PLAINSBORO, N.J., Oct. 19, 2004 (PRIMEZONE) -- Integra LifeSciences Holdings Corporation (Nasdaq:IART) today announced plans to market and sell the MAYFIELD® Infinity Support System in the United States through its Integra NeuroSciences™ sales force. The new MAYFIELD Infinity Support System is a head support system that provides a unique method for simultaneous application of a head support (adult, pediatric, or general purpose) and a skull clamp (ages 5+) during delicate neurosurgical procedures requiring both devices. The Integra NeuroSciences direct sales force will market and sell the MAYFIELD Infinity Support System to neurosurgeons who specialize in neuro-trauma and pediatric neurosurgery.

The MAYFIELD Infinity Support System is the first system designed for the application of both head support and a skull clamp. It was created for use with patients who cannot safely withstand the clamping forces exerted on the head by a skull clamp alone. It is an adjunct to the MAYFIELD® Skull Clamp Systems already used by hospitals performing neurosurgical procedures. The new system supports the static weight of the head on a horseshoe or general-purpose headrest, while allowing for the simultaneous application of a skull clamp (ages 5+) to prevent movement during surgical procedures. This is especially important for young patients (ages 5+) without solid cranial sutures and trauma patients who may have sustained fractures.

"We designed the MAYFIELD Infinity Support System after consultation with many neurosurgeons in the United States," said Jim McCafferty, Vice President of Marketing for the MAYFIELD® product line. "This system provides an example of our ability to continually advance the MAYFIELD product line, which has been used by neurosurgeons for over thirty years, to meet patient care needs."

The MAYFIELD Infinity System is comprised of a coupler, which connects the system to the MAYFIELD® base unit, two horseshoe headrests (adult and pediatric sizes), and a general purpose headrest with interchangeable mini gel pads. The system features numerous adjustment mechanisms that neurosurgeons can use to position the patient's head as desired, including controls for vertical and lateral adjustments, and a ball and socket mechanism to enable a tilt in any axis.

The MAYFIELD product line is highly regarded for enhancing surgeon effectiveness and patient safety and leads the market in intraoperative cranial stabilization, which we estimate to be a $20 million market worldwide. Integra LifeSciences Corporation acquired the MAYFIELD product line in May 2004.

Integra LifeSciences Holdings Corporation is a diversified medical technology company that develops, manufactures, and markets medical devices for use in a variety of applications. The primary applications for our products are neuro-trauma and neurosurgery, plastic and reconstructive surgery and general surgery. Integra is a leader in applying the principles of biotechnology to medical devices that improve patients' quality of life. Our corporate headquarters are in Plainsboro, New Jersey, and we have manufacturing and research facilities located throughout the world. We have approximately 1,200 employees. Please visit our website at (http://www.Integra-LS.com).

This news release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements concerning the future use of the MAYFIELD Infinity Support System. Such forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from predicted or expected results. Among other things, physicians' willingness to use this system may affect the prospects for its use in clinical procedures. In addition, the economic, competitive, governmental, technological and other factors identified under the heading "Factors That May Affect Our Future Performance" included in the Business section of Integra's Annual Report on Form 10-K for the year ended December 31, 2003 and information contained in subsequent filings with the Securities and Exchange Commission could affect actual results.

"MAYFIELD" is a registered trademark of SM USA, Inc., a wholly owned subsidiary of Schaerer Mayfield USA, Inc.

CONTACT:
Integra LifeSciences Holdings Corporation
John B. Henneman, III
Executive Vice President
Chief Administrative Officer
(609) 936-2481
jhenneman@Integra-LS.com

Maria Platsis
Director of Corporate Development and Investor Relations
(609) 936-2333
mplatsis@Integra-LS.com