<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:b95f3504-ac62-40e7-97f2-bf3a82bc4bf6,g:e3d327f8-a12c-4b0c-a092-860a9884dfb1-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:iart="http://integralife.com/20240930" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types1="http://www.xbrl.org/dtr/type/2020-01-21" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2022-03-31" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://integralife.com/20240930">
  <xs:import namespace="http://fasb.org/srt/2024" schemaLocation="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2024" schemaLocation="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2020-01-21" schemaLocation="https://www.xbrl.org/dtr/type/2020-01-21/types.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2022-03-31" schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/country/2024" schemaLocation="https://xbrl.sec.gov/country/2024/country-2024.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2024" schemaLocation="https://xbrl.sec.gov/dei/2024/dei-2024.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2024" schemaLocation="https://xbrl.sec.gov/ecd/2024/ecd-2024.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="iart-20240930_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="iart-20240930_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="iart-20240930_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="iart-20240930_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="Cover" roleURI="http://integralife.com/role/Cover">
        <link:definition>0000001 - Document - Cover</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMEUNAUDITED" roleURI="http://integralife.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMEUNAUDITED">
        <link:definition>9952151 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (UNAUDITED)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED" roleURI="http://integralife.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED">
        <link:definition>9952152 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITEDParenthetical" roleURI="http://integralife.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITEDParenthetical">
        <link:definition>9952153 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED) (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED" roleURI="http://integralife.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED">
        <link:definition>9952154 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCONSOLIDATEDSTATEMENTSOFCHANGESINSHAREHOLDERSEQUITYUNAUDITED" roleURI="http://integralife.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCHANGESINSHAREHOLDERSEQUITYUNAUDITED">
        <link:definition>9952155 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY (UNAUDITED)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BASISOFPRESENTATION" roleURI="http://integralife.com/role/BASISOFPRESENTATION">
        <link:definition>9952156 - Disclosure - BASIS OF PRESENTATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACQUISITIONSANDDIVESTITURES" roleURI="http://integralife.com/role/ACQUISITIONSANDDIVESTITURES">
        <link:definition>9952157 - Disclosure - ACQUISITIONS AND DIVESTITURES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="REVENUESFROMCONTRACTSWITHCUSTOMERS" roleURI="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERS">
        <link:definition>9952158 - Disclosure - REVENUES FROM CONTRACTS WITH CUSTOMERS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INVENTORIES" roleURI="http://integralife.com/role/INVENTORIES">
        <link:definition>9952159 - Disclosure - INVENTORIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GOODWILLANDOTHERINTANGIBLEASSETS" roleURI="http://integralife.com/role/GOODWILLANDOTHERINTANGIBLEASSETS">
        <link:definition>9952160 - Disclosure - GOODWILL AND OTHER INTANGIBLE ASSETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBT" roleURI="http://integralife.com/role/DEBT">
        <link:definition>9952161 - Disclosure - DEBT</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DERIVATIVEINSTRUMENTS" roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTS">
        <link:definition>9952162 - Disclosure - DERIVATIVE INSTRUMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATION" roleURI="http://integralife.com/role/STOCKBASEDCOMPENSATION">
        <link:definition>9952163 - Disclosure - STOCK-BASED COMPENSATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RETIREMENTPLANS" roleURI="http://integralife.com/role/RETIREMENTPLANS">
        <link:definition>9952164 - Disclosure - RETIREMENT PLANS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESANDRELATEDPARTYLEASES" roleURI="http://integralife.com/role/LEASESANDRELATEDPARTYLEASES">
        <link:definition>9952165 - Disclosure - LEASES AND RELATED PARTY LEASES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="TREASURYSTOCK" roleURI="http://integralife.com/role/TREASURYSTOCK">
        <link:definition>9952166 - Disclosure - TREASURY STOCK</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXES" roleURI="http://integralife.com/role/INCOMETAXES">
