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  <xs:element id="iart_MilestonePaymentTwoMember" abstract="true" name="MilestonePaymentTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_BioDEarnoutPaymentsandMedihoneyEarnoutPaymentsMember" abstract="true" name="BioDEarnoutPaymentsandMedihoneyEarnoutPaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_RevenueBasedPerformanceMilestonesIn2023Member" abstract="true" name="RevenueBasedPerformanceMilestonesIn2023Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_BusinessCombinationContingentConsiderationNumberOfLiabilities" abstract="false" name="BusinessCombinationContingentConsiderationNumberOfLiabilities" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="iart_SegmentReportingInformationNumberOfProductsOffered" abstract="false" name="SegmentReportingInformationNumberOfProductsOffered" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="iart_RestOfTheWorldMember" abstract="true" name="RestOfTheWorldMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iart_NetInvestmentHedgeMember" abstract="true" name="NetInvestmentHedgeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_ShortTermInvestmentsFairValueDisclosure" abstract="false" name="ShortTermInvestmentsFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_PensionPlanAssetsFairValueDisclosure" abstract="false" name="PensionPlanAssetsFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_PensionProjectBenefitObligationLiabilitiesFairValueDisclosure" abstract="false" name="PensionProjectBenefitObligationLiabilitiesFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
