<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<xsd:schema attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://integralife.com/20200630" xmlns:iart="http://integralife.com/20200630" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsd="http://www.w3.org/2001/XMLSchema">
  <xsd:import namespace="http://fasb.org/srt-types/2020-01-31" schemaLocation="http://xbrl.fasb.org/srt/2020/elts/srt-types-2020-01-31.xsd" />
  <xsd:import namespace="http://fasb.org/srt/2020-01-31" schemaLocation="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd" />
  <xsd:import namespace="http://fasb.org/us-gaap/2020-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd" />
  <xsd:import namespace="http://fasb.org/us-roles/2020-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2020/elts/us-roles-2020-01-31.xsd" />
  <xsd:import namespace="http://fasb.org/us-types/2020-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2020/elts/us-types-2020-01-31.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" />
  <xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/country/2020-01-31" schemaLocation="https://xbrl.sec.gov/country/2020/country-2020-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/currency/2020-01-31" schemaLocation="https://xbrl.sec.gov/currency/2020/currency-2020-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/dei/2019-01-31" schemaLocation="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/exch/2020-01-31" schemaLocation="https://xbrl.sec.gov/exch/2020/exch-2020-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/naics/2017-01-31" schemaLocation="http://xbrl.sec.gov/naics/2017/naics-2017-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/sic/2020-01-31" schemaLocation="https://xbrl.sec.gov/sic/2020/sic-2020-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/stpr/2018-01-31" schemaLocation="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd" />
  <xsd:annotation>
    <xsd:appinfo>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="iart-20200630_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="iart-20200630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="iart-20200630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="iart-20200630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple" />
      <link:roleType id="BasisOfPresentation" roleURI="http://integralife.com/role/BasisOfPresentation">
        <link:definition>2101100 - Disclosure - BASIS OF PRESENTATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisOfPresentationPolicies" roleURI="http://integralife.com/role/BasisOfPresentationPolicies">
        <link:definition>2201201 - Disclosure - BASIS OF PRESENTATION (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessDevelopment" roleURI="http://integralife.com/role/BusinessDevelopment">
        <link:definition>2105100 - Disclosure - BUSINESS DEVELOPMENT</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessDevelopmentAssetAcquisitionNarrativeDetails" roleURI="http://integralife.com/role/BusinessDevelopmentAssetAcquisitionNarrativeDetails">
        <link:definition>2405404 - Disclosure - BUSINESS DEVELOPMENT - Asset Acquisition, Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessDevelopmentBusinessCombinationNarrativeDetails" roleURI="http://integralife.com/role/BusinessDevelopmentBusinessCombinationNarrativeDetails">
        <link:definition>2405402 - Disclosure - BUSINESS DEVELOPMENT - Business Combination, Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessDevelopmentBusinessCombinationScheduleOfPurchasePriceAllocationDetails" roleURI="http://integralife.com/role/BusinessDevelopmentBusinessCombinationScheduleOfPurchasePriceAllocationDetails">
        <link:definition>2405403 - Disclosure - BUSINESS DEVELOPMENT - Business Combination, Schedule of Purchase Price Allocation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessDevelopmentTables" roleURI="http://integralife.com/role/BusinessDevelopmentTables">
        <link:definition>2305301 - Disclosure - BUSINESS DEVELOPMENT (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsAndContingencies" roleURI="http://integralife.com/role/CommitmentsAndContingencies">
        <link:definition>2131100 - Disclosure - COMMITMENTS AND CONTINGENCIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsAndContingenciesFairValueContingentConsiderationBalanceInformationDetails" roleURI="http://integralife.com/role/CommitmentsAndContingenciesFairValueContingentConsiderationBalanceInformationDetails">
        <link:definition>2431402 - Disclosure - COMMITMENTS AND CONTINGENCIES - Fair Value Contingent Consideration, Balance Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsAndContingenciesNarrativeDetails" roleURI="http://integralife.com/role/CommitmentsAndContingenciesNarrativeDetails">
        <link:definition>2431403 - Disclosure - COMMITMENTS AND CONTINGENCIES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsAndContingenciesTables" roleURI="http://integralife.com/role/CommitmentsAndContingenciesTables">