        <link:definition>9952167 - Disclosure - INCOME TAXES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETINCOMEPERSHARE" roleURI="http://integralife.com/role/NETINCOMEPERSHARE">
        <link:definition>9952168 - Disclosure - NET INCOME PER SHARE</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACCUMULATEDOTHERCOMPREHENSIVELOSSINCOME" roleURI="http://integralife.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSINCOME">
        <link:definition>9952169 - Disclosure - ACCUMULATED OTHER COMPREHENSIVE (LOSS) INCOME</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTANDGEOGRAPHICINFORMATION" roleURI="http://integralife.com/role/SEGMENTANDGEOGRAPHICINFORMATION">
        <link:definition>9952170 - Disclosure - SEGMENT AND GEOGRAPHIC INFORMATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIES" roleURI="http://integralife.com/role/COMMITMENTSANDCONTINGENCIES">
        <link:definition>9952171 - Disclosure - COMMITMENTS AND CONTINGENCIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BASISOFPRESENTATIONPolicies" roleURI="http://integralife.com/role/BASISOFPRESENTATIONPolicies">
        <link:definition>9954471 - Disclosure - BASIS OF PRESENTATION (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACQUISITIONSANDDIVESTITURESTables" roleURI="http://integralife.com/role/ACQUISITIONSANDDIVESTITURESTables">
        <link:definition>9954472 - Disclosure - ACQUISITIONS AND DIVESTITURES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="REVENUESFROMCONTRACTSWITHCUSTOMERSTables" roleURI="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSTables">
        <link:definition>9954473 - Disclosure - REVENUES FROM CONTRACTS WITH CUSTOMERS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INVENTORIESTables" roleURI="http://integralife.com/role/INVENTORIESTables">
        <link:definition>9954474 - Disclosure - INVENTORIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GOODWILLANDOTHERINTANGIBLEASSETSTables" roleURI="http://integralife.com/role/GOODWILLANDOTHERINTANGIBLEASSETSTables">
        <link:definition>9954475 - Disclosure - GOODWILL AND OTHER INTANGIBLE ASSETS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTTables" roleURI="http://integralife.com/role/DEBTTables">
        <link:definition>9954476 - Disclosure - DEBT (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DERIVATIVEINSTRUMENTSTables" roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSTables">
        <link:definition>9954477 - Disclosure - DERIVATIVE INSTRUMENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESANDRELATEDPARTYLEASESTables" roleURI="http://integralife.com/role/LEASESANDRELATEDPARTYLEASESTables">
        <link:definition>9954478 - Disclosure - LEASES AND RELATED PARTY LEASES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESTables" roleURI="http://integralife.com/role/INCOMETAXESTables">
        <link:definition>9954479 - Disclosure - INCOME TAXES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETINCOMEPERSHARETables" roleURI="http://integralife.com/role/NETINCOMEPERSHARETables">
        <link:definition>9954480 - Disclosure - NET INCOME PER SHARE (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACCUMULATEDOTHERCOMPREHENSIVELOSSINCOMETables" roleURI="http://integralife.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSINCOMETables">
        <link:definition>9954481 - Disclosure - ACCUMULATED OTHER COMPREHENSIVE (LOSS) INCOME (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTANDGEOGRAPHICINFORMATIONTables" roleURI="http://integralife.com/role/SEGMENTANDGEOGRAPHICINFORMATIONTables">
        <link:definition>9954482 - Disclosure - SEGMENT AND GEOGRAPHIC INFORMATION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESTables" roleURI="http://integralife.com/role/COMMITMENTSANDCONTINGENCIESTables">
        <link:definition>9954483 - Disclosure - COMMITMENTS AND CONTINGENCIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BASISOFPRESENTATIONNarrativeDetails" roleURI="http://integralife.com/role/BASISOFPRESENTATIONNarrativeDetails">
        <link:definition>9954484 - Disclosure - BASIS OF PRESENTATION - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACQUISITIONSANDDIVESTITURESNarrativeDetails" roleURI="http://integralife.com/role/ACQUISITIONSANDDIVESTITURESNarrativeDetails">
        <link:definition>9954485 - Disclosure - ACQUISITIONS AND DIVESTITURES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACQUISITIONSANDDIVESTITURESBusinessCombinationScheduleofPurchasePriceAllocationDetails" roleURI="http://integralife.com/role/ACQUISITIONSANDDIVESTITURESBusinessCombinationScheduleofPurchasePriceAllocationDetails">
        <link:definition>9954486 - Disclosure - ACQUISITIONS AND DIVESTITURES - Business Combination, Schedule of Purchase Price Allocation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeDetails" roleURI="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeDetails">
        <link:definition>9954487 - Disclosure - REVENUES FROM CONTRACTS WITH CUSTOMERS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="REVENUESFROMCONTRACTSWITHCUSTOMERSScheduleofChangesinContractAssetsandLiabilitiesDetails" roleURI="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSScheduleofChangesinContractAssetsandLiabilitiesDetails">
