<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:b7ac0ddc-1414-4659-b13b-d21590eafc4f,g:a6a84afc-46d9-41ce-92dc-1f2a661f257e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://integralife.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCHANGESINSHAREHOLDERSEQUITYUNAUDITED" xlink:type="simple" xlink:href="iart-20220930.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCHANGESINSHAREHOLDERSEQUITYUNAUDITED"/>
  <link:definitionLink xlink:role="http://integralife.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCHANGESINSHAREHOLDERSEQUITYUNAUDITED" xlink:type="extended" id="i9b43b1440ffd4ec1b30fb1a932a33a1f_CONDENSEDCONSOLIDATEDSTATEMENTSOFCHANGESINSHAREHOLDERSEQUITYUNAUDITED">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_855a19a1-2b02-43b5-9d07-746087a0a0a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_855a19a1-2b02-43b5-9d07-746087a0a0a6" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_53bf73e5-2c9f-4ffa-816f-856c04b0f249" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_53bf73e5-2c9f-4ffa-816f-856c04b0f249" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_cb331183-4787-4e29-98ab-55b0fe8222ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:to="loc_us-gaap_StockholdersEquity_cb331183-4787-4e29-98ab-55b0fe8222ce" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_b66aff59-75df-4f32-bb8a-74ccc5e48828" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:to="loc_us-gaap_TreasuryStockCommonShares_b66aff59-75df-4f32-bb8a-74ccc5e48828" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_57e81a91-17db-4bfb-aa58-2fc10f7f1b09" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:to="loc_us-gaap_NetIncomeLoss_57e81a91-17db-4bfb-aa58-2fc10f7f1b09" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_5fc3eaa3-188e-4e81-8c60-aa332869d779" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_5fc3eaa3-188e-4e81-8c60-aa332869d779" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_45045a93-4fd7-4b39-9fca-df5ad8407e19" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_45045a93-4fd7-4b39-9fca-df5ad8407e19" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_4503310a-d55b-44f1-97df-165802e904d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_4503310a-d55b-44f1-97df-165802e904d0" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_5453c881-4780-4948-9fbd-18f2ab8ee0e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_5453c881-4780-4948-9fbd-18f2ab8ee0e8" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_823c23a9-edfd-47ec-89fa-a613132936b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_823c23a9-edfd-47ec-89fa-a613132936b9" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_e0d633f8-cfa5-47cb-9d16-d9b7c7f56899" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_e0d633f8-cfa5-47cb-9d16-d9b7c7f56899" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_0b1c0bd2-30df-44c6-983a-8d2227efb246" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_0b1c0bd2-30df-44c6-983a-8d2227efb246" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_ec2a863e-d78c-4911-a4d0-612337ae2aac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_ec2a863e-d78c-4911-a4d0-612337ae2aac" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdateExtensibleList_6cc3b33a-2500-4bb5-87af-d85aed82726c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingStandardsUpdateExtensibleList"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_d370c817-69ec-41eb-a8fe-139f0048ec6f" xlink:to="loc_us-gaap_AccountingStandardsUpdateExtensibleList_6cc3b33a-2500-4bb5-87af-d85aed82726c" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_1da87731-8c66-4386-8f6c-1db27d2e011b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_7cf38bfe-7f5e-4040-ae8a-02e4c08c9638" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_6d649e23-0b9f-47a4-a5bf-ea0252b3c5bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_ce39cdac-f14f-46c1-bd7f-7f75a9ab9bc7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_855a19a1-2b02-43b5-9d07-746087a0a0a6" xlink:to="loc_us-gaap_StatementTable_ce39cdac-f14f-46c1-bd7f-7f75a9ab9bc7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_2d85ae46-8679-4058-aa94-8bb86e01d7dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_ce39cdac-f14f-46c1-bd7f-7f75a9ab9bc7" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_2d85ae46-8679-4058-aa94-8bb86e01d7dd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_2d85ae46-8679-4058-aa94-8bb86e01d7dd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2d85ae46-8679-4058-aa94-8bb86e01d7dd" xlink:to="loc_us-gaap_EquityComponentDomain_2d85ae46-8679-4058-aa94-8bb86e01d7dd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_f91acf54-9831-49dc-802c-6662e5b00581" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2d85ae46-8679-4058-aa94-8bb86e01d7dd" xlink:to="loc_us-gaap_EquityComponentDomain_f91acf54-9831-49dc-802c-6662e5b00581" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_c59f6aed-37d1-4e42-9a3e-4cb91d675dd9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_f91acf54-9831-49dc-802c-6662e5b00581" xlink:to="loc_us-gaap_CommonStockMember_c59f6aed-37d1-4e42-9a3e-4cb91d675dd9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_acfc3627-84e1-460a-9abf-2e2c28f9ff46" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockCommonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_f91acf54-9831-49dc-802c-6662e5b00581" xlink:to="loc_us-gaap_TreasuryStockCommonMember_acfc3627-84e1-460a-9abf-2e2c28f9ff46" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_801a8182-d4a1-42f0-b087-221cb6c59c37" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_f91acf54-9831-49dc-802c-6662e5b00581" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_801a8182-d4a1-42f0-b087-221cb6c59c37" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_23e63e7b-0920-48c8-930b-901ecf341167" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_f91acf54-9831-49dc-802c-6662e5b00581" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_23e63e7b-0920-48c8-930b-901ecf341167" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_720973e5-09c9-44ee-b252-3ea2cd94448f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_f91acf54-9831-49dc-802c-6662e5b00581" xlink:to="loc_us-gaap_RetainedEarningsMember_720973e5-09c9-44ee-b252-3ea2cd94448f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_2c056102-939b-4098-a6c5-c67ba58d2b4b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_ce39cdac-f14f-46c1-bd7f-7f75a9ab9bc7" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_2c056102-939b-4098-a6c5-c67ba58d2b4b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_2c056102-939b-4098-a6c5-c67ba58d2b4b_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_2c056102-939b-4098-a6c5-c67ba58d2b4b" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_2c056102-939b-4098-a6c5-c67ba58d2b4b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_dc4ae37b-d0c6-4e0f-8d11-a90320c1e4b7" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_2c056102-939b-4098-a6c5-c67ba58d2b4b" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_dc4ae37b-d0c6-4e0f-8d11-a90320c1e4b7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_4ffc1df8-9350-4d43-a5e0-f02f5b56a601" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_dc4ae37b-d0c6-4e0f-8d11-a90320c1e4b7" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_4ffc1df8-9350-4d43-a5e0-f02f5b56a601" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/BASISOFPRESENTATIONScheduleofRestructuringChargesDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#BASISOFPRESENTATIONScheduleofRestructuringChargesDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/BASISOFPRESENTATIONScheduleofRestructuringChargesDetails" xlink:type="extended" id="i3adf5f0b572f4f239d6b768ff9a1b570_BASISOFPRESENTATIONScheduleofRestructuringChargesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_dac5bf53-27c4-488e-a3ae-6b1d6a360c92" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveRollForward_0d09c7cb-5354-4faa-bcdf-5da829bb9e7d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringReserveRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_dac5bf53-27c4-488e-a3ae-6b1d6a360c92" xlink:to="loc_us-gaap_RestructuringReserveRollForward_0d09c7cb-5354-4faa-bcdf-5da829bb9e7d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_842d3787-57cc-47c9-8a6b-d56342d729e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_0d09c7cb-5354-4faa-bcdf-5da829bb9e7d" xlink:to="loc_us-gaap_RestructuringReserve_842d3787-57cc-47c9-8a6b-d56342d729e4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_1c7ff55a-1a00-4f7f-a0ed-a9ca31a21bf8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_0d09c7cb-5354-4faa-bcdf-5da829bb9e7d" xlink:to="loc_us-gaap_RestructuringCharges_1c7ff55a-1a00-4f7f-a0ed-a9ca31a21bf8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveAccrualAdjustment1_e55df6e0-48ad-4ecc-92ad-e24cddcbabd9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringReserveAccrualAdjustment1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_0d09c7cb-5354-4faa-bcdf-5da829bb9e7d" xlink:to="loc_us-gaap_RestructuringReserveAccrualAdjustment1_e55df6e0-48ad-4ecc-92ad-e24cddcbabd9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_3be7617b-cc9d-4dc9-9d8c-59c800322367" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringReserve"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_d765598f-775d-4ec8-9700-2885fb11b384" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_dac5bf53-27c4-488e-a3ae-6b1d6a360c92" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_d765598f-775d-4ec8-9700-2885fb11b384" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_7f7fedd5-3834-4fec-ba92-ca9296f752db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_d765598f-775d-4ec8-9700-2885fb11b384" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_7f7fedd5-3834-4fec-ba92-ca9296f752db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_7f7fedd5-3834-4fec-ba92-ca9296f752db_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_7f7fedd5-3834-4fec-ba92-ca9296f752db" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_7f7fedd5-3834-4fec-ba92-ca9296f752db_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_945e8d6a-c18b-4666-aa7c-4b237706c307" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_7f7fedd5-3834-4fec-ba92-ca9296f752db" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_945e8d6a-c18b-4666-aa7c-4b237706c307" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_55bbd233-9864-4c58-aacb-bee60757a632" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_945e8d6a-c18b-4666-aa7c-4b237706c307" xlink:to="loc_us-gaap_CostOfSalesMember_55bbd233-9864-4c58-aacb-bee60757a632" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_f810b311-4d08-48d4-8e6f-0dfeecfaf174" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_945e8d6a-c18b-4666-aa7c-4b237706c307" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_f810b311-4d08-48d4-8e6f-0dfeecfaf174" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_e1d6bd80-9b36-4217-ba96-e237f8bd9eca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_945e8d6a-c18b-4666-aa7c-4b237706c307" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_e1d6bd80-9b36-4217-ba96-e237f8bd9eca" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/BASISOFPRESENTATIONNarrativeDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#BASISOFPRESENTATIONNarrativeDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/BASISOFPRESENTATIONNarrativeDetails" xlink:type="extended" id="i4ed73a203f0b4d1ba88ad15042d2e24f_BASISOFPRESENTATIONNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_90b3321a-be13-475d-a940-cf67065ad883" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebt_7a728876-9c29-4b98-a1d3-109bfe09a25f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertibleDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_90b3321a-be13-475d-a940-cf67065ad883" xlink:to="loc_us-gaap_ConvertibleDebt_7a728876-9c29-4b98-a1d3-109bfe09a25f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_9c1f09cd-d33a-4fd6-a1a5-a9d02459b7fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_90b3321a-be13-475d-a940-cf67065ad883" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_9c1f09cd-d33a-4fd6-a1a5-a9d02459b7fc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_a287d10d-2115-41a7-93e0-6550c43b9033" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_90b3321a-be13-475d-a940-cf67065ad883" xlink:to="loc_us-gaap_RestructuringReserve_a287d10d-2115-41a7-93e0-6550c43b9033" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_e752d568-e607-4ca4-b33f-f768d5ce9421" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_90b3321a-be13-475d-a940-cf67065ad883" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_e752d568-e607-4ca4-b33f-f768d5ce9421" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_2403f749-9ce5-4680-9eff-893ac5549cda" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_e752d568-e607-4ca4-b33f-f768d5ce9421" xlink:to="loc_us-gaap_DebtInstrumentAxis_2403f749-9ce5-4680-9eff-893ac5549cda" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_2403f749-9ce5-4680-9eff-893ac5549cda_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_2403f749-9ce5-4680-9eff-893ac5549cda" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_2403f749-9ce5-4680-9eff-893ac5549cda_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_5bcb5ea2-5755-4f56-b078-0534d935c0c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_2403f749-9ce5-4680-9eff-893ac5549cda" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_5bcb5ea2-5755-4f56-b078-0534d935c0c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_TwoThousandTwentyFiveSeniorConvertibleNotesMember_bb018e98-e465-48b8-9e16-c9f4878e2cfb" xlink:href="iart-20220930.xsd#iart_TwoThousandTwentyFiveSeniorConvertibleNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_5bcb5ea2-5755-4f56-b078-0534d935c0c5" xlink:to="loc_iart_TwoThousandTwentyFiveSeniorConvertibleNotesMember_bb018e98-e465-48b8-9e16-c9f4878e2cfb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_14f4e397-29d1-4d1f-b708-679a21be8537" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_e752d568-e607-4ca4-b33f-f768d5ce9421" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_14f4e397-29d1-4d1f-b708-679a21be8537" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_14f4e397-29d1-4d1f-b708-679a21be8537_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_14f4e397-29d1-4d1f-b708-679a21be8537" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_14f4e397-29d1-4d1f-b708-679a21be8537_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_8e899d09-0371-44d7-bc24-d4cfa735ef1c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_14f4e397-29d1-4d1f-b708-679a21be8537" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_8e899d09-0371-44d7-bc24-d4cfa735ef1c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_2058cc92-1531-4b96-8467-05e8aa3184e3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_8e899d09-0371-44d7-bc24-d4cfa735ef1c" xlink:to="loc_us-gaap_ConvertibleDebtMember_2058cc92-1531-4b96-8467-05e8aa3184e3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_ea8b3666-8a5b-475b-b326-4b6e1052ddd6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_e752d568-e607-4ca4-b33f-f768d5ce9421" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_ea8b3666-8a5b-475b-b326-4b6e1052ddd6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_ea8b3666-8a5b-475b-b326-4b6e1052ddd6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_ea8b3666-8a5b-475b-b326-4b6e1052ddd6" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_ea8b3666-8a5b-475b-b326-4b6e1052ddd6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_5eb7279c-5a57-4270-9d14-d77bc1947128" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_ea8b3666-8a5b-475b-b326-4b6e1052ddd6" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_5eb7279c-5a57-4270-9d14-d77bc1947128" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ClosureOfFacilityMember_c4f0979e-3263-4375-90bb-5dc05d9fd394" xlink:href="iart-20220930.xsd#iart_ClosureOfFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_5eb7279c-5a57-4270-9d14-d77bc1947128" xlink:to="loc_iart_ClosureOfFacilityMember_c4f0979e-3263-4375-90bb-5dc05d9fd394" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ExecutiveReorganizationMember_a6e51bd2-0116-4ab7-bc78-42a47e34338a" xlink:href="iart-20220930.xsd#iart_ExecutiveReorganizationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_5eb7279c-5a57-4270-9d14-d77bc1947128" xlink:to="loc_iart_ExecutiveReorganizationMember_a6e51bd2-0116-4ab7-bc78-42a47e34338a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_OutsourcingPlansMember_c1741321-6c25-4feb-a92d-07cddeb41c53" xlink:href="iart-20220930.xsd#iart_OutsourcingPlansMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_5eb7279c-5a57-4270-9d14-d77bc1947128" xlink:to="loc_iart_OutsourcingPlansMember_c1741321-6c25-4feb-a92d-07cddeb41c53" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/BASISOFPRESENTATIONAdoptionof202006Details" xlink:type="simple" xlink:href="iart-20220930.xsd#BASISOFPRESENTATIONAdoptionof202006Details"/>
  <link:definitionLink xlink:role="http://integralife.com/role/BASISOFPRESENTATIONAdoptionof202006Details" xlink:type="extended" id="iad3f97f9062e424fb08710b0a44167fc_BASISOFPRESENTATIONAdoptionof202006Details">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_27912d04-665d-4a99-8a37-019e298b8f2c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_607dcd48-c2fa-4c2a-9a27-3e4bda44292f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_27912d04-665d-4a99-8a37-019e298b8f2c" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_607dcd48-c2fa-4c2a-9a27-3e4bda44292f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtNoncurrent_f7082f94-ca91-478b-85c9-dbd1d952ad39" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertibleDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_27912d04-665d-4a99-8a37-019e298b8f2c" xlink:to="loc_us-gaap_ConvertibleDebtNoncurrent_f7082f94-ca91-478b-85c9-dbd1d952ad39" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_c0950807-84b5-49ee-aaab-139f513bb6e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_27912d04-665d-4a99-8a37-019e298b8f2c" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_c0950807-84b5-49ee-aaab-139f513bb6e6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_29b4bb21-0044-49a7-8937-9d3b6b6b1dd9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_27912d04-665d-4a99-8a37-019e298b8f2c" xlink:to="loc_us-gaap_AdditionalPaidInCapital_29b4bb21-0044-49a7-8937-9d3b6b6b1dd9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_ef18ab03-0243-4f9d-b4ca-9d88844bb899" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_27912d04-665d-4a99-8a37-019e298b8f2c" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_ef18ab03-0243-4f9d-b4ca-9d88844bb899" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_eac88e0e-f5c6-407b-98f4-1d04d36d2f99" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_ef18ab03-0243-4f9d-b4ca-9d88844bb899" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_eac88e0e-f5c6-407b-98f4-1d04d36d2f99" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_eac88e0e-f5c6-407b-98f4-1d04d36d2f99_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_eac88e0e-f5c6-407b-98f4-1d04d36d2f99" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_eac88e0e-f5c6-407b-98f4-1d04d36d2f99_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_00586450-4043-44e3-b04f-f676a3218350" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_eac88e0e-f5c6-407b-98f4-1d04d36d2f99" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_00586450-4043-44e3-b04f-f676a3218350" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_dc507e0a-f90a-4f3a-a44c-c209c4e8e80d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_00586450-4043-44e3-b04f-f676a3218350" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_dc507e0a-f90a-4f3a-a44c-c209c4e8e80d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CumulativeEffectPeriodOfAdoptionAdjustmentDebtDiscountReclassificationMember_fe2b5ab5-f5fb-4e60-b944-0473fc87b587" xlink:href="iart-20220930.xsd#iart_CumulativeEffectPeriodOfAdoptionAdjustmentDebtDiscountReclassificationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_dc507e0a-f90a-4f3a-a44c-c209c4e8e80d" xlink:to="loc_iart_CumulativeEffectPeriodOfAdoptionAdjustmentDebtDiscountReclassificationMember_fe2b5ab5-f5fb-4e60-b944-0473fc87b587" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CumulativeEffectPeriodOfAdoptionAdjustmentDebtDiscountAmortizationAndEquityCostsReclassificationMember_53d00fcd-20cb-4bb5-8cf0-50d2768a347e" xlink:href="iart-20220930.xsd#iart_CumulativeEffectPeriodOfAdoptionAdjustmentDebtDiscountAmortizationAndEquityCostsReclassificationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_dc507e0a-f90a-4f3a-a44c-c209c4e8e80d" xlink:to="loc_iart_CumulativeEffectPeriodOfAdoptionAdjustmentDebtDiscountAmortizationAndEquityCostsReclassificationMember_53d00fcd-20cb-4bb5-8cf0-50d2768a347e" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/ACQUISITIONSANDDIVESTITURESDivestituresNarrativeDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#ACQUISITIONSANDDIVESTITURESDivestituresNarrativeDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/ACQUISITIONSANDDIVESTITURESDivestituresNarrativeDetails" xlink:type="extended" id="i3537e2e4e778433a88a982e385d600d6_ACQUISITIONSANDDIVESTITURESDivestituresNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration_966fd24d-2265-48c4-b0fd-c630e80d1127" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration_966fd24d-2265-48c4-b0fd-c630e80d1127" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_601effb3-d2a4-4ada-936d-c012bb0f9c69" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromDivestitureOfBusinesses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_601effb3-d2a4-4ada-936d-c012bb0f9c69" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DisposalGroupIncludingDiscontinuedOperationConsiderationContingentConsideration_bcf1c787-a921-4e2c-ae42-eab77c7b9440" xlink:href="iart-20220930.xsd#iart_DisposalGroupIncludingDiscontinuedOperationConsiderationContingentConsideration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_iart_DisposalGroupIncludingDiscontinuedOperationConsiderationContingentConsideration_bcf1c787-a921-4e2c-ae42-eab77c7b9440" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DisposalGroupIncludingDiscontinuedOperationConsiderationContingentConsiderationPeriod_4bbbd1ce-70a8-4230-a577-29880b57d0f1" xlink:href="iart-20220930.xsd#iart_DisposalGroupIncludingDiscontinuedOperationConsiderationContingentConsiderationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_iart_DisposalGroupIncludingDiscontinuedOperationConsiderationContingentConsiderationPeriod_4bbbd1ce-70a8-4230-a577-29880b57d0f1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashDivestedFromDeconsolidation_dc496fa1-e98b-4c82-88ab-98212ce0cca3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashDivestedFromDeconsolidation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_us-gaap_CashDivestedFromDeconsolidation_dc496fa1-e98b-4c82-88ab-98212ce0cca3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_5ab8db91-f2c4-45df-9980-2638927ecf8c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_5ab8db91-f2c4-45df-9980-2638927ecf8c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DiscontinuedOperationContinuingInvolvementPrepaidAsset_f17aff8c-191a-4341-bcbc-3b6198d25390" xlink:href="iart-20220930.xsd#iart_DiscontinuedOperationContinuingInvolvementPrepaidAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_iart_DiscontinuedOperationContinuingInvolvementPrepaidAsset_f17aff8c-191a-4341-bcbc-3b6198d25390" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DiscontinuedOperationContinuingInvolvementPrepaidAssetsCurrent_1416caba-a57a-4874-8234-8885cfdb98a1" xlink:href="iart-20220930.xsd#iart_DiscontinuedOperationContinuingInvolvementPrepaidAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_iart_DiscontinuedOperationContinuingInvolvementPrepaidAssetsCurrent_1416caba-a57a-4874-8234-8885cfdb98a1" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DiscontinuedOperationContinuingInvolvementPrepaidAssetsNoncurrent_6fa41a2a-55b9-4eee-b351-4b31d5f021cb" xlink:href="iart-20220930.xsd#iart_DiscontinuedOperationContinuingInvolvementPrepaidAssetsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_iart_DiscontinuedOperationContinuingInvolvementPrepaidAssetsNoncurrent_6fa41a2a-55b9-4eee-b351-4b31d5f021cb" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DisposalGroupIncludingDiscontinuedOperationPaymentRelatedToContractTermination_84562ed1-1ea2-4ab0-b1e4-6fd322759ca9" xlink:href="iart-20220930.xsd#iart_DisposalGroupIncludingDiscontinuedOperationPaymentRelatedToContractTermination"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_iart_DisposalGroupIncludingDiscontinuedOperationPaymentRelatedToContractTermination_84562ed1-1ea2-4ab0-b1e4-6fd322759ca9" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DisposalGroupIncludingDiscontinuedOperationTransitionalSupplyAgreementPayable_1e073927-0984-4593-8379-4f810d39263b" xlink:href="iart-20220930.xsd#iart_DisposalGroupIncludingDiscontinuedOperationTransitionalSupplyAgreementPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_iart_DisposalGroupIncludingDiscontinuedOperationTransitionalSupplyAgreementPayable_1e073927-0984-4593-8379-4f810d39263b" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_0ff84238-e6c9-4ae9-8ab6-98ed5f58f6cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_0ff84238-e6c9-4ae9-8ab6-98ed5f58f6cf" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_4fee2750-1e6c-45f3-af78-19b23fb9d25c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_4fee2750-1e6c-45f3-af78-19b23fb9d25c" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_BusinessCombinationWorkingCapitalAdjustment_9b366f7f-a80f-4dac-81ab-a993a76dc629" xlink:href="iart-20220930.xsd#iart_BusinessCombinationWorkingCapitalAdjustment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_iart_BusinessCombinationWorkingCapitalAdjustment_9b366f7f-a80f-4dac-81ab-a993a76dc629" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_3097cba4-266d-4719-a93e-3f8b3983c93f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_53210a32-a0c9-4809-908e-701cc41bb841" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_3097cba4-266d-4719-a93e-3f8b3983c93f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_184013d0-e1d8-42f5-a036-356680b71010" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_3097cba4-266d-4719-a93e-3f8b3983c93f" xlink:to="loc_srt_CounterpartyNameAxis_184013d0-e1d8-42f5-a036-356680b71010" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_184013d0-e1d8-42f5-a036-356680b71010_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_184013d0-e1d8-42f5-a036-356680