<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:6456a09b-fea2-4bf6-b299-b3de112290cb,g:c8939f4a-cf00-43d4-a476-9d07e8aaad3e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://integralife.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="iart-20251030.xsd#DocumentandEntityInformation"/>
  <link:definitionLink xlink:role="http://integralife.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_a102b56b-093e-4ce7-a6e2-2c75342b3437" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_EntitiesTable_a102b56b-093e-4ce7-a6e2-2c75342b3437" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressesAddressTypeAxis_ca29831e-93c5-46ff-9dad-13a7707f76dc" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressesAddressTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_a102b56b-093e-4ce7-a6e2-2c75342b3437" xlink:to="loc_dei_EntityAddressesAddressTypeAxis_ca29831e-93c5-46ff-9dad-13a7707f76dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AddressTypeDomain_ca29831e-93c5-46ff-9dad-13a7707f76dc_default" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AddressTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_EntityAddressesAddressTypeAxis_ca29831e-93c5-46ff-9dad-13a7707f76dc" xlink:to="loc_dei_AddressTypeDomain_ca29831e-93c5-46ff-9dad-13a7707f76dc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AddressTypeDomain_8205797e-e15f-4155-aace-97c8b6d2d24a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AddressTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_EntityAddressesAddressTypeAxis_ca29831e-93c5-46ff-9dad-13a7707f76dc" xlink:to="loc_dei_AddressTypeDomain_8205797e-e15f-4155-aace-97c8b6d2d24a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_9b028612-be18-430b-b8a2-6131d35982d1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_DocumentType_9b028612-be18-430b-b8a2-6131d35982d1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_d6082fcd-f884-4e56-bc5c-7466e06a040c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_DocumentPeriodEndDate_d6082fcd-f884-4e56-bc5c-7466e06a040c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_41c23680-2247-427d-bcc5-84d9e35c7003" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_EntityRegistrantName_41c23680-2247-427d-bcc5-84d9e35c7003" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_e6d6ad34-92ea-418d-9675-5b698feec8a6" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_EntityIncorporationStateCountryCode_e6d6ad34-92ea-418d-9675-5b698feec8a6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_b9d12387-d1a5-4078-9a50-57d607c0d473" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_EntityFileNumber_b9d12387-d1a5-4078-9a50-57d607c0d473" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_39dd5e7e-6471-41e9-baf1-92fd96966318" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_EntityTaxIdentificationNumber_39dd5e7e-6471-41e9-baf1-92fd96966318" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_b826345a-624d-46d1-8a51-36663cfc2d4c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_EntityAddressAddressLine1_b826345a-624d-46d1-8a51-36663cfc2d4c" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_730093f4-4617-48a4-9d25-528a083e8348" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_EntityAddressCityOrTown_730093f4-4617-48a4-9d25-528a083e8348" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_dddb1fa8-9f10-42d7-b19f-8d54dccfd285" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_EntityAddressStateOrProvince_dddb1fa8-9f10-42d7-b19f-8d54dccfd285" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_44217f6b-5397-4d4f-8397-19e9350d45e8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_EntityAddressPostalZipCode_44217f6b-5397-4d4f-8397-19e9350d45e8" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_16fabfed-467e-41af-beeb-1793a637d4b1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_CityAreaCode_16fabfed-467e-41af-beeb-1793a637d4b1" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_98897785-1066-4135-bd3c-8cf029471bab" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_LocalPhoneNumber_98897785-1066-4135-bd3c-8cf029471bab" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_d35b206a-ddc8-4519-9e01-16a5968d706b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_WrittenCommunications_d35b206a-ddc8-4519-9e01-16a5968d706b" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_eb94de27-31a0-47e0-b423-e7425c083145" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_SolicitingMaterial_eb94de27-31a0-47e0-b423-e7425c083145" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_ebea554b-673a-4c99-81dd-07f740a3cef8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_PreCommencementTenderOffer_ebea554b-673a-4c99-81dd-07f740a3cef8" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_010a7548-17b5-4e52-959a-ebe2c5b42b4d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_010a7548-17b5-4e52-959a-ebe2c5b42b4d" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_cfa6147c-f9ec-492c-a99f-eb656a6973b4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_Security12bTitle_cfa6147c-f9ec-492c-a99f-eb656a6973b4" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_c6361600-3e1d-4358-a8fd-e66eab5070be" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_TradingSymbol_c6361600-3e1d-4358-a8fd-e66eab5070be" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_52f904d7-3982-4f6a-8f57-0213ba5d34f7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_SecurityExchangeName_52f904d7-3982-4f6a-8f57-0213ba5d34f7" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_19e5794c-949d-42c5-b69d-5f0bf6d27ec4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_EntityEmergingGrowthCompany_19e5794c-949d-42c5-b69d-5f0bf6d27ec4" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_b06a7cfe-7f02-4070-9047-95e62e08d2ef" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_EntityCentralIndexKey_b06a7cfe-7f02-4070-9047-95e62e08d2ef" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_c8aeec08-f45d-4f28-b35e-c9fa02fd1330" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_468b9bbb-d96e-4e64-9e5a-7b8b40610a03" xlink:to="loc_dei_AmendmentFlag_c8aeec08-f45d-4f28-b35e-c9fa02fd1330" xlink:type="arc" order="21"/>
  </link:definitionLink>
</link:linkbase>
