<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:33b1762c-b576-4a54-9112-15a78661a29c,g:cbca90b5-ad11-43fc-bead-ebc5bec8dc7f-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://integralife.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="iart-20231212.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://integralife.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_de704902-badc-4174-a137-8e6d47ab4d7f" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_f71c2ae5-26ca-4f68-a386-c15ffc46135b" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntitiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_de704902-badc-4174-a137-8e6d47ab4d7f" xlink:to="loc_dei_EntitiesTable_f71c2ae5-26ca-4f68-a386-c15ffc46135b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressesAddressTypeAxis_e5668239-f30b-465e-afd8-76ce70cea0ad" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressesAddressTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_f71c2ae5-26ca-4f68-a386-c15ffc46135b" xlink:to="loc_dei_EntityAddressesAddressTypeAxis_e5668239-f30b-465e-afd8-76ce70cea0ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AddressTypeDomain_387a99dc-2dc6-4422-9d05-5e5edef3afcc" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AddressTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityAddressesAddressTypeAxis_e5668239-f30b-465e-afd8-76ce70cea0ad" xlink:to="loc_dei_AddressTypeDomain_387a99dc-2dc6-4422-9d05-5e5edef3afcc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityInformationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_f71c2ae5-26ca-4f68-a386-c15ffc46135b" xlink:to="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_6fad23e9-4478-4f48-81af-411ae5a1dd71" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_DocumentType_6fad23e9-4478-4f48-81af-411ae5a1dd71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_d9509edb-3f24-4f10-ab51-a41090d9f6b1" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_DocumentPeriodEndDate_d9509edb-3f24-4f10-ab51-a41090d9f6b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_8cccf5f1-cfdd-4e37-a797-d76e92f913e3" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_EntityRegistrantName_8cccf5f1-cfdd-4e37-a797-d76e92f913e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_10590300-c503-4427-840e-94eb1f106d7f" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_EntityIncorporationStateCountryCode_10590300-c503-4427-840e-94eb1f106d7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_3e69fd8e-b881-421d-b681-0c3391c08e2c" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_EntityFileNumber_3e69fd8e-b881-421d-b681-0c3391c08e2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_73f735ed-430f-4ad8-a95d-c43b8e07e52c" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_EntityTaxIdentificationNumber_73f735ed-430f-4ad8-a95d-c43b8e07e52c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_69d2784a-01c3-4124-b252-b93ffdf4eea6" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_EntityAddressAddressLine1_69d2784a-01c3-4124-b252-b93ffdf4eea6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_82023d79-b933-40c2-82fc-e90486e17055" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_EntityAddressCityOrTown_82023d79-b933-40c2-82fc-e90486e17055" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_eeeaed77-94b4-4114-9f4c-2ee39a2d74a0" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_EntityAddressStateOrProvince_eeeaed77-94b4-4114-9f4c-2ee39a2d74a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_76c3a1f8-272a-4b8c-aa8e-6d60f9e55c78" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_EntityAddressPostalZipCode_76c3a1f8-272a-4b8c-aa8e-6d60f9e55c78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_0ce03672-1e12-49a9-8fad-78445181434d" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_CityAreaCode_0ce03672-1e12-49a9-8fad-78445181434d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_5f84c6f6-acf0-4b1d-8627-0d71dfb1af24" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_LocalPhoneNumber_5f84c6f6-acf0-4b1d-8627-0d71dfb1af24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_eb9dee8a-c095-4243-9d0c-17966b3bebc9" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_WrittenCommunications_eb9dee8a-c095-4243-9d0c-17966b3bebc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_436f9da2-0114-4169-aae1-cd52b6ac2445" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_SolicitingMaterial_436f9da2-0114-4169-aae1-cd52b6ac2445" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_a518a9dd-afd8-446f-8a45-3302493e3734" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_PreCommencementTenderOffer_a518a9dd-afd8-446f-8a45-3302493e3734" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_e52acdfd-f0a8-40d2-9f45-7e2cda3e6e50" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_e52acdfd-f0a8-40d2-9f45-7e2cda3e6e50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_63d422a0-b4f3-4f8a-a9d9-d5dabd5b7712" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_Security12bTitle_63d422a0-b4f3-4f8a-a9d9-d5dabd5b7712" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_d4f942fa-7b21-4279-9b32-576ee4945f54" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_TradingSymbol_d4f942fa-7b21-4279-9b32-576ee4945f54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_bc8b0f70-8b6c-4775-b73a-4acd461042a9" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_SecurityExchangeName_bc8b0f70-8b6c-4775-b73a-4acd461042a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_362dc7f6-d741-4702-b781-0c7ca18341a5" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_EntityEmergingGrowthCompany_362dc7f6-d741-4702-b781-0c7ca18341a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_c5c662c9-22e9-46a5-8d84-451b64a98db9" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_EntityCentralIndexKey_c5c662c9-22e9-46a5-8d84-451b64a98db9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_4329e0a7-3f88-4049-bcdf-a544e8e8f158" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_66a9b874-3107-4f13-8b2e-be353a495113" xlink:to="loc_dei_AmendmentFlag_4329e0a7-3f88-4049-bcdf-a544e8e8f158" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