        <link:definition>9954488 - Disclosure - REVENUES FROM CONTRACTS WITH CUSTOMERS - Schedule of Changes in Contract Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeRevenueRemainingPerformanceObligationDetails" roleURI="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeRevenueRemainingPerformanceObligationDetails">
        <link:definition>9954489 - Disclosure - REVENUES FROM CONTRACTS WITH CUSTOMERS - Narrative, Revenue Remaining Performance Obligation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeRevenueRemainingPerformanceObligationDetails_1" roleURI="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeRevenueRemainingPerformanceObligationDetails_1">
        <link:definition>9954489 - Disclosure - REVENUES FROM CONTRACTS WITH CUSTOMERS - Narrative, Revenue Remaining Performance Obligation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="REVENUESFROMCONTRACTSWITHCUSTOMERSScheduleofRevenuesDisaggregatedbyMajorSourceDetails" roleURI="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSScheduleofRevenuesDisaggregatedbyMajorSourceDetails">
        <link:definition>9954490 - Disclosure - REVENUES FROM CONTRACTS WITH CUSTOMERS - Schedule of Revenues Disaggregated by Major Source (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INVENTORIESScheduleofNetInventoriesDetails" roleURI="http://integralife.com/role/INVENTORIESScheduleofNetInventoriesDetails">
        <link:definition>9954491 - Disclosure - INVENTORIES - Schedule of Net Inventories (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GOODWILLANDOTHERINTANGIBLEASSETSScheduleofChangesinCarryingAmountofGoodwillDetails" roleURI="http://integralife.com/role/GOODWILLANDOTHERINTANGIBLEASSETSScheduleofChangesinCarryingAmountofGoodwillDetails">
        <link:definition>9954492 - Disclosure - GOODWILL AND OTHER INTANGIBLE ASSETS - Schedule of Changes in Carrying Amount of Goodwill (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GOODWILLANDOTHERINTANGIBLEASSETSComponentsofCompanysIdentifiableIntangibleAssetsDetails" roleURI="http://integralife.com/role/GOODWILLANDOTHERINTANGIBLEASSETSComponentsofCompanysIdentifiableIntangibleAssetsDetails">
        <link:definition>9954493 - Disclosure - GOODWILL AND OTHER INTANGIBLE ASSETS - Components of Company's Identifiable Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GOODWILLANDOTHERINTANGIBLEASSETSNarrativeDetails" roleURI="http://integralife.com/role/GOODWILLANDOTHERINTANGIBLEASSETSNarrativeDetails">
        <link:definition>9954494 - Disclosure - GOODWILL AND OTHER INTANGIBLE ASSETS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTNarrativeDetails" roleURI="http://integralife.com/role/DEBTNarrativeDetails">
        <link:definition>9954495 - Disclosure - DEBT - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTMaximumTotalLeverageRatioTableDetails" roleURI="http://integralife.com/role/DEBTMaximumTotalLeverageRatioTableDetails">
        <link:definition>9954496 - Disclosure - DEBT - Maximum Total Leverage Ratio Table (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTContractualMaturityTableDetails" roleURI="http://integralife.com/role/DEBTContractualMaturityTableDetails">
        <link:definition>9954497 - Disclosure - DEBT - Contractual Maturity Table (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DERIVATIVEINSTRUMENTSScheduleofDerivativeInstrumentsDetails" roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSScheduleofDerivativeInstrumentsDetails">
        <link:definition>9954498 - Disclosure - DERIVATIVE INSTRUMENTS - Schedule of Derivative Instruments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DERIVATIVEINSTRUMENTSNarrativeDetails" roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSNarrativeDetails">
        <link:definition>9954499 - Disclosure - DERIVATIVE INSTRUMENTS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DERIVATIVEINSTRUMENTSScheduleofCrossCurrencySwapDerivativesDetails" roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSScheduleofCrossCurrencySwapDerivativesDetails">
        <link:definition>9954500 - Disclosure - DERIVATIVE INSTRUMENTS - Schedule of Cross Currency Swap Derivatives (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DERIVATIVEINSTRUMENTSScheduleofNetInvestmentHedgesDerivativesDetails" roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSScheduleofNetInvestmentHedgesDerivativesDetails">
        <link:definition>9954501 - Disclosure - DERIVATIVE INSTRUMENTS - Schedule of Net Investment Hedges Derivatives (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DERIVATIVEINSTRUMENTSFairValueofDerivativeInstrumentsByBalanceSheetLocationDetails" roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSFairValueofDerivativeInstrumentsByBalanceSheetLocationDetails">
        <link:definition>9954502 - Disclosure - DERIVATIVE INSTRUMENTS - Fair Value of Derivative Instruments By Balance Sheet Location (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DERIVATIVEINSTRUMENTSEffectofDerivativeInstrumentsDesignatedCashFlowHedgesonStatementsofOperationsDetails" roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSEffectofDerivativeInstrumentsDesignatedCashFlowHedgesonStatementsofOperationsDetails">
