted diluted net
  income per share        $  0.34     $  0.36     $  0.46     $  0.49




               INTEGRA LIFESCIENCES HOLDINGS CORPORATION
           RECONCILIATION OF NON-GAAP ADJUSTMENTS - GUIDANCE

 (In thousands, except per share amounts)

                             Projected Three             Projected
                               Months Ended             Year Ended
                            December 31, 2007       December 31, 2007
                           -------------------     -------------------
                             Low         High        Low         High
 GAAP net income           $17,112     $18,256     $49,386     $52,331

 Non-GAAP adjustments:

  Acquisition-related
   charges                     500         500       1,250       1,250
  Facility consolidation,
   manufacturing transfer
   and system integration
   charges                     250         250       1,249       1,249
  Employee termination
   and related costs
                                --          --         123         123
  Charges associated with
   discontinued/withdrawn
   product lines                --          --         500         500

  Income tax expense
   (benefit) related to
   above adjustments          (255)       (255)     (1,060)     (1,060)
                           -------     -------     -------     -------

  Total of non-GAAP
   adjustments                 495         495       2,062       2,062
                           -------     -------     -------     -------

 Adjusted net income        17,607      18,751      51,448      54,393
 Add back of after tax
  interest expense              --          --           3           3
                           -------     -------     -------     -------
 Adjusted net income for
  diluted earnings per
  share                    $17,607     $18,751     $51,451     $54,396

 Weighted average common
  shares outstanding
  for diluted net income
  per share
                            30,560      30,560      30,235      30,235

 GAAP diluted net income
  per share                $  0.56     $  0.60     $  1.63     $  1.73
   Non-GAAP adjustments
    detailed above (per
    share)                    0.02        0.01        0.07        0.07
                           -------     -------     -------     -------
 Adjusted diluted net
  income per share         $  0.58     $  0.61     $  1.70     $  1.80



 (1) "MAYFIELD" is a registered trademark of SM USA, Inc., a wholly
     owned subsidiary of Schaerer Mayfield USA, Inc.

This news release was distributed by PrimeNewswire, www.primenewswire.com

SOURCE: Integra LifeSciences Holdings Corp.

Integra LifeSciences Holdings Corporation
         Maureen B. Bellantoni, Executive Vice President and 
          Chief Financial Officer
           (609) 936-6822
           maureen.bellantoni@Integra-LS.com
         John Bostjancic, Vice President, Corporate Development and 
          Investor Relations
           (609) 936-2239
           jbostjancic@Integra-LS.com

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