b71010" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_184013d0-e1d8-42f5-a036-356680b71010_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_31ef018f-7d61-4213-bb10-91d2de3ff232" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_184013d0-e1d8-42f5-a036-356680b71010" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_31ef018f-7d61-4213-bb10-91d2de3ff232" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ConsortiumofFocusedOrthopedistsLLCMember_e876ccdf-57f8-47e2-b5b7-b2a50337af4f" xlink:href="iart-20220930.xsd#iart_ConsortiumofFocusedOrthopedistsLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_31ef018f-7d61-4213-bb10-91d2de3ff232" xlink:to="loc_iart_ConsortiumofFocusedOrthopedistsLLCMember_e876ccdf-57f8-47e2-b5b7-b2a50337af4f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_9b7c6d30-d759-47bd-a262-37fab16240ac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupClassificationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_3097cba4-266d-4719-a93e-3f8b3983c93f" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_9b7c6d30-d759-47bd-a262-37fab16240ac" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_9b7c6d30-d759-47bd-a262-37fab16240ac_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_9b7c6d30-d759-47bd-a262-37fab16240ac" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_9b7c6d30-d759-47bd-a262-37fab16240ac_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_cda68ddf-f4b6-4e2d-9294-2041d1dd46cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_9b7c6d30-d759-47bd-a262-37fab16240ac" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_cda68ddf-f4b6-4e2d-9294-2041d1dd46cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_0df34540-98dd-4c14-8bc3-e1d8de6cada2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_cda68ddf-f4b6-4e2d-9294-2041d1dd46cb" xlink:to="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_0df34540-98dd-4c14-8bc3-e1d8de6cada2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_3117a290-bf75-45ad-8fb7-d3c6ba64f124" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_3097cba4-266d-4719-a93e-3f8b3983c93f" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_3117a290-bf75-45ad-8fb7-d3c6ba64f124" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_3117a290-bf75-45ad-8fb7-d3c6ba64f124_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_3117a290-bf75-45ad-8fb7-d3c6ba64f124" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_3117a290-bf75-45ad-8fb7-d3c6ba64f124_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_faf98348-5ad0-4724-993a-4e04f8763401" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_3117a290-bf75-45ad-8fb7-d3c6ba64f124" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_faf98348-5ad0-4724-993a-4e04f8763401" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_TraditionalWoundCareMember_3bc75e38-e93f-478b-a1b2-04938a4273f3" xlink:href="iart-20220930.xsd#iart_TraditionalWoundCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_faf98348-5ad0-4724-993a-4e04f8763401" xlink:to="loc_iart_TraditionalWoundCareMember_3bc75e38-e93f-478b-a1b2-04938a4273f3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ExtremityOrthopedicsMember_d5799dc2-59f6-4cdd-bf93-c0099e90d5f4" xlink:href="iart-20220930.xsd#iart_ExtremityOrthopedicsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_faf98348-5ad0-4724-993a-4e04f8763401" xlink:to="loc_iart_ExtremityOrthopedicsMember_d5799dc2-59f6-4cdd-bf93-c0099e90d5f4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_cc9badc5-4377-47b8-b212-0ade5ebbc4fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_3097cba4-266d-4719-a93e-3f8b3983c93f" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_cc9badc5-4377-47b8-b212-0ade5ebbc4fd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_cc9badc5-4377-47b8-b212-0ade5ebbc4fd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_cc9badc5-4377-47b8-b212-0ade5ebbc4fd" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_cc9badc5-4377-47b8-b212-0ade5ebbc4fd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_35ac0a7d-0e6e-498e-ab6f-da7df1eaa020" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_cc9badc5-4377-47b8-b212-0ade5ebbc4fd" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_35ac0a7d-0e6e-498e-ab6f-da7df1eaa020" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ACellIncMember_fa076b19-0dd0-4bfc-948f-6c663a4c15e0" xlink:href="iart-20220930.xsd#iart_ACellIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_35ac0a7d-0e6e-498e-ab6f-da7df1eaa020" xlink:to="loc_iart_ACellIncMember_fa076b19-0dd0-4bfc-948f-6c663a4c15e0" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/ACQUISITIONSANDDIVESTITURESBusinessCombinationNarrativeDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#ACQUISITIONSANDDIVESTITURESBusinessCombinationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/ACQUISITIONSANDDIVESTITURESBusinessCombinationNarrativeDetails" xlink:type="extended" id="ibf41efbf2a844c3aa31ee005558d30b5_ACQUISITIONSANDDIVESTITURESBusinessCombinationNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_e1547744-2648-4e3b-8ded-bca730c329a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_68b27e29-abfb-413c-b1c8-cd5246a72f90" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e1547744-2648-4e3b-8ded-bca730c329a2" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_68b27e29-abfb-413c-b1c8-cd5246a72f90" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_f8ff0b00-8d76-4ca0-92dd-93f0eea1bdee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e1547744-2648-4e3b-8ded-bca730c329a2" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_f8ff0b00-8d76-4ca0-92dd-93f0eea1bdee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_BusinessCombinationWorkingCapitalAdjustment_2748559e-fef2-40b3-a9e1-31030b0de7d7" xlink:href="iart-20220930.xsd#iart_BusinessCombinationWorkingCapitalAdjustment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e1547744-2648-4e3b-8ded-bca730c329a2" xlink:to="loc_iart_BusinessCombinationWorkingCapitalAdjustment_2748559e-fef2-40b3-a9e1-31030b0de7d7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_BusinessCombinationIntangibleAssetAcquiredDiscountRate_78a32398-e5dd-4828-9bc5-c2b755b381a6" xlink:href="iart-20220930.xsd#iart_BusinessCombinationIntangibleAssetAcquiredDiscountRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e1547744-2648-4e3b-8ded-bca730c329a2" xlink:to="loc_iart_BusinessCombinationIntangibleAssetAcquiredDiscountRate_78a32398-e5dd-4828-9bc5-c2b755b381a6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_42e35294-a921-41c8-8177-2745a028a2f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e1547744-2648-4e3b-8ded-bca730c329a2" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_42e35294-a921-41c8-8177-2745a028a2f7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_642c10bc-95ef-49e2-abaa-b61415a6f49f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e1547744-2648-4e3b-8ded-bca730c329a2" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_642c10bc-95ef-49e2-abaa-b61415a6f49f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_a44c4912-5a49-474e-bd93-945c97257cfa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e1547744-2648-4e3b-8ded-bca730c329a2" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_a44c4912-5a49-474e-bd93-945c97257cfa" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_4191169e-8889-4661-abd5-bdea38b793e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_a44c4912-5a49-474e-bd93-945c97257cfa" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_4191169e-8889-4661-abd5-bdea38b793e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4191169e-8889-4661-abd5-bdea38b793e9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_4191169e-8889-4661-abd5-bdea38b793e9" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4191169e-8889-4661-abd5-bdea38b793e9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2a9f5558-b917-43e3-8f5f-a4e8e16834fa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_4191169e-8889-4661-abd5-bdea38b793e9" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2a9f5558-b917-43e3-8f5f-a4e8e16834fa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ACellIncMember_cc226565-cedd-4b5a-82af-a066d712c271" xlink:href="iart-20220930.xsd#iart_ACellIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2a9f5558-b917-43e3-8f5f-a4e8e16834fa" xlink:to="loc_iart_ACellIncMember_cc226565-cedd-4b5a-82af-a066d712c271" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/ACQUISITIONSANDDIVESTITURESBusinessCombinationScheduleofPurchasePriceAllocationDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#ACQUISITIONSANDDIVESTITURESBusinessCombinationScheduleofPurchasePriceAllocationDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/ACQUISITIONSANDDIVESTITURESBusinessCombinationScheduleofPurchasePriceAllocationDetails" xlink:type="extended" id="i6ff1c25a464543308d2395cb3fbb10f4_ACQUISITIONSANDDIVESTITURESBusinessCombinationScheduleofPurchasePriceAllocationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract_1a04f0da-9c0c-4b24-8aa6-d5ae84bb249d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract_1a04f0da-9c0c-4b24-8aa6-d5ae84bb249d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_273aef34-f659-47a8-99f0-0ee23492a961" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract_1a04f0da-9c0c-4b24-8aa6-d5ae84bb249d" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_273aef34-f659-47a8-99f0-0ee23492a961" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_0c58b6ac-f374-42c8-b14c-13377ff1d42d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract_1a04f0da-9c0c-4b24-8aa6-d5ae84bb249d" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_0c58b6ac-f374-42c8-b14c-13377ff1d42d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_1f8ae7f4-50f5-426d-b895-56dfc43ebaa5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract_1a04f0da-9c0c-4b24-8aa6-d5ae84bb249d" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_1f8ae7f4-50f5-426d-b895-56dfc43ebaa5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_cb1518cb-2fe2-4353-b7c4-5cdf83ae8329" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract_1a04f0da-9c0c-4b24-8aa6-d5ae84bb249d" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_cb1518cb-2fe2-4353-b7c4-5cdf83ae8329" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_a927677f-ff60-45c6-9a87-f6122050cb07" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract_1a04f0da-9c0c-4b24-8aa6-d5ae84bb249d" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_a927677f-ff60-45c6-9a87-f6122050cb07" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_3fad9432-d08b-4c35-8ad2-cbc2ad51f84b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_3fad9432-d08b-4c35-8ad2-cbc2ad51f84b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_39624f52-6783-4202-9564-657f670d02aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_39624f52-6783-4202-9564-657f670d02aa" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_7a30e468-e7ae-41f3-b96b-3345430c208f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_Goodwill_7a30e468-e7ae-41f3-b96b-3345430c208f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRightOfUseAssetOperatingLeases_abf4e576-03db-426d-8fbc-c2fe2672e544" xlink:href="iart-20220930.xsd#iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRightOfUseAssetOperatingLeases"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRightOfUseAssetOperatingLeases_abf4e576-03db-426d-8fbc-c2fe2672e544" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssets_aaacf483-6567-4dcf-901d-6714292d9c15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssets_aaacf483-6567-4dcf-901d-6714292d9c15" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_72ec3ff9-c380-46a8-a930-d87b9405f8ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_72ec3ff9-c380-46a8-a930-d87b9405f8ec" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedAssetsAcquiredIncludingGoodwill_e3eb1489-ce50-490e-80f5-a6a496b94c7d" xlink:href="iart-20220930.xsd#iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedAssetsAcquiredIncludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedAssetsAcquiredIncludingGoodwill_e3eb1489-ce50-490e-80f5-a6a496b94c7d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_250bc537-fcd3-410d-a614-3582a09fd652" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_250bc537-fcd3-410d-a614-3582a09fd652" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_49273d84-d9f2-4aef-8a96-a55fa3d9206e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_250bc537-fcd3-410d-a614-3582a09fd652" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_49273d84-d9f2-4aef-8a96-a55fa3d9206e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses_bc8f5be1-24c6-4097-aa05-4c7b0c04ed95" xlink:href="iart-20220930.xsd#iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_250bc537-fcd3-410d-a614-3582a09fd652" xlink:to="loc_iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses_bc8f5be1-24c6-4097-aa05-4c7b0c04ed95" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesCurrentPortionOfLeaseLiabilityOperatingLeases_b3e02adb-bd4c-47f3-a42e-fc8761c43646" xlink:href="iart-20220930.xsd#iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesCurrentPortionOfLeaseLiabilityOperatingLeases"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_250bc537-fcd3-410d-a614-3582a09fd652" xlink:to="loc_iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesCurrentPortionOfLeaseLiabilityOperatingLeases_b3e02adb-bd4c-47f3-a42e-fc8761c43646" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_c90eb78e-a5c5-4b58-882e-9cafbd3e2448" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_250bc537-fcd3-410d-a614-3582a09fd652" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_c90eb78e-a5c5-4b58-882e-9cafbd3e2448" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_71f500b5-2370-4035-a457-f7da0a795129" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_71f500b5-2370-4035-a457-f7da0a795129" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLeaseLiabilityOperatingLeases_6f027ab7-8f5f-43e5-89b0-4ee509166b9a" xlink:href="iart-20220930.xsd#iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLeaseLiabilityOperatingLeases"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLeaseLiabilityOperatingLeases_6f027ab7-8f5f-43e5-89b0-4ee509166b9a" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_cb982724-367d-4de1-adbc-b2f14c1b4ded" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_cb982724-367d-4de1-adbc-b2f14c1b4ded" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContingentLiability_c7751fb7-cd56-47ca-9088-f1eaa047e245" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContingentLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContingentLiability_c7751fb7-cd56-47ca-9088-f1eaa047e245" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_2035a649-4465-4c06-9b77-26719672706f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_2035a649-4465-4c06-9b77-26719672706f" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_9c01d27c-1c19-4cd9-8f00-ef2f42c89eed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_9c01d27c-1c19-4cd9-8f00-ef2f42c89eed" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_02c73389-78d8-496e-a106-3d5779c4506e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_02c73389-78d8-496e-a106-3d5779c4506e" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3e76ee29-7819-4995-ad06-6fa22d2ad6ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_b75745b0-7b8f-4cca-961f-3a605772ee80" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3e76ee29-7819-4995-ad06-6fa22d2ad6ad" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_8e23116a-e5d0-43fb-badb-6edf8c7fc774" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3e76ee29-7819-4995-ad06-6fa22d2ad6ad" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_8e23116a-e5d0-43fb-badb-6edf8c7fc774" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_8e23116a-e5d0-43fb-badb-6edf8c7fc774_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_8e23116a-e5d0-43fb-badb-6edf8c7fc774" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_8e23116a-e5d0-43fb-badb-6edf8c7fc774_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_f92a9558-7524-4ad4-b2e2-2e6ea499f791" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_8e23116a-e5d0-43fb-badb-6edf8c7fc774" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_f92a9558-7524-4ad4-b2e2-2e6ea499f791" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ACellIncMember_3d3f4a7e-8802-4f9a-843c-65892c0460f6" xlink:href="iart-20220930.xsd#iart_ACellIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_f92a9558-7524-4ad4-b2e2-2e6ea499f791" xlink:to="loc_iart_ACellIncMember_3d3f4a7e-8802-4f9a-843c-65892c0460f6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_4af17de4-ae9c-49c0-b82d-4f6aefee039b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3e76ee29-7819-4995-ad06-6fa22d2ad6ad" xlink:to="loc_srt_RangeAxis_4af17de4-ae9c-49c0-b82d-4f6aefee039b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_4af17de4-ae9c-49c0-b82d-4f6aefee039b_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_4af17de4-ae9c-49c0-b82d-4f6aefee039b" xlink:to="loc_srt_RangeMember_4af17de4-ae9c-49c0-b82d-4f6aefee039b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_ae74d7a2-6e02-4354-a3f7-595b2f101427" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_4af17de4-ae9c-49c0-b82d-4f6aefee039b" xlink:to="loc_srt_RangeMember_ae74d7a2-6e02-4354-a3f7-595b2f101427" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_252771fa-b83a-4210-ade9-957d30d50a37" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_ae74d7a2-6e02-4354-a3f7-595b2f101427" xlink:to="loc_srt_MinimumMember_252771fa-b83a-4210-ade9-957d30d50a37" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_8cbb023b-cdef-4989-a1e0-667f147631e6" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_ae74d7a2-6e02-4354-a3f7-595b2f101427" xlink:to="loc_srt_MaximumMember_8cbb023b-cdef-4989-a1e0-667f147631e6" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeDetails" xlink:type="extended" id="i3e9d197cc86e4b80b1e2a8f7334041d3_REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_64442ea6-49d9-4c54-aba0-c33ce44e1d7f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ReturnPolicyIssueOfCreditNumberOfDaysFromShipment_0fa92bec-5115-4e22-9044-d487e12c3aff" xlink:href="iart-20220930.xsd#iart_ReturnPolicyIssueOfCreditNumberOfDaysFromShipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_64442ea6-49d9-4c54-aba0-c33ce44e1d7f" xlink:to="loc_iart_ReturnPolicyIssueOfCreditNumberOfDaysFromShipment_0fa92bec-5115-4e22-9044-d487e12c3aff" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_277b46ab-e57f-437c-a889-8b470a1422f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_64442ea6-49d9-4c54-aba0-c33ce44e1d7f" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_277b46ab-e57f-437c-a889-8b470a1422f1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRecallExpense_b4eeb850-1968-4fde-adf1-5392fa3ab9f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryRecallExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_64442ea6-49d9-4c54-aba0-c33ce44e1d7f" xlink:to="loc_us-gaap_InventoryRecallExpense_b4eeb850-1968-4fde-adf1-5392fa3ab9f5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_b10dfc29-ae3f-4ab6-bb35-bb113ee6483f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_64442ea6-49d9-4c54-aba0-c33ce44e1d7f" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_b10dfc29-ae3f-4ab6-bb35-bb113ee6483f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_958d1417-1cb5-4360-8188-fd9eaeb69fa9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_64442ea6-49d9-4c54-aba0-c33ce44e1d7f" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_958d1417-1cb5-4360-8188-fd9eaeb69fa9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationPercentage_9b7fcacc-23f0-47e3-a223-d309aa07f183" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_64442ea6-49d9-4c54-aba0-c33ce44e1d7f" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationPercentage_9b7fcacc-23f0-47e3-a223-d309aa07f183" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_317d7449-0b26-4cd5-9629-4633e6d8e9a1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_64442ea6-49d9-4c54-aba0-c33ce44e1d7f" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_317d7449-0b26-4cd5-9629-4633e6d8e9a1" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_RevenueProductWarrantyPeriod_3123a181-9c7c-499d-b98d-84342faa593f" xlink:href="iart-20220930.xsd#iart_RevenueProductWarrantyPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_64442ea6-49d9-4c54-aba0-c33ce44e1d7f" xlink:to="loc_iart_RevenueProductWarrantyPeriod_3123a181-9c7c-499d-b98d-84342faa593f" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_db641cc4-4946-4e4c-8362-d657d71f5fd8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_64442ea6-49d9-4c54-aba0-c33ce44e1d7f" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_db641cc4-4946-4e4c-8362-d657d71f5fd8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_a359354f-579a-47fc-b81d-01faed43fe75" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_db641cc4-4946-4e4c-8362-d657d71f5fd8" xlink:to="loc_srt_ProductOrServiceAxis_a359354f-579a-47fc-b81d-01faed43fe75" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_a359354f-579a-47fc-b81d-01faed43fe75_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_a359354f-579a-47fc-b81d-01faed43fe75" xlink:to="loc_srt_ProductsAndServicesDomain_a359354f-579a-47fc-b81d-01faed43fe75_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_c0aa3526-6d6f-489d-837a-26f62c900339" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_a359354f-579a-47fc-b81d-01faed43fe75" xlink:to="loc_srt_ProductsAndServicesDomain_c0aa3526-6d6f-489d-837a-26f62c900339" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ProductReturnMember_26756d04-996a-434b-bfe2-a12fbc55541f" xlink:href="iart-20220930.xsd#iart_ProductReturnMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_c0aa3526-6d6f-489d-837a-26f62c900339" xlink:to="loc_iart_ProductReturnMember_26756d04-996a-434b-bfe2-a12fbc55541f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeRevenueRemainingPerformanceObligationDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeRevenueRemainingPerformanceObligationDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeRevenueRemainingPerformanceObligationDetails" xlink:type="extended" id="ia8b5053f930648fb8b4adeccae30ffdd_REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeRevenueRemainingPerformanceObligationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_9a28f401-8ea9-477e-ab59-1a14d232e9d7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationPercentage_b92b0ebc-1b99-4571-b83d-69c0c1d01f1f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_9a28f401-8ea9-477e-ab59-1a14d232e9d7" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationPercentage_b92b0ebc-1b99-4571-b83d-69c0c1d01f1f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_fc05b457-5c87-4ab1-b781-5517e831a364" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_9a28f401-8ea9-477e-ab59-1a14d232e9d7" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_fc05b457-5c87-4ab1-b781-5517e831a364" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_2c127b5b-0e48-4116-be24-1870bde11a6b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_9a28f401-8ea9-477e-ab59-1a14d232e9d7" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_2c127b5b-0e48-4116-be24-1870bde11a6b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_b648319e-8d65-4a4e-a821-f0efaa159961" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_2c127b5b-0e48-4116-be24-1870bde11a6b" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_b648319e-8d65-4a4e-a821-f0efaa159961" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeRevenueRemainingPerformanceObligationDetails_1" xlink:type="simple" xlink:href="iart-20220930.xsd#REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeRevenueRemainingPerformanceObligationDetails_1"/>