        <link:definition>9954503 - Disclosure - DERIVATIVE INSTRUMENTS - Effect of Derivative Instruments Designated Cash Flow Hedges on Statements of Operations (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DERIVATIVEINSTRUMENTSScheduleofDerivativesNotDesignatedasHedgingInstrumentsDetails" roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSScheduleofDerivativesNotDesignatedasHedgingInstrumentsDetails">
        <link:definition>9954504 - Disclosure - DERIVATIVE INSTRUMENTS - Schedule of Derivatives Not Designated as Hedging Instruments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONNarrativeDetails" roleURI="http://integralife.com/role/STOCKBASEDCOMPENSATIONNarrativeDetails">
        <link:definition>9954505 - Disclosure - STOCK-BASED COMPENSATION - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RETIREMENTPLANSNarrativeDetails" roleURI="http://integralife.com/role/RETIREMENTPLANSNarrativeDetails">
        <link:definition>9954506 - Disclosure - RETIREMENT PLANS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESANDRELATEDPARTYLEASESNarrativeDetails" roleURI="http://integralife.com/role/LEASESANDRELATEDPARTYLEASESNarrativeDetails">
        <link:definition>9954507 - Disclosure - LEASES AND RELATED PARTY LEASES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESANDRELATEDPARTYLEASESSupplementalBalanceSheetInformationDetails" roleURI="http://integralife.com/role/LEASESANDRELATEDPARTYLEASESSupplementalBalanceSheetInformationDetails">
        <link:definition>9954508 - Disclosure - LEASES AND RELATED PARTY LEASES - Supplemental Balance Sheet Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESANDRELATEDPARTYLEASESSupplementalCashFlowInformationDetails" roleURI="http://integralife.com/role/LEASESANDRELATEDPARTYLEASESSupplementalCashFlowInformationDetails">
        <link:definition>9954509 - Disclosure - LEASES AND RELATED PARTY LEASES - Supplemental Cash Flow Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESANDRELATEDPARTYLEASESFutureMinimumLeasePaymentUnderOperatingLeasesDetails" roleURI="http://integralife.com/role/LEASESANDRELATEDPARTYLEASESFutureMinimumLeasePaymentUnderOperatingLeasesDetails">
        <link:definition>9954510 - Disclosure - LEASES AND RELATED PARTY LEASES - Future Minimum Lease Payment Under Operating Leases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESANDRELATEDPARTYLEASESFutureMinimumLeasePaymentUnderOperatingLeasesDetails_1" roleURI="http://integralife.com/role/LEASESANDRELATEDPARTYLEASESFutureMinimumLeasePaymentUnderOperatingLeasesDetails_1">
        <link:definition>9954510 - Disclosure - LEASES AND RELATED PARTY LEASES - Future Minimum Lease Payment Under Operating Leases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="TREASURYSTOCKNarrativeDetails" roleURI="http://integralife.com/role/TREASURYSTOCKNarrativeDetails">
        <link:definition>9954511 - Disclosure - TREASURY STOCK - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESSummaryofEffectiveTaxRateDetails" roleURI="http://integralife.com/role/INCOMETAXESSummaryofEffectiveTaxRateDetails">
        <link:definition>9954512 - Disclosure - INCOME TAXES - Summary of Effective Tax Rate (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESNarrativeDetails" roleURI="http://integralife.com/role/INCOMETAXESNarrativeDetails">
        <link:definition>9954513 - Disclosure - INCOME TAXES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETINCOMEPERSHAREBasicandDilutedNetIncomePerShareDetails" roleURI="http://integralife.com/role/NETINCOMEPERSHAREBasicandDilutedNetIncomePerShareDetails">
        <link:definition>9954514 - Disclosure - NET INCOME PER SHARE - Basic and Diluted Net Income Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETINCOMEPERSHARENarrativeDetails" roleURI="http://integralife.com/role/NETINCOMEPERSHARENarrativeDetails">
        <link:definition>9954515 - Disclosure - NET INCOME PER SHARE - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACCUMULATEDOTHERCOMPREHENSIVELOSSINCOMEScheduleofComprehensiveIncomeLossDetails" roleURI="http://integralife.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSINCOMEScheduleofComprehensiveIncomeLossDetails">
        <link:definition>9954516 - Disclosure - ACCUMULATED OTHER COMPREHENSIVE (LOSS) INCOME - Schedule of Comprehensive Income (Loss) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACCUMULATEDOTHERCOMPREHENSIVELOSSINCOMEScheduleofChangesinAccumulatedOtherComprehensiveIncomeLossbyComponentDetails" roleURI="http://integralife.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSINCOMEScheduleofChangesinAccumulatedOtherComprehensiveIncomeLossbyComponentDetails">
        <link:definition>9954517 - Disclosure - ACCUMULATED OTHER COMPREHENSIVE (LOSS) INCOME - Schedule of Changes in Accumulated Other Comprehensive Income (Loss) by Component (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACCUMULATEDOTHERCOMPREHENSIVELOSSINCOMENarrativeDetails" roleURI="http://integralife.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSINCOMENarrativeDetails">
        <link:definition>9954518 - Disclosure - ACCUMULATED OTHER COMPREHENSIVE (LOSS) INCOME - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTANDGEOGRAPHICINFORMATIONNarrativeDetails" roleURI="http://integralife.com/role/SEGMENTANDGEOGRAPHICINFORMATIONNarrativeDetails">