        <link:definition>2331301 - Disclosure - COMMITMENTS AND CONTINGENCIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ComprehensiveIncomeLoss" roleURI="http://integralife.com/role/ComprehensiveIncomeLoss">
        <link:definition>2129100 - Disclosure - COMPREHENSIVE INCOME (LOSS)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ComprehensiveIncomeLossNarrativeDetails" roleURI="http://integralife.com/role/ComprehensiveIncomeLossNarrativeDetails">
        <link:definition>2429404 - Disclosure - COMPREHENSIVE INCOME (LOSS) - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ComprehensiveIncomeLossScheduleOfChangesInAccumulatedOtherComprehensiveIncomeByComponentDetails" roleURI="http://integralife.com/role/ComprehensiveIncomeLossScheduleOfChangesInAccumulatedOtherComprehensiveIncomeByComponentDetails">
        <link:definition>2429403 - Disclosure - COMPREHENSIVE INCOME (LOSS) - Schedule of Changes in Accumulated Other Comprehensive Income by Component (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ComprehensiveIncomeLossScheduleOfComprehensiveIncomeDetails" roleURI="http://integralife.com/role/ComprehensiveIncomeLossScheduleOfComprehensiveIncomeDetails">
        <link:definition>2429402 - Disclosure - COMPREHENSIVE INCOME (LOSS) - Schedule of Comprehensive Income (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ComprehensiveIncomeLossTables" roleURI="http://integralife.com/role/ComprehensiveIncomeLossTables">
        <link:definition>2329301 - Disclosure - COMPREHENSIVE INCOME (LOSS) (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedBalanceSheetsUnaudited" roleURI="http://integralife.com/role/CondensedConsolidatedBalanceSheetsUnaudited">
        <link:definition>1002000 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedBalanceSheetsUnauditedParenthetical" roleURI="http://integralife.com/role/CondensedConsolidatedBalanceSheetsUnauditedParenthetical">
        <link:definition>1002501 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED) (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsOfCashFlowsUnaudited" roleURI="http://integralife.com/role/CondensedConsolidatedStatementsOfCashFlowsUnaudited">
        <link:definition>1003000 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsOfChangesInShareholdersEquityUnaudited" roleURI="http://integralife.com/role/CondensedConsolidatedStatementsOfChangesInShareholdersEquityUnaudited">
        <link:definition>1004000 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDER'S EQUITY (UNAUDITED)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsOfChangesInShareholdersEquityUnauditedParenthetical" roleURI="http://integralife.com/role/CondensedConsolidatedStatementsOfChangesInShareholdersEquityUnauditedParenthetical">
        <link:definition>1004001 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDER'S EQUITY (UNAUDITED) (PARENTHETICAL)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsOfOperationsAndComprehensiveIncomeLossUnaudited" roleURI="http://integralife.com/role/CondensedConsolidatedStatementsOfOperationsAndComprehensiveIncomeLossUnaudited">
        <link:definition>1001000 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME / (LOSS) (UNAUDITED)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Debt" roleURI="http://integralife.com/role/Debt">
        <link:definition>2118100 - Disclosure - DEBT</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DebtContractualMaturityTableDetails" roleURI="http://integralife.com/role/DebtContractualMaturityTableDetails">
        <link:definition>2418404 - Disclosure - DEBT - Contractual Maturity Table (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DebtMaximumTotalLeverageRatioTableDetails" roleURI="http://integralife.com/role/DebtMaximumTotalLeverageRatioTableDetails">
        <link:definition>2418403 - Disclosure - DEBT - Maximum Total Leverage Ratio Table (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DebtNarrativeDetails" roleURI="http://integralife.com/role/DebtNarrativeDetails">
        <link:definition>2418402 - Disclosure - DEBT - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DebtTables" roleURI="http://integralife.com/role/DebtTables">
        <link:definition>2318301 - Disclosure - DEBT (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstruments" roleURI="http://integralife.com/role/DerivativeInstruments">
        <link:definition>2121100 - Disclosure - DERIVATIVE INSTRUMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsEffectOfDerivativeInstrumentsDesignatedCashFlowHedgesOnStatementsOfOperationsDetails" roleURI="http://integralife.com/role/DerivativeInstrumentsEffectOfDerivativeInstrumentsDesignatedCashFlowHedgesOnStatementsOfOperationsDetails">
        <link:definition>2421407 - Disclosure - DERIVATIVE INSTRUMENTS - Effect of Derivative Instruments Designated Cash Flow Hedges on Statements of Operations (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsFairValueOfDerivativeInstrumentsByBalanceSheetLocationDetails" roleURI="http://integralife.com/role/DerivativeInstrumentsFairValueOfDerivativeInstrumentsByBalanceSheetLocationDetails">