  <link:definitionLink xlink:role="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeRevenueRemainingPerformanceObligationDetails_1" xlink:type="extended" id="ia35818cc46694f9696c630416ddfc62f_REVENUESFROMCONTRACTSWITHCUSTOMERSNarrativeRevenueRemainingPerformanceObligationDetails_1">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_9a28f401-8ea9-477e-ab59-1a14d232e9d7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationPercentage_b92b0ebc-1b99-4571-b83d-69c0c1d01f1f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_9a28f401-8ea9-477e-ab59-1a14d232e9d7" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationPercentage_b92b0ebc-1b99-4571-b83d-69c0c1d01f1f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_fc05b457-5c87-4ab1-b781-5517e831a364" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_9a28f401-8ea9-477e-ab59-1a14d232e9d7" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_fc05b457-5c87-4ab1-b781-5517e831a364" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_2c127b5b-0e48-4116-be24-1870bde11a6b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_9a28f401-8ea9-477e-ab59-1a14d232e9d7" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_2c127b5b-0e48-4116-be24-1870bde11a6b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSScheduleofRevenuesDisaggregatedbyMajorSourceDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#REVENUESFROMCONTRACTSWITHCUSTOMERSScheduleofRevenuesDisaggregatedbyMajorSourceDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/REVENUESFROMCONTRACTSWITHCUSTOMERSScheduleofRevenuesDisaggregatedbyMajorSourceDetails" xlink:type="extended" id="ic24f1158786148c58daa41bcae546a1a_REVENUESFROMCONTRACTSWITHCUSTOMERSScheduleofRevenuesDisaggregatedbyMajorSourceDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_7687b318-f0b0-4f57-9530-8b1619113946" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_13762ebd-37c7-4782-b09f-ed7b1b73bf53" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_7687b318-f0b0-4f57-9530-8b1619113946" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_13762ebd-37c7-4782-b09f-ed7b1b73bf53" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_9ea4bd0c-cc76-42c1-bcdc-cb6e32aa8d67" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_7687b318-f0b0-4f57-9530-8b1619113946" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_9ea4bd0c-cc76-42c1-bcdc-cb6e32aa8d67" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_64d2a862-2e10-4d01-b18a-b1e569074927" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_9ea4bd0c-cc76-42c1-bcdc-cb6e32aa8d67" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_64d2a862-2e10-4d01-b18a-b1e569074927" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_64d2a862-2e10-4d01-b18a-b1e569074927_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_64d2a862-2e10-4d01-b18a-b1e569074927" xlink:to="loc_us-gaap_SegmentDomain_64d2a862-2e10-4d01-b18a-b1e569074927_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_d0a0de34-bb8a-4dbb-82c9-e9d6b3b02dca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_64d2a862-2e10-4d01-b18a-b1e569074927" xlink:to="loc_us-gaap_SegmentDomain_d0a0de34-bb8a-4dbb-82c9-e9d6b3b02dca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CodmanSpecialtySurgicalMember_123c0238-d750-4430-9bc9-0abb93698a4c" xlink:href="iart-20220930.xsd#iart_CodmanSpecialtySurgicalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_d0a0de34-bb8a-4dbb-82c9-e9d6b3b02dca" xlink:to="loc_iart_CodmanSpecialtySurgicalMember_123c0238-d750-4430-9bc9-0abb93698a4c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_TissueTechnologiesMember_28ae07ec-1f08-4319-8158-11b6a14a811a" xlink:href="iart-20220930.xsd#iart_TissueTechnologiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_d0a0de34-bb8a-4dbb-82c9-e9d6b3b02dca" xlink:to="loc_iart_TissueTechnologiesMember_28ae07ec-1f08-4319-8158-11b6a14a811a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_1b4222eb-76f6-47c0-af47-6db59c20fdca" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_9ea4bd0c-cc76-42c1-bcdc-cb6e32aa8d67" xlink:to="loc_srt_ProductOrServiceAxis_1b4222eb-76f6-47c0-af47-6db59c20fdca" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_1b4222eb-76f6-47c0-af47-6db59c20fdca_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_1b4222eb-76f6-47c0-af47-6db59c20fdca" xlink:to="loc_srt_ProductsAndServicesDomain_1b4222eb-76f6-47c0-af47-6db59c20fdca_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_3f952b3c-c8b3-47f6-b422-a902d2cef531" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_1b4222eb-76f6-47c0-af47-6db59c20fdca" xlink:to="loc_srt_ProductsAndServicesDomain_3f952b3c-c8b3-47f6-b422-a902d2cef531" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_NeurosurgeryMember_f1ccf833-dd75-427d-91b9-52f7eab1a8a1" xlink:href="iart-20220930.xsd#iart_NeurosurgeryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3f952b3c-c8b3-47f6-b422-a902d2cef531" xlink:to="loc_iart_NeurosurgeryMember_f1ccf833-dd75-427d-91b9-52f7eab1a8a1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InstrumentsMember_37c19cdb-c305-4e48-816c-89f972d7e6ef" xlink:href="iart-20220930.xsd#iart_InstrumentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3f952b3c-c8b3-47f6-b422-a902d2cef531" xlink:to="loc_iart_InstrumentsMember_37c19cdb-c305-4e48-816c-89f972d7e6ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_RegenerativeSkinAndWoundMember_57d172c7-01c9-4b32-804b-5b7d4d2333a8" xlink:href="iart-20220930.xsd#iart_RegenerativeSkinAndWoundMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3f952b3c-c8b3-47f6-b422-a902d2cef531" xlink:to="loc_iart_RegenerativeSkinAndWoundMember_57d172c7-01c9-4b32-804b-5b7d4d2333a8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_PrivateLabelMember_70f6be3b-1c62-40da-888c-75b492b84a9a" xlink:href="iart-20220930.xsd#iart_PrivateLabelMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3f952b3c-c8b3-47f6-b422-a902d2cef531" xlink:to="loc_iart_PrivateLabelMember_70f6be3b-1c62-40da-888c-75b492b84a9a" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/GOODWILLANDOTHERINTANGIBLEASSETSScheduleofChangesinCarryingAmountofGoodwillDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#GOODWILLANDOTHERINTANGIBLEASSETSScheduleofChangesinCarryingAmountofGoodwillDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/GOODWILLANDOTHERINTANGIBLEASSETSScheduleofChangesinCarryingAmountofGoodwillDetails" xlink:type="extended" id="i0a1142092ac14930b26a508082d5023c_GOODWILLANDOTHERINTANGIBLEASSETSScheduleofChangesinCarryingAmountofGoodwillDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillLineItems_174482c3-50da-450d-813a-9d9aaeae1c53" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillRollForward_7e5aeb9f-e4dd-4933-9a41-1ffc8ea2c229" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_174482c3-50da-450d-813a-9d9aaeae1c53" xlink:to="loc_us-gaap_GoodwillRollForward_7e5aeb9f-e4dd-4933-9a41-1ffc8ea2c229" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_3f788653-9305-4acd-b37b-b5a02b83a2f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_7e5aeb9f-e4dd-4933-9a41-1ffc8ea2c229" xlink:to="loc_us-gaap_Goodwill_3f788653-9305-4acd-b37b-b5a02b83a2f3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillWrittenOffRelatedToSaleOfBusinessUnit_e85e2acf-bb20-4b77-b6e1-d7495372e410" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillWrittenOffRelatedToSaleOfBusinessUnit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_7e5aeb9f-e4dd-4933-9a41-1ffc8ea2c229" xlink:to="loc_us-gaap_GoodwillWrittenOffRelatedToSaleOfBusinessUnit_e85e2acf-bb20-4b77-b6e1-d7495372e410" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_a7b375e7-92f6-467f-9773-5c72ec075943" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillForeignCurrencyTranslationGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_7e5aeb9f-e4dd-4933-9a41-1ffc8ea2c229" xlink:to="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_a7b375e7-92f6-467f-9773-5c72ec075943" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_9fc04ac5-7649-4005-a31d-c114104e882d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_1f2bb407-cc58-4a09-b1bc-26af2d070596" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfGoodwillTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_GoodwillLineItems_174482c3-50da-450d-813a-9d9aaeae1c53" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_1f2bb407-cc58-4a09-b1bc-26af2d070596" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_87cf70fb-aab8-4705-b0f4-2ee28f238741" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_1f2bb407-cc58-4a09-b1bc-26af2d070596" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_87cf70fb-aab8-4705-b0f4-2ee28f238741" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_87cf70fb-aab8-4705-b0f4-2ee28f238741_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_87cf70fb-aab8-4705-b0f4-2ee28f238741" xlink:to="loc_us-gaap_SegmentDomain_87cf70fb-aab8-4705-b0f4-2ee28f238741_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_685b5830-7482-4d48-84d8-ecaba4021fc3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_87cf70fb-aab8-4705-b0f4-2ee28f238741" xlink:to="loc_us-gaap_SegmentDomain_685b5830-7482-4d48-84d8-ecaba4021fc3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CodmanSpecialtySurgicalMember_5d87cea5-3e14-4961-9eca-46298c89f89d" xlink:href="iart-20220930.xsd#iart_CodmanSpecialtySurgicalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_685b5830-7482-4d48-84d8-ecaba4021fc3" xlink:to="loc_iart_CodmanSpecialtySurgicalMember_5d87cea5-3e14-4961-9eca-46298c89f89d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_TissueTechnologiesMember_867d9bc9-cf3e-4199-8955-c0af1b01f93e" xlink:href="iart-20220930.xsd#iart_TissueTechnologiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_685b5830-7482-4d48-84d8-ecaba4021fc3" xlink:to="loc_iart_TissueTechnologiesMember_867d9bc9-cf3e-4199-8955-c0af1b01f93e" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/GOODWILLANDOTHERINTANGIBLEASSETSComponentsofCompanysIdentifiableIntangibleAssetsDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#GOODWILLANDOTHERINTANGIBLEASSETSComponentsofCompanysIdentifiableIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/GOODWILLANDOTHERINTANGIBLEASSETSComponentsofCompanysIdentifiableIntangibleAssetsDetails" xlink:type="extended" id="i33113ad5c6e14c25a787042f6e157836_GOODWILLANDOTHERINTANGIBLEASSETSComponentsofCompanysIdentifiableIntangibleAssetsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_df973c7d-6dc3-45cd-96d0-45f86ce24d70" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_3592438a-cb2a-40d7-9d58-06c326197859" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_df973c7d-6dc3-45cd-96d0-45f86ce24d70" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_3592438a-cb2a-40d7-9d58-06c326197859" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CostOfDefiniteAndIndefiniteLivedIntangibleAssetsGrossExcludingGoodwill_fe3a2131-0d0a-413a-bfd1-29a639f92044" xlink:href="iart-20220930.xsd#iart_CostOfDefiniteAndIndefiniteLivedIntangibleAssetsGrossExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_df973c7d-6dc3-45cd-96d0-45f86ce24d70" xlink:to="loc_iart_CostOfDefiniteAndIndefiniteLivedIntangibleAssetsGrossExcludingGoodwill_fe3a2131-0d0a-413a-bfd1-29a639f92044" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_226d220f-b982-4153-be06-9d3003c50af2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_df973c7d-6dc3-45cd-96d0-45f86ce24d70" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_226d220f-b982-4153-be06-9d3003c50af2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DefiniteAndIndefiniteLivedIntangibleAssetsNetExcludingGoodwill_590a245e-d21e-4edd-b1cc-d5826bc4e8d4" xlink:href="iart-20220930.xsd#iart_DefiniteAndIndefiniteLivedIntangibleAssetsNetExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_df973c7d-6dc3-45cd-96d0-45f86ce24d70" xlink:to="loc_iart_DefiniteAndIndefiniteLivedIntangibleAssetsNetExcludingGoodwill_590a245e-d21e-4edd-b1cc-d5826bc4e8d4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_75e20fe5-d9f8-4732-b645-a3573ba76650" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_df973c7d-6dc3-45cd-96d0-45f86ce24d70" xlink:to="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_75e20fe5-d9f8-4732-b645-a3573ba76650" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_5d7171d4-3707-4a8d-8150-20662d232e1a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_75e20fe5-d9f8-4732-b645-a3573ba76650" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_5d7171d4-3707-4a8d-8150-20662d232e1a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5d7171d4-3707-4a8d-8150-20662d232e1a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_5d7171d4-3707-4a8d-8150-20662d232e1a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5d7171d4-3707-4a8d-8150-20662d232e1a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d4b27288-9a79-498a-878f-9b8ca6520b19" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_5d7171d4-3707-4a8d-8150-20662d232e1a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d4b27288-9a79-498a-878f-9b8ca6520b19" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CompletedTechnologyMember_99670c6f-e49d-4b72-981d-e64eda0d70e9" xlink:href="iart-20220930.xsd#iart_CompletedTechnologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d4b27288-9a79-498a-878f-9b8ca6520b19" xlink:to="loc_iart_CompletedTechnologyMember_99670c6f-e49d-4b72-981d-e64eda0d70e9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRelationshipsMember_2ce1e835-cc38-45a7-bb82-a64aae526e9b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CustomerRelationshipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d4b27288-9a79-498a-878f-9b8ca6520b19" xlink:to="loc_us-gaap_CustomerRelationshipsMember_2ce1e835-cc38-45a7-bb82-a64aae526e9b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_TrademarksBrandNamesMember_8dbbbcb6-54a8-442d-b621-ed07dcb2c6a3" xlink:href="iart-20220930.xsd#iart_TrademarksBrandNamesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d4b27288-9a79-498a-878f-9b8ca6520b19" xlink:to="loc_iart_TrademarksBrandNamesMember_8dbbbcb6-54a8-442d-b621-ed07dcb2c6a3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_SupplierRelationShipsMember_327124c2-6c6c-40fd-9773-599f7501ff42" xlink:href="iart-20220930.xsd#iart_SupplierRelationShipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d4b27288-9a79-498a-878f-9b8ca6520b19" xlink:to="loc_iart_SupplierRelationShipsMember_327124c2-6c6c-40fd-9773-599f7501ff42" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_AllOtherMember_271d8659-f287-4904-83d9-01c27998b337" xlink:href="iart-20220930.xsd#iart_AllOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d4b27288-9a79-498a-878f-9b8ca6520b19" xlink:to="loc_iart_AllOtherMember_271d8659-f287-4904-83d9-01c27998b337" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_50a6c4d2-1e96-4684-be34-fb1d8cd1c877" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_75e20fe5-d9f8-4732-b645-a3573ba76650" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_50a6c4d2-1e96-4684-be34-fb1d8cd1c877" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_50a6c4d2-1e96-4684-be34-fb1d8cd1c877_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_50a6c4d2-1e96-4684-be34-fb1d8cd1c877" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_50a6c4d2-1e96-4684-be34-fb1d8cd1c877_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_3430bbac-2474-427e-bfcd-a6090ae6ea72" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_50a6c4d2-1e96-4684-be34-fb1d8cd1c877" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_3430bbac-2474-427e-bfcd-a6090ae6ea72" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeNamesMember_f5b296d5-b583-4d39-80ab-0023634cdfd6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TradeNamesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_3430bbac-2474-427e-bfcd-a6090ae6ea72" xlink:to="loc_us-gaap_TradeNamesMember_f5b296d5-b583-4d39-80ab-0023634cdfd6" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/GOODWILLANDOTHERINTANGIBLEASSETSNarrativeDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#GOODWILLANDOTHERINTANGIBLEASSETSNarrativeDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/GOODWILLANDOTHERINTANGIBLEASSETSNarrativeDetails" xlink:type="extended" id="i34b433a02cf44d94aab675ccd6cea4ac_GOODWILLANDOTHERINTANGIBLEASSETSNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_66906f13-6358-4d14-ab90-af7bcfaeb073" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationIntangibleAssets_2c2bb46c-2ec3-40f8-bbb4-f828d58be573" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_66906f13-6358-4d14-ab90-af7bcfaeb073" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationIntangibleAssets_2c2bb46c-2ec3-40f8-bbb4-f828d58be573" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f4ec39e5-916e-4552-98ff-d833b71d5637" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_66906f13-6358-4d14-ab90-af7bcfaeb073" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f4ec39e5-916e-4552-98ff-d833b71d5637" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_1dab2e7d-e414-41ee-9262-f4cad0779251" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupClassificationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f4ec39e5-916e-4552-98ff-d833b71d5637" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_1dab2e7d-e414-41ee-9262-f4cad0779251" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_1dab2e7d-e414-41ee-9262-f4cad0779251_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_1dab2e7d-e414-41ee-9262-f4cad0779251" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_1dab2e7d-e414-41ee-9262-f4cad0779251_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_d037d191-45aa-44f8-87b3-cc9e5b140684" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_1dab2e7d-e414-41ee-9262-f4cad0779251" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_d037d191-45aa-44f8-87b3-cc9e5b140684" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_169bdfb6-ee66-4245-b9b7-e74c24c3ee6d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_d037d191-45aa-44f8-87b3-cc9e5b140684" xlink:to="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_169bdfb6-ee66-4245-b9b7-e74c24c3ee6d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_717ac61b-14d8-4f36-ad79-7eed09ce9fef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f4ec39e5-916e-4552-98ff-d833b71d5637" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_717ac61b-14d8-4f36-ad79-7eed09ce9fef" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_717ac61b-14d8-4f36-ad79-7eed09ce9fef_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_717ac61b-14d8-4f36-ad79-7eed09ce9fef" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_717ac61b-14d8-4f36-ad79-7eed09ce9fef_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_1da85ae6-089c-4003-b620-c7a9aaeb658a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_717ac61b-14d8-4f36-ad79-7eed09ce9fef" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_1da85ae6-089c-4003-b620-c7a9aaeb658a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_TraditionalWoundCareMember_e9c57b9b-b656-4434-bb22-e81bfd44dc7e" xlink:href="iart-20220930.xsd#iart_TraditionalWoundCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_1da85ae6-089c-4003-b620-c7a9aaeb658a" xlink:to="loc_iart_TraditionalWoundCareMember_e9c57b9b-b656-4434-bb22-e81bfd44dc7e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ed06a14e-b22a-4500-8f28-d0093a2acc30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_f4ec39e5-916e-4552-98ff-d833b71d5637" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ed06a14e-b22a-4500-8f28-d0093a2acc30" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ed06a14e-b22a-4500-8f28-d0093a2acc30_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ed06a14e-b22a-4500-8f28-d0093a2acc30" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ed06a14e-b22a-4500-8f28-d0093a2acc30_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_c6d1c603-f55b-4ea4-b620-83063a31d35a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ed06a14e-b22a-4500-8f28-d0093a2acc30" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_c6d1c603-f55b-4ea4-b620-83063a31d35a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRelationshipsMember_d0125543-7be9-4de7-b4f6-847f978fb441" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CustomerRelationshipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_c6d1c603-f55b-4ea4-b620-83063a31d35a" xlink:to="loc_us-gaap_CustomerRelationshipsMember_d0125543-7be9-4de7-b4f6-847f978fb441" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/DEBTNarrativeDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#DEBTNarrativeDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/DEBTNarrativeDetails" xlink:type="extended" id="i1c5985df0bc0412986a11d390c5656b8_DEBTNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_534a1e9b-dd0e-4a5a-ace8-ac8574e43ded" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_534a1e9b-dd0e-4a5a-ace8-ac8574e43ded" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_c5f44a82-d0c8-4d08-959e-5670045d258f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_c5f44a82-d0c8-4d08-959e-5670045d258f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_31e41660-809e-4a2e-92f9-f40805103ebd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityCommitmentFeePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_31e41660-809e-4a2e-92f9-f40805103ebd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_88f1a8fd-5cab-4540-b48d-e485493909fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCredit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_LineOfCredit_88f1a8fd-5cab-4540-b48d-e485493909fc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate_4af6914e-6686-48d7-81bc-41b510093f01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtWeightedAverageInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_DebtWeightedAverageInterestRate_4af6914e-6686-48d7-81bc-41b510093f01" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtCurrent_532eadcb-a077-4ce2-b385-1a85a870d53a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SecuredDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_SecuredDebtCurrent_532eadcb-a077-4ce2-b385-1a85a870d53a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_7d57d8fc-6ea4-486a-a270-9aebd38f1887" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_7d57d8fc-6ea4-486a-a270-9aebd38f1887" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_84e62e7d-8fa4-4a0b-950f-32c104baedbc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_84e62e7d-8fa4-4a0b-950f-32c104baedbc" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestPaymentsYearOne_e1696b5d-e176-4ddc-b19f-e22af87e2a04" xlink:href="iart-20220930.xsd#iart_InterestPaymentsYearOne"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_iart_InterestPaymentsYearOne_e1696b5d-e176-4ddc-b19f-e22af87e2a04" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestPaymentsYearTwo_42ff7af7-965e-420a-b603-fc3d98275e05" xlink:href="iart-20220930.xsd#iart_InterestPaymentsYearTwo"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_iart_InterestPaymentsYearTwo_42ff7af7-965e-420a-b603-fc3d98275e05" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestPaymentsYearThree_c19074c3-91b4-40a8-a0d5-b86c36fbb36c" xlink:href="iart-20220930.xsd#iart_InterestPaymentsYearThree"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_iart_InterestPaymentsYearThree_c19074c3-91b4-40a8-a0d5-b86c36fbb36c" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestPaymentsYearFour_000eaf06-a822-4b8a-b1ce-3799c78c13c4" xlink:href="iart-20220930.xsd#iart_InterestPaymentsYearFour"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_iart_InterestPaymentsYearFour_000eaf06-a822-4b8a-b1ce-3799c78c13c4" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_6d07a348-ad8f-4b38-8766-ae3d01a9fffd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_6d07a348-ad8f-4b38-8766-ae3d01a9fffd" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_a802b2e6-690c-4b16-8d18-3ef8cdd55908" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_a802b2e6-690c-4b16-8d18-3ef8cdd55908" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_da82873e-3542-4b50-995b-7b7d36dea1ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_da82873e-3542-4b50-995b-7b7d36dea1ce" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_47d7d265-c9ff-4bdc-901a-8803ae6c04fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_47d7d265-c9ff-4bdc-901a-8803ae6c04fd" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsGross_0be5d5c2-1775-4d76-bed1-0f9ba42d8b8d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredFinanceCostsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_DeferredFinanceCostsGross_0be5d5c2-1775-4d76-bed1-0f9ba42d8b8d" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_94448187-daaa-4e99-a56a-b734c752be2f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_94448187-daaa-4e99-a56a-b734c752be2f" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_3973824d-bfb6-4cd8-bd95-309785843ddc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_3973824d-bfb6-4cd8-bd95-309785843ddc" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DebtInstrumentMaximumSellingPriceOfCommonStockOfTheConversionPriceDuringPeriod_f116af59-6cea-4eea-b1f8-deb329bc8e46" xlink:href="iart-20220930.xsd#iart_DebtInstrumentMaximumSellingPriceOfCommonStockOfTheConversionPriceDuringPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_iart_DebtInstrumentMaximumSellingPriceOfCommonStockOfTheConversionPriceDuringPeriod_f116af59-6cea-4eea-b1f8-deb329bc8e46" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DebtInstrumentMaximumAverageConversionValueOfNotes_e25e088d-3706-44d2-8431-d121319f362f" xlink:href="iart-20220930.xsd#iart_DebtInstrumentMaximumAverageConversionValueOfNotes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_iart_DebtInstrumentMaximumAverageConversionValueOfNotes_e25e088d-3706-44d2-8431-d121319f362f" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_b88ae4f1-c8fd-42c2-b34c-25a723db277c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_b88ae4f1-c8fd-42c2-b34c-25a723db277c" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_PaymentsForOptionIndexToIssuersEquity_cafa7b92-b0c5-4ed0-a3ea-cd61f301d9fe" xlink:href="iart-20220930.xsd#iart_PaymentsForOptionIndexToIssuersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_iart_PaymentsForOptionIndexToIssuersEquity_cafa7b92-b0c5-4ed0-a3ea-cd61f301d9fe" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfWarrants_832544e5-98cd-44a0-b361-fd785497bd6a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfWarrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfWarrants_832544e5-98cd-44a0-b361-fd785497bd6a" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityStrikePrice1_90fd136a-40dd-4c58-b05e-4c117096020c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OptionIndexedToIssuersEquityStrikePrice1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityStrikePrice1_90fd136a-40dd-4c58-b05e-4c117096020c" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_c04cd577-a7a1-4b9d-9727-004e66fa476d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_c04cd577-a7a1-4b9d-9727-004e66fa476d" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtNoncurrent_f9078cb5-abcd-4262-a6a0-a35a3ae4a37b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertibleDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_ConvertibleDebtNoncurrent_f9078cb5-abcd-4262-a6a0-a35a3ae4a37b" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_6411275c-e45c-409e-8453-a1e531f7aa16" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_6411275c-e45c-409e-8453-a1e531f7aa16" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFairValue_9e48fd25-0c8b-4d42-89fe-4dca02130db3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_DebtInstrumentFairValue_9e48fd25-0c8b-4d42-89fe-4dca02130db3" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebtExcludingAmortization_5c37a351-7e7b-4e76-961c-c5e57071d05c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpenseDebtExcludingAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_InterestExpenseDebtExcludingAmortization_5c37a351-7e7b-4e76-961c-c5e57071d05c" xlink:type="arc" order="29"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_TransferorsInterestsInTransferredFinancialAssetsMaximumInvestmentLimit_725531de-5fd3-4502-8fad-dea3e7489351" xlink:href="iart-20220930.xsd#iart_TransferorsInterestsInTransferredFinancialAssetsMaximumInvestmentLimit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_iart_TransferorsInterestsInTransferredFinancialAssetsMaximumInvestmentLimit_725531de-5fd3-4502-8fad-dea3e7489351" xlink:type="arc" order="30"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_SecuredLongTermDebtSecuritizationProgram_756f6e48-df1e-4154-b0af-207ebc59f868" xlink:href="iart-20220930.xsd#iart_SecuredLongTermDebtSecuritizationProgram"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_iart_SecuredLongTermDebtSecuritizationProgram_756f6e48-df1e-4154-b0af-207ebc59f868" xlink:type="arc" order="31"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DebtWeightedAverageInterestRateFromSecuritization_452a9f36-4dad-490a-920a-b745c6681b9d" xlink:href="iart-20220930.xsd#iart_DebtWeightedAverageInterestRateFromSecuritization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_iart_DebtWeightedAverageInterestRateFromSecuritization_452a9f36-4dad-490a-920a-b745c6681b9d" xlink:type="arc" order="32"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_SecuritizationFacilityFairValueOfAmountOutstanding_323e742a-3e26-4edc-b932-a37c794dd8f3" xlink:href="iart-20220930.xsd#iart_SecuritizationFacilityFairValueOfAmountOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_iart_SecuritizationFacilityFairValueOfAmountOutstanding_323e742a-3e26-4edc-b932-a37c794dd8f3" xlink:type="arc" order="33"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_aa8f695c-d50f-4a5a-9075-98d99c2fd438" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3bae73d8-5b9c-4377-b879-25a21d73faa5" xlink:to="loc_us-gaap_DebtInstrumentTable_aa8f695c-d50f-4a5a-9075-98d99c2fd438" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_46907033-c0db-4fe5-a106-02c62b072bc3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_aa8f695c-d50f-4a5a-9075-98d99c2fd438" xlink:to="loc_us-gaap_DebtInstrumentAxis_46907033-c0db-4fe5-a106-02c62b072bc3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_46907033-c0db-4fe5-a106-02c62b072bc3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_46907033-c0db-4fe5-a106-02c62b072bc3" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_46907033-c0db-4fe5-a106-02c62b072bc3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_74b683cb-0f26-4933-a10b-804d7e442ece" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_46907033-c0db-4fe5-a106-02c62b072bc3" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_74b683cb-0f26-4933-a10b-804d7e442ece" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_SeniorCreditFacilityMember_3f36458a-d1a2-4f79-9388-c96d34df45b0" xlink:href="iart-20220930.xsd#iart_SeniorCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_74b683cb-0f26-4933-a10b-804d7e442ece" xlink:to="loc_iart_SeniorCreditFacilityMember_3f36458a-d1a2-4f79-9388-c96d34df45b0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_TermLoanFacilityMember_c5779bce-a779-49d0-91c5-89abcf8c91c6" xlink:href="iart-20220930.xsd#iart_TermLoanFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_74b683cb-0f26-4933-a10b-804d7e442ece" xlink:to="loc_iart_TermLoanFacilityMember_c5779bce-a779-49d0-91c5-89abcf8c91c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_TwoThousandTwentyFiveSeniorConvertibleNotesMember_effcd5df-ca2c-45e4-8608-33bcf2e25619" xlink:href="iart-20220930.xsd#iart_TwoThousandTwentyFiveSeniorConvertibleNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_74b683cb-0f26-4933-a10b-804d7e442ece" xlink:to="loc_iart_TwoThousandTwentyFiveSeniorConvertibleNotesMember_effcd5df-ca2c-45e4-8608-33bcf2e25619" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_c899f814-1b61-4d7f-9daa-f81a0e0f3098" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_aa8f695c-d50f-4a5a-9075-98d99c2fd438" xlink:to="loc_us-gaap_CreditFacilityAxis_c899f814-1b61-4d7f-9daa-f81a0e0f3098" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_c899f814-1b61-4d7f-9daa-f81a0e0f3098_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_c899f814-1b61-4d7f-9daa-f81a0e0f3098" xlink:to="loc_us-gaap_CreditFacilityDomain_c899f814-1b61-4d7f-9daa-f81a0e0f3098_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_0a3559e5-20e9-4bba-b7ed-ef34df36dc4a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_c899f814-1b61-4d7f-9daa-f81a0e0f3098" xlink:to="loc_us-gaap_CreditFacilityDomain_0a3559e5-20e9-4bba-b7ed-ef34df36dc4a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtMember_a6692bae-d8fe-4f7b-bb19-1bb5470dd7ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_0a3559e5-20e9-4bba-b7ed-ef34df36dc4a" xlink:to="loc_us-gaap_SecuredDebtMember_a6692bae-d8fe-4f7b-bb19-1bb5470dd7ea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_953f584c-7986-44fa-ab6f-ca85c4ff171e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_0a3559e5-20e9-4bba-b7ed-ef34df36dc4a" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_953f584c-7986-44fa-ab6f-ca85c4ff171e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StandbyLettersOfCreditMember_c456ff51-8a60-4fe3-b66c-d6f668ab2f96" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StandbyLettersOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_0a3559e5-20e9-4bba-b7ed-ef34df36dc4a" xlink:to="loc_us-gaap_StandbyLettersOfCreditMember_c456ff51-8a60-4fe3-b66c-d6f668ab2f96" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_SwinglineLoanMember_3bc3bb73-8650-47bc-88ba-5afb25d35272" xlink:href="iart-20220930.xsd#iart_SwinglineLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_0a3559e5-20e9-4bba-b7ed-ef34df36dc4a" xlink:to="loc_iart_SwinglineLoanMember_3bc3bb73-8650-47bc-88ba-5afb25d35272" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_9909b99f-ffbf-45e0-8ee8-5edb5af36f61" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_aa8f695c-d50f-4a5a-9075-98d99c2fd438" xlink:to="loc_srt_RangeAxis_9909b99f-ffbf-45e0-8ee8-5edb5af36f61" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_9909b99f-ffbf-45e0-8ee8-5edb5af36f61_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_9909b99f-ffbf-45e0-8ee8-5edb5af36f61" xlink:to="loc_srt_RangeMember_9909b99f-ffbf-45e0-8ee8-5edb5af36f61_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_674add52-46ea-4627-bd77-06d68e239299" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_9909b99f-ffbf-45e0-8ee8-5edb5af36f61" xlink:to="loc_srt_RangeMember_674add52-46ea-4627-bd77-06d68e239299" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_9bce3747-b178-4f5b-b674-bb634b78cfd9" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_674add52-46ea-4627-bd77-06d68e239299" xlink:to="loc_srt_MinimumMember_9bce3747-b178-4f5b-b674-bb634b78cfd9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_00a15ea7-07f2-404e-9e1b-fe28ee525b1c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_674add52-46ea-4627-bd77-06d68e239299" xlink:to="loc_srt_MaximumMember_00a15ea7-07f2-404e-9e1b-fe28ee525b1c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_41d6760e-5aa1-4f7f-9bf8-190221dff822" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_aa8f695c-d50f-4a5a-9075-98d99c2fd438" xlink:to="loc_us-gaap_VariableRateAxis_41d6760e-5aa1-4f7f-9bf8-190221dff822" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_41d6760e-5aa1-4f7f-9bf8-190221dff822_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_41d6760e-5aa1-4f7f-9bf8-190221dff822" xlink:to="loc_us-gaap_VariableRateDomain_41d6760e-5aa1-4f7f-9bf8-190221dff822_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_1a143887-dea2-4d66-9ac4-6d4b113a1522" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_41d6760e-5aa1-4f7f-9bf8-190221dff822" xlink:to="loc_us-gaap_VariableRateDomain_1a143887-dea2-4d66-9ac4-6d4b113a1522" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EurodollarMember_6a32bafa-225c-46e2-ab08-79bbb1873edb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EurodollarMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_1a143887-dea2-4d66-9ac4-6d4b113a1522" xlink:to="loc_us-gaap_EurodollarMember_6a32bafa-225c-46e2-ab08-79bbb1873edb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsEffectiveSwapRateMember_13047209-a45b-49ee-829b-46c0146018f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FederalFundsEffectiveSwapRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_1a143887-dea2-4d66-9ac4-6d4b113a1522" xlink:to="loc_us-gaap_FederalFundsEffectiveSwapRateMember_13047209-a45b-49ee-829b-46c0146018f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_OneMonthEurodollarRateMember_f30d1a72-f7a3-4026-a865-cec23046a653" xlink:href="iart-20220930.xsd#iart_OneMonthEurodollarRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_1a143887-dea2-4d66-9ac4-6d4b113a1522" xlink:to="loc_iart_OneMonthEurodollarRateMember_f30d1a72-f7a3-4026-a865-cec23046a653" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_87792a0d-7e35-45c7-9360-6261c7d63175" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_aa8f695c-d50f-4a5a-9075-98d99c2fd438" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_87792a0d-7e35-45c7-9360-6261c7d63175" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_87792a0d-7e35-45c7-9360-6261c7d63175_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_87792a0d-7e35-45c7-9360-6261c7d63175" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_87792a0d-7e35-45c7-9360-6261c7d63175_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_85386764-732a-42d5-ba7e-a267a7dde24b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_87792a0d-7e35-45c7-9360-6261c7d63175" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_85386764-732a-42d5-ba7e-a267a7dde24b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_fa57d6ff-2712-47ae-bd7d-cf026dca6b4b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_85386764-732a-42d5-ba7e-a267a7dde24b" xlink:to="loc_us-gaap_ConvertibleDebtMember_fa57d6ff-2712-47ae-bd7d-cf026dca6b4b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityEquityAxis_460d2227-3dfa-4626-b200-40936f1448db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OptionIndexedToIssuersEquityEquityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_aa8f695c-d50f-4a5a-9075-98d99c2fd438" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityEquityAxis_460d2227-3dfa-4626-b200-40936f1448db" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_460d2227-3dfa-4626-b200-40936f1448db_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityEquityAxis_460d2227-3dfa-4626-b200-40936f1448db" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_460d2227-3dfa-4626-b200-40936f1448db_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_7298ddd3-4cdf-4521-b114-a339c9e25816" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityEquityAxis_460d2227-3dfa-4626-b200-40936f1448db" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_7298ddd3-4cdf-4521-b114-a339c9e25816" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CallOptionMember_92ef6c6c-1890-4d8c-a0a4-e9cb59589729" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CallOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_7298ddd3-4cdf-4521-b114-a339c9e25816" xlink:to="loc_us-gaap_CallOptionMember_92ef6c6c-1890-4d8c-a0a4-e9cb59589729" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_2eb07978-fd2d-415e-ac29-28d6be6d58fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_aa8f695c-d50f-4a5a-9075-98d99c2fd438" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_2eb07978-fd2d-415e-ac29-28d6be6d58fc" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2eb07978-fd2d-415e-ac29-28d6be6d58fc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_2eb07978-fd2d-415e-ac29-28d6be6d58fc" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2eb07978-fd2d-415e-ac29-28d6be6d58fc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_64010a7a-abac-4053-a8e2-a155b576659c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_2eb07978-fd2d-415e-ac29-28d6be6d58fc" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_64010a7a-abac-4053-a8e2-a155b576659c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_43e4c0b5-c0af-4b11-bed8-b3b168baea3f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_64010a7a-abac-4053-a8e2-a155b576659c" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_43e4c0b5-c0af-4b11-bed8-b3b168baea3f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/DEBTMaximumTotalLeverageRatioTableDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#DEBTMaximumTotalLeverageRatioTableDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/DEBTMaximumTotalLeverageRatioTableDetails" xlink:type="extended" id="i8d473cd029e24ea5a812e20227e8a55c_DEBTMaximumTotalLeverageRatioTableDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_3434bdf8-66d6-40d1-85ec-3007c61eb20e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DebtInstrumentCovenantMaximumLeverageRatio_79266043-843d-4cf8-8986-7a7fd93d377f" xlink:href="iart-20220930.xsd#iart_DebtInstrumentCovenantMaximumLeverageRatio"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3434bdf8-66d6-40d1-85ec-3007c61eb20e" xlink:to="loc_iart_DebtInstrumentCovenantMaximumLeverageRatio_79266043-843d-4cf8-8986-7a7fd93d377f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_385db917-8f59-4047-a8a8-479c84b49507" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3434bdf8-66d6-40d1-85ec-3007c61eb20e" xlink:to="loc_us-gaap_DebtInstrumentTable_385db917-8f59-4047-a8a8-479c84b49507" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DebtCovenantPeriodAxis_a5cb3a2f-89d2-40f4-a2c0-e9624ab9010d" xlink:href="iart-20220930.xsd#iart_DebtCovenantPeriodAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_385db917-8f59-4047-a8a8-479c84b49507" xlink:to="loc_iart_DebtCovenantPeriodAxis_a5cb3a2f-89d2-40f4-a2c0-e9624ab9010d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DebtCovenantPeriodDomain_a5cb3a2f-89d2-40f4-a2c0-e9624ab9010d_default" xlink:href="iart-20220930.xsd#iart_DebtCovenantPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_iart_DebtCovenantPeriodAxis_a5cb3a2f-89d2-40f4-a2c0-e9624ab9010d" xlink:to="loc_iart_DebtCovenantPeriodDomain_a5cb3a2f-89d2-40f4-a2c0-e9624ab9010d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DebtCovenantPeriodDomain_457242a1-d730-44fb-9a82-344daf04c48b" xlink:href="iart-20220930.xsd#iart_DebtCovenantPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_iart_DebtCovenantPeriodAxis_a5cb3a2f-89d2-40f4-a2c0-e9624ab9010d" xlink:to="loc_iart_DebtCovenantPeriodDomain_457242a1-d730-44fb-9a82-344daf04c48b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DebtCovenantPeriod8Member_43d958f7-c390-4e6b-9874-eb1685d17329" xlink:href="iart-20220930.xsd#iart_DebtCovenantPeriod8Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_iart_DebtCovenantPeriodDomain_457242a1-d730-44fb-9a82-344daf04c48b" xlink:to="loc_iart_DebtCovenantPeriod8Member_43d958f7-c390-4e6b-9874-eb1685d17329" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DebtCovenantPeriod9Member_064b429c-d493-4f1d-b64a-5a7a7d6cda77" xlink:href="iart-20220930.xsd#iart_DebtCovenantPeriod9Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_iart_DebtCovenantPeriodDomain_457242a1-d730-44fb-9a82-344daf04c48b" xlink:to="loc_iart_DebtCovenantPeriod9Member_064b429c-d493-4f1d-b64a-5a7a7d6cda77" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_56ecff81-c31b-4d5f-a187-4abbaa0930e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_385db917-8f59-4047-a8a8-479c84b49507" xlink:to="loc_us-gaap_DebtInstrumentAxis_56ecff81-c31b-4d5f-a187-4abbaa0930e4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_56ecff81-c31b-4d5f-a187-4abbaa0930e4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_56ecff81-c31b-4d5f-a187-4abbaa0930e4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_56ecff81-c31b-4d5f-a187-4abbaa0930e4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_e1ee1cfc-7c56-47c3-891b-bde5f786be06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_56ecff81-c31b-4d5f-a187-4abbaa0930e4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_e1ee1cfc-7c56-47c3-891b-bde5f786be06" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_SeniorCreditFacilityMember_73eb90c5-29dd-4c6a-beba-96aa6d7661cb" xlink:href="iart-20220930.xsd#iart_SeniorCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e1ee1cfc-7c56-47c3-891b-bde5f786be06" xlink:to="loc_iart_SeniorCreditFacilityMember_73eb90c5-29dd-4c6a-beba-96aa6d7661cb" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSScheduleofDerivativesDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#DERIVATIVEINSTRUMENTSScheduleofDerivativesDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/DERIVATIVEINSTRUMENTSScheduleofDerivativesDetails" xlink:type="extended" id="i4b34d0d8790f44acae93c8e20edd454a_DERIVATIVEINSTRUMENTSScheduleofDerivativesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_d3ccba01-32aa-4b90-a117-96507eab7b36" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_576bb211-1a0e-463a-a06d-66385935010f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_d3ccba01-32aa-4b90-a117-96507eab7b36" xlink:to="loc_us-gaap_DerivativeNotionalAmount_576bb211-1a0e-463a-a06d-66385935010f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFixedInterestRate_2db8bcc0-7dc6-459d-b5e9-ef38e8e443a4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFixedInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_d3ccba01-32aa-4b90-a117-96507eab7b36" xlink:to="loc_us-gaap_DerivativeFixedInterestRate_2db8bcc0-7dc6-459d-b5e9-ef38e8e443a4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_f0304267-d09d-44f4-9df8-605dc42f3e40" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_d3ccba01-32aa-4b90-a117-96507eab7b36" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_f0304267-d09d-44f4-9df8-605dc42f3e40" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_c0e49e83-5ddf-4abe-9207-3eaab6d8e4d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_d3ccba01-32aa-4b90-a117-96507eab7b36" xlink:to="loc_us-gaap_DerivativeTable_c0e49e83-5ddf-4abe-9207-3eaab6d8e4d5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_5107ac47-724e-4544-9f0b-c6c6f66fc0d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_c0e49e83-5ddf-4abe-9207-3eaab6d8e4d5" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_5107ac47-724e-4544-9f0b-c6c6f66fc0d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_5107ac47-724e-4544-9f0b-c6c6f66fc0d5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_5107ac47-724e-4544-9f0b-c6c6f66fc0d5" xlink:to="loc_us-gaap_HedgingRelationshipDomain_5107ac47-724e-4544-9f0b-c6c6f66fc0d5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_c31c5611-61b3-4aef-be69-2be9161a46ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_5107ac47-724e-4544-9f0b-c6c6f66fc0d5" xlink:to="loc_us-gaap_HedgingRelationshipDomain_c31c5611-61b3-4aef-be69-2be9161a46ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_85476862-6a84-42d8-896a-b3a59927d182" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_c31c5611-61b3-4aef-be69-2be9161a46ec" xlink:to="loc_us-gaap_CashFlowHedgingMember_85476862-6a84-42d8-896a-b3a59927d182" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_78107f6b-9cc5-4c5d-9156-27de8b30de1f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_c0e49e83-5ddf-4abe-9207-3eaab6d8e4d5" xlink:to="loc_us-gaap_HedgingDesignationAxis_78107f6b-9cc5-4c5d-9156-27de8b30de1f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_78107f6b-9cc5-4c5d-9156-27de8b30de1f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_78107f6b-9cc5-4c5d-9156-27de8b30de1f" xlink:to="loc_us-gaap_HedgingDesignationDomain_78107f6b-9cc5-4c5d-9156-27de8b30de1f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_b0c934d2-d9fd-4709-80f9-a30aa0d5d876" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_78107f6b-9cc5-4c5d-9156-27de8b30de1f" xlink:to="loc_us-gaap_HedgingDesignationDomain_b0c934d2-d9fd-4709-80f9-a30aa0d5d876" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_9b64d113-eccb-40c5-9efb-fd95b0d777f6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_b0c934d2-d9fd-4709-80f9-a30aa0d5d876" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_9b64d113-eccb-40c5-9efb-fd95b0d777f6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_c9bec4e5-34cf-491e-80ef-73fefd2e544f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_c0e49e83-5ddf-4abe-9207-3eaab6d8e4d5" xlink:to="loc_us-gaap_VariableRateAxis_c9bec4e5-34cf-491e-80ef-73fefd2e544f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_c9bec4e5-34cf-491e-80ef-73fefd2e544f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_c9bec4e5-34cf-491e-80ef-73fefd2e544f" xlink:to="loc_us-gaap_VariableRateDomain_c9bec4e5-34cf-491e-80ef-73fefd2e544f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_7017dc7a-09cd-400f-8775-09b97896635c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_c9bec4e5-34cf-491e-80ef-73fefd2e544f" xlink:to="loc_us-gaap_VariableRateDomain_7017dc7a-09cd-400f-8775-09b97896635c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_OneMonthUSDLIBORMember_75a7cb53-86bb-477c-9251-493de48e1c65" xlink:href="iart-20220930.xsd#iart_OneMonthUSDLIBORMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_7017dc7a-09cd-400f-8775-09b97896635c" xlink:to="loc_iart_OneMonthUSDLIBORMember_75a7cb53-86bb-477c-9251-493de48e1c65" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_cf27e299-0758-43cc-b866-4d1164500b52" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_c0e49e83-5ddf-4abe-9207-3eaab6d8e4d5" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_cf27e299-0758-43cc-b866-4d1164500b52" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_cf27e299-0758-43cc-b866-4d1164500b52_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_cf27e299-0758-43cc-b866-4d1164500b52" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_cf27e299-0758-43cc-b866-4d1164500b52_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_1dab3723-6a4e-4f30-9757-5d6fdc49c1f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_cf27e299-0758-43cc-b866-4d1164500b52" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_1dab3723-6a4e-4f30-9757-5d6fdc49c1f3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestRateSwapDesignatedDecember132017Tranche1Member_9ddc514c-2c25-43eb-b28f-ada5e0eb485a" xlink:href="iart-20220930.xsd#iart_InterestRateSwapDesignatedDecember132017Tranche1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1dab3723-6a4e-4f30-9757-5d6fdc49c1f3" xlink:to="loc_iart_InterestRateSwapDesignatedDecember132017Tranche1Member_9ddc514c-2c25-43eb-b28f-ada5e0eb485a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestRateSwapDesignatedDecember132017Tranche2Member_99f3858f-65d8-48ce-a046-e5b965b4e77f" xlink:href="iart-20220930.xsd#iart_InterestRateSwapDesignatedDecember132017Tranche2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1dab3723-6a4e-4f30-9757-5d6fdc49c1f3" xlink:to="loc_iart_InterestRateSwapDesignatedDecember132017Tranche2Member_99f3858f-65d8-48ce-a046-e5b965b4e77f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestRateSwapDesignatedDecember132017Tranche3Member_9b7e15f8-6e70-4573-a857-985882e32238" xlink:href="iart-20220930.xsd#iart_InterestRateSwapDesignatedDecember132017Tranche3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1dab3723-6a4e-4f30-9757-5d6fdc49c1f3" xlink:to="loc_iart_InterestRateSwapDesignatedDecember132017Tranche3Member_9b7e15f8-6e70-4573-a857-985882e32238" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestRateSwapDesignatedOctober102018Tranche1Member_5a7e8bda-d84d-48dd-ae0f-1b974b1e58bc" xlink:href="iart-20220930.xsd#iart_InterestRateSwapDesignatedOctober102018Tranche1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1dab3723-6a4e-4f30-9757-5d6fdc49c1f3" xlink:to="loc_iart_InterestRateSwapDesignatedOctober102018Tranche1Member_5a7e8bda-d84d-48dd-ae0f-1b974b1e58bc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestRateSwapDesignatedOctober102018Tranche2Member_b4b0c469-7917-4d15-887a-5e88227d26c3" xlink:href="iart-20220930.xsd#iart_InterestRateSwapDesignatedOctober102018Tranche2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1dab3723-6a4e-4f30-9757-5d6fdc49c1f3" xlink:to="loc_iart_InterestRateSwapDesignatedOctober102018Tranche2Member_b4b0c469-7917-4d15-887a-5e88227d26c3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestRateSwapDesignatedOctober102018Tranche3Member_0a054393-d056-420c-af67-66e491770fb7" xlink:href="iart-20220930.xsd#iart_InterestRateSwapDesignatedOctober102018Tranche3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1dab3723-6a4e-4f30-9757-5d6fdc49c1f3" xlink:to="loc_iart_InterestRateSwapDesignatedOctober102018Tranche3Member_0a054393-d056-420c-af67-66e491770fb7" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestRateSwapDesignatedDecember182018Tranche1Member_feeb95bf-3958-4ffc-b0ee-772728aaa9a0" xlink:href="iart-20220930.xsd#iart_InterestRateSwapDesignatedDecember182018Tranche1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1dab3723-6a4e-4f30-9757-5d6fdc49c1f3" xlink:to="loc_iart_InterestRateSwapDesignatedDecember182018Tranche1Member_feeb95bf-3958-4ffc-b0ee-772728aaa9a0" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestRateSwapDesignatedDecember182018Tranche2Member_deaec048-3c82-4bd2-af7f-960d10a75ef8" xlink:href="iart-20220930.xsd#iart_InterestRateSwapDesignatedDecember182018Tranche2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1dab3723-6a4e-4f30-9757-5d6fdc49c1f3" xlink:to="loc_iart_InterestRateSwapDesignatedDecember182018Tranche2Member_deaec048-3c82-4bd2-af7f-960d10a75ef8" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestRateSwapDesignatedDecember152020Tranche1Member_3a8d96be-4ea2-4e94-8aad-26b723f18f59" xlink:href="iart-20220930.xsd#iart_InterestRateSwapDesignatedDecember152020Tranche1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1dab3723-6a4e-4f30-9757-5d6fdc49c1f3" xlink:to="loc_iart_InterestRateSwapDesignatedDecember152020Tranche1Member_3a8d96be-4ea2-4e94-8aad-26b723f18f59" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_InterestRateSwapDesignatedDecember152020Tranche2Member_4a83b6e9-4670-4272-a188-ca3651c8ee28" xlink:href="iart-20220930.xsd#iart_InterestRateSwapDesignatedDecember152020Tranche2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1dab3723-6a4e-4f30-9757-5d6fdc49c1f3" xlink:to="loc_iart_InterestRateSwapDesignatedDecember152020Tranche2Member_4a83b6e9-4670-4272-a188-ca3651c8ee28" xlink:type="arc" order="9"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSNarrativeDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#DERIVATIVEINSTRUMENTSNarrativeDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/DERIVATIVEINSTRUMENTSNarrativeDetails" xlink:type="extended" id="ia2162bbc59ab4ef192d89eff5a4ec68b_DERIVATIVEINSTRUMENTSNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_a2b870ab-72b4-4cbb-aa2a-e4e321db6439" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_28fa6342-2eb3-4070-bed3-f0dae0492cba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_a2b870ab-72b4-4cbb-aa2a-e4e321db6439" xlink:to="loc_us-gaap_DerivativeNotionalAmount_28fa6342-2eb3-4070-bed3-f0dae0492cba" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DerivativeNotionalAmountTerminated_021c64b7-7058-4e37-b6fc-b38665a56217" xlink:href="iart-20220930.xsd#iart_DerivativeNotionalAmountTerminated"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_a2b870ab-72b4-4cbb-aa2a-e4e321db6439" xlink:to="loc_iart_DerivativeNotionalAmountTerminated_021c64b7-7058-4e37-b6fc-b38665a56217" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_8587db95-d87d-4f15-bf7a-6880f5acbbc2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_a2b870ab-72b4-4cbb-aa2a-e4e321db6439" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_8587db95-d87d-4f15-bf7a-6880f5acbbc2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGain_11268913-3b76-4784-a4c3-ad29154d45ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_a2b870ab-72b4-4cbb-aa2a-e4e321db6439" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGain_11268913-3b76-4784-a4c3-ad29154d45ea" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_dd013f3c-960a-4609-8c17-698bef59bbf9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_a2b870ab-72b4-4cbb-aa2a-e4e321db6439" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_dd013f3c-960a-4609-8c17-698bef59bbf9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_9ac03f95-1731-462