        <link:definition>9954519 - Disclosure - SEGMENT AND GEOGRAPHIC INFORMATION - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTANDGEOGRAPHICINFORMATIONNetSalesandProfitbyReportableSegmentDetails" roleURI="http://integralife.com/role/SEGMENTANDGEOGRAPHICINFORMATIONNetSalesandProfitbyReportableSegmentDetails">
        <link:definition>9954520 - Disclosure - SEGMENT AND GEOGRAPHIC INFORMATION - Net Sales and Profit by Reportable Segment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTANDGEOGRAPHICINFORMATIONTotalRevenuebyMajorGeographicAreaDetails" roleURI="http://integralife.com/role/SEGMENTANDGEOGRAPHICINFORMATIONTotalRevenuebyMajorGeographicAreaDetails">
        <link:definition>9954521 - Disclosure - SEGMENT AND GEOGRAPHIC INFORMATION - Total Revenue by Major Geographic Area (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESFairValueContingentConsiderationBalanceInformationDetails" roleURI="http://integralife.com/role/COMMITMENTSANDCONTINGENCIESFairValueContingentConsiderationBalanceInformationDetails">
        <link:definition>9954522 - Disclosure - COMMITMENTS AND CONTINGENCIES - Fair Value Contingent Consideration, Balance Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESNarrativeDetails" roleURI="http://integralife.com/role/COMMITMENTSANDCONTINGENCIESNarrativeDetails">
        <link:definition>9954523 - Disclosure - COMMITMENTS AND CONTINGENCIES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="iart_SecuredLongTermDebtSecuritizationProgramNoncurrent" abstract="false" name="SecuredLongTermDebtSecuritizationProgramNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_AmortizationOfDebtIssuanceCostsAndDebtRefinancedFees" abstract="false" name="AmortizationOfDebtIssuanceCostsAndDebtRefinancedFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_NoncashLeaseExpense" abstract="false" name="NoncashLeaseExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_MergersAcquisitionsAndDispositionsAbstract" abstract="true" name="MergersAcquisitionsAndDispositionsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="iart_AssetsAndLiabilitiesLesseeTableTextBlock" abstract="false" name="AssetsAndLiabilitiesLesseeTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="iart_CashFlowLesseeTableTextBlock" abstract="false" name="CashFlowLesseeTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="iart_AcclarentInc.Member" abstract="true" name="AcclarentInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DurepairRegenerationMatrixMember" abstract="true" name="DurepairRegenerationMatrixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_BusinessCombinationIntangibleAssetAcquiredDiscountRate" abstract="false" name="BusinessCombinationIntangibleAssetAcquiredDiscountRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="iart_PaymentsForAssetAcquisitions" abstract="false" name="PaymentsForAssetAcquisitions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_CompletedTechnologyMember" abstract="true" name="CompletedTechnologyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRightOfUseAssetOperatingLeases" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRightOfUseAssetOperatingLeases" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedAssetsAcquiredIncludingGoodwill" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedAssetsAcquiredIncludingGoodwill" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContractWithCustomerLiabilityCurrent" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContractWithCustomerLiabilityCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesEmployeeRelatedLiabilities" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesEmployeeRelatedLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedLiabilities" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesLeaseLiabilityOperatingLeases" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesLeaseLiabilityOperatingLeases" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLeaseLiabilityOperatingLeases" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLeaseLiabilityOperatingLeases" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_ReturnPolicyIssueOfCreditNumberOfDaysFromShipment" abstract="false" name="ReturnPolicyIssueOfCreditNumberOfDaysFromShipment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="iart_RevenueProductWarrantyPeriod" abstract="false" name="RevenueProductWarrantyPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="iart_ChangeInContractWithCustomerAssetRollForward" abstract="true" name="ChangeInContractWithCustomerAssetRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="iart_ContractWithCustomerAssetNetOfReclassifiedToReceivable" abstract="false" name="ContractWithCustomerAssetNetOfReclassifiedToReceivable" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_ChangeInContractWithCustomerLiabilityRollForward" abstract="true" name="ChangeInContractWithCustomerLiabilityRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="iart_ContractWithCustomerLiabilityNetOfRevenueRecognized" abstract="false" name="ContractWithCustomerLiabilityNetOfRevenueRecognized" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_ContractWithCustomerLiabilityIncreaseDecreaseFromForeignCurrencyTranslation" abstract="false" name="ContractWithCustomerLiabilityIncreaseDecreaseFromForeignCurrencyTranslation" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_CodmanSpecialtySurgicalMember" abstract="true" name="CodmanSpecialtySurgicalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_TissueTechnologiesMember" abstract="true" name="TissueTechnologiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_NeurosurgeryMember" abstract="true" name="NeurosurgeryMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_InstrumentsMember" abstract="true" name="InstrumentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_ENTMember" abstract="true" name="ENTMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_RegenerativeSkinAndWoundMember" abstract="true" name="RegenerativeSkinAndWoundMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_PrivateLabelMember" abstract="true" name="PrivateLabelMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_TrademarksBrandNamesMember" abstract="true" name="TrademarksBrandNamesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_SupplierRelationShipsMember" abstract="true" name="SupplierRelationShipsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_AllOtherMember" abstract="true" name="AllOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_CostOfDefiniteAndIndefiniteLivedIntangibleAssetsGrossExcludingGoodwill" abstract="false" name="CostOfDefiniteAndIndefiniteLivedIntangibleAssetsGrossExcludingGoodwill" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_DefiniteAndIndefiniteLivedIntangibleAssetsNetExcludingGoodwill" abstract="false" name="DefiniteAndIndefiniteLivedIntangibleAssetsNetExcludingGoodwill" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_CompletedTechnologySurgiMendMember" abstract="true" name="CompletedTechnologySurgiMendMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_CompletedTechnologyPriMatrixMember" abstract="true" name="CompletedTechnologyPriMatrixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_ReportingUnitMeasurementInput" abstract="false" name="ReportingUnitMeasurementInput" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="iart_GoodwillImpairmentSensitivityAnalysisReportingUnitMeasurementInputIncreaseDecrease" abstract="false" name="GoodwillImpairmentSensitivityAnalysisReportingUnitMeasurementInputIncreaseDecrease" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="iart_GoodwillImpairmentSensitivityAnalysisReportingUnitFairValueIncreaseDecreasePercent" abstract="false" name="GoodwillImpairmentSensitivityAnalysisReportingUnitFairValueIncreaseDecreasePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="iart_IndefiniteLivedIntangibleAssetsMeasurementInput" abstract="false" name="IndefiniteLivedIntangibleAssetsMeasurementInput" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="iart_SeniorCreditFacilityMember" abstract="true" name="SeniorCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_TermLoanFacilityMember" abstract="true" name="TermLoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_TwoThousandTwentyFiveSeniorConvertibleNotesMember" abstract="true" name="TwoThousandTwentyFiveSeniorConvertibleNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_SwinglineLoanMember" abstract="true" name="SwinglineLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_DebtInstrumentBasisSpreadAdjustmentOnVariableRate" abstract="false" name="DebtInstrumentBasisSpreadAdjustmentOnVariableRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="iart_InterestPaymentsReminderOfFiscalYear" abstract="false" name="InterestPaymentsReminderOfFiscalYear" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_InterestPaymentsYearOne" abstract="false" name="InterestPaymentsYearOne" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_InterestPaymentsYearTwo" abstract="false" name="InterestPaymentsYearTwo" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_InterestPaymentsYearThree" abstract="false" name="InterestPaymentsYearThree" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_InterestPaymentsYearFour" abstract="false" name="InterestPaymentsYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_DebtInstrumentMaximumSellingPriceOfCommonStockOfTheConversionPriceDuringPeriod" abstract="false" name="DebtInstrumentMaximumSellingPriceOfCommonStockOfTheConversionPriceDuringPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="iart_DebtInstrumentMaximumAverageConversionValueOfNotes" abstract="false" name="DebtInstrumentMaximumAverageConversionValueOfNotes" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="iart_DebtInstrumentCombinationSettlementForDebtConversionMinimumSettledInCashPerPrincipalAmount" abstract="false" name="DebtInstrumentCombinationSettlementForDebtConversionMinimumSettledInCashPerPrincipalAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_PaymentsForOptionIndexToIssuersEquity" abstract="false" name="PaymentsForOptionIndexToIssuersEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_TransferorsInterestsInTransferredFinancialAssetsMaximumInvestmentLimit" abstract="false" name="TransferorsInterestsInTransferredFinancialAssetsMaximumInvestmentLimit" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_TransferorsInterestsInTransferredFinancialAssetsIssuanceCosts" abstract="false" name="TransferorsInterestsInTransferredFinancialAssetsIssuanceCosts" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_DebtInstrumentSecuritizationFacilityAgreementTerm" abstract="false" name="DebtInstrumentSecuritizationFacilityAgreementTerm" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="iart_TransferorsInterestsInTransferredFinancialAssetsUnamortizedIssuanceCosts" abstract="false" name="TransferorsInterestsInTransferredFinancialAssetsUnamortizedIssuanceCosts" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_SecuredLongTermDebtSecuritizationProgram" abstract="false" name="SecuredLongTermDebtSecuritizationProgram" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_DebtWeightedAverageInterestRateFromSecuritization" abstract="false" name="DebtWeightedAverageInterestRateFromSecuritization" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="iart_SecuritizationFacilityFairValueOfAmountOutstanding" abstract="false" name="SecuritizationFacilityFairValueOfAmountOutstanding" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_DebtCovenantPeriodAxis" abstract="true" name="DebtCovenantPeriodAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="iart_DebtCovenantPeriodDomain" abstract="true" name="DebtCovenantPeriodDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_DebtCovenantPeriod1Member" abstract="true" name="DebtCovenantPeriod1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_DebtCovenantPeriod2Member" abstract="true" name="DebtCovenantPeriod2Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_DebtCovenantPeriod3Member" abstract="true" name="DebtCovenantPeriod3Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_DebtCovenantPeriod4Member" abstract="true" name="DebtCovenantPeriod4Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DebtInstrumentCovenantMaximumLeverageRatio" abstract="false" name="DebtInstrumentCovenantMaximumLeverageRatio" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="iart_LongTermDebtMaturityAfterYearThree" abstract="false" name="LongTermDebtMaturityAfterYearThree" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedDecember132017Tranche2Member" abstract="true" name="InterestRateSwapDesignatedDecember132017Tranche2Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedDecember132017Tranche3Member" abstract="true" name="InterestRateSwapDesignatedDecember132017Tranche3Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedOctober102018Tranche1Member" abstract="true" name="InterestRateSwapDesignatedOctober102018Tranche1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedOctober102018Tranche2Member" abstract="true" name="InterestRateSwapDesignatedOctober102018Tranche2Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedOctober102018Tranche3Member" abstract="true" name="InterestRateSwapDesignatedOctober102018Tranche3Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedDecember182018Tranche1Member" abstract="true" name="InterestRateSwapDesignatedDecember182018Tranche1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedDecember182018Tranche2Member" abstract="true" name="InterestRateSwapDesignatedDecember182018Tranche2Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedDecember152020Tranche1Member" abstract="true" name="InterestRateSwapDesignatedDecember152020Tranche1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedDecember152020Tranche2Member" abstract="true" name="InterestRateSwapDesignatedDecember152020Tranche2Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedMarch312023Member" abstract="true" name="InterestRateSwapDesignatedMarch312023Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_CodmanMember" abstract="true" name="CodmanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_DerivativeNotionalAmountSettled" abstract="false" name="DerivativeNotionalAmountSettled" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_DerivativeNotionalAmountTerminated" abstract="false" name="DerivativeNotionalAmountTerminated" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_GainLossOnSettlementOfDerivative" abstract="false" name="GainLossOnSettlementOfDerivative" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_IntercompanyLoanQuarterlyPayment" abstract="false" name="IntercompanyLoanQuarterlyPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_CrossCurrencyInterestRateContractOneMember" abstract="true" name="CrossCurrencyInterestRateContractOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_CrossCurrencyInterestRateContractTwoMember" abstract="true" name="CrossCurrencyInterestRateContractTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_CrossCurrencyInterestRateContractThreeMember" abstract="true" name="CrossCurrencyInterestRateContractThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_CrossCurrencyInterestRateContractFourMember" abstract="true" name="CrossCurrencyInterestRateContractFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_AccruedExpensesAndOtherCurrentLiabilitiesMember" abstract="true" name="AccruedExpensesAndOtherCurrentLiabilitiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_PerformanceStockAndRestrictedStockAwardsMember" abstract="true" name="PerformanceStockAndRestrictedStockAwardsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_EmployeeMember" abstract="true" name="EmployeeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_DirectorsandCertainExecutiveOfficersMember" abstract="true" name="DirectorsandCertainExecutiveOfficersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_ShareBasedPaymentArrangementPlanModificationExpirationPeriod" abstract="false" name="ShareBasedPaymentArrangementPlanModificationExpirationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="iart_DefinedBenefitPlanDeferPaymentAndTaxationBaseSalaryPercentage" abstract="false" name="DefinedBenefitPlanDeferPaymentAndTaxationBaseSalaryPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="iart_DefinedBenefitPlanDeferPaymentAndTaxationBonusAndOtherCompensationPercentage" abstract="false" name="DefinedBenefitPlanDeferPaymentAndTaxationBonusAndOtherCompensationPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="iart_FiveYearOptionLeasePeriodOneMember" abstract="true" name="FiveYearOptionLeasePeriodOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_FiveYearOptionLeasePeriodTwoMember" abstract="true" name="FiveYearOptionLeasePeriodTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_LesseeOperatingLeaseNumberOfRenewalOptions" abstract="false" name="LesseeOperatingLeaseNumberOfRenewalOptions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="iart_PercentOfManufacturingFacilityOwnedByCorporationWhoseShareholdersAreTrustsWhoseBeneficiariesIncludeFamilyMembersOfCompanysFormerDirector" abstract="false" name="PercentOfManufacturingFacilityOwnedByCorporationWhoseShareholdersAreTrustsWhoseBeneficiariesIncludeFamilyMembersOfCompanysFormerDirector" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="iart_AnnualRateOfLeaseAgreement" abstract="false" name="AnnualRateOfLeaseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_CashFlowLesseeAbstract" abstract="true" name="CashFlowLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="iart_RightOfUseAssetObtainedInExchangeForLeaseLiabilityAbstract" abstract="true" name="RightOfUseAssetObtainedInExchangeForLeaseLiabilityAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="iart_RelatedPartiesMember" abstract="true" name="RelatedPartiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_ThirdPartiesMember" abstract="true" name="ThirdPartiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_A2023ShareRepurchaseProgramMember" abstract="true" name="A2023ShareRepurchaseProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_AcceleratedShareRepurchasesSharesReceivedAtInception" abstract="false" name="AcceleratedShareRepurchasesSharesReceivedAtInception" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="iart_AcceleratedShareRepurchasesPercentageOfExpectedTotalRepurchased" abstract="false" name="AcceleratedShareRepurchasesPercentageOfExpectedTotalRepurchased" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="iart_AcceleratedShareRepurchasesAdditionalSharesReceived" abstract="false" name="AcceleratedShareRepurchasesAdditionalSharesReceived" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="iart_SegmentReportingInformationNumberOfProductsOffered" abstract="false" name="SegmentReportingInformationNumberOfProductsOffered" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="iart_RestOfWorldMember" abstract="true" name="RestOfWorldMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_ArkisBioSciencesInc.Member" abstract="true" name="ArkisBioSciencesInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_DermaSciencesMember" abstract="true" name="DermaSciencesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_ACellMember" abstract="true" name="ACellMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_SurgicalInnovationAssociatesIncMember" abstract="true" name="SurgicalInnovationAssociatesIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_ContingentConsiderationLiabilityMember" abstract="true" name="ContingentConsiderationLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_ACellIncMember" abstract="true" name="ACellIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_PlainsboroNewJerseyManufacturingFacilityMember" abstract="true" name="PlainsboroNewJerseyManufacturingFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_MilestonePaymentOneMember" abstract="true" name="MilestonePaymentOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_MilestonePaymentTwoMember" abstract="true" name="MilestonePaymentTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_BioDEarnoutPaymentsandMedihoneyEarnoutPaymentsMember" abstract="true" name="BioDEarnoutPaymentsandMedihoneyEarnoutPaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_RevenueBasedPerformanceMilestonesMember" abstract="true" name="RevenueBasedPerformanceMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_FDAApprovalOfPremarketApprovalMember" abstract="true" name="FDAApprovalOfPremarketApprovalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_BusinessCombinationContingentConsiderationNumberOfLiabilities" abstract="false" name="BusinessCombinationContingentConsiderationNumberOfLiabilities" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="iart_BusinessAcquisitionNumberOfContingentLiabilities" abstract="false" name="BusinessAcquisitionNumberOfContingentLiabilities" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
</xs:schema>