        <link:definition>2421406 - Disclosure - DERIVATIVE INSTRUMENTS - Fair Value of Derivative Instruments By Balance Sheet Location (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsNarrativeDetails" roleURI="http://integralife.com/role/DerivativeInstrumentsNarrativeDetails">
        <link:definition>2421403 - Disclosure - DERIVATIVE INSTRUMENTS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsScheduleOfCrossCurrencySwapDerivativesDetails" roleURI="http://integralife.com/role/DerivativeInstrumentsScheduleOfCrossCurrencySwapDerivativesDetails">
        <link:definition>2421404 - Disclosure - DERIVATIVE INSTRUMENTS - Schedule of Cross Currency Swap Derivatives (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsScheduleOfDerivativesDetails" roleURI="http://integralife.com/role/DerivativeInstrumentsScheduleOfDerivativesDetails">
        <link:definition>2421402 - Disclosure - DERIVATIVE INSTRUMENTS - Schedule of Derivatives (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsScheduleOfNetInvestmentHedgesDerivativesDetails" roleURI="http://integralife.com/role/DerivativeInstrumentsScheduleOfNetInvestmentHedgesDerivativesDetails">
        <link:definition>2421405 - Disclosure - DERIVATIVE INSTRUMENTS - Schedule of Net Investment Hedges Derivatives (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsTables" roleURI="http://integralife.com/role/DerivativeInstrumentsTables">
        <link:definition>2321301 - Disclosure - DERIVATIVE INSTRUMENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DocumentAndEntityInformation" roleURI="http://integralife.com/role/DocumentAndEntityInformation">
        <link:definition>0001000 - Document - DOCUMENT AND ENTITY INFORMATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangibleAssets" roleURI="http://integralife.com/role/GoodwillAndOtherIntangibleAssets">
        <link:definition>2114100 - Disclosure - GOODWILL AND OTHER INTANGIBLE ASSETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangibleAssetsComponentsOfCompanysIdentifiableIntangibleAssetsDetails" roleURI="http://integralife.com/role/GoodwillAndOtherIntangibleAssetsComponentsOfCompanysIdentifiableIntangibleAssetsDetails">
        <link:definition>2414403 - Disclosure - GOODWILL AND OTHER INTANGIBLE ASSETS - Components of Company's Identifiable Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangibleAssetsNarrativeDetails" roleURI="http://integralife.com/role/GoodwillAndOtherIntangibleAssetsNarrativeDetails">
        <link:definition>2414404 - Disclosure - GOODWILL AND OTHER INTANGIBLE ASSETS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangibleAssetsScheduleOfChangesInCarryingAmountOfGoodwillDetails" roleURI="http://integralife.com/role/GoodwillAndOtherIntangibleAssetsScheduleOfChangesInCarryingAmountOfGoodwillDetails">
        <link:definition>2414402 - Disclosure - GOODWILL AND OTHER INTANGIBLE ASSETS - Schedule of Changes in Carrying Amount of Goodwill (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangibleAssetsTables" roleURI="http://integralife.com/role/GoodwillAndOtherIntangibleAssetsTables">
        <link:definition>2314301 - Disclosure - GOODWILL AND OTHER INTANGIBLE ASSETS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxes" roleURI="http://integralife.com/role/IncomeTaxes">
        <link:definition>2127100 - Disclosure - INCOME TAXES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesNarrativeDetails" roleURI="http://integralife.com/role/IncomeTaxesNarrativeDetails">
        <link:definition>2427403 - Disclosure - INCOME TAXES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesSummaryOfEffectiveTaxRateDetails" roleURI="http://integralife.com/role/IncomeTaxesSummaryOfEffectiveTaxRateDetails">
        <link:definition>2427402 - Disclosure - INCOME TAXES - Summary of Effective Tax Rate (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesTables" roleURI="http://integralife.com/role/IncomeTaxesTables">
        <link:definition>2327301 - Disclosure - INCOME TAXES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Inventories" roleURI="http://integralife.com/role/Inventories">
        <link:definition>2113100 - Disclosure - INVENTORIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="InventoriesScheduleOfNetInventoriesDetails" roleURI="http://integralife.com/role/InventoriesScheduleOfNetInventoriesDetails">
        <link:definition>2413402 - Disclosure - INVENTORIES - Schedule of Net Inventories (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="InventoriesTables" roleURI="http://integralife.com/role/InventoriesTables">
        <link:definition>2313301 - Disclosure - INVENTORIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesAndRelatedPartyLeases" roleURI="http://integralife.com/role/LeasesAndRelatedPartyLeases">