d-8b1b-662536fd185c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_a2b870ab-72b4-4cbb-aa2a-e4e321db6439" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_9ac03f95-1731-462d-8b1b-662536fd185c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_IntercompanyLoanQuarterlyPayment_5d1d2a4e-a01e-48d3-9187-1653e4fbe506" xlink:href="iart-20220930.xsd#iart_IntercompanyLoanQuarterlyPayment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_a2b870ab-72b4-4cbb-aa2a-e4e321db6439" xlink:to="loc_iart_IntercompanyLoanQuarterlyPayment_5d1d2a4e-a01e-48d3-9187-1653e4fbe506" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_0fa3a302-f786-4b4f-a7e8-153d72fad90c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_a2b870ab-72b4-4cbb-aa2a-e4e321db6439" xlink:to="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_0fa3a302-f786-4b4f-a7e8-153d72fad90c" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossReclassificationBeforeTax_69793aaa-43fd-467d-ba46-fae9684542b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossReclassificationBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_a2b870ab-72b4-4cbb-aa2a-e4e321db6439" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossReclassificationBeforeTax_69793aaa-43fd-467d-ba46-fae9684542b8" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_09a5026d-1d14-4cdd-812d-e303de509654" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_a2b870ab-72b4-4cbb-aa2a-e4e321db6439" xlink:to="loc_us-gaap_DerivativeTable_09a5026d-1d14-4cdd-812d-e303de509654" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_b46188b8-5580-4c24-82d8-bf79d77c2738" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_09a5026d-1d14-4cdd-812d-e303de509654" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_b46188b8-5580-4c24-82d8-bf79d77c2738" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_b46188b8-5580-4c24-82d8-bf79d77c2738_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_b46188b8-5580-4c24-82d8-bf79d77c2738" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_b46188b8-5580-4c24-82d8-bf79d77c2738_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_5cb13d0a-79b1-47c0-ae36-3438751ffd0a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_b46188b8-5580-4c24-82d8-bf79d77c2738" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_5cb13d0a-79b1-47c0-ae36-3438751ffd0a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_9698ba79-d369-4e3d-8d1b-b50b6ed2ff20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_5cb13d0a-79b1-47c0-ae36-3438751ffd0a" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_9698ba79-d369-4e3d-8d1b-b50b6ed2ff20" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrencySwapMember_d0776972-e3df-455b-924c-92b507160e92" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CurrencySwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_5cb13d0a-79b1-47c0-ae36-3438751ffd0a" xlink:to="loc_us-gaap_CurrencySwapMember_d0776972-e3df-455b-924c-92b507160e92" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_112f8fc4-9bdf-404f-b31a-6642f7155fc6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_5cb13d0a-79b1-47c0-ae36-3438751ffd0a" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_112f8fc4-9bdf-404f-b31a-6642f7155fc6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ForeignExchangeForwardEnteredAndSettledInTheSamePeriodMember_a89810f0-827e-418d-a6b0-b98a7ad2705e" xlink:href="iart-20220930.xsd#iart_ForeignExchangeForwardEnteredAndSettledInTheSamePeriodMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_5cb13d0a-79b1-47c0-ae36-3438751ffd0a" xlink:to="loc_iart_ForeignExchangeForwardEnteredAndSettledInTheSamePeriodMember_a89810f0-827e-418d-a6b0-b98a7ad2705e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionAxis_34a10bdb-e115-4438-8f61-a163a52244d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PositionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_09a5026d-1d14-4cdd-812d-e303de509654" xlink:to="loc_us-gaap_PositionAxis_34a10bdb-e115-4438-8f61-a163a52244d4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionDomain_34a10bdb-e115-4438-8f61-a163a52244d4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PositionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PositionAxis_34a10bdb-e115-4438-8f61-a163a52244d4" xlink:to="loc_us-gaap_PositionDomain_34a10bdb-e115-4438-8f61-a163a52244d4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionDomain_74f8894b-eab8-467b-b69a-4ccec7b0a15b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PositionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PositionAxis_34a10bdb-e115-4438-8f61-a163a52244d4" xlink:to="loc_us-gaap_PositionDomain_74f8894b-eab8-467b-b69a-4ccec7b0a15b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongMember_05c580e0-d680-40b9-87b6-884ed20371f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PositionDomain_74f8894b-eab8-467b-b69a-4ccec7b0a15b" xlink:to="loc_us-gaap_LongMember_05c580e0-d680-40b9-87b6-884ed20371f7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortMember_53708049-3c77-4758-90ad-a8801fc82ff7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PositionDomain_74f8894b-eab8-467b-b69a-4ccec7b0a15b" xlink:to="loc_us-gaap_ShortMember_53708049-3c77-4758-90ad-a8801fc82ff7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_d148ea39-5903-4f5f-a2c3-0d72bce47b59" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_09a5026d-1d14-4cdd-812d-e303de509654" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_d148ea39-5903-4f5f-a2c3-0d72bce47b59" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d148ea39-5903-4f5f-a2c3-0d72bce47b59_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_d148ea39-5903-4f5f-a2c3-0d72bce47b59" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d148ea39-5903-4f5f-a2c3-0d72bce47b59_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1424433b-cf43-49d0-bc86-01bf64da2247" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_d148ea39-5903-4f5f-a2c3-0d72bce47b59" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1424433b-cf43-49d0-bc86-01bf64da2247" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CodmanMember_958a6b4e-aa53-42f9-b0e5-22812c2914b3" xlink:href="iart-20220930.xsd#iart_CodmanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1424433b-cf43-49d0-bc86-01bf64da2247" xlink:to="loc_iart_CodmanMember_958a6b4e-aa53-42f9-b0e5-22812c2914b3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_1deb6ec1-2b56-4e4c-b2b7-8dd67e058523" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_09a5026d-1d14-4cdd-812d-e303de509654" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_1deb6ec1-2b56-4e4c-b2b7-8dd67e058523" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_1deb6ec1-2b56-4e4c-b2b7-8dd67e058523_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_1deb6ec1-2b56-4e4c-b2b7-8dd67e058523" xlink:to="loc_us-gaap_HedgingRelationshipDomain_1deb6ec1-2b56-4e4c-b2b7-8dd67e058523_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_fcf95423-74be-4cbe-be96-2d4c3759562b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_1deb6ec1-2b56-4e4c-b2b7-8dd67e058523" xlink:to="loc_us-gaap_HedgingRelationshipDomain_fcf95423-74be-4cbe-be96-2d4c3759562b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_66394aec-a437-4e4c-a8e7-bab49903d7b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_fcf95423-74be-4cbe-be96-2d4c3759562b" xlink:to="loc_us-gaap_CashFlowHedgingMember_66394aec-a437-4e4c-a8e7-bab49903d7b8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_260944b2-c91e-4299-90a3-c704d8f79fdf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_fcf95423-74be-4cbe-be96-2d4c3759562b" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_260944b2-c91e-4299-90a3-c704d8f79fdf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_9bfc96b7-29f0-4153-9c82-89c710e13b00" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_fcf95423-74be-4cbe-be96-2d4c3759562b" xlink:to="loc_us-gaap_NondesignatedMember_9bfc96b7-29f0-4153-9c82-89c710e13b00" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_13db74da-7c61-4460-a0e5-c164819faf10" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_09a5026d-1d14-4cdd-812d-e303de509654" xlink:to="loc_us-gaap_HedgingDesignationAxis_13db74da-7c61-4460-a0e5-c164819faf10" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_13db74da-7c61-4460-a0e5-c164819faf10_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_13db74da-7c61-4460-a0e5-c164819faf10" xlink:to="loc_us-gaap_HedgingDesignationDomain_13db74da-7c61-4460-a0e5-c164819faf10_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_8f6aad9b-cf7d-4e2f-a457-9d5cd870efc9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_13db74da-7c61-4460-a0e5-c164819faf10" xlink:to="loc_us-gaap_HedgingDesignationDomain_8f6aad9b-cf7d-4e2f-a457-9d5cd870efc9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_e8936afd-c312-42fb-9c6f-4fd71969f11e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_8f6aad9b-cf7d-4e2f-a457-9d5cd870efc9" xlink:to="loc_us-gaap_NondesignatedMember_e8936afd-c312-42fb-9c6f-4fd71969f11e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_18895442-3779-4d52-8309-072b5596722d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_8f6aad9b-cf7d-4e2f-a457-9d5cd870efc9" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_18895442-3779-4d52-8309-072b5596722d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_da2daaa1-79d6-4e18-9e9d-9bcf3e4ca8e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_09a5026d-1d14-4cdd-812d-e303de509654" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_da2daaa1-79d6-4e18-9e9d-9bcf3e4ca8e5" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_da2daaa1-79d6-4e18-9e9d-9bcf3e4ca8e5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_da2daaa1-79d6-4e18-9e9d-9bcf3e4ca8e5" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_da2daaa1-79d6-4e18-9e9d-9bcf3e4ca8e5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_dfa03bba-d609-4c15-a65e-e3dbd12b7b00" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_da2daaa1-79d6-4e18-9e9d-9bcf3e4ca8e5" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_dfa03bba-d609-4c15-a65e-e3dbd12b7b00" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_f8133010-72c8-4e08-93fe-7f239c0d7cb4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_dfa03bba-d609-4c15-a65e-e3dbd12b7b00" xlink:to="loc_us-gaap_SubsequentEventMember_f8133010-72c8-4e08-93fe-7f239c0d7cb4" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSScheduleofCrossCurrencySwapDerivativesDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#DERIVATIVEINSTRUMENTSScheduleofCrossCurrencySwapDerivativesDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/DERIVATIVEINSTRUMENTSScheduleofCrossCurrencySwapDerivativesDetails" xlink:type="extended" id="i81fd735aa593456bb0f6fafee724d2a8_DERIVATIVEINSTRUMENTSScheduleofCrossCurrencySwapDerivativesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_21803522-8e69-4f83-9812-7d6513da3103" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFixedInterestRate_a91b76cc-6104-46cc-904a-4e206f1c629a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFixedInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_21803522-8e69-4f83-9812-7d6513da3103" xlink:to="loc_us-gaap_DerivativeFixedInterestRate_a91b76cc-6104-46cc-904a-4e206f1c629a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_8ff3ca4b-e8e8-4b26-bd32-3f9ecad12c89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_21803522-8e69-4f83-9812-7d6513da3103" xlink:to="loc_us-gaap_DerivativeNotionalAmount_8ff3ca4b-e8e8-4b26-bd32-3f9ecad12c89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_d295851d-d52a-4276-ab0a-474d730c7fdf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_21803522-8e69-4f83-9812-7d6513da3103" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_d295851d-d52a-4276-ab0a-474d730c7fdf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_8c58a4b5-de96-4d6f-9a64-6e05a62e7b53" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_21803522-8e69-4f83-9812-7d6513da3103" xlink:to="loc_us-gaap_DerivativeTable_8c58a4b5-de96-4d6f-9a64-6e05a62e7b53" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_5b4d8efe-0c04-40fc-97d6-8c98988b4dcd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_8c58a4b5-de96-4d6f-9a64-6e05a62e7b53" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_5b4d8efe-0c04-40fc-97d6-8c98988b4dcd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_5b4d8efe-0c04-40fc-97d6-8c98988b4dcd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_5b4d8efe-0c04-40fc-97d6-8c98988b4dcd" xlink:to="loc_us-gaap_HedgingRelationshipDomain_5b4d8efe-0c04-40fc-97d6-8c98988b4dcd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_44e9bb58-433a-430a-9cb2-fd1e943957bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_5b4d8efe-0c04-40fc-97d6-8c98988b4dcd" xlink:to="loc_us-gaap_HedgingRelationshipDomain_44e9bb58-433a-430a-9cb2-fd1e943957bb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_4c7ec623-d1d1-4f8f-b26d-60b8fd0b6fa6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_44e9bb58-433a-430a-9cb2-fd1e943957bb" xlink:to="loc_us-gaap_CashFlowHedgingMember_4c7ec623-d1d1-4f8f-b26d-60b8fd0b6fa6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_d0bbef14-d30c-4cf6-b5d4-5010c9ca564f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_8c58a4b5-de96-4d6f-9a64-6e05a62e7b53" xlink:to="loc_us-gaap_HedgingDesignationAxis_d0bbef14-d30c-4cf6-b5d4-5010c9ca564f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_d0bbef14-d30c-4cf6-b5d4-5010c9ca564f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_d0bbef14-d30c-4cf6-b5d4-5010c9ca564f" xlink:to="loc_us-gaap_HedgingDesignationDomain_d0bbef14-d30c-4cf6-b5d4-5010c9ca564f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_e526001a-6877-429e-9f62-51196fa0d8ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_d0bbef14-d30c-4cf6-b5d4-5010c9ca564f" xlink:to="loc_us-gaap_HedgingDesignationDomain_e526001a-6877-429e-9f62-51196fa0d8ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_1b4ce8f4-3621-4a9e-89d9-17083e1a5b9b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_e526001a-6877-429e-9f62-51196fa0d8ab" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_1b4ce8f4-3621-4a9e-89d9-17083e1a5b9b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_4478a82d-770a-42a5-b819-75b58ee90a2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_8c58a4b5-de96-4d6f-9a64-6e05a62e7b53" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_4478a82d-770a-42a5-b819-75b58ee90a2d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4478a82d-770a-42a5-b819-75b58ee90a2d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_4478a82d-770a-42a5-b819-75b58ee90a2d" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4478a82d-770a-42a5-b819-75b58ee90a2d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3739befe-8c17-4309-8e7e-4e6899ff4b33" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_4478a82d-770a-42a5-b819-75b58ee90a2d" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3739befe-8c17-4309-8e7e-4e6899ff4b33" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CodmanMember_9388f067-5840-4281-b7ba-d7d70b209f1e" xlink:href="iart-20220930.xsd#iart_CodmanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3739befe-8c17-4309-8e7e-4e6899ff4b33" xlink:to="loc_iart_CodmanMember_9388f067-5840-4281-b7ba-d7d70b209f1e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_72763b41-35b1-43b5-a5ac-26b613120d87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_8c58a4b5-de96-4d6f-9a64-6e05a62e7b53" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_72763b41-35b1-43b5-a5ac-26b613120d87" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_72763b41-35b1-43b5-a5ac-26b613120d87_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_72763b41-35b1-43b5-a5ac-26b613120d87" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_72763b41-35b1-43b5-a5ac-26b613120d87_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_88e8a99d-6f29-4810-86ac-b8603ccc06e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_72763b41-35b1-43b5-a5ac-26b613120d87" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_88e8a99d-6f29-4810-86ac-b8603ccc06e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_09b5e730-ee9a-483d-adb0-eb9b36b45784" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_88e8a99d-6f29-4810-86ac-b8603ccc06e9" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_09b5e730-ee9a-483d-adb0-eb9b36b45784" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CrossCurrencyInterestRateContractOneMember_71169ca9-e8d1-4273-9d2b-edd36e4eff1d" xlink:href="iart-20220930.xsd#iart_CrossCurrencyInterestRateContractOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CrossCurrencyInterestRateContractMember_09b5e730-ee9a-483d-adb0-eb9b36b45784" xlink:to="loc_iart_CrossCurrencyInterestRateContractOneMember_71169ca9-e8d1-4273-9d2b-edd36e4eff1d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CrossCurrencyInterestRateContractTwoMember_45b5e520-5542-4688-bddd-d69f505a5683" xlink:href="iart-20220930.xsd#iart_CrossCurrencyInterestRateContractTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CrossCurrencyInterestRateContractMember_09b5e730-ee9a-483d-adb0-eb9b36b45784" xlink:to="loc_iart_CrossCurrencyInterestRateContractTwoMember_45b5e520-5542-4688-bddd-d69f505a5683" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CrossCurrencyInterestRateContractThreeMember_f315e2c5-083f-4b06-93d3-8b293364445b" xlink:href="iart-20220930.xsd#iart_CrossCurrencyInterestRateContractThreeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CrossCurrencyInterestRateContractMember_09b5e730-ee9a-483d-adb0-eb9b36b45784" xlink:to="loc_iart_CrossCurrencyInterestRateContractThreeMember_f315e2c5-083f-4b06-93d3-8b293364445b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionAxis_6d28410c-0a85-4789-9b73-cdbabbe172ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PositionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_8c58a4b5-de96-4d6f-9a64-6e05a62e7b53" xlink:to="loc_us-gaap_PositionAxis_6d28410c-0a85-4789-9b73-cdbabbe172ea" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionDomain_6d28410c-0a85-4789-9b73-cdbabbe172ea_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PositionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PositionAxis_6d28410c-0a85-4789-9b73-cdbabbe172ea" xlink:to="loc_us-gaap_PositionDomain_6d28410c-0a85-4789-9b73-cdbabbe172ea_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionDomain_3da4b470-9645-4bc9-8087-b6c97d94cb17" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PositionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PositionAxis_6d28410c-0a85-4789-9b73-cdbabbe172ea" xlink:to="loc_us-gaap_PositionDomain_3da4b470-9645-4bc9-8087-b6c97d94cb17" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongMember_fd421b4d-10aa-425d-bef3-43ac3007c0ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PositionDomain_3da4b470-9645-4bc9-8087-b6c97d94cb17" xlink:to="loc_us-gaap_LongMember_fd421b4d-10aa-425d-bef3-43ac3007c0ae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortMember_091708dc-93ab-44a5-82e2-6ba3f06ff69c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PositionDomain_3da4b470-9645-4bc9-8087-b6c97d94cb17" xlink:to="loc_us-gaap_ShortMember_091708dc-93ab-44a5-82e2-6ba3f06ff69c" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSScheduleofNetInvestmentHedgesDerivativesDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#DERIVATIVEINSTRUMENTSScheduleofNetInvestmentHedgesDerivativesDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/DERIVATIVEINSTRUMENTSScheduleofNetInvestmentHedgesDerivativesDetails" xlink:type="extended" id="i07512dd47e5f45abbfa299d905275e71_DERIVATIVEINSTRUMENTSScheduleofNetInvestmentHedgesDerivativesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_b3586587-de5e-4773-9d0f-953a73aef119" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFixedInterestRate_5ea435d5-bc64-411e-b18c-b001558921f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFixedInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_b3586587-de5e-4773-9d0f-953a73aef119" xlink:to="loc_us-gaap_DerivativeFixedInterestRate_5ea435d5-bc64-411e-b18c-b001558921f0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_638a80c6-1856-45d6-84d7-93e199904d35" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_b3586587-de5e-4773-9d0f-953a73aef119" xlink:to="loc_us-gaap_DerivativeNotionalAmount_638a80c6-1856-45d6-84d7-93e199904d35" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_630c658e-028a-457b-a2ea-bafa61d60582" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_b3586587-de5e-4773-9d0f-953a73aef119" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_630c658e-028a-457b-a2ea-bafa61d60582" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_ef62bf43-b7ea-4f0d-ab61-704b3a1e35a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_b3586587-de5e-4773-9d0f-953a73aef119" xlink:to="loc_us-gaap_DerivativeTable_ef62bf43-b7ea-4f0d-ab61-704b3a1e35a3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_1fed45b4-7727-41f8-b915-68f29b4b81d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_ef62bf43-b7ea-4f0d-ab61-704b3a1e35a3" xlink:to="loc_us-gaap_HedgingDesignationAxis_1fed45b4-7727-41f8-b915-68f29b4b81d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_1fed45b4-7727-41f8-b915-68f29b4b81d6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_1fed45b4-7727-41f8-b915-68f29b4b81d6" xlink:to="loc_us-gaap_HedgingDesignationDomain_1fed45b4-7727-41f8-b915-68f29b4b81d6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_6ded50db-1b14-422d-b72d-ff4a977c1bdd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_1fed45b4-7727-41f8-b915-68f29b4b81d6" xlink:to="loc_us-gaap_HedgingDesignationDomain_6ded50db-1b14-422d-b72d-ff4a977c1bdd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_767bb175-ca29-4a92-8ea7-65c868e1da4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_6ded50db-1b14-422d-b72d-ff4a977c1bdd" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_767bb175-ca29-4a92-8ea7-65c868e1da4d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_af9a17e4-61e9-467f-b7e8-1eae39971b3d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_ef62bf43-b7ea-4f0d-ab61-704b3a1e35a3" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_af9a17e4-61e9-467f-b7e8-1eae39971b3d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_af9a17e4-61e9-467f-b7e8-1eae39971b3d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_af9a17e4-61e9-467f-b7e8-1eae39971b3d" xlink:to="loc_us-gaap_HedgingRelationshipDomain_af9a17e4-61e9-467f-b7e8-1eae39971b3d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_3a106557-ab52-4ecb-b693-60d462ba15dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_af9a17e4-61e9-467f-b7e8-1eae39971b3d" xlink:to="loc_us-gaap_HedgingRelationshipDomain_3a106557-ab52-4ecb-b693-60d462ba15dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_9a636335-801f-42bd-a563-2da4b4ea3672" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_3a106557-ab52-4ecb-b693-60d462ba15dc" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_9a636335-801f-42bd-a563-2da4b4ea3672" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_224da1a7-5416-4645-9cc6-8f5abd3fc474" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_ef62bf43-b7ea-4f0d-ab61-704b3a1e35a3" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_224da1a7-5416-4645-9cc6-8f5abd3fc474" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_224da1a7-5416-4645-9cc6-8f5abd3fc474_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_224da1a7-5416-4645-9cc6-8f5abd3fc474" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_224da1a7-5416-4645-9cc6-8f5abd3fc474_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_970d28b1-3e78-4682-b06c-a7d45b5c1e63" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_224da1a7-5416-4645-9cc6-8f5abd3fc474" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_970d28b1-3e78-4682-b06c-a7d45b5c1e63" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_7e978609-94d0-4690-9281-ffcc677c8989" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_970d28b1-3e78-4682-b06c-a7d45b5c1e63" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_7e978609-94d0-4690-9281-ffcc677c8989" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CrossCurrencyInterestRateContractOneMember_b41c6f74-74b0-4f90-abf2-2d5c3d0c18c4" xlink:href="iart-20220930.xsd#iart_CrossCurrencyInterestRateContractOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CrossCurrencyInterestRateContractMember_7e978609-94d0-4690-9281-ffcc677c8989" xlink:to="loc_iart_CrossCurrencyInterestRateContractOneMember_b41c6f74-74b0-4f90-abf2-2d5c3d0c18c4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CrossCurrencyInterestRateContractTwoMember_090f4676-6ac9-4e0f-a7f6-d07947703dd4" xlink:href="iart-20220930.xsd#iart_CrossCurrencyInterestRateContractTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CrossCurrencyInterestRateContractMember_7e978609-94d0-4690-9281-ffcc677c8989" xlink:to="loc_iart_CrossCurrencyInterestRateContractTwoMember_090f4676-6ac9-4e0f-a7f6-d07947703dd4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CrossCurrencyInterestRateContractThreeMember_b97f591d-f751-4a75-8447-e050e4da2742" xlink:href="iart-20220930.xsd#iart_CrossCurrencyInterestRateContractThreeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CrossCurrencyInterestRateContractMember_7e978609-94d0-4690-9281-ffcc677c8989" xlink:to="loc_iart_CrossCurrencyInterestRateContractThreeMember_b97f591d-f751-4a75-8447-e050e4da2742" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CrossCurrencyInterestRateContractFourMember_e2866e98-767b-4cd4-905f-36427147d8bb" xlink:href="iart-20220930.xsd#iart_CrossCurrencyInterestRateContractFourMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CrossCurrencyInterestRateContractMember_7e978609-94d0-4690-9281-ffcc677c8989" xlink:to="loc_iart_CrossCurrencyInterestRateContractFourMember_e2866e98-767b-4cd4-905f-36427147d8bb" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionAxis_27b59ae8-c24e-4d66-8e3e-886ac5355278" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PositionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_ef62bf43-b7ea-4f0d-ab61-704b3a1e35a3" xlink:to="loc_us-gaap_PositionAxis_27b59ae8-c24e-4d66-8e3e-886ac5355278" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionDomain_27b59ae8-c24e-4d66-8e3e-886ac5355278_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PositionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PositionAxis_27b59ae8-c24e-4d66-8e3e-886ac5355278" xlink:to="loc_us-gaap_PositionDomain_27b59ae8-c24e-4d66-8e3e-886ac5355278_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositionDomain_86f3eb28-b357-439a-bce4-4a418adec118" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PositionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PositionAxis_27b59ae8-c24e-4d66-8e3e-886ac5355278" xlink:to="loc_us-gaap_PositionDomain_86f3eb28-b357-439a-bce4-4a418adec118" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongMember_6666daef-2ccd-46fe-8dc2-887b03c0394e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PositionDomain_86f3eb28-b357-439a-bce4-4a418adec118" xlink:to="loc_us-gaap_LongMember_6666daef-2ccd-46fe-8dc2-887b03c0394e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortMember_3c07c7ae-261f-4cbc-912b-ab5d96e653ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PositionDomain_86f3eb28-b357-439a-bce4-4a418adec118" xlink:to="loc_us-gaap_ShortMember_3c07c7ae-261f-4cbc-912b-ab5d96e653ff" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSFairValueofDerivativeInstrumentsByBalanceSheetLocationDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#DERIVATIVEINSTRUMENTSFairValueofDerivativeInstrumentsByBalanceSheetLocationDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/DERIVATIVEINSTRUMENTSFairValueofDerivativeInstrumentsByBalanceSheetLocationDetails" xlink:type="extended" id="ibf7ce656a68b44a1bde174744c98ae60_DERIVATIVEINSTRUMENTSFairValueofDerivativeInstrumentsByBalanceSheetLocationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_bb937ba6-dc73-4881-9758-1e7ad7e7e02a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_ea1c3afd-0589-4fbd-97ac-31ceb7cd1acd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_bb937ba6-dc73-4881-9758-1e7ad7e7e02a" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_ea1c3afd-0589-4fbd-97ac-31ceb7cd1acd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_e96c69f0-6afc-4eaa-bea8-0ba670bd804c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_bb937ba6-dc73-4881-9758-1e7ad7e7e02a" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_e96c69f0-6afc-4eaa-bea8-0ba670bd804c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_bef6d4b8-c4bf-46b9-bcd9-bab5ebf8470b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_bb937ba6-dc73-4881-9758-1e7ad7e7e02a" xlink:to="loc_us-gaap_DerivativeNotionalAmount_bef6d4b8-c4bf-46b9-bcd9-bab5ebf8470b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_db7646bb-f7e6-4bd1-8aa6-56c25381b6ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_bb937ba6-dc73-4881-9758-1e7ad7e7e02a" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_db7646bb-f7e6-4bd1-8aa6-56c25381b6ff" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_649721d8-d99c-471b-b8c3-187e3d8db14f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_db7646bb-f7e6-4bd1-8aa6-56c25381b6ff" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_649721d8-d99c-471b-b8c3-187e3d8db14f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_649721d8-d99c-471b-b8c3-187e3d8db14f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_649721d8-d99c-471b-b8c3-187e3d8db14f" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_649721d8-d99c-471b-b8c3-187e3d8db14f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_6f72ad6c-0e48-4609-8475-3cbef3a0d991" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_649721d8-d99c-471b-b8c3-187e3d8db14f" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_6f72ad6c-0e48-4609-8475-3cbef3a0d991" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_e221446e-8f9d-4b7f-946f-b9036bec2bb4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_6f72ad6c-0e48-4609-8475-3cbef3a0d991" xlink:to="loc_us-gaap_InterestRateSwapMember_e221446e-8f9d-4b7f-946f-b9036bec2bb4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_7a67af3f-5cac-4b23-858f-99518f849c15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_6f72ad6c-0e48-4609-8475-3cbef3a0d991" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_7a67af3f-5cac-4b23-858f-99518f849c15" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_9fbec8bb-af06-43a2-9ecd-77e5a8bb058e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_db7646bb-f7e6-4bd1-8aa6-56c25381b6ff" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_9fbec8bb-af06-43a2-9ecd-77e5a8bb058e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_9fbec8bb-af06-43a2-9ecd-77e5a8bb058e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_9fbec8bb-af06-43a2-9ecd-77e5a8bb058e" xlink:to="loc_us-gaap_HedgingRelationshipDomain_9fbec8bb-af06-43a2-9ecd-77e5a8bb058e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_53883047-335c-4b39-a625-afbdd8e1ee7d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_9fbec8bb-af06-43a2-9ecd-77e5a8bb058e" xlink:to="loc_us-gaap_HedgingRelationshipDomain_53883047-335c-4b39-a625-afbdd8e1ee7d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_1456d13a-9727-4650-89f6-ba230fd5b87c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_53883047-335c-4b39-a625-afbdd8e1ee7d" xlink:to="loc_us-gaap_CashFlowHedgingMember_1456d13a-9727-4650-89f6-ba230fd5b87c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_2826032d-8999-4c54-807f-b2f2cb44fbcf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_53883047-335c-4b39-a625-afbdd8e1ee7d" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_2826032d-8999-4c54-807f-b2f2cb44fbcf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_953929dd-f155-42c1-ab34-91dfd98c778a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_db7646bb-f7e6-4bd1-8aa6-56c25381b6ff" xlink:to="loc_us-gaap_HedgingDesignationAxis_953929dd-f155-42c1-ab34-91dfd98c778a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_953929dd-f155-42c1-ab34-91dfd98c778a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_953929dd-f155-42c1-ab34-91dfd98c778a" xlink:to="loc_us-gaap_HedgingDesignationDomain_953929dd-f155-42c1-ab34-91dfd98c778a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_a18154f6-c5e5-44ea-9583-0ff2ea6719b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_953929dd-f155-42c1-ab34-91dfd98c778a" xlink:to="loc_us-gaap_HedgingDesignationDomain_a18154f6-c5e5-44ea-9583-0ff2ea6719b2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_1da69f50-c9a0-46d3-bdb6-9353df76dd8d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_a18154f6-c5e5-44ea-9583-0ff2ea6719b2" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_1da69f50-c9a0-46d3-bdb6-9353df76dd8d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_e6a68c4e-ea38-41a1-ab6f-11776366f39d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_db7646bb-f7e6-4bd1-8aa6-56c25381b6ff" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_e6a68c4e-ea38-41a1-ab6f-11776366f39d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_e6a68c4e-ea38-41a1-ab6f-11776366f39d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_e6a68c4e-ea38-41a1-ab6f-11776366f39d" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_e6a68c4e-ea38-41a1-ab6f-11776366f39d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_09b6e3c1-fe23-4975-8653-65231a217908" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_e6a68c4e-ea38-41a1-ab6f-11776366f39d" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_09b6e3c1-fe23-4975-8653-65231a217908" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_421e7eed-a2b6-41fa-a2ef-194a1a2586fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_09b6e3c1-fe23-4975-8653-65231a217908" xlink:to="loc_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_421e7eed-a2b6-41fa-a2ef-194a1a2586fe" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsMember_54a19a99-1476-40fe-86ae-71bbd3577da7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_09b6e3c1-fe23-4975-8653-65231a217908" xlink:to="loc_us-gaap_OtherAssetsMember_54a19a99-1476-40fe-86ae-71bbd3577da7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_AccruedExpensesAndOtherCurrentLiabilitiesMember_11fcde52-2386-4bd9-915e-8645bc82c53f" xlink:href="iart-20220930.xsd#iart_AccruedExpensesAndOtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_09b6e3c1-fe23-4975-8653-65231a217908" xlink:to="loc_iart_AccruedExpensesAndOtherCurrentLiabilitiesMember_11fcde52-2386-4bd9-915e-8645bc82c53f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesMember_83b9d19a-70f2-4acc-a7be-db46b5fd79b7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_09b6e3c1-fe23-4975-8653-65231a217908" xlink:to="loc_us-gaap_OtherLiabilitiesMember_83b9d19a-70f2-4acc-a7be-db46b5fd79b7" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSEffectofDerivativeInstrumentsDesignatedCashFlowHedgesonStatementsofOperationsDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#DERIVATIVEINSTRUMENTSEffectofDerivativeInstrumentsDesignatedCashFlowHedgesonStatementsofOperationsDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/DERIVATIVEINSTRUMENTSEffectofDerivativeInstrumentsDesignatedCashFlowHedgesonStatementsofOperationsDetails" xlink:type="extended" id="if6f2541fe5c4453fbdf94d35553f569d_DERIVATIVEINSTRUMENTSEffectofDerivativeInstrumentsDesignatedCashFlowHedgesonStatementsofOperationsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_e1e7ce5c-3779-434e-b673-094c78af9e66" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_c5ace4e9-0b63-427c-ad4e-7c4d81ec08b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AOCIAttributableToParentNetOfTaxRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_e1e7ce5c-3779-434e-b673-094c78af9e66" xlink:to="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_c5ace4e9-0b63-427c-ad4e-7c4d81ec08b4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_9a981580-8b79-4504-be09-c515ba163800" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_c5ace4e9-0b63-427c-ad4e-7c4d81ec08b4" xlink:to="loc_us-gaap_StockholdersEquity_9a981580-8b79-4504-be09-c515ba163800" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_cc727a95-b89f-4d3c-86bb-af2a909699a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_c5ace4e9-0b63-427c-ad4e-7c4d81ec08b4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_cc727a95-b89f-4d3c-86bb-af2a909699a0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_71403a81-79fe-4156-babf-79ae6c4f2e06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_c5ace4e9-0b63-427c-ad4e-7c4d81ec08b4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_71403a81-79fe-4156-babf-79ae6c4f2e06" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_b2122815-5a55-442c-b19a-1fb7e353f2c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_2fd425c2-1d7f-48ed-90a6-7428c84662ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_e1e7ce5c-3779-434e-b673-094c78af9e66" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_2fd425c2-1d7f-48ed-90a6-7428c84662ba" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_d479957a-f571-4ad8-8cea-d97f9c07c227" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_2fd425c2-1d7f-48ed-90a6-7428c84662ba" xlink:to="loc_us-gaap_HedgingDesignationAxis_d479957a-f571-4ad8-8cea-d97f9c07c227" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_d479957a-f571-4ad8-8cea-d97f9c07c227_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_d479957a-f571-4ad8-8cea-d97f9c07c227" xlink:to="loc_us-gaap_HedgingDesignationDomain_d479957a-f571-4ad8-8cea-d97f9c07c227_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_37bdcf0d-59ea-4da0-884c-ed3d8d57289f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_d479957a-f571-4ad8-8cea-d97f9c07c227" xlink:to="loc_us-gaap_HedgingDesignationDomain_37bdcf0d-59ea-4da0-884c-ed3d8d57289f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_59c6f91f-43ef-4efa-9a90-0f35d9744195" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_37bdcf0d-59ea-4da0-884c-ed3d8d57289f" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_59c6f91f-43ef-4efa-9a90-0f35d9744195" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_23f49e59-8135-4395-9b29-e89b30563f1e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_2fd425c2-1d7f-48ed-90a6-7428c84662ba" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_23f49e59-8135-4395-9b29-e89b30563f1e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_23f49e59-8135-4395-9b29-e89b30563f1e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_23f49e59-8135-4395-9b29-e89b30563f1e" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_23f49e59-8135-4395-9b29-e89b30563f1e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_83f11676-d6ac-4c70-a3e7-a23dcc660545" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_23f49e59-8135-4395-9b29-e89b30563f1e" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_83f11676-d6ac-4c70-a3e7-a23dcc660545" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_40030f5e-e118-4e18-adc3-a83b7fbb6b0f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_83f11676-d6ac-4c70-a3e7-a23dcc660545" xlink:to="loc_us-gaap_InterestRateSwapMember_40030f5e-e118-4e18-adc3-a83b7fbb6b0f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_0794cff4-ddb9-4165-9196-411246b7c3fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_83f11676-d6ac-4c70-a3e7-a23dcc660545" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_0794cff4-ddb9-4165-9196-411246b7c3fb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_f3825ea8-f305-47da-881b-5f74344d736e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_2fd425c2-1d7f-48ed-90a6-7428c84662ba" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_f3825ea8-f305-47da-881b-5f74344d736e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_f3825ea8-f305-47da-881b-5f74344d736e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_f3825ea8-f305-47da-881b-5f74344d736e" xlink:to="loc_us-gaap_HedgingRelationshipDomain_f3825ea8-f305-47da-881b-5f74344d736e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_ffb2993a-2434-44be-b154-109810a34eed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_f3825ea8-f305-47da-881b-5f74344d736e" xlink:to="loc_us-gaap_HedgingRelationshipDomain_ffb2993a-2434-44be-b154-109810a34eed" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_386a2877-5dff-4084-97fc-57ecbcaf8746" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_ffb2993a-2434-44be-b154-109810a34eed" xlink:to="loc_us-gaap_CashFlowHedgingMember_386a2877-5dff-4084-97fc-57ecbcaf8746" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_d0c1e7fa-1de5-4453-a2b8-934005460e02" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_ffb2993a-2434-44be-b154-109810a34eed" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_d0c1e7fa-1de5-4453-a2b8-934005460e02" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_0950c448-3105-4b6d-a4cd-1524fe411da7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_2fd425c2-1d7f-48ed-90a6-7428c84662ba" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_0950c448-3105-4b6d-a4cd-1524fe411da7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_0950c448-3105-4b6d-a4cd-1524fe411da7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_0950c448-3105-4b6d-a4cd-1524fe411da7" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_0950c448-3105-4b6d-a4cd-1524fe411da7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_d3bed672-f52a-49b3-9a2e-da989946b649" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_0950c448-3105-4b6d-a4cd-1524fe411da7" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_d3bed672-f52a-49b3-9a2e-da989946b649" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseMember_822cf1f9-e522-4341-9236-0f9701884215" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_d3bed672-f52a-49b3-9a2e-da989946b649" xlink:to="loc_us-gaap_InterestExpenseMember_822cf1f9-e522-4341-9236-0f9701884215" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpenseMember_c851c044-d4d5-4692-be27-4cfa38a800c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_d3bed672-f52a-49b3-9a2e-da989946b649" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpenseMember_c851c044-d4d5-4692-be27-4cfa38a800c0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeMember_fc8ec326-2d83-457e-81d3-0be7f1242a01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_d3bed672-f52a-49b3-9a2e-da989946b649" xlink:to="loc_us-gaap_InterestIncomeMember_fc8ec326-2d83-457e-81d3-0be7f1242a01" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_5633dd13-fd1c-42a5-b55d-b156a7bd9cb4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_2fd425c2-1d7f-48ed-90a6-7428c84662ba" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_5633dd13-fd1c-42a5-b55d-b156a7bd9cb4" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_5633dd13-fd1c-42a5-b55d-b156a7bd9cb4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_5633dd13-fd1c-42a5-b55d-b156a7bd9cb4" xlink:to="loc_us-gaap_EquityComponentDomain_5633dd13-fd1c-42a5-b55d-b156a7bd9cb4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_1d1fd985-1556-4dc4-8b55-e18ed83efa2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_5633dd13-fd1c-42a5-b55d-b156a7bd9cb4" xlink:to="loc_us-gaap_EquityComponentDomain_1d1fd985-1556-4dc4-8b55-e18ed83efa2e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_632c5595-c3e7-4c32-af63-cadde645155c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_1d1fd985-1556-4dc4-8b55-e18ed83efa2e" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_632c5595-c3e7-4c32-af63-cadde645155c" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/DERIVATIVEINSTRUMENTSScheduleofgainandlossDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#DERIVATIVEINSTRUMENTSScheduleofgainandlossDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/DERIVATIVEINSTRUMENTSScheduleofgainandlossDetails" xlink:type="extended" id="i058dc18bab4746a5a2dfda09e4cc1c0a_DERIVATIVEINSTRUMENTSScheduleofgainandlossDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_cb83bf04-d5a6-4943-833f-63f1042e1820" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_6e840d87-967e-497b-ad50-c1992a7303a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_cb83bf04-d5a6-4943-833f-63f1042e1820" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_6e840d87-967e-497b-ad50-c1992a7303a5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_f89a57c0-38f9-4f13-896e-57455d3f41bd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_cb83bf04-d5a6-4943-833f-63f1042e1820" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_f89a57c0-38f9-4f13-896e-57455d3f41bd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_91154fb3-564e-48fc-86c5-0e78adfe350f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_f89a57c0-38f9-4f13-896e-57455d3f41bd" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_91154fb3-564e-48fc-86c5-0e78adfe350f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_91154fb3-564e-48fc-86c5-0e78adfe350f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_91154fb3-564e-48fc-86c5-0e78adfe350f" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_91154fb3-564e-48fc-86c5-0e78adfe350f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_838edd5b-7d06-426c-8474-f5f803830c5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_91154fb3-564e-48fc-86c5-0e78adfe350f" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_838edd5b-7d06-426c-8474-f5f803830c5f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_2a8f4d1f-7430-446e-9ad6-3fdd8fb6caaa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_838edd5b-7d06-426c-8474-f5f803830c5f" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_2a8f4d1f-7430-446e-9ad6-3fdd8fb6caaa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrencySwapMember_a4259fc8-d2a8-4d27-9150-689efb78d373" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CurrencySwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_838edd5b-7d06-426c-8474-f5f803830c5f" xlink:to="loc_us-gaap_CurrencySwapMember_a4259fc8-d2a8-4d27-9150-689efb78d373" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/STOCKBASEDCOMPENSATIONNarrativeDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#STOCKBASEDCOMPENSATIONNarrativeDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/STOCKBASEDCOMPENSATIONNarrativeDetails" xlink:type="extended" id="i00f148c95beb4cbb9484feac98d6cc17_STOCKBASEDCOMPENSATIONNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a5177967-c1bb-4d1b-a126-6207992db2fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_18702691-f7b1-4535-9ab7-613a5b595457" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a5177967-c1bb-4d1b-a126-6207992db2fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_18702691-f7b1-4535-9ab7-613a5b595457" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_f6dc4027-ade3-43e8-a2b8-d2339dab8715" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a5177967-c1bb-4d1b-a126-6207992db2fc" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_f6dc4027-ade3-43e8-a2b8-d2339dab8715" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_622a3294-b1a0-4551-bec7-19eb18077126" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a5177967-c1bb-4d1b-a126-6207992db2fc" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_622a3294-b1a0-4551-bec7-19eb18077126" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_b490ed42-ad7e-4208-8612-20f7acfd7b65" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a5177967-c1bb-4d1b-a126-6207992db2fc" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_b490ed42-ad7e-4208-8612-20f7acfd7b65" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_6cd00ae1-9b32-480e-a8cb-29cc089b052a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a5177967-c1bb-4d1b-a126-6207992db2fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_6cd00ae1-9b32-480e-a8cb-29cc089b052a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_4fc7c0e7-f49e-4df8-b087-38b2c5d6b714" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a5177967-c1bb-4d1b-a126-6207992db2fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_4fc7c0e7-f49e-4df8-b087-38b2c5d6b714" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_b6bd6ce5-990b-496b-a768-8c6de446a269" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a5177967-c1bb-4d1b-a126-6207992db2fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_b6bd6ce5-990b-496b-a768-8c6de446a269" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_409fe5d7-2a84-47ff-84cb-de19f1065122" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a5177967-c1bb-4d1b-a126-6207992db2fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_409fe5d7-2a84-47ff-84cb-de19f1065122" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_f07c27ea-d0b9-4bde-9224-0be225e2dab8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a5177967-c1bb-4d1b-a126-6207992db2fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_f07c27ea-d0b9-4bde-9224-0be225e2dab8" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_aedf489b-6f4f-43a4-84e4-7a0eaef85706" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a5177967-c1bb-4d1b-a126-6207992db2fc" xlink:to="loc_dei_DocumentPeriodEndDate_aedf489b-6f4f-43a4-84e4-7a0eaef85706" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ed1d89a4-f5d7-40f9-a2f7-506b2b4d23e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a5177967-c1bb-4d1b-a126-6207992db2fc" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ed1d89a4-f5d7-40f9-a2f7-506b2b4d23e6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_254aa759-ff60-4a92-b1ee-4684e6b3c8fb" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ed1d89a4-f5d7-40f9-a2f7-506b2b4d23e6" xlink:to="loc_srt_RangeAxis_254aa759-ff60-4a92-b1ee-4684e6b3c8fb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_254aa759-ff60-4a92-b1ee-4684e6b3c8fb_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_254aa759-ff60-4a92-b1ee-4684e6b3c8fb" xlink:to="loc_srt_RangeMember_254aa759-ff60-4a92-b1ee-4684e6b3c8fb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_ea07b404-8235-4f5d-b15c-b410cbf945dc" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_254aa759-ff60-4a92-b1ee-4684e6b3c8fb" xlink:to="loc_srt_RangeMember_ea07b404-8235-4f5d-b15c-b410cbf945dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_f7883241-f145-4234-9ed8-a7b47420b5a3" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_ea07b404-8235-4f5d-b15c-b410cbf945dc" xlink:to="loc_srt_MinimumMember_f7883241-f145-4234-9ed8-a7b47420b5a3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_231a654f-d207-4f50-aac8-631adf32c325" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_ea07b404-8235-4f5d-b15c-b410cbf945dc" xlink:to="loc_srt_MaximumMember_231a654f-d207-4f50-aac8-631adf32c325" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_efe8a221-cef8-4f06-af8d-74856d1e5fc0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ed1d89a4-f5d7-40f9-a2f7-506b2b4d23e6" xlink:to="loc_us-gaap_AwardTypeAxis_efe8a221-cef8-4f06-af8d-74856d1e5fc0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_efe8a221-cef8-4f06-af8d-74856d1e5fc0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_efe8a221-cef8-4f06-af8d-74856d1e5fc0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_efe8a221-cef8-4f06-af8d-74856d1e5fc0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2f7844ca-ded0-46e8-a767-08e92df4966c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_efe8a221-cef8-4f06-af8d-74856d1e5fc0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2f7844ca-ded0-46e8-a767-08e92df4966c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_5f21b7b6-ee4c-414f-9ca6-4e201a0ced08" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2f7844ca-ded0-46e8-a767-08e92df4966c" xlink:to="loc_us-gaap_EmployeeStockOptionMember_5f21b7b6-ee4c-414f-9ca6-4e201a0ced08" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_1ecd402c-369a-477e-bea0-604fb9293632" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2f7844ca-ded0-46e8-a767-08e92df4966c" xlink:to="loc_us-gaap_RestrictedStockMember_1ecd402c-369a-477e-bea0-604fb9293632" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_PerformanceStockAndRestrictedStockAwardsMember_955d659b-ff9e-48a8-9534-ab8c4635314a" xlink:href="iart-20220930.xsd#iart_PerformanceStockAndRestrictedStockAwardsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2f7844ca-ded0-46e8-a767-08e92df4966c" xlink:to="loc_iart_PerformanceStockAndRestrictedStockAwardsMember_955d659b-ff9e-48a8-9534-ab8c4635314a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_1977dca5-4920-4d7d-ad79-2212d3c402ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2f7844ca-ded0-46e8-a767-08e92df4966c" xlink:to="loc_us-gaap_PerformanceSharesMember_1977dca5-4920-4d7d-ad79-2212d3c402ad" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualAxis_25d06126-0b37-49c5-ab61-9590844f4e70" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_ed1d89a4-f5d7-40f9-a2f7-506b2b4d23e6" xlink:to="loc_srt_TitleOfIndividualAxis_25d06126-0b37-49c5-ab61-9590844f4e70" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_25d06126-0b37-49c5-ab61-9590844f4e70_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_TitleOfIndividualAxis_25d06126-0b37-49c5-ab61-9590844f4e70" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_25d06126-0b37-49c5-ab61-9590844f4e70_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_7b13f85b-8ba4-41f9-b810-6908ad108655" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_TitleOfIndividualAxis_25d06126-0b37-49c5-ab61-9590844f4e70" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_7b13f85b-8ba4-41f9-b810-6908ad108655" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_DirectorMember_baef3c8c-e51d-4766-a009-9aefe6b0c7f3" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_DirectorMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_7b13f85b-8ba4-41f9-b810-6908ad108655" xlink:to="loc_srt_DirectorMember_baef3c8c-e51d-4766-a009-9aefe6b0c7f3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_EmployeeMember_c6725a6d-cf18-4404-b690-9fe283986497" xlink:href="iart-20220930.xsd#iart_EmployeeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_7b13f85b-8ba4-41f9-b810-6908ad108655" xlink:to="loc_iart_EmployeeMember_c6725a6d-cf18-4404-b690-9fe283986497" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DirectorsandCertainExecutiveOfficersMember_bbe0b59c-3ca4-4146-a497-4d1c5f02a607" xlink:href="iart-20220930.xsd#iart_DirectorsandCertainExecutiveOfficersMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_7b13f85b-8ba4-41f9-b810-6908ad108655" xlink:to="loc_iart_DirectorsandCertainExecutiveOfficersMember_bbe0b59c-3ca4-4146-a497-4d1c5f02a607" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/LEASESANDRELATEDPARTYLEASESNarrativeDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#LEASESANDRELATEDPARTYLEASESNarrativeDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/LEASESANDRELATEDPARTYLEASESNarrativeDetails" xlink:type="extended" id="i169ed11bd98c44f4877d7bfc93bd1072_LEASESANDRELATEDPARTYLEASESNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasedAssetsLineItems_da0275c3-3a57-4323-a734-7faef5e41f2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasedAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_LesseeOperatingLeaseNumberOfRenewalOptions_3d2c71c2-1591-4189-8166-4c1c498f036b" xlink:href="iart-20220930.xsd#iart_LesseeOperatingLeaseNumberOfRenewalOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_da0275c3-3a57-4323-a734-7faef5e41f2e" xlink:to="loc_iart_LesseeOperatingLeaseNumberOfRenewalOptions_3d2c71c2-1591-4189-8166-4c1c498f036b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseExpense_6e543734-fd2a-4164-b662-4b220947ffbf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_da0275c3-3a57-4323-a734-7faef5e41f2e" xlink:to="loc_us-gaap_OperatingLeaseExpense_6e543734-fd2a-4164-b662-4b220947ffbf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_PercentOfManufacturingFacilityOwnedByCorporationWhoseShareholdersAreTrustsWhoseBeneficiariesIncludeFamilyMembersOfCompanysFormerDirector_9b794c47-3fc8-4154-8a2f-0fff68804166" xlink:href="iart-20220930.xsd#iart_PercentOfManufacturingFacilityOwnedByCorporationWhoseShareholdersAreTrustsWhoseBeneficiariesIncludeFamilyMembersOfCompanysFormerDirector"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_da0275c3-3a57-4323-a734-7faef5e41f2e" xlink:to="loc_iart_PercentOfManufacturingFacilityOwnedByCorporationWhoseShareholdersAreTrustsWhoseBeneficiariesIncludeFamilyMembersOfCompanysFormerDirector_9b794c47-3fc8-4154-8a2f-0fff68804166" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_AnnualRateOfLeaseAgreement_22b2bb94-5ffe-4656-9465-157be8ddf0d8" xlink:href="iart-20220930.xsd#iart_AnnualRateOfLeaseAgreement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_da0275c3-3a57-4323-a734-7faef5e41f2e" xlink:to="loc_iart_AnnualRateOfLeaseAgreement_22b2bb94-5ffe-4656-9465-157be8ddf0d8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_f3716d5e-beef-46fb-841f-44b14fc4d8ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_da0275c3-3a57-4323-a734-7faef5e41f2e" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_f3716d5e-beef-46fb-841f-44b14fc4d8ce" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseOptionToExtend_fe579cfd-3120-4f70-8fc3-92ef930564f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseOptionToExtend"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_da0275c3-3a57-4323-a734-7faef5e41f2e" xlink:to="loc_us-gaap_LesseeOperatingLeaseOptionToExtend_fe579cfd-3120-4f70-8fc3-92ef930564f3" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_81a46062-1307-48b2-ad9f-0a9374e5d5c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfOperatingLeasedAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_da0275c3-3a57-4323-a734-7faef5e41f2e" xlink:to="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_81a46062-1307-48b2-ad9f-0a9374e5d5c5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1d7f13b5-afd0-4def-8d3c-9adf373cb203" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_81a46062-1307-48b2-ad9f-0a9374e5d5c5" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1d7f13b5-afd0-4def-8d3c-9adf373cb203" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_1d7f13b5-afd0-4def-8d3c-9adf373cb203_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1d7f13b5-afd0-4def-8d3c-9adf373cb203" xlink:to="loc_us-gaap_RelatedPartyDomain_1d7f13b5-afd0-4def-8d3c-9adf373cb203_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_735d2a40-7856-4d66-a3c5-26d8ab30ea2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1d7f13b5-afd0-4def-8d3c-9adf373cb203" xlink:to="loc_us-gaap_RelatedPartyDomain_735d2a40-7856-4d66-a3c5-26d8ab30ea2e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_AffiliatedEntityMember_8eace966-9468-465a-a729-58c2116fddb9" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_AffiliatedEntityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_735d2a40-7856-4d66-a3c5-26d8ab30ea2e" xlink:to="loc_srt_AffiliatedEntityMember_8eace966-9468-465a-a729-58c2116fddb9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermAxis_4d4666f5-661a-43a6-8f1e-9c8862d53284" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseContractualTermAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_81a46062-1307-48b2-ad9f-0a9374e5d5c5" xlink:to="loc_us-gaap_LeaseContractualTermAxis_4d4666f5-661a-43a6-8f1e-9c8862d53284" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_4d4666f5-661a-43a6-8f1e-9c8862d53284_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LeaseContractualTermAxis_4d4666f5-661a-43a6-8f1e-9c8862d53284" xlink:to="loc_us-gaap_LeaseContractualTermDomain_4d4666f5-661a-43a6-8f1e-9c8862d53284_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_63e56ad6-bc6e-483b-938e-afa1f03e5a87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LeaseContractualTermAxis_4d4666f5-661a-43a6-8f1e-9c8862d53284" xlink:to="loc_us-gaap_LeaseContractualTermDomain_63e56ad6-bc6e-483b-938e-afa1f03e5a87" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_FiveYearOptionLeasePeriodOneMember_37264efc-8cd4-4125-bf49-e00511193e0f" xlink:href="iart-20220930.xsd#iart_FiveYearOptionLeasePeriodOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeaseContractualTermDomain_63e56ad6-bc6e-483b-938e-afa1f03e5a87" xlink:to="loc_iart_FiveYearOptionLeasePeriodOneMember_37264efc-8cd4-4125-bf49-e00511193e0f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_FiveYearOptionLeasePeriodTwoMember_4f6dc9cc-4b68-49d3-855c-70991ad36f01" xlink:href="iart-20220930.xsd#iart_FiveYearOptionLeasePeriodTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeaseContractualTermDomain_63e56ad6-bc6e-483b-938e-afa1f03e5a87" xlink:to="loc_iart_FiveYearOptionLeasePeriodTwoMember_4f6dc9cc-4b68-49d3-855c-70991ad36f01" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/LEASESANDRELATEDPARTYLEASESSupplementalBalanceSheetInformationDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#LEASESANDRELATEDPARTYLEASESSupplementalBalanceSheetInformationDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/LEASESANDRELATEDPARTYLEASESSupplementalBalanceSheetInformationDetails" xlink:type="extended" id="i096b764d75cc450c951570af7ba935bc_LEASESANDRELATEDPARTYLEASESSupplementalBalanceSheetInformationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_04e3255c-10ac-4aa8-8af7-845d6578525f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_a2dd1df8-a9eb-49c8-aa72-e9620e6c19fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_04e3255c-10ac-4aa8-8af7-845d6578525f" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_a2dd1df8-a9eb-49c8-aa72-e9620e6c19fc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_cb09f6e2-28ab-4221-921f-c9491317da6b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_04e3255c-10ac-4aa8-8af7-845d6578525f" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_cb09f6e2-28ab-4221-921f-c9491317da6b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_fd693506-1a7f-48dd-8f06-efa832f04d9d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_04e3255c-10ac-4aa8-8af7-845d6578525f" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_fd693506-1a7f-48dd-8f06-efa832f04d9d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_fb984012-c09e-4b3e-b113-b800218c2890" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_04e3255c-10ac-4aa8-8af7-845d6578525f" xlink:to="loc_us-gaap_OperatingLeaseLiability_fb984012-c09e-4b3e-b113-b800218c2890" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_c0f6ef73-588e-472e-9965-55edf65fa151" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_04e3255c-10ac-4aa8-8af7-845d6578525f" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_c0f6ef73-588e-472e-9965-55edf65fa151" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_7f4d472e-2839-4b2e-b764-6232c693e123" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_04e3255c-10ac-4aa8-8af7-845d6578525f" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_7f4d472e-2839-4b2e-b764-6232c693e123" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_32be71e0-6bc9-4da1-aca9-91469be86c33" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_04e3255c-10ac-4aa8-8af7-845d6578525f" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_32be71e0-6bc9-4da1-aca9-91469be86c33" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1afed6b2-26ad-47e5-95be-a04e02eeceb5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_32be71e0-6bc9-4da1-aca9-91469be86c33" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1afed6b2-26ad-47e5-95be-a04e02eeceb5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_1afed6b2-26ad-47e5-95be-a04e02eeceb5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1afed6b2-26ad-47e5-95be-a04e02eeceb5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_1afed6b2-26ad-47e5-95be-a04e02eeceb5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ba8b9bbf-41af-413d-bf44-e1f211a5971b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1afed6b2-26ad-47e5-95be-a04e02eeceb5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ba8b9bbf-41af-413d-bf44-e1f211a5971b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingMember_30f93da4-5dcd-456d-80ca-6c3544c9c1fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BuildingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ba8b9bbf-41af-413d-bf44-e1f211a5971b" xlink:to="loc_us-gaap_BuildingMember_30f93da4-5dcd-456d-80ca-6c3544c9c1fd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VehiclesMember_86094012-5ba8-44e1-9883-e28f3c8b4d5e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VehiclesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ba8b9bbf-41af-413d-bf44-e1f211a5971b" xlink:to="loc_us-gaap_VehiclesMember_86094012-5ba8-44e1-9883-e28f3c8b4d5e" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/LEASESANDRELATEDPARTYLEASESFutureMinimumLeasePaymentUnderOperatingLeasesDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#LEASESANDRELATEDPARTYLEASESFutureMinimumLeasePaymentUnderOperatingLeasesDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/LEASESANDRELATEDPARTYLEASESFutureMinimumLeasePaymentUnderOperatingLeasesDetails" xlink:type="extended" id="iba58bdcd27da4430adfed3480be2a189_LEASESANDRELATEDPARTYLEASESFutureMinimumLeasePaymentUnderOperatingLeasesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasedAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_1eb82f46-1702-4f07-acc9-decfe2090ce7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_1eb82f46-1702-4f07-acc9-decfe2090ce7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_780de67c-2a7a-41a5-a40a-c0d999a01d2c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_780de67c-2a7a-41a5-a40a-c0d999a01d2c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_543aa2a2-88f8-4fa0-8a49-3aa1df914a8b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_543aa2a2-88f8-4fa0-8a49-3aa1df914a8b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_685a11e2-8442-492a-936c-013afb45bfe2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_685a11e2-8442-492a-936c-013afb45bfe2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_1f20c1aa-af89-44e4-a866-68a776813b40" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_1f20c1aa-af89-44e4-a866-68a776813b40" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_765aff5a-4b44-413e-ad8a-683dc92bb14d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_765aff5a-4b44-413e-ad8a-683dc92bb14d" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_aab41dbe-b33e-4c3d-8d27-16955b528672" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_aab41dbe-b33e-4c3d-8d27-16955b528672" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_ec962967-8aaa-4a86-adee-73627783fa74" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_ec962967-8aaa-4a86-adee-73627783fa74" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_6a805841-81b8-43af-af53-1a7513e4c1d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_6a805841-81b8-43af-af53-1a7513e4c1d8" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_4d012bf8-5f23-4b3f-8941-0c5b845f74ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:to="loc_us-gaap_OperatingLeaseLiability_4d012bf8-5f23-4b3f-8941-0c5b845f74ae" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_88ce0f47-b85a-4b9a-9b87-8093b6600b86" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_88ce0f47-b85a-4b9a-9b87-8093b6600b86" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_afd208b2-2d17-41d2-b4ea-3b455638c9a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_afd208b2-2d17-41d2-b4ea-3b455638c9a2" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_08f827df-3433-4434-a59e-21166dab5284" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfOperatingLeasedAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_e51b93fb-bcdf-4064-baac-78f9a8713f7c" xlink:to="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_08f827df-3433-4434-a59e-21166dab5284" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_94d0e49c-1d2e-4c3c-92ec-a10dda747613" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_08f827df-3433-4434-a59e-21166dab5284" xlink:to="loc_srt_CounterpartyNameAxis_94d0e49c-1d2e-4c3c-92ec-a10dda747613" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_94d0e49c-1d2e-4c3c-92ec-a10dda747613_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_94d0e49c-1d2e-4c3c-92ec-a10dda747613" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_94d0e49c-1d2e-4c3c-92ec-a10dda747613_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_9639e03a-cfb3-40a8-a15f-5135cfb8c505" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_94d0e49c-1d2e-4c3c-92ec-a10dda747613" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_9639e03a-cfb3-40a8-a15f-5135cfb8c505" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_RelatedPartiesMember_e1f223ad-9645-4a46-807c-eb000ab67682" xlink:href="iart-20220930.xsd#iart_RelatedPartiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_9639e03a-cfb3-40a8-a15f-5135cfb8c505" xlink:to="loc_iart_RelatedPartiesMember_e1f223ad-9645-4a46-807c-eb000ab67682" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ThirdPartiesMember_8e499775-212f-41dd-ac26-753d42ca5bce" xlink:href="iart-20220930.xsd#iart_ThirdPartiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_9639e03a-cfb3-40a8-a15f-5135cfb8c505" xlink:to="loc_iart_ThirdPartiesMember_8e499775-212f-41dd-ac26-753d42ca5bce" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSScheduleofChangesinAccumulatedOtherComprehensiveIncomebyComponentDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#ACCUMULATEDOTHERCOMPREHENSIVELOSSScheduleofChangesinAccumulatedOtherComprehensiveIncomebyComponentDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSScheduleofChangesinAccumulatedOtherComprehensiveIncomebyComponentDetails" xlink:type="extended" id="id0f9778a550e4f909658c7e4a8a291b7_ACCUMULATEDOTHERCOMPREHENSIVELOSSScheduleofChangesinAccumulatedOtherComprehensiveIncomebyComponentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_62ef4255-660b-433b-bf5b-76747ebd3aec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_d36583fc-1265-4a5b-bd80-56f92c7ce4da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AOCIAttributableToParentNetOfTaxRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_62ef4255-660b-433b-bf5b-76747ebd3aec" xlink:to="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_d36583fc-1265-4a5b-bd80-56f92c7ce4da" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_e5794c20-576e-4878-9046-ec0bc665e74e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_d36583fc-1265-4a5b-bd80-56f92c7ce4da" xlink:to="loc_us-gaap_StockholdersEquity_e5794c20-576e-4878-9046-ec0bc665e74e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_0243cb6b-cf72-4cfa-9710-af2cf51c15f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_d36583fc-1265-4a5b-bd80-56f92c7ce4da" xlink:to="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_0243cb6b-cf72-4cfa-9710-af2cf51c15f3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_4af6af99-aec8-49c1-8ad4-0ca3aa61a20e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_d36583fc-1265-4a5b-bd80-56f92c7ce4da" xlink:to="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_4af6af99-aec8-49c1-8ad4-0ca3aa61a20e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_65fb6ddf-3ca4-4b25-bc81-20e86bdba3d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_d36583fc-1265-4a5b-bd80-56f92c7ce4da" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_65fb6ddf-3ca4-4b25-bc81-20e86bdba3d4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_9de52018-0dbb-4734-8dd4-7576dab2436c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_80f13ef7-5d6a-48f6-8e80-1433b4ad3115" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_62ef4255-660b-433b-bf5b-76747ebd3aec" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_80f13ef7-5d6a-48f6-8e80-1433b4ad3115" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_f00dd163-3d19-4e34-ab44-2a7c6f88b6dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_80f13ef7-5d6a-48f6-8e80-1433b4ad3115" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_f00dd163-3d19-4e34-ab44-2a7c6f88b6dd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_f00dd163-3d19-4e34-ab44-2a7c6f88b6dd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f00dd163-3d19-4e34-ab44-2a7c6f88b6dd" xlink:to="loc_us-gaap_EquityComponentDomain_f00dd163-3d19-4e34-ab44-2a7c6f88b6dd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_871000c7-b8eb-4072-88e8-b629397f776a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f00dd163-3d19-4e34-ab44-2a7c6f88b6dd" xlink:to="loc_us-gaap_EquityComponentDomain_871000c7-b8eb-4072-88e8-b629397f776a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_d77ea505-bdbb-4b07-a889-60f51b7e9365" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_871000c7-b8eb-4072-88e8-b629397f776a" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_d77ea505-bdbb-4b07-a889-60f51b7e9365" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_fe979a18-0003-47e4-8007-da64777e0434" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_d77ea505-bdbb-4b07-a889-60f51b7e9365" xlink:to="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_fe979a18-0003-47e4-8007-da64777e0434" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_863a5d0d-72ec-4b6b-b9a7-772b3e5726ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_d77ea505-bdbb-4b07-a889-60f51b7e9365" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_863a5d0d-72ec-4b6b-b9a7-772b3e5726ef" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_1e774560-a97f-49c7-bcf8-037a968462e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_d77ea505-bdbb-4b07-a889-60f51b7e9365" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_1e774560-a97f-49c7-bcf8-037a968462e5" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSNarrativeDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#ACCUMULATEDOTHERCOMPREHENSIVELOSSNarrativeDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSNarrativeDetails" xlink:type="extended" id="i0e03d33ba8d54c1e89e537fe3a7533e3_ACCUMULATEDOTHERCOMPREHENSIVELOSSNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_dc1e4139-683f-4c72-aed4-3da8057db673" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_419a8afb-eb73-4ebd-82bb-ba8343e83d80" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_dc1e4139-683f-4c72-aed4-3da8057db673" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_419a8afb-eb73-4ebd-82bb-ba8343e83d80" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_15165b47-ca73-4c8a-9aee-193c3eaed9e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_dc1e4139-683f-4c72-aed4-3da8057db673" xlink:to="loc_us-gaap_InvestmentIncomeInterest_15165b47-ca73-4c8a-9aee-193c3eaed9e1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_7d43f5ff-898f-4ffd-ba0c-89be1e44d0cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_dc1e4139-683f-4c72-aed4-3da8057db673" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_7d43f5ff-898f-4ffd-ba0c-89be1e44d0cf" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_55fe9194-7783-4d52-af07-4115e9b40fee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_7d43f5ff-898f-4ffd-ba0c-89be1e44d0cf" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_55fe9194-7783-4d52-af07-4115e9b40fee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_55fe9194-7783-4d52-af07-4115e9b40fee_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_55fe9194-7783-4d52-af07-4115e9b40fee" xlink:to="loc_us-gaap_EquityComponentDomain_55fe9194-7783-4d52-af07-4115e9b40fee_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_040fc73b-89c5-4155-94a2-6affb46d4025" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_55fe9194-7783-4d52-af07-4115e9b40fee" xlink:to="loc_us-gaap_EquityComponentDomain_040fc73b-89c5-4155-94a2-6affb46d4025" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_cb619f1e-d829-4949-9492-0461e7880fd4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_040fc73b-89c5-4155-94a2-6affb46d4025" xlink:to="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_cb619f1e-d829-4949-9492-0461e7880fd4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_50bd2b4d-2abf-4e85-91ee-90972d657fec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_7d43f5ff-898f-4ffd-ba0c-89be1e44d0cf" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_50bd2b4d-2abf-4e85-91ee-90972d657fec" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_50bd2b4d-2abf-4e85-91ee-90972d657fec_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_50bd2b4d-2abf-4e85-91ee-90972d657fec" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_50bd2b4d-2abf-4e85-91ee-90972d657fec_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_663747b9-db93-47fc-be84-2f4e982c4f54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_50bd2b4d-2abf-4e85-91ee-90972d657fec" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_663747b9-db93-47fc-be84-2f4e982c4f54" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_a456beab-8c7d-4842-8bcc-75af25266770" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_663747b9-db93-47fc-be84-2f4e982c4f54" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_a456beab-8c7d-4842-8bcc-75af25266770" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/SEGMENTANDGEOGRAPHICINFORMATIONNarrativeDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#SEGMENTANDGEOGRAPHICINFORMATIONNarrativeDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/SEGMENTANDGEOGRAPHICINFORMATIONNarrativeDetails" xlink:type="extended" id="ibec8db335a58443e834d688d0aa69725_SEGMENTANDGEOGRAPHICINFORMATIONNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_d143fcc8-45cc-4d34-b3ba-41a8cef86332" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_d08f4c1e-0179-44e4-9c26-f7b1c616598b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_d143fcc8-45cc-4d34-b3ba-41a8cef86332" xlink:to="loc_us-gaap_NumberOfReportableSegments_d08f4c1e-0179-44e4-9c26-f7b1c616598b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_SegmentReportingInformationNumberOfProductsOffered_d6d99be3-4207-4566-8e1e-921950d51633" xlink:href="iart-20220930.xsd#iart_SegmentReportingInformationNumberOfProductsOffered"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_d143fcc8-45cc-4d34-b3ba-41a8cef86332" xlink:to="loc_iart_SegmentReportingInformationNumberOfProductsOffered_d6d99be3-4207-4566-8e1e-921950d51633" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_4c97ec57-22e1-47bf-b96e-d96e96525137" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_d143fcc8-45cc-4d34-b3ba-41a8cef86332" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_4c97ec57-22e1-47bf-b96e-d96e96525137" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_e5314337-9f2c-4e3a-8e60-e7d57df5ff64" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_4c97ec57-22e1-47bf-b96e-d96e96525137" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_e5314337-9f2c-4e3a-8e60-e7d57df5ff64" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_e5314337-9f2c-4e3a-8e60-e7d57df5ff64_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_e5314337-9f2c-4e3a-8e60-e7d57df5ff64" xlink:to="loc_us-gaap_SegmentDomain_e5314337-9f2c-4e3a-8e60-e7d57df5ff64_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_aa6d8560-ef3a-4a5e-b0ee-cabe824b6268" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_e5314337-9f2c-4e3a-8e60-e7d57df5ff64" xlink:to="loc_us-gaap_SegmentDomain_aa6d8560-ef3a-4a5e-b0ee-cabe824b6268" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CodmanSpecialtySurgicalMember_7c7ca562-41ed-4606-a6dd-4404ad106ef1" xlink:href="iart-20220930.xsd#iart_CodmanSpecialtySurgicalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_aa6d8560-ef3a-4a5e-b0ee-cabe824b6268" xlink:to="loc_iart_CodmanSpecialtySurgicalMember_7c7ca562-41ed-4606-a6dd-4404ad106ef1" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/SEGMENTANDGEOGRAPHICINFORMATIONNetSalesandProfitbyReportableSegmentDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#SEGMENTANDGEOGRAPHICINFORMATIONNetSalesandProfitbyReportableSegmentDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/SEGMENTANDGEOGRAPHICINFORMATIONNetSalesandProfitbyReportableSegmentDetails" xlink:type="extended" id="i92108cec6abe45d0ab2f7fa1244ccdbc_SEGMENTANDGEOGRAPHICINFORMATIONNetSalesandProfitbyReportableSegmentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_fbab00a6-4f0a-40d3-826a-e831d12aeca8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationOperatingIncomeLossAbstract_c9ab9c92-5355-4780-9f93-6689c676a3c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentReportingInformationOperatingIncomeLossAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