<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019c94fc-3eee-7e2d-ac05-75710e138186,g:30ca8461-a6e3-4df3-94f1-3a7449f80097-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://integralife.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="iart-20260226.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://integralife.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019c94fc-3eee-7ad9-90f1-8a4001948ec5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_019c94fc-3eee-701c-a9ad-82cad2469022" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntitiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019c94fc-3eee-7ad9-90f1-8a4001948ec5" xlink:to="loc_dei_EntitiesTable_019c94fc-3eee-701c-a9ad-82cad2469022" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressesAddressTypeAxis_019c94fc-3eee-7957-9bbe-811cf26e8434" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressesAddressTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_019c94fc-3eee-701c-a9ad-82cad2469022" xlink:to="loc_dei_EntityAddressesAddressTypeAxis_019c94fc-3eee-7957-9bbe-811cf26e8434" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AddressTypeDomain_019c94fc-3eee-738f-a302-07e267e2ab7f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AddressTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityAddressesAddressTypeAxis_019c94fc-3eee-7957-9bbe-811cf26e8434" xlink:to="loc_dei_AddressTypeDomain_019c94fc-3eee-738f-a302-07e267e2ab7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityInformationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_019c94fc-3eee-701c-a9ad-82cad2469022" xlink:to="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019c94fc-3eee-7555-afe6-bd3f368da8e7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_DocumentType_019c94fc-3eee-7555-afe6-bd3f368da8e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019c94fc-3eee-70a7-b640-2cfe8b8606b5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_DocumentPeriodEndDate_019c94fc-3eee-70a7-b640-2cfe8b8606b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019c94fc-3eee-7724-a838-c09bb918a551" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_EntityRegistrantName_019c94fc-3eee-7724-a838-c09bb918a551" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019c94fc-3eee-7106-a4fc-0e51d16eac09" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019c94fc-3eee-7106-a4fc-0e51d16eac09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019c94fc-3eee-71e1-9370-ce8882ddd48a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_EntityFileNumber_019c94fc-3eee-71e1-9370-ce8882ddd48a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019c94fc-3eee-79f5-8ab0-bd8f31b2d550" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_EntityTaxIdentificationNumber_019c94fc-3eee-79f5-8ab0-bd8f31b2d550" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019c94fc-3eee-7a35-9ffc-c601435486ee" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_EntityAddressAddressLine1_019c94fc-3eee-7a35-9ffc-c601435486ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019c94fc-3eee-7751-8d6f-110af9ca87b5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_EntityAddressCityOrTown_019c94fc-3eee-7751-8d6f-110af9ca87b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019c94fc-3eee-7722-91c1-04cf20014c97" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_EntityAddressStateOrProvince_019c94fc-3eee-7722-91c1-04cf20014c97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019c94fc-3eee-7a2b-b160-825a9a169e9c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_EntityAddressPostalZipCode_019c94fc-3eee-7a2b-b160-825a9a169e9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019c94fc-3eee-774e-b4ca-4dab530ee1b6" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_CityAreaCode_019c94fc-3eee-774e-b4ca-4dab530ee1b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019c94fc-3eee-7557-b9e7-c503cf2af3b7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_LocalPhoneNumber_019c94fc-3eee-7557-b9e7-c503cf2af3b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019c94fc-3eee-7417-a51d-0b7604bcf3c5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_WrittenCommunications_019c94fc-3eee-7417-a51d-0b7604bcf3c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019c94fc-3eee-74c7-a6d2-67b090d3d8a7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_SolicitingMaterial_019c94fc-3eee-74c7-a6d2-67b090d3d8a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019c94fc-3eee-781e-8d9c-04014fe152bf" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_PreCommencementTenderOffer_019c94fc-3eee-781e-8d9c-04014fe152bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019c94fc-3eee-7b38-b7a9-eec42af4fc43" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019c94fc-3eee-7b38-b7a9-eec42af4fc43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019c94fc-3eee-7aef-9667-a9b309c0436f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_Security12bTitle_019c94fc-3eee-7aef-9667-a9b309c0436f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019c94fc-3eee-74df-9771-64521f27b483" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_TradingSymbol_019c94fc-3eee-74df-9771-64521f27b483" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019c94fc-3eee-73af-b294-0581848047c8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_SecurityExchangeName_019c94fc-3eee-73af-b294-0581848047c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019c94fc-3eee-739f-8e66-4b7e6d61f519" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_EntityEmergingGrowthCompany_019c94fc-3eee-739f-8e66-4b7e6d61f519" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019c94fc-3eee-75f1-a385-806b184033c8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_EntityCentralIndexKey_019c94fc-3eee-75f1-a385-806b184033c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019c94fc-3eee-7958-8fcb-f1ae628382dc" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_019c94fc-3eee-76d8-ad35-e008f8c29c79" xlink:to="loc_dei_AmendmentFlag_019c94fc-3eee-7958-8fcb-f1ae628382dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