        <link:definition>2125100 - Disclosure - LEASES AND RELATED PARTY LEASES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesAndRelatedPartyLeasesFutureMinimumLeasePaymentUnderOperatingLeasesAfterAdoptionOf842Details" roleURI="http://integralife.com/role/LeasesAndRelatedPartyLeasesFutureMinimumLeasePaymentUnderOperatingLeasesAfterAdoptionOf842Details">
        <link:definition>2425405 - Disclosure - LEASES AND RELATED PARTY LEASES - Future Minimum Lease Payment Under Operating Leases, After Adoption of 842 (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesAndRelatedPartyLeasesFutureMinimumLeasePaymentUnderOperatingLeasesAfterAdoptionOf842DetailsCalc2" roleURI="http://integralife.com/role/LeasesAndRelatedPartyLeasesFutureMinimumLeasePaymentUnderOperatingLeasesAfterAdoptionOf842DetailsCalc2">
        <link:definition>2425405 - Disclosure - LEASES AND RELATED PARTY LEASES - Future Minimum Lease Payment Under Operating Leases, After Adoption of 842 (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesAndRelatedPartyLeasesNarrativeDetails" roleURI="http://integralife.com/role/LeasesAndRelatedPartyLeasesNarrativeDetails">
        <link:definition>2425402 - Disclosure - LEASES AND RELATED PARTY LEASES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesAndRelatedPartyLeasesSupplementalBalanceSheetInformationDetails" roleURI="http://integralife.com/role/LeasesAndRelatedPartyLeasesSupplementalBalanceSheetInformationDetails">
        <link:definition>2425403 - Disclosure - LEASES AND RELATED PARTY LEASES - Supplemental Balance Sheet Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesAndRelatedPartyLeasesSupplementalCashFlowInformationDetails" roleURI="http://integralife.com/role/LeasesAndRelatedPartyLeasesSupplementalCashFlowInformationDetails">
        <link:definition>2425404 - Disclosure - LEASES AND RELATED PARTY LEASES - Supplemental Cash Flow Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesAndRelatedPartyLeasesTables" roleURI="http://integralife.com/role/LeasesAndRelatedPartyLeasesTables">
        <link:definition>2325301 - Disclosure - LEASES AND RELATED PARTY LEASES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetIncomeLossPerShare" roleURI="http://integralife.com/role/NetIncomeLossPerShare">
        <link:definition>2128100 - Disclosure - NET INCOME (LOSS) PER SHARE</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetIncomeLossPerShareBasicAndDilutedNetIncomePerShareDetails" roleURI="http://integralife.com/role/NetIncomeLossPerShareBasicAndDilutedNetIncomePerShareDetails">
        <link:definition>2428402 - Disclosure - NET INCOME (LOSS) PER SHARE - Basic and Diluted Net Income Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetIncomeLossPerShareNarrativeDetails" roleURI="http://integralife.com/role/NetIncomeLossPerShareNarrativeDetails">
        <link:definition>2428403 - Disclosure - NET INCOME (LOSS) PER SHARE - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetIncomeLossPerShareTables" roleURI="http://integralife.com/role/NetIncomeLossPerShareTables">
        <link:definition>2328301 - Disclosure - NET INCOME (LOSS) PER SHARE (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RetirementPlans" roleURI="http://integralife.com/role/RetirementPlans">
        <link:definition>2124100 - Disclosure - RETIREMENT PLANS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RetirementPlansNarrativeDetails" roleURI="http://integralife.com/role/RetirementPlansNarrativeDetails">
        <link:definition>2424401 - Disclosure - RETIREMENT PLANS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenuesFromContractsWithCustomers" roleURI="http://integralife.com/role/RevenuesFromContractsWithCustomers">
        <link:definition>2111100 - Disclosure - REVENUES FROM CONTRACTS WITH CUSTOMERS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenuesFromContractsWithCustomersNarrativeDetails" roleURI="http://integralife.com/role/RevenuesFromContractsWithCustomersNarrativeDetails">
        <link:definition>2411402 - Disclosure - REVENUES FROM CONTRACTS WITH CUSTOMERS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenuesFromContractsWithCustomersNarrativeRevenueRemainingPerformanceObligationDetails" roleURI="http://integralife.com/role/RevenuesFromContractsWithCustomersNarrativeRevenueRemainingPerformanceObligationDetails">
        <link:definition>2411403 - Disclosure - REVENUES FROM CONTRACTS WITH CUSTOMERS - Narrative, Revenue Remaining Performance Obligation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenuesFromContractsWithCustomersScheduleOfChangesInContractAssetsAndLiabilitiesDetails" roleURI="http://integralife.com/role/RevenuesFromContractsWithCustomersScheduleOfChangesInContractAssetsAndLiabilitiesDetails">
        <link:definition>2411404 - Disclosure - REVENUES FROM CONTRACTS WITH CUSTOMERS - Schedule of Changes in Contract Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenuesFromContractsWithCustomersScheduleOfRevenuesDisaggregatedByMajorSourceDetails" roleURI="http://integralife.com/role/RevenuesFromContractsWithCustomersScheduleOfRevenuesDisaggregatedByMajorSourceDetails">