_fbab00a6-4f0a-40d3-826a-e831d12aeca8" xlink:to="loc_us-gaap_SegmentReportingInformationOperatingIncomeLossAbstract_c9ab9c92-5355-4780-9f93-6689c676a3c5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_13b7d5f6-e6e1-48d3-a151-3eb796e97e60" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationOperatingIncomeLossAbstract_c9ab9c92-5355-4780-9f93-6689c676a3c5" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_13b7d5f6-e6e1-48d3-a151-3eb796e97e60" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationProfitLossAbstract_f43d7b72-047e-4ca8-9153-7b40764cc396" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentReportingInformationProfitLossAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_fbab00a6-4f0a-40d3-826a-e831d12aeca8" xlink:to="loc_us-gaap_SegmentReportingInformationProfitLossAbstract_f43d7b72-047e-4ca8-9153-7b40764cc396" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_86e2f167-0bc2-492d-8802-e845777add2a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationProfitLossAbstract_f43d7b72-047e-4ca8-9153-7b40764cc396" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_86e2f167-0bc2-492d-8802-e845777add2a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_b7c95214-8c62-4f34-acf8-e558d7b5d126" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationProfitLossAbstract_f43d7b72-047e-4ca8-9153-7b40764cc396" xlink:to="loc_us-gaap_OperatingIncomeLoss_b7c95214-8c62-4f34-acf8-e558d7b5d126" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_991e62ca-59ed-4662-b604-c9b8e01afac5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_fbab00a6-4f0a-40d3-826a-e831d12aeca8" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_991e62ca-59ed-4662-b604-c9b8e01afac5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_4801fe30-148d-447c-91e4-373733147ace" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_991e62ca-59ed-4662-b604-c9b8e01afac5" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_4801fe30-148d-447c-91e4-373733147ace" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_4801fe30-148d-447c-91e4-373733147ace_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_4801fe30-148d-447c-91e4-373733147ace" xlink:to="loc_us-gaap_SegmentDomain_4801fe30-148d-447c-91e4-373733147ace_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_f7680223-b6b8-46ef-b594-52f1df71b1d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_4801fe30-148d-447c-91e4-373733147ace" xlink:to="loc_us-gaap_SegmentDomain_f7680223-b6b8-46ef-b594-52f1df71b1d4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_CodmanSpecialtySurgicalMember_8f610e1f-c42c-4cb6-96de-32d1cb865bba" xlink:href="iart-20220930.xsd#iart_CodmanSpecialtySurgicalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_f7680223-b6b8-46ef-b594-52f1df71b1d4" xlink:to="loc_iart_CodmanSpecialtySurgicalMember_8f610e1f-c42c-4cb6-96de-32d1cb865bba" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_TissueTechnologiesMember_cc724714-d22f-4b16-9bcf-16a0244f5c3e" xlink:href="iart-20220930.xsd#iart_TissueTechnologiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_f7680223-b6b8-46ef-b594-52f1df71b1d4" xlink:to="loc_iart_TissueTechnologiesMember_cc724714-d22f-4b16-9bcf-16a0244f5c3e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_3ab88d40-12f7-462a-b759-9f2745e3f03b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_991e62ca-59ed-4662-b604-c9b8e01afac5" xlink:to="loc_srt_ConsolidationItemsAxis_3ab88d40-12f7-462a-b759-9f2745e3f03b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_3ab88d40-12f7-462a-b759-9f2745e3f03b_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_3ab88d40-12f7-462a-b759-9f2745e3f03b" xlink:to="loc_srt_ConsolidationItemsDomain_3ab88d40-12f7-462a-b759-9f2745e3f03b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_2e0f0d4e-7ca0-40b5-b210-886f0d8072cb" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_3ab88d40-12f7-462a-b759-9f2745e3f03b" xlink:to="loc_srt_ConsolidationItemsDomain_2e0f0d4e-7ca0-40b5-b210-886f0d8072cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_d608414d-a4b2-4992-bad0-95c5e5db086b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_2e0f0d4e-7ca0-40b5-b210-886f0d8072cb" xlink:to="loc_us-gaap_OperatingSegmentsMember_d608414d-a4b2-4992-bad0-95c5e5db086b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateNonSegmentMember_8ff2cd07-4eb1-4e2c-af43-18ea615ae942" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateNonSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_2e0f0d4e-7ca0-40b5-b210-886f0d8072cb" xlink:to="loc_us-gaap_CorporateNonSegmentMember_8ff2cd07-4eb1-4e2c-af43-18ea615ae942" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/SEGMENTANDGEOGRAPHICINFORMATIONTotalRevenuebyMajorGeographicAreaDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#SEGMENTANDGEOGRAPHICINFORMATIONTotalRevenuebyMajorGeographicAreaDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/SEGMENTANDGEOGRAPHICINFORMATIONTotalRevenuebyMajorGeographicAreaDetails" xlink:type="extended" id="i655c961233e1475cad370c163519c3a7_SEGMENTANDGEOGRAPHICINFORMATIONTotalRevenuebyMajorGeographicAreaDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_457b4406-43fb-4d09-bad3-87dc4c6b4f39" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_e3cee3d2-f807-4983-af18-2db932c34ea3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_457b4406-43fb-4d09-bad3-87dc4c6b4f39" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_e3cee3d2-f807-4983-af18-2db932c34ea3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_476fd7eb-5844-4241-9b99-7c51b53d0fec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_457b4406-43fb-4d09-bad3-87dc4c6b4f39" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_476fd7eb-5844-4241-9b99-7c51b53d0fec" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_4d00a880-24b2-4746-a34f-a0efec6795e9" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_476fd7eb-5844-4241-9b99-7c51b53d0fec" xlink:to="loc_srt_StatementGeographicalAxis_4d00a880-24b2-4746-a34f-a0efec6795e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_4d00a880-24b2-4746-a34f-a0efec6795e9_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_4d00a880-24b2-4746-a34f-a0efec6795e9" xlink:to="loc_srt_SegmentGeographicalDomain_4d00a880-24b2-4746-a34f-a0efec6795e9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_bff1e033-0d9a-4d20-a714-c9f915cec7d5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_4d00a880-24b2-4746-a34f-a0efec6795e9" xlink:to="loc_srt_SegmentGeographicalDomain_bff1e033-0d9a-4d20-a714-c9f915cec7d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_051dac46-cee9-40c3-a8a6-a6e9fdb3c974" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_bff1e033-0d9a-4d20-a714-c9f915cec7d5" xlink:to="loc_country_US_051dac46-cee9-40c3-a8a6-a6e9fdb3c974" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EuropeMember_4966acb2-d1ac-4808-b425-e845924b2013" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_EuropeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_bff1e033-0d9a-4d20-a714-c9f915cec7d5" xlink:to="loc_srt_EuropeMember_4966acb2-d1ac-4808-b425-e845924b2013" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_AsiaPacificMember_841c85de-300f-4892-8b06-10a6e345c783" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_AsiaPacificMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_bff1e033-0d9a-4d20-a714-c9f915cec7d5" xlink:to="loc_srt_AsiaPacificMember_841c85de-300f-4892-8b06-10a6e345c783" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_RestOfWorldMember_8f9f9bd2-9419-48e5-ab0e-0d3df5e5c57d" xlink:href="iart-20220930.xsd#iart_RestOfWorldMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_bff1e033-0d9a-4d20-a714-c9f915cec7d5" xlink:to="loc_iart_RestOfWorldMember_8f9f9bd2-9419-48e5-ab0e-0d3df5e5c57d" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/COMMITMENTSANDCONTINGENCIESFairValueContingentConsiderationBalanceInformationDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#COMMITMENTSANDCONTINGENCIESFairValueContingentConsiderationBalanceInformationDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/COMMITMENTSANDCONTINGENCIESFairValueContingentConsiderationBalanceInformationDetails" xlink:type="extended" id="i30515a7c58144f54b429554de1a4814c_COMMITMENTSANDCONTINGENCIESFairValueContingentConsiderationBalanceInformationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_f786f1ab-e560-4fc4-8f8c-b0fdd904be38" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_8c3d7506-32c8-402f-a1eb-4b8c399dc276" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_f786f1ab-e560-4fc4-8f8c-b0fdd904be38" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_8c3d7506-32c8-402f-a1eb-4b8c399dc276" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_e41ccaf1-b3cc-41d3-89e1-dfd54425ce51" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_8c3d7506-32c8-402f-a1eb-4b8c399dc276" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_e41ccaf1-b3cc-41d3-89e1-dfd54425ce51" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchases_fd74a5c4-60ed-4d7b-b94d-1dc8c2f4aa71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchases"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_8c3d7506-32c8-402f-a1eb-4b8c399dc276" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchases_fd74a5c4-60ed-4d7b-b94d-1dc8c2f4aa71" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_FairValueMeasurementwithUnobservableInputsReconciliationLiabilityTransfersFromLongTermtoCurrent_7da3b6c3-1868-4eba-b5b4-6dd7f9f2042f" xlink:href="iart-20220930.xsd#iart_FairValueMeasurementwithUnobservableInputsReconciliationLiabilityTransfersFromLongTermtoCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_8c3d7506-32c8-402f-a1eb-4b8c399dc276" xlink:to="loc_iart_FairValueMeasurementwithUnobservableInputsReconciliationLiabilityTransfersFromLongTermtoCurrent_7da3b6c3-1868-4eba-b5b4-6dd7f9f2042f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_6742ab35-fa46-4eca-ae23-7d837bccb0a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_8c3d7506-32c8-402f-a1eb-4b8c399dc276" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_6742ab35-fa46-4eca-ae23-7d837bccb0a5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_076f0eb9-2d51-4d60-8f80-04dfc4504ebb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_62c47be6-755a-48b7-a5a3-9fbfc11f4b11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_f786f1ab-e560-4fc4-8f8c-b0fdd904be38" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_62c47be6-755a-48b7-a5a3-9fbfc11f4b11" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_c0001193-8f7b-4181-b7e1-38e84eded175" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_62c47be6-755a-48b7-a5a3-9fbfc11f4b11" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_c0001193-8f7b-4181-b7e1-38e84eded175" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_c0001193-8f7b-4181-b7e1-38e84eded175_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_c0001193-8f7b-4181-b7e1-38e84eded175" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_c0001193-8f7b-4181-b7e1-38e84eded175_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_b798e855-91b5-482f-ac16-f91e9e9672ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_c0001193-8f7b-4181-b7e1-38e84eded175" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_b798e855-91b5-482f-ac16-f91e9e9672ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ArkisBioSciencesInc.Member_26fda502-53dc-43ed-81d8-181e5860e934" xlink:href="iart-20220930.xsd#iart_ArkisBioSciencesInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_b798e855-91b5-482f-ac16-f91e9e9672ec" xlink:to="loc_iart_ArkisBioSciencesInc.Member_26fda502-53dc-43ed-81d8-181e5860e934" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DermaSciencesMember_c8ea3dab-ab16-4933-90d2-3c057906394d" xlink:href="iart-20220930.xsd#iart_DermaSciencesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_b798e855-91b5-482f-ac16-f91e9e9672ec" xlink:to="loc_iart_DermaSciencesMember_c8ea3dab-ab16-4933-90d2-3c057906394d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ACellMember_eed05593-af20-4dee-98f9-a617280ee8a7" xlink:href="iart-20220930.xsd#iart_ACellMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_b798e855-91b5-482f-ac16-f91e9e9672ec" xlink:to="loc_iart_ACellMember_eed05593-af20-4dee-98f9-a617280ee8a7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_66abb570-6957-4b6e-8eba-aed37374791c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_62c47be6-755a-48b7-a5a3-9fbfc11f4b11" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_66abb570-6957-4b6e-8eba-aed37374791c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_66abb570-6957-4b6e-8eba-aed37374791c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_66abb570-6957-4b6e-8eba-aed37374791c" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_66abb570-6957-4b6e-8eba-aed37374791c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_2a1c57f9-9c3e-4cbe-af82-804d50d64c64" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_66abb570-6957-4b6e-8eba-aed37374791c" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_2a1c57f9-9c3e-4cbe-af82-804d50d64c64" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ContingentConsiderationLiabilityMember_a9d8f4dc-6013-488d-8c21-155c547889b5" xlink:href="iart-20220930.xsd#iart_ContingentConsiderationLiabilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_2a1c57f9-9c3e-4cbe-af82-804d50d64c64" xlink:to="loc_iart_ContingentConsiderationLiabilityMember_a9d8f4dc-6013-488d-8c21-155c547889b5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_960c6113-4438-46c4-bc46-99c983f2088e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_62c47be6-755a-48b7-a5a3-9fbfc11f4b11" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_960c6113-4438-46c4-bc46-99c983f2088e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_960c6113-4438-46c4-bc46-99c983f2088e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_960c6113-4438-46c4-bc46-99c983f2088e" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_960c6113-4438-46c4-bc46-99c983f2088e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6bd92bd3-f351-4893-ad89-073a51a60bbd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_960c6113-4438-46c4-bc46-99c983f2088e" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6bd92bd3-f351-4893-ad89-073a51a60bbd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_bcf67fef-4ae5-4d65-93b8-cbda3bd25936" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6bd92bd3-f351-4893-ad89-073a51a60bbd" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_bcf67fef-4ae5-4d65-93b8-cbda3bd25936" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_056f2ae6-5bf8-45c1-81a7-e02ad2ab3545" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_62c47be6-755a-48b7-a5a3-9fbfc11f4b11" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_056f2ae6-5bf8-45c1-81a7-e02ad2ab3545" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_056f2ae6-5bf8-45c1-81a7-e02ad2ab3545_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_056f2ae6-5bf8-45c1-81a7-e02ad2ab3545" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_056f2ae6-5bf8-45c1-81a7-e02ad2ab3545_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_b34b6d62-7eb4-4d4f-9fa7-4722370d1916" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_056f2ae6-5bf8-45c1-81a7-e02ad2ab3545" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_b34b6d62-7eb4-4d4f-9fa7-4722370d1916" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_90790800-f5ec-4ce5-81a2-3830b23bf028" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_b34b6d62-7eb4-4d4f-9fa7-4722370d1916" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_90790800-f5ec-4ce5-81a2-3830b23bf028" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncurrentLiabilitiesMember_8ce8c673-f82b-48dc-aecb-ea7607b4c256" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNoncurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_b34b6d62-7eb4-4d4f-9fa7-4722370d1916" xlink:to="loc_us-gaap_OtherNoncurrentLiabilitiesMember_8ce8c673-f82b-48dc-aecb-ea7607b4c256" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://integralife.com/role/COMMITMENTSANDCONTINGENCIESNarrativeDetails" xlink:type="simple" xlink:href="iart-20220930.xsd#COMMITMENTSANDCONTINGENCIESNarrativeDetails"/>
  <link:definitionLink xlink:role="http://integralife.com/role/COMMITMENTSANDCONTINGENCIESNarrativeDetails" xlink:type="extended" id="ia8ac1b12c5724bf6ad0c5b8bfff78ebd_COMMITMENTSANDCONTINGENCIESNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_646f543c-ef80-495a-a836-074a7660064e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_e5cd08d6-5575-41d2-91ea-d4df7d9ca1c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_646f543c-ef80-495a-a836-074a7660064e" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_e5cd08d6-5575-41d2-91ea-d4df7d9ca1c8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_b63e1d8e-b62f-4d84-824b-488938dab241" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_646f543c-ef80-495a-a836-074a7660064e" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_b63e1d8e-b62f-4d84-824b-488938dab241" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContingentLiability_da9253a6-597f-4c55-a8bf-f5f2fb75f3ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContingentLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_646f543c-ef80-495a-a836-074a7660064e" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContingentLiability_da9253a6-597f-4c55-a8bf-f5f2fb75f3ee" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_161051eb-fbab-4064-9f81-129bc3ec76eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_646f543c-ef80-495a-a836-074a7660064e" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_161051eb-fbab-4064-9f81-129bc3ec76eb" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_5ca1276c-cc32-4dea-940d-088ef76d466b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_646f543c-ef80-495a-a836-074a7660064e" xlink:to="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_5ca1276c-cc32-4dea-940d-088ef76d466b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_BusinessCombinationContingentConsiderationNumberOfLiabilities_0a6e0679-6a8e-4577-9b9b-22894a15caf9" xlink:href="iart-20220930.xsd#iart_BusinessCombinationContingentConsiderationNumberOfLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_646f543c-ef80-495a-a836-074a7660064e" xlink:to="loc_iart_BusinessCombinationContingentConsiderationNumberOfLiabilities_0a6e0679-6a8e-4577-9b9b-22894a15caf9" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_5476c310-6cce-4d4f-867f-3b70f5327940" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_646f543c-ef80-495a-a836-074a7660064e" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_5476c310-6cce-4d4f-867f-3b70f5327940" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_034aa7b3-3852-4ebf-ba05-ad0cfe7d5906" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_646f543c-ef80-495a-a836-074a7660064e" xlink:to="loc_us-gaap_LossContingenciesTable_034aa7b3-3852-4ebf-ba05-ad0cfe7d5906" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_38471a9e-fd3c-4820-a4dd-4dfc308de1ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_034aa7b3-3852-4ebf-ba05-ad0cfe7d5906" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_38471a9e-fd3c-4820-a4dd-4dfc308de1ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_38471a9e-fd3c-4820-a4dd-4dfc308de1ae_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_38471a9e-fd3c-4820-a4dd-4dfc308de1ae" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_38471a9e-fd3c-4820-a4dd-4dfc308de1ae_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_16847ead-e29e-47e3-89a9-9f664327de1e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_38471a9e-fd3c-4820-a4dd-4dfc308de1ae" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_16847ead-e29e-47e3-89a9-9f664327de1e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ArkisBioSciencesInc.Member_671fa99a-c4c4-47cf-831e-228e0d511232" xlink:href="iart-20220930.xsd#iart_ArkisBioSciencesInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_16847ead-e29e-47e3-89a9-9f664327de1e" xlink:to="loc_iart_ArkisBioSciencesInc.Member_671fa99a-c4c4-47cf-831e-228e0d511232" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_DermaSciencesMember_53f9e965-98eb-457e-8914-a66839c33aa0" xlink:href="iart-20220930.xsd#iart_DermaSciencesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_16847ead-e29e-47e3-89a9-9f664327de1e" xlink:to="loc_iart_DermaSciencesMember_53f9e965-98eb-457e-8914-a66839c33aa0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationByTypeAxis_0866b2d9-0d3b-46b5-8014-f1a8ab00c9f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_034aa7b3-3852-4ebf-ba05-ad0cfe7d5906" xlink:to="loc_us-gaap_ContingentConsiderationByTypeAxis_0866b2d9-0d3b-46b5-8014-f1a8ab00c9f3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_0866b2d9-0d3b-46b5-8014-f1a8ab00c9f3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_0866b2d9-0d3b-46b5-8014-f1a8ab00c9f3" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_0866b2d9-0d3b-46b5-8014-f1a8ab00c9f3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_4a797f52-b9f3-4894-8c25-1d889ff7fcd6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_0866b2d9-0d3b-46b5-8014-f1a8ab00c9f3" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_4a797f52-b9f3-4894-8c25-1d889ff7fcd6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_MilestonePaymentOneMember_7e6f4bf2-5e84-4be6-b753-314836292c4a" xlink:href="iart-20220930.xsd#iart_MilestonePaymentOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_4a797f52-b9f3-4894-8c25-1d889ff7fcd6" xlink:to="loc_iart_MilestonePaymentOneMember_7e6f4bf2-5e84-4be6-b753-314836292c4a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_MilestonePaymentTwoMember_a723c76d-97b4-4766-ad43-e7dbdfd96b68" xlink:href="iart-20220930.xsd#iart_MilestonePaymentTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_4a797f52-b9f3-4894-8c25-1d889ff7fcd6" xlink:to="loc_iart_MilestonePaymentTwoMember_a723c76d-97b4-4766-ad43-e7dbdfd96b68" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_BioDEarnoutPaymentsandMedihoneyEarnoutPaymentsMember_206d7935-da27-4f2f-be65-5f2ef5a82a37" xlink:href="iart-20220930.xsd#iart_BioDEarnoutPaymentsandMedihoneyEarnoutPaymentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_4a797f52-b9f3-4894-8c25-1d889ff7fcd6" xlink:to="loc_iart_BioDEarnoutPaymentsandMedihoneyEarnoutPaymentsMember_206d7935-da27-4f2f-be65-5f2ef5a82a37" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_712ad48a-cd59-4cdd-8b2e-a496db2a0327" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_034aa7b3-3852-4ebf-ba05-ad0cfe7d5906" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_712ad48a-cd59-4cdd-8b2e-a496db2a0327" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_712ad48a-cd59-4cdd-8b2e-a496db2a0327_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_712ad48a-cd59-4cdd-8b2e-a496db2a0327" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_712ad48a-cd59-4cdd-8b2e-a496db2a0327_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_5ee017db-e26e-4b08-a50b-dd129f7ae95d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_712ad48a-cd59-4cdd-8b2e-a496db2a0327" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_5ee017db-e26e-4b08-a50b-dd129f7ae95d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncurrentLiabilitiesMember_cb8e9d0e-ff5b-4a23-922c-67c787982941" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNoncurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_5ee017db-e26e-4b08-a50b-dd129f7ae95d" xlink:to="loc_us-gaap_OtherNoncurrentLiabilitiesMember_cb8e9d0e-ff5b-4a23-922c-67c787982941" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_AccruedExpensesAndOtherCurrentLiabilitiesMember_3e7c077f-e006-4a69-98f1-0d140b284eef" xlink:href="iart-20220930.xsd#iart_AccruedExpensesAndOtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_5ee017db-e26e-4b08-a50b-dd129f7ae95d" xlink:to="loc_iart_AccruedExpensesAndOtherCurrentLiabilitiesMember_3e7c077f-e006-4a69-98f1-0d140b284eef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_63e0817a-140f-437b-baee-59cd95dd8c5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_034aa7b3-3852-4ebf-ba05-ad0cfe7d5906" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_63e0817a-140f-437b-baee-59cd95dd8c5c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_63e0817a-140f-437b-baee-59cd95dd8c5c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_63e0817a-140f-437b-baee-59cd95dd8c5c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_63e0817a-140f-437b-baee-59cd95dd8c5c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_59f60647-7e3e-4c35-b165-8f28ac6c1dd8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_63e0817a-140f-437b-baee-59cd95dd8c5c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_59f60647-7e3e-4c35-b165-8f28ac6c1dd8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_707eb871-0094-4b17-93c6-efafc63d4eaa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_59f60647-7e3e-4c35-b165-8f28ac6c1dd8" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_707eb871-0094-4b17-93c6-efafc63d4eaa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_b2ab5ef6-5668-41b7-a01c-62b3c583b212" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_034aa7b3-3852-4ebf-ba05-ad0cfe7d5906" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_b2ab5ef6-5668-41b7-a01c-62b3c583b212" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_b2ab5ef6-5668-41b7-a01c-62b3c583b212_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_b2ab5ef6-5668-41b7-a01c-62b3c583b212" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_b2ab5ef6-5668-41b7-a01c-62b3c583b212_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_81bac238-3440-40db-ad00-ee2cd405c77b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_b2ab5ef6-5668-41b7-a01c-62b3c583b212" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_81bac238-3440-40db-ad00-ee2cd405c77b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_iart_ContingentConsiderationLiabilityMember_54d60abe-ced0-4c4d-999c-acee3e5046df" xlink:href="iart-20220930.xsd#iart_ContingentConsiderationLiabilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_81bac238-3440-40db-ad00-ee2cd405c77b" xlink:to="loc_iart_ContingentConsiderationLiabilityMember_54d60abe-ced0-4c4d-999c-acee3e5046df" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="simple" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-roles-2022.xsd#eedm"/>
  <link:definitionLink xlink:role="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfAdoptionMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate202006Member" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingStandardsUpdate202006Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember" xlink:to="loc_us-gaap_AccountingStandardsUpdate202006Member" xlink:type="arc" order="0"/>
  </link:definitionLink>
</link:linkbase>
