<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:5062e116-6a99-4a79-a38c-639b0818c986,g:b1772efb-8719-40e0-aeca-0cd8c1f215bd-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://integralife.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="iart-20230815.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://integralife.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_cfcb8118-42d4-4952-9041-e53d918749b3" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_04871c27-9e90-4302-90b0-aece3ebf7b5f" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntitiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_cfcb8118-42d4-4952-9041-e53d918749b3" xlink:to="loc_dei_EntitiesTable_04871c27-9e90-4302-90b0-aece3ebf7b5f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressesAddressTypeAxis_55907721-a3f6-4a4a-8a4d-52ae17ab67e5" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressesAddressTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_04871c27-9e90-4302-90b0-aece3ebf7b5f" xlink:to="loc_dei_EntityAddressesAddressTypeAxis_55907721-a3f6-4a4a-8a4d-52ae17ab67e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AddressTypeDomain_197d886d-0db9-40ee-a729-8b580677645e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AddressTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityAddressesAddressTypeAxis_55907721-a3f6-4a4a-8a4d-52ae17ab67e5" xlink:to="loc_dei_AddressTypeDomain_197d886d-0db9-40ee-a729-8b580677645e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityInformationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_04871c27-9e90-4302-90b0-aece3ebf7b5f" xlink:to="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_32532591-13ac-4892-ab5e-8186c177586c" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_DocumentType_32532591-13ac-4892-ab5e-8186c177586c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_6aecef75-32ce-411a-8357-93d75b1e61b7" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_DocumentPeriodEndDate_6aecef75-32ce-411a-8357-93d75b1e61b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_b4612c26-bef7-4b0d-8b84-095864d70dc2" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_EntityRegistrantName_b4612c26-bef7-4b0d-8b84-095864d70dc2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_10154887-e62f-4bce-9ee6-7ec44c36ee33" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_EntityIncorporationStateCountryCode_10154887-e62f-4bce-9ee6-7ec44c36ee33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_df77fd99-aea8-48a9-bac4-bfff327c1df7" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_EntityFileNumber_df77fd99-aea8-48a9-bac4-bfff327c1df7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_341e74a8-16c4-494c-97d5-b7bc6757903c" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_EntityTaxIdentificationNumber_341e74a8-16c4-494c-97d5-b7bc6757903c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_e8e92ebd-ad96-4519-9501-eaa2535a9cae" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_EntityAddressAddressLine1_e8e92ebd-ad96-4519-9501-eaa2535a9cae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_9f13aabf-423a-46be-a406-1d3b7d2673fa" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_EntityAddressCityOrTown_9f13aabf-423a-46be-a406-1d3b7d2673fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_a2faba77-e3db-4f22-93f3-faf89cc0a66d" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_EntityAddressStateOrProvince_a2faba77-e3db-4f22-93f3-faf89cc0a66d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_fa200360-3da6-4ba9-ad14-bb9c3db05d94" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_EntityAddressPostalZipCode_fa200360-3da6-4ba9-ad14-bb9c3db05d94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_f6cae9ec-928b-4bc6-997e-3b1ed0da9dd3" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_CityAreaCode_f6cae9ec-928b-4bc6-997e-3b1ed0da9dd3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_76faf287-0a3e-4af7-917c-22d227c43fc3" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_LocalPhoneNumber_76faf287-0a3e-4af7-917c-22d227c43fc3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_70622b60-6c1d-44bd-95cb-b6a4c8852eee" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_WrittenCommunications_70622b60-6c1d-44bd-95cb-b6a4c8852eee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_5782dffc-cdb5-4a27-b092-803701148020" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_SolicitingMaterial_5782dffc-cdb5-4a27-b092-803701148020" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_15d5076f-c4b2-47fb-a6a6-4d1caceb42df" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_PreCommencementTenderOffer_15d5076f-c4b2-47fb-a6a6-4d1caceb42df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_e991a7f2-f62f-44e1-9bfc-70cddcf1701e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_e991a7f2-f62f-44e1-9bfc-70cddcf1701e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_0fb7fe65-32aa-4139-be31-e52fc56d3620" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_Security12bTitle_0fb7fe65-32aa-4139-be31-e52fc56d3620" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_0b0f3441-9545-4145-bf9d-9bd9eced801d" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_TradingSymbol_0b0f3441-9545-4145-bf9d-9bd9eced801d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_a31953e8-633b-4df5-b94e-0a3e555d0f24" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_SecurityExchangeName_a31953e8-633b-4df5-b94e-0a3e555d0f24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_9da67b44-8978-41b8-9cf1-dbd7b75e0f41" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_EntityEmergingGrowthCompany_9da67b44-8978-41b8-9cf1-dbd7b75e0f41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_d850ace1-3bac-429b-ba85-bfe97305dbc2" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_EntityCentralIndexKey_d850ace1-3bac-429b-ba85-bfe97305dbc2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_3a6b4962-7a5b-43bd-a372-fab5dc154034" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_dcb24339-8a45-4a77-9195-786ab2db887d" xlink:to="loc_dei_AmendmentFlag_3a6b4962-7a5b-43bd-a372-fab5dc154034" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