        <link:definition>2411405 - Disclosure - REVENUES FROM CONTRACTS WITH CUSTOMERS - Schedule of Revenues Disaggregated by Major Source (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenuesFromContractsWithCustomersTables" roleURI="http://integralife.com/role/RevenuesFromContractsWithCustomersTables">
        <link:definition>2311301 - Disclosure - REVENUES FROM CONTRACTS WITH CUSTOMERS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentAndGeographicInformation" roleURI="http://integralife.com/role/SegmentAndGeographicInformation">
        <link:definition>2130100 - Disclosure - SEGMENT AND GEOGRAPHIC INFORMATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentAndGeographicInformationNarrativeDetails" roleURI="http://integralife.com/role/SegmentAndGeographicInformationNarrativeDetails">
        <link:definition>2430402 - Disclosure - SEGMENT AND GEOGRAPHIC INFORMATION - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentAndGeographicInformationNetSalesAndProfitByReportableSegmentDetails" roleURI="http://integralife.com/role/SegmentAndGeographicInformationNetSalesAndProfitByReportableSegmentDetails">
        <link:definition>2430403 - Disclosure - SEGMENT AND GEOGRAPHIC INFORMATION - Net Sales and Profit by Reportable Segment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentAndGeographicInformationTables" roleURI="http://integralife.com/role/SegmentAndGeographicInformationTables">
        <link:definition>2330301 - Disclosure - SEGMENT AND GEOGRAPHIC INFORMATION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentAndGeographicInformationTotalRevenueByMajorGeographicAreaDetails" roleURI="http://integralife.com/role/SegmentAndGeographicInformationTotalRevenueByMajorGeographicAreaDetails">
        <link:definition>2430404 - Disclosure - SEGMENT AND GEOGRAPHIC INFORMATION - Total Revenue by Major Geographic Area (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensation" roleURI="http://integralife.com/role/StockBasedCompensation">
        <link:definition>2123100 - Disclosure - STOCK-BASED COMPENSATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationNarrativeDetails" roleURI="http://integralife.com/role/StockBasedCompensationNarrativeDetails">
        <link:definition>2423401 - Disclosure - STOCK-BASED COMPENSATION - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="TreasuryStock" roleURI="http://integralife.com/role/TreasuryStock">
        <link:definition>2126100 - Disclosure - TREASURY STOCK</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="TreasuryStockNarrativeDetails" roleURI="http://integralife.com/role/TreasuryStockNarrativeDetails">
        <link:definition>2426401 - Disclosure - TREASURY STOCK - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:element id="iart_AcceleratedShareRepurchasesPercentageOfExpectedTotalRepurchased" name="AcceleratedShareRepurchasesPercentageOfExpectedTotalRepurchased" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_AccruedExpensesAndOtherCurrentLiabilitiesMember" name="AccruedExpensesAndOtherCurrentLiabilitiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_AcquiredFinitelivedIntangibleAssetsDiscountRate" name="AcquiredFinitelivedIntangibleAssetsDiscountRate" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant" />
  <xsd:element id="iart_AdditionalEPSShares" name="AdditionalEPSShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="iart_AllOtherMember" name="AllOtherMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_AmortizationOfDebtIssuanceCostsAndDebtRefinancedFees" name="AmortizationOfDebtIssuanceCostsAndDebtRefinancedFees" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="iart_AnnualRateOfLeaseAgreement" name="AnnualRateOfLeaseAgreement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_ArkisBioSciencesInc.Member" name="ArkisBioSciencesInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet" name="AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_AssetAcquisitionAxis" name="AssetAcquisitionAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_AssetAcquisitionConsiderationTransferred" name="AssetAcquisitionConsiderationTransferred" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="iart_AssetAcquisitionDevelopmentMilestonePaymentToBePaid" name="AssetAcquisitionDevelopmentMilestonePaymentToBePaid" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="iart_AssetAcquisitionDomain" name="AssetAcquisitionDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_AssetAcquisitionMaximumContingentDevelopmentMilestonePaymentsIfCircumstancesMet" name="AssetAcquisitionMaximumContingentDevelopmentMilestonePaymentsIfCircumstancesMet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="iart_AssetAcquisitionMaximumFutureConsiderationTransferredIfCircumstancesMet" name="AssetAcquisitionMaximumFutureConsiderationTransferredIfCircumstancesMet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="iart_AssetAcquisitionNumberOfAssetsAcquired" name="AssetAcquisitionNumberOfAssetsAcquired" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="iart_AssetAcquisitionOptionToAcquirePeriodSubsequentToCommercialSaleIfCircumstancesMet" name="AssetAcquisitionOptionToAcquirePeriodSubsequentToCommercialSaleIfCircumstancesMet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_AssetsAndLiabilitiesLesseeTableTextBlock" name="AssetsAndLiabilitiesLesseeTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_BioDEarnoutPaymentsandMedihoneyEarnoutPaymentsMember" name="BioDEarnoutPaymentsandMedihoneyEarnoutPaymentsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_BusinessCombinationAndAssetAcquisitionDisclosureTextBlock" name="BusinessCombinationAndAssetAcquisitionDisclosureTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_BusinessCombinationContingentConsiderationNumberOfLiabilities" name="BusinessCombinationContingentConsiderationNumberOfLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayableAccruedExpensesAndOtherLiabilities" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayableAccruedExpensesAndOtherLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="iart_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedAssetsAcquiredIncludingGoodwill" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedAssetsAcquiredIncludingGoodwill" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="iart_CashFlowLesseeAbstract" name="CashFlowLesseeAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_CashFlowLesseeTableTextBlock" name="CashFlowLesseeTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_CertainPurchasersMember" name="CertainPurchasersMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_ChangeInContractWithCustomerAssetRollForward" name="ChangeInContractWithCustomerAssetRollForward" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_ChangeInContractWithCustomerLiabilityRollForward" name="ChangeInContractWithCustomerLiabilityRollForward" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_ChangesInAssetsAndLiabilitiesAbstract" name="ChangesInAssetsAndLiabilitiesAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_CodmanMember" name="CodmanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_CodmanSpecialtySurgicalMember" name="CodmanSpecialtySurgicalMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_CompletedTechnologyMember" name="CompletedTechnologyMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_ContingentConsiderationLiabilityMember" name="ContingentConsiderationLiabilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_ContractWithCustomerAssetNetOfReclassifiedToReceivable" name="ContractWithCustomerAssetNetOfReclassifiedToReceivable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="iart_ContractWithCustomerLiabilityIncreaseFromForeignCurrencyTranslation" name="ContractWithCustomerLiabilityIncreaseFromForeignCurrencyTranslation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="iart_ContractWithCustomerLiabilityTransferFromLongTermToShortTerm" name="ContractWithCustomerLiabilityTransferFromLongTermToShortTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="iart_CostOfDefiniteAndIndefiniteLivedIntangibleAssetsGrossExcludingGoodwill" name="CostOfDefiniteAndIndefiniteLivedIntangibleAssetsGrossExcludingGoodwill" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="iart_CrossCurrencyInterestRateContractFiveMember" name="CrossCurrencyInterestRateContractFiveMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_CrossCurrencyInterestRateContractFourMember" name="CrossCurrencyInterestRateContractFourMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_CrossCurrencyInterestRateContractOneMember" name="CrossCurrencyInterestRateContractOneMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_CrossCurrencyInterestRateContractThreeMember" name="CrossCurrencyInterestRateContractThreeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_CrossCurrencyInterestRateContractTwoMember" name="CrossCurrencyInterestRateContractTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_DebtAccountsReceivableSecuritizationTerm" name="DebtAccountsReceivableSecuritizationTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_DebtCovenantPeriod1Member" name="DebtCovenantPeriod1Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_DebtCovenantPeriod2Member" name="DebtCovenantPeriod2Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_DebtCovenantPeriod3Member" name="DebtCovenantPeriod3Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_DebtCovenantPeriod4Member" name="DebtCovenantPeriod4Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_DebtCovenantPeriodAxis" name="DebtCovenantPeriodAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_DebtCovenantPeriodDomain" name="DebtCovenantPeriodDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_DebtInstrumentCovenantMaximumLeverageRatio" name="DebtInstrumentCovenantMaximumLeverageRatio" nillable="true" substitutionGroup="xbrli:item" type="xbrli:pureItemType" xbrli:periodType="instant" />
  <xsd:element id="iart_DebtInstrumentMaximumAverageConversionValueOfNotes" name="DebtInstrumentMaximumAverageConversionValueOfNotes" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_DebtInstrumentMaximumSellingPriceOfCommonStockOfTheConversionPriceDuringPeriod" name="DebtInstrumentMaximumSellingPriceOfCommonStockOfTheConversionPriceDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_DebtWeightedAverageInterestRateFromSecuritization" name="DebtWeightedAverageInterestRateFromSecuritization" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="iart_DeferredTaxAssetMember" name="DeferredTaxAssetMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_DefinedBenefitPlanDeferPaymentAndTaxationBaseSalaryPercentage" name="DefinedBenefitPlanDeferPaymentAndTaxationBaseSalaryPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_DefinedBenefitPlanDeferPaymentAndTaxationBonusAndOtherCompensationPercentage" name="DefinedBenefitPlanDeferPaymentAndTaxationBonusAndOtherCompensationPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_DefiniteAndIndefiniteLivedIntangibleAssetsNetExcludingGoodwill" name="DefiniteAndIndefiniteLivedIntangibleAssetsNetExcludingGoodwill" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="iart_DermaSciencesMember" name="DermaSciencesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_DirectorsandCertainExecutiveOfficersMember" name="DirectorsandCertainExecutiveOfficersMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_EffectiveIncomeTaxRateReconciliationTaxHolidayPerShare" name="EffectiveIncomeTaxRateReconciliationTaxHolidayPerShare" nillable="true" substitutionGroup="xbrli:item" type="num:perShareItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_EmployeeMember" name="EmployeeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_ExtremityOrthopedicsMember" name="ExtremityOrthopedicsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_FiveYearOptionLeaseFromNovember12032ThroughOctober312037Member" name="FiveYearOptionLeaseFromNovember12032ThroughOctober312037Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_FiveYearOptionLeaseFromNovember12037ThroughOctober312042Member" name="FiveYearOptionLeaseFromNovember12037ThroughOctober312042Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InstrumentsMember" name="InstrumentsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_IntegratedShoulderCollaborationInc.Member" name="IntegratedShoulderCollaborationInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InterestRateSwapDesignatedDecember132017Tranche1Member" name="InterestRateSwapDesignatedDecember132017Tranche1Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InterestRateSwapDesignatedDecember132017Tranche2Member" name="InterestRateSwapDesignatedDecember132017Tranche2Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InterestRateSwapDesignatedDecember132017Tranche3Member" name="InterestRateSwapDesignatedDecember132017Tranche3Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InterestRateSwapDesignatedDecember132017Tranche4Member" name="InterestRateSwapDesignatedDecember132017Tranche4Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InterestRateSwapDesignatedDecember132017Tranche5Member" name="InterestRateSwapDesignatedDecember132017Tranche5Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InterestRateSwapDesignatedDecember182018Tranche1Member" name="InterestRateSwapDesignatedDecember182018Tranche1Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InterestRateSwapDesignatedDecember182018Tranche2Member" name="InterestRateSwapDesignatedDecember182018Tranche2Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InterestRateSwapDesignatedFebruary62017Tranche1Member" name="InterestRateSwapDesignatedFebruary62017Tranche1Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InterestRateSwapDesignatedFebruary62017Tranche2Member" name="InterestRateSwapDesignatedFebruary62017Tranche2Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InterestRateSwapDesignatedMarch272017Member" name="InterestRateSwapDesignatedMarch272017Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InterestRateSwapDesignatedOctober102018Tranche1Member" name="InterestRateSwapDesignatedOctober102018Tranche1Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InterestRateSwapDesignatedOctober102018Tranche2Member" name="InterestRateSwapDesignatedOctober102018Tranche2Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_InterestRateSwapDesignatedOctober102018Tranche3Member" name="InterestRateSwapDesignatedOctober102018Tranche3Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour" name="LesseeOperatingLeaseLiabilityToBePaidAfterYearFour" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="iart_LesseeOperatingLeaseNumberOfRenewalOptions" name="LesseeOperatingLeaseNumberOfRenewalOptions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_MilestonePaymentOneMember" name="MilestonePaymentOneMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_MilestonePaymentTwoMember" name="MilestonePaymentTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_NeurosurgeryMember" name="NeurosurgeryMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_NoncashOrPartNoncashLeaseExpense" name="NoncashOrPartNoncashLeaseExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_OneMonthEurodollarRateMember" name="OneMonthEurodollarRateMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_OneMonthUSDLIBORMember" name="OneMonthUSDLIBORMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_OptionToExtendLeaseYears" name="OptionToExtendLeaseYears" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_OrthopedicsandTissueTechnologiesMember" name="OrthopedicsandTissueTechnologiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_PaymentsForOptionIndexToIssuersEquity" name="PaymentsForOptionIndexToIssuersEquity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="iart_PercentOfManufacturingFacilityOwnedByCorporationWhoseShareholdersAreTrustsWhoseBeneficiariesIncludeFamilyMembersOfCompanysFormerDirector" name="PercentOfManufacturingFacilityOwnedByCorporationWhoseShareholdersAreTrustsWhoseBeneficiariesIncludeFamilyMembersOfCompanysFormerDirector" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_PerformanceSharesandRestrictedUnitsMember" name="PerformanceSharesandRestrictedUnitsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_PerformanceStockAndRestrictedStockAwardsMember" name="PerformanceStockAndRestrictedStockAwardsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_PrivateLabelMember" name="PrivateLabelMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_ReboundTherapeuticsCorporationMember" name="ReboundTherapeuticsCorporationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_RegenerativeSkinAndWoundMember" name="RegenerativeSkinAndWoundMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_RelatedPartiesMember" name="RelatedPartiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_RestOfWorldMember" name="RestOfWorldMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_ReturnPolicyIssueOfCreditNumberOfDaysFromShipment" name="ReturnPolicyIssueOfCreditNumberOfDaysFromShipment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_RevenueFromContractWithCustomerProductsShippedWithNoAlternativeUseAndRightOfPaymentForPerformanceManufacturingPeriod" name="RevenueFromContractWithCustomerProductsShippedWithNoAlternativeUseAndRightOfPaymentForPerformanceManufacturingPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_RevenueProductWarrantyPeriod" name="RevenueProductWarrantyPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_RightOfUseAssetObtainedInExchangeForLeaseLiabilityAbstract" name="RightOfUseAssetObtainedInExchangeForLeaseLiabilityAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_ScheduleOfAssetAcquisitionLineItems" name="ScheduleOfAssetAcquisitionLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_ScheduleOfAssetAcquisitionTable" name="ScheduleOfAssetAcquisitionTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_SecuredLongTermDebtSecuritizationProgramNoncurrent" name="SecuredLongTermDebtSecuritizationProgramNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="iart_SecuritizationFacilityFairValueOfAmountOutstanding" name="SecuritizationFacilityFairValueOfAmountOutstanding" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="iart_SegmentReportingInformationNumberOfProductsOffered" name="SegmentReportingInformationNumberOfProductsOffered" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_SeniorCreditFacilityMember" name="SeniorCreditFacilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPlans" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPlans" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_SupplierRelationShipsMember" name="SupplierRelationShipsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_SwapOneMember" name="SwapOneMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_SwapThreeMember" name="SwapThreeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_SwapTwoMember" name="SwapTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_SwinglineLoanMember" name="SwinglineLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_TermLoanFacilityMember" name="TermLoanFacilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_ThirdPartiesMember" name="ThirdPartiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_ThreeMonthUSDLIBORMember" name="ThreeMonthUSDLIBORMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="iart_TrademarksBrandNamesMember" name="TrademarksBrandNamesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="iart_TransferorsInterestsInTransferredFinancialAssetsMaximumInvestmentLimit" name="TransferorsInterestsInTransferredFinancialAssetsMaximumInvestmentLimit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="iart_TwoThousandTwentyFiveSeniorConvertibleNotesMember" name="TwoThousandTwentyFiveSeniorConvertibleNotesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
</xsd:schema